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Diabetes (New York, N.Y.), ISSN 1939-327X, 05/2016, Volume 65, Issue 5, pp. 1190 - 1195
Pharmacologically induced glycosuria elicits adaptive responses in glucose homeostasis and hormone release. In type 2 diabetes (T2D), along with decrements in... 
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Glucose Intolerance - metabolism | Glycosuria - chemically induced | Carbohydrate Metabolism - drug effects | Lipolysis - drug effects | Benzhydryl Compounds - administration & dosage | Humans | Glucagon-Like Peptide 1 - blood | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Glucagon - blood | Glucose Intolerance - blood | Glucose Intolerance - drug therapy | Benzhydryl Compounds - adverse effects | Hypoglycemic Agents - administration & dosage | Time Factors | Glucosides - therapeutic use | C-Reactive Protein - analysis | Benzhydryl Compounds - therapeutic use | Insulin Secretion | Glucosides - adverse effects | Hypoglycemic Agents - therapeutic use | 3-Hydroxybutyric Acid - blood | Sodium-Glucose Transporter 2 - metabolism | Glucose Intolerance - urine | 3-Hydroxybutyric Acid - agonists | Renal Elimination - drug effects | Sodium-Glucose Transporter 2 Inhibitors | Membrane Transport Modulators - administration & dosage | Diabetes Mellitus, Type 2 - urine | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Algorithms | Glucosides - administration & dosage | 3-Hydroxybutyric Acid - metabolism | Lipid Metabolism - drug effects | Membrane Transport Modulators - therapeutic use | Glucagon - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Membrane Transport Modulators - adverse effects | Hypoglycemic Agents - adverse effects | Energy Metabolism - drug effects | Type 2 diabetes | Care and treatment | Glucagon | Dosage and administration | Triglycerides | Research | Insulin | Index Medicus | Abridged Index Medicus
Journal Article
Nutrition, Metabolism and Cardiovascular Diseases, ISSN 0939-4753, 2013, Volume 23, Issue 11, pp. 1086 - 1092
Abstract Background and aims Resveratrol, the most investigated dietary compound in studies aimed at linking wine consumption to human health, is an extremely... 
Cardiovascular | Phytoestrogen | Red wine | Resveratrol metabolism | Resveratrol | Cardiac & Cardiovascular Systems | Endocrinology & Metabolism | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Nutrition & Dietetics | Science & Technology | Nuclear Receptor Coactivator 2 - agonists | Humans | Neoplasm Proteins - antagonists & inhibitors | Stilbenes - chemistry | Stilbenes - pharmacology | Estrogen Receptor beta - metabolism | Adenocarcinoma - metabolism | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - genetics | Glucuronides - metabolism | Glucuronides - pharmacology | MCF-7 Cells | Sulfates - chemistry | Estrogen Antagonists - chemistry | Glucosides - chemistry | Antineoplastic Agents, Phytogenic - metabolism | Clone Cells | Neoplasm Proteins - genetics | Binding Sites | Estrogen Receptor beta - antagonists & inhibitors | Peptide Fragments - genetics | Phytoestrogens - pharmacology | Glucuronides - chemistry | Recombinant Proteins - chemistry | Estrogen Receptor alpha - antagonists & inhibitors | Sulfates - pharmacology | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Glucosides - metabolism | Estrogen Receptor alpha - genetics | Peptide Fragments - agonists | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Phytoestrogens - metabolism | Stereoisomerism | Phytoestrogens - chemistry | Estrogen Antagonists - pharmacology | Stilbenes - metabolism | Nuclear Receptor Coactivator 2 - metabolism | Neoplasm Proteins - metabolism | Breast Neoplasms - metabolism | Estrogen Receptor beta - agonists | Estrogen Receptor alpha - metabolism | Female | Recombinant Proteins - metabolism | Glucosides - pharmacology | Peptide Fragments - metabolism | Sulfates - metabolism | Antineoplastic Agents, Phytogenic - chemistry | Estrogen Antagonists - metabolism | Nuclear Receptor Coactivator 2 - antagonists & inhibitors | Neoplasm Proteins - agonists | Antineoplastic Agents, Phytogenic - pharmacology | Nuclear Receptor Coactivator 2 - genetics | Metabolites | Beverages | Index Medicus
Journal Article
The Plant journal : for cell and molecular biology, ISSN 0960-7412, 10/2011, Volume 68, Issue 2, pp. 273 - 286
Summary Cyanogenic glucosides are amino acid‐derived defence compounds found in a large number of vascular plants. Their hydrolysis by specific β‐glucosidases... 
Sorghum bicolor | cytochrome P450 | Lotus japonicus | Manihot esculenta | gene clustering | cyanogenic glucosides | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Sorghum - enzymology | Multigene Family | DNA, Complementary - genetics | Cytochrome P-450 Enzyme System - metabolism | Manihot - enzymology | Phylogeny | Glucosyltransferases - metabolism | Glucosides - genetics | Gene Expression Regulation, Plant | Glucosides - chemistry | Molecular Structure | Plant Proteins - metabolism | Sorghum - genetics | Plant Leaves - enzymology | Glycosides - chemistry | Glucosyltransferases - genetics | Manihot - metabolism | Nitriles - metabolism | Genome, Plant - genetics | Tobacco - metabolism | Loteae - metabolism | Manihot - genetics | Sorghum - metabolism | RNA, Plant - genetics | Glucosides - metabolism | Biological Evolution | Gene Expression Regulation, Enzymologic | Hydrogen Cyanide - metabolism | Plant Proteins - genetics | Plant Leaves - genetics | Plant Leaves - metabolism | Glycosides - metabolism | Tobacco - genetics | Nitriles - chemistry | Cytochrome P-450 Enzyme System - genetics | Loteae - enzymology | Glucosides - biosynthesis | Mutation | Loteae - genetics | Hydrolysis | Legumes | Enzymes | Beans | Genes | Genetic research | Physiological aspects | Nitriles | Mimosaceae | Plant biology | Biosynthesis | Genomics | Plant resistance | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e54442 - e54442
Sodium/glucose cotransporter 2 (SGLT2) inhibitors are oral hypoglycemic agents used to treat patients with diabetes mellitus. SGLT2 inhibitors block... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Diabetes Mellitus - pathology | Epithelial Cells - metabolism | Gene Expression - drug effects | Diabetes Mellitus - genetics | Transcription Factor AP-1 - genetics | Epithelial Cells - drug effects | Humans | Diabetic Nephropathies - drug therapy | NF-kappa B - metabolism | Smad3 Protein - metabolism | Transcription Factor AP-1 - metabolism | Sodium-Glucose Transporter 1 - genetics | Smad3 Protein - genetics | Sodium-Glucose Transporter 1 - metabolism | Phosphorylation - drug effects | Interleukin-6 - metabolism | Transforming Growth Factor beta1 - pharmacology | Sodium-Glucose Transporter 2 - genetics | Collagen Type IV - metabolism | Sodium-Glucose Transporter 1 - antagonists & inhibitors | Promoter Regions, Genetic | Diabetic Nephropathies - pathology | Glucosides - pharmacology | Kidney Tubules, Proximal - pathology | Interleukin-6 - genetics | Sodium-Glucose Transporter 2 - metabolism | Diabetic Nephropathies - metabolism | Diabetes Mellitus - drug therapy | Diabetes Mellitus - metabolism | Toll-Like Receptor 4 - genetics | Diabetic Nephropathies - genetics | Epithelial Cells - pathology | Glucose - pharmacology | Toll-Like Receptor 4 - metabolism | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | NF-kappa B - genetics | Kidney Tubules, Proximal - metabolism | Collagen Type IV - genetics | Protein Binding | Benzhydryl Compounds - pharmacology | Kidney Tubules, Proximal - drug effects | Physiological aspects | Care and treatment | Genetic aspects | Research | Transforming growth factors | Diabetic nephropathies | Chromatin | Immunoprecipitation | Transforming growth factor-b | Interleukin | Clinical trials | Systematic review | Smad3 protein | Glucose | Kinases | Interleukin 6 | Proteins | Hyperglycemia | Rodents | Toll-like receptors | Collagen (type IV) | Hypoglycemic agents | Inhibition | Growth factors | Deoxyribonucleic acid--DNA | Immune system | Binding | Glucose transporter | Medical research | NF-κB protein | Diabetes mellitus | Markers | Activator protein 1 | Blocking | Reabsorption | Inflammation | Gene expression | Glucose transport | Medicine | High mobility group proteins | Hospitals | Inhibitors | Nephropathy | Sodium | Fibrosis | Kidney diseases | Diabetes | Transporter | Adenosine triphosphatase | Kidney transplantation | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
BMC plant biology, ISSN 1471-2229, 09/2012, Volume 12, Issue 1, pp. 162 - 162
.... This study will attempt to provide further insight into the profile of olive phenolic compounds during fruit development and to identify the major genetic determinants of phenolic metabolism. Results... 
Secoiridoids | Olea europaea | Phenolics | RT-qPCR | Secondary metabolism | Transcriptome | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Species Specificity | Genes, Plant | Phenylethyl Alcohol - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Gene Expression Profiling | Olea - genetics | RNA, Messenger - metabolism | Glucosides - genetics | Iridoids | Pyrans - metabolism | Iridoid Glucosides - metabolism | Plant Proteins - metabolism | Fruit - metabolism | Plant Oils - analysis | Real-Time Polymerase Chain Reaction | Fruit - genetics | Prephenate Dehydrogenase - genetics | RNA, Messenger - genetics | Biosynthetic Pathways | Phenols - metabolism | Glucosides - metabolism | Metabolomics - methods | Phenylethyl Alcohol - metabolism | Fruit - growth & development | Plant Proteins - genetics | Olea - growth & development | Olea - metabolism | Plant Oils - metabolism | Cytochrome P-450 Enzyme System - genetics | Prephenate Dehydrogenase - metabolism | Amplified Fragment Length Polymorphism Analysis | Olive | Sterols | Fruit | Functional foods | Analysis | Development | Genetic transcription | Plants | Plant metabolites | Acids | Metabolites | Olive oil | Gene expression | Manuscripts | Fruits | Cultivars | Environmental conditions | Index Medicus
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 11, pp. e108994 - e108994
Background and Objective: Sodium glucose cotransporter 2 (SGLT2) is the main luminal glucose transporter in the kidney. SGLT2 inhibition results in glycosuria... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Benzoates - therapeutic use | Toll-Like Receptor 2 - genetics | Diabetic Nephropathies - etiology | Transforming Growth Factor beta1 - metabolism | Glucose Transporter Type 1 - metabolism | Male | RNA, Messenger - metabolism | Nitric Oxide Synthase Type III - deficiency | Glucosides - therapeutic use | Chemokine CCL2 - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - complications | Diabetes Mellitus, Experimental - metabolism | Benzhydryl Compounds - therapeutic use | Diabetic Nephropathies - prevention & control | Benzimidazoles - therapeutic use | Sodium-Glucose Transporter 2 - genetics | Hypoglycemic Agents - therapeutic use | Glucosides - pharmacology | Kidney Tubules, Proximal - pathology | Albuminuria - etiology | Blood Glucose - analysis | Sodium-Glucose Transporter 2 - metabolism | Diabetic Nephropathies - metabolism | Mice, Inbred C57BL | Chemokine CCL2 - genetics | Transforming Growth Factor beta1 - genetics | Toll-Like Receptor 2 - metabolism | Nitric Oxide Synthase Type III - genetics | Fibronectins - metabolism | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | Mice, Knockout | Animals | Glucose Transporter Type 1 - genetics | Kidney Tubules, Proximal - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Benzhydryl Compounds - pharmacology | Fibronectins - genetics | Mice | Streptozocin - toxicity | Blood Glucose - metabolism | Kidney Tubules, Proximal - drug effects | Drugs | Transcription | Syngeneic grafts | Streptozocin | Genomics | Transforming growth factor | Glucose | Macrophages | Blood | Fibronectin | Proteins | Atrophy | Hyperglycemia | Rodents | Toll-like receptors | Physiology | Inhibition | Protein transport | Immune system | Creatinine | Glucose transporter | Medical research | Kidneys | Cytokines | Diabetes mellitus | Reabsorption | Histology | Inflammation | Metabolism | Gene expression | Nephropathy | Sodium | Nitric oxide | Fibrosis | Angiotensin | Insulin resistance | Research design | Kidney diseases | Diabetes | Transporter | Monocyte chemoattractant protein 1 | Kidney transplantation | Best practice | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, pp. e0157672 - e0157672
... (NCHD) and treated with/without the SGLT-2 inhibitor, ipragliflozin. We compared metabolic parameters, gene expression for transcripts related to glucose and fat metabolism, and glycogen content in the kidney and the liver among the groups... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Thiophenes - therapeutic use | Diabetes Mellitus, Experimental - drug therapy | Fatty Acid Synthases - metabolism | Gluconeogenesis - drug effects | Body Weight - drug effects | Hyperglycemia - complications | Male | RNA, Messenger - metabolism | Obesity - blood | Diabetes Mellitus, Experimental - blood | Kidney - metabolism | Glycogen - metabolism | Liver - drug effects | Hyperglycemia - pathology | Glucosides - therapeutic use | Lipid Metabolism - genetics | Diabetes Mellitus, Experimental - complications | Fatty Acid Synthases - genetics | Diet, Carbohydrate-Restricted | Forkhead Box Protein O1 - metabolism | Glucose Tolerance Test | Glucosides - pharmacology | Kidney - drug effects | Obesity - complications | Sodium-Glucose Transporter 2 - metabolism | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Insulin Resistance | Thiophenes - pharmacology | Energy Intake - drug effects | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Obesity - pathology | Triglycerides - metabolism | Up-Regulation - drug effects | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Gluconeogenesis - genetics | Hyperglycemia - blood | Cyclic AMP Response Element-Binding Protein - metabolism | Lipid Metabolism - drug effects | Diabetes Mellitus, Experimental - pathology | Forkhead Box Protein O1 - genetics | Diet therapy | Low-carbohydrate diet | Ion transport | Physiological aspects | Insulin resistance | Research | Health aspects | Fat metabolism | Body fat | Liver | Body weight | Parameter sensitivity | Glucose | Accumulation | Glucose metabolism | Low carbohydrate diet | Rodents | Gluconeogenesis | Carbohydrates | Obesity | Nutrient deficiency | Kidneys | Glycogen | Diabetes mellitus | Metabolism | Gene expression | Insulin | Inhibitors | Sodium | Diet | Mice | Metabolic disorders | Index Medicus
Journal Article