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physiological aspects (169) 169
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glucose metabolism (157) 157
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genetics & heredity (148) 148
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abridged index medicus (135) 135
phosphoenolpyruvate carboxykinase - genetics (128) 128
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rna, messenger - metabolism (125) 125
cell biology (121) 121
molecular sequence data (121) 121
phosphoenolpyruvate carboxykinase - metabolism (121) 121
phosphorylation (121) 121
genetic aspects (120) 120
phosphatases (120) 120
mice, knockout (114) 114
enzymes (113) 113
insulin - blood (112) 112
gene-expression (111) 111
rodents (110) 110
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phosphoenolpyruvate carboxykinase (83) 83
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insulin - pharmacology (75) 75
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amino acid sequence (74) 74
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hypoglycemic agents - pharmacology (67) 67
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PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, pp. e67665 - e67665
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2016, Volume 126, Issue 11, pp. 4372 - 4386
Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant.... 
RAT-LIVER | MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | DE-NOVO LIPOGENESIS | TRANSCRIPTION FACTOR FOXO1 | FATTY LIVER-DISEASE | OB/OB MICE | ELEMENT-BINDING PROTEIN | HEPATIC STEATOSIS | ADIPOSE-TISSUE | PLASMA TRIGLYCERIDES | Glucose Intolerance - metabolism | Glucose-6-Phosphatase - genetics | Fatty Liver - pathology | Humans | Male | Glucose - biosynthesis | Glucose Intolerance - pathology | Fatty Liver - chemically induced | Glycolysis - drug effects | Glycolysis - genetics | Lipogenesis - genetics | Female | Glucose Intolerance - chemically induced | Insulin - genetics | Nuclear Proteins - genetics | Fatty Liver - genetics | Forkhead Box Protein O1 - metabolism | Glucose Intolerance - genetics | Fatty Liver - metabolism | Fructose - toxicity | Insulin Resistance | Glucose - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | Glucose-6-Phosphatase - metabolism | Mice, Knockout | Transcription Factors - metabolism | Insulin - metabolism | Animals | Signal Transduction - drug effects | Lipogenesis - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Forkhead Box Protein O1 - genetics | Obesity | Analysis | Insulin resistance | Genetic aspects | Genetic transcription | Research | Risk factors | Protein binding | Glucose | Metabolites | Rodents | Liver | Index Medicus | Abridged Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 06/2011, Volume 60, Issue 6, pp. 1805 - 1812
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 7, pp. e11428 - e11428
Journal Article
by Wessel, Jennifer and Chu, Auey Y and Willems, Sara and Wang, Shuai and Yaghootkar, Hanieh and Brody, Jennifer and Dauriz, Marco and Hivert, Marie-France and Raghavan, Sridharan and Lipovich, Leonard and Hidalgo, Bertha and Fox, Keolu and Huffman, Jennifer and An, Ping and Lu, Yingchang and Rasmussen-Torvik, Laura and Grarup, Niels and Ehm, Margaret G and Li, Li and Balidge, Abigail S and Stancáková, Alena and Abrol, Ravinder and Besse, Céline and Boland, Anne and Bork-Jensen, Jette and Fornage, Myriam and Freitag, Christine and Garcia, Melissa and Guo, Xiuqing and Hara, Kazuo and Isaacs, Aaron and Jakobsdottir, Margret and Lange, Leslie and Layton, Jill C and Li, Man and Zhao, Jing Hua and Meidtner, Karina and Morrison, Alanna and Nalls, Michael and Peters, Marjolein and Sabater-Lleal, Maria and Schurmann, Claudia and Silveira, Angela and Smith, G.D and Southam, Lorraine and Stoiber, Marcus H and Strawbridge, Rona and Taylor, Kent and Varga, Tibor V and Allin, Kristine H and Amin, Najaf and Aponte, Jennifer L and Aung, Tin and Barbieri, Caterina and Bihlmeyer, Nathan A and Boehnke, Michael and Bombieri, Cristina and Bowden, Donald and Burns, Sean M and Chen, Yuning and Chen, Yii-Deri and Cheng, Ching-Yu and Correa, D.D and Czajkowski, Jacek and Dehghan, Abbas and Ehret, Georg and Eiriksdottir, Gudny and Escher, Stefan A and Farmaki, Aliki-Eleni and Frånberg, Mattias and Gambaro, Giovanni and Giulianini, Franco and Goddard, William A and Goel, Anuj and Gottesman, Rebecca and Grove, Megan and Gustafsson, Stefan and Hai, Yang and Hallmans, Göran and Heo, Jiyoung and Hoffmann, Per and Ikram, Kamran and Jensen, Richard and Jørgensen, Marit and Jorgensen, Torben and Karaleftheri, Maria and Khor, C.C and Kirkpatrick, Anea and Kraja, Aldi and Kuusisto, Johanna and Lange, Ethan and Lee, I.T and Lee, Wen-Jane and Leong, Aaron and Liao, Jie and Liu, Chunyu and Liu, Yongmei and Lindgren, Cecilia and Linneberg, Allan and Malerba, Giovanni and ... and The EPIC-InterAct Consortium and EPIC-InterAct Consortium and Numerisk analys och datalogi (NADA) and Naturvetenskapliga fakulteten and Stockholms universitet and Science for Life Laboratory (SciLifeLab)
Nature Communications, ISSN 2041-1723, 01/2015, Volume 6, Issue 1, pp. 5897 - 5897
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2010, Volume 120, Issue 7, pp. 2355 - 2369
Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPIRATORY-CHAIN | SKELETAL-MUSCLE | PHOSPHOENOLPYRUVATE CARBOXYKINASE | ACTIVATED PROTEIN-KINASE | GLUCOKINASE TRANSLOCATION | GLUCOSE-METABOLISM | COACTIVATOR TORC2 | AICA RIBOSIDE | UPSTREAM KINASE | ISOLATED RAT HEPATOCYTES | Glucose-6-Phosphatase - genetics | Hypoglycemic Agents - metabolism | Diabetes Mellitus, Type 2 - genetics | Gluconeogenesis - drug effects | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Metformin - metabolism | AMP-Activated Protein Kinases | Hyperglycemia - genetics | Liver - drug effects | Protein-Serine-Threonine Kinases - metabolism | Liver - metabolism | Metformin - pharmacology | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Glucose - genetics | Glucose - pharmacology | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Mice, Knockout | Hyperglycemia - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Up-Regulation - drug effects | Animals | Gluconeogenesis - genetics | Glucose-6-Phosphatase - biosynthesis | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Glucose - metabolism | Mice | Protein-Serine-Threonine Kinases - pharmacology | Type 2 diabetes | Control | Usage | Genetic aspects | Research | Metformin | Gene expression | Drug therapy | Health aspects | Gluconeogenesis | Index Medicus | Abridged Index Medicus | Up-Regulation | Glucose-6-Phosphatase | gluconeogenesis, animal models | Liver | Protein-Serine-Threonine Kinases | Glucose | LKB1 | Life Sciences | Hypoglycemic Agents | Phosphoenolpyruvate Carboxykinase (ATP) | Human health and pathology | Hyperglycemia | Hepatocytes | AMPK | Endocrinology and metabolism | Diabetes Mellitus, Type 2
Journal Article
by Horikoshi, Momoko and Mӓgi, Reedik and Bunt, Martijn and Surakka, Ida and Sarin, A.-P and Mahajan, Anubha and Marullo, Letizia and Thorleifsson, Gudmar and Hӓgg, Sara and Hottenga, Jouke Jan and Ladenvall, Claes and Ried, Janina and Winkler, Thomas W and Willems, Sara and Pervjakova, Natalia and Esko, Tõnu and Beekman, Marian and Nelson, Christopher P and Willenborg, Christina and Wiltshire, Steven and Ferreira, Teresa and Fernandez, Juan and Gaulton, Kyle and Steinthorsdottir, Valgerdur and Hamsten, Anders and Magnusson, Patrik K. E and Willemsen, Gonneke and Milaneschi, Yuri and Robertson, Neil R and Groves, Christopher and Bennett, Amanda and Lehtimӓki, Terho and Viikari, Jorma and Rung, Johan and Lyssenko, Valeriya and Perola, Markus and Heid, Iris and Herder, Christian and Grallert, Harald and Müller-Nurasyid, Martina and Roden, Michael and Hypponen, Elina and Isaacs, Aaron and Leeuwen, Elisa and Karssen, Lennart and Mihailov, Evelin and Houwing-Duistermaat, Jeanine and De Craen, Anton J. M and Deelen, Joris and Havulinna, Aki and Blades, Matthew and Hengstenberg, Christian and Erdmann, Jeanette and Schunkert, Heribert and Kaprio, Jaakko and Tobin, Martin and Samani, Nilesh and Lind, Lars and Salomaa, Veikko and Lindgren, Cecilia M and Slagboom, Eline and Metspalu, Anes and Duijn, Cornelia and Eriksson, Johan G and Peters, Annette and Gieger, Christian and Jula, Antti and Groop, Leif and Raitakari, Olli T and Power, Christopher and Penninx, Brenda and Geus, Eco and Smit, Johannes H and Boomsma, Dorret and Pedersen, Nancy L and Ingelsson, Erik and Thorsteinsdottir, Unnur and Zwart, John-Anker and Ripatti, Samuli and Prokopenko, Inga and McCarthy, Mark and Morris, Anew and Engage Consortium and ENGAGE Consortium and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Kardiovaskulär epidemiologi and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi
PL o S Genetics (Online), ISSN 1553-7390, 01/2015, Volume 11, Issue 7, pp. e1005230 - e1005230
Journal Article
by Mahajan, Anubha and Sim, Xueling and Ng, Hui Jin and Manning, Alisa and Rivas, Manuel A and Highland, Heather M and Locke, Adam E and Grarup, Niels and Im, Hae Kyung and Cingolani, Pablo and Flannick, Jason and Fontanillas, Pierre and Fuchsberger, Christian and Gaulton, Kyle J and Teslovich, Tanya M and Rayner, N. William and Robertson, Neil R and Beer, Nicola L and Rundle, Jana K and Bork-Jensen, Jette and Ladenvall, Claes and Blancher, Christine and Buck, David and Buck, Gemma and Burtt, Noël P and Gabriel, Stacey and Gjesing, Anette P and Groves, Christopher J and Hollensted, Mette and Huyghe, Jeroen R and Jackson, Anne U and Jun, Goo and Justesen, Johanne Marie and Mangino, Massimo and Murphy, Jacquelyn and Neville, Matt and Onofrio, Robert and Small, Kerrin S and Stringham, Heather M and Syvänen, Ann-Christine and Trakalo, Joseph and Abecasis, Goncalo and Bell, Graeme I and Blangero, John and Cox, Nancy J and Duggirala, Ravindranath and Hanis, Craig L and Seielstad, Mark and Wilson, James G and Christensen, Cramer and Brandslund, Ivan and Rauramaa, Rainer and Surdulescu, Gabriela L and Doney, Alex S. F and Lannfelt, Lars and Linneberg, Allan and Isomaa, Bo and Tuomi, Tiinamaija and Jørgensen, Marit E and Jørgensen, Torben and Kuusisto, Johanna and Uusitupa, Matti and Salomaa, Veikko and Spector, Timothy D and Morris, Andrew D and Palmer, Colin N. A and Collins, Francis S and Mohlke, Karen L and Bergman, Richard N and Ingelsson, Erik and Lind, Lars and Tuomilehto, Jaakko and Hansen, Torben and Watanabe, Richard M and Prokopenko, Inga and Dupuis, Josee and Karpe, Fredrik and Groop, Leif and Laakso, Markku and Pedersen, Oluf and Florez, Jose C and Morris, Andrew P and Altshuler, David and Meigs, James B and Boehnke, Michael and McCarthy, Mark I and Lindgren, Cecilia M and Gloyn, Anna L and Abboud, Hanna E and Afzal, Uzma and Aguilar, David and Arya, Rector and Atzmon, Gil and Aung, Tin and Banks, Eric and Barroso, Inês and Barzilai, Nir and Below, Jennifer E and Bharadwaj, Dwaipayan and Blackwell, Thomas W and ... and Go T2D Consortium and T2D-GENES Consortium and T2D-GENES consortium and GoT2D consortium and On Behalf of the T2D-GENES consortium and GoT2D consortium and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Molekylär medicin and Geriatrik and Kardiovaskulär epidemiologi and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi and Institutionen för folkhälso- och vårdvetenskap
PLoS Genetics, ISSN 1553-7390, 01/2015, Volume 11, Issue 1, pp. e1004876 - e1004876
Journal Article