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amino acid sequence (56) 56
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1. Full Text Ceramides and glucosylceramides are independent antagonists of insulin signaling
by Chavez, Jose A and Siddique, M. Mobin and Wang, Siew Tein and Ching, Jianhong and Shayman, James A and Summers, Scott A
The Journal of biological chemistry, ISSN 0021-9258, 01/2014, Volume 289, Issue 2, pp. 723 - 734
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | Adipocytes - cytology | Male | Adipocytes - drug effects | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Adipose Tissue - metabolism | Glucosyltransferases - metabolism | Myoblasts - drug effects | Myoblasts - metabolism | RNA Interference | Diet, High-Fat | Myoblasts - cytology | Glucosyltransferases - genetics | Cell Line | Ceramides - metabolism | Mice, Inbred C57BL | Insulin Resistance | Glucosylceramides - physiology | 3T3-L1 Cells | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Ceramides - pharmacology | Insulin - metabolism | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Adipocytes - metabolism | Muscle Fibers, Skeletal - cytology | Signal Transduction - physiology | Mice | Glucosylceramides - metabolism | Index Medicus | Molecular Bases of Disease | Ceramide | Sphingolipid | Glucose Transport | Glucosylceramide | Lipotoxicity | Metabolism | Insulin | Glycerosphingolipid
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2. Full Text P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells
by Chapman, Jacqueline V and Gouazé-Andersson, Valérie and Karimi, Ramin and Messner, Maria C and Cabot, Myles C
Experimental cell research, ISSN 0014-4827, 2011, Volume 317, Issue 12, pp. 1736 - 1745
P-glycoprotein | Ceramide | P-glycoprotein antagonists | C6-ceramide | Drug resistance | Ovarian cancer | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Glucosyltransferases - antagonists & inhibitors | Antineoplastic Agents, Hormonal - pharmacology | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Ovarian Neoplasms - pathology | Antineoplastic Combined Chemotherapy Protocols | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Blotting, Western | Ceramides - pharmacology | Drug Synergism | Glucosyltransferases - metabolism | Tamoxifen - pharmacology | Female | Ovarian Neoplasms - metabolism | Tumor Cells, Cultured | Ovarian Neoplasms - drug therapy | Drug Resistance, Neoplasm - drug effects | Drug resistance in microorganisms | Cancer | Glycoproteins | Pharmacology | Cellular biology | Antagonist drugs | Index Medicus | drug resistance | ovarian cancer
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3. Full Text Identification of New Antifungal Agents Targeting Chitin Synthesis by a Chemical-Genetic Method
by Li, Yan and Sun, Hongmin and Zhu, Xiaohong and Bian, Cong and Wang, Yanchang and Si, Shuyi
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2019, Volume 24, Issue 17, p. 3155
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Small Molecule Libraries - pharmacology | Saccharomyces cerevisiae - genetics | Chitin - biosynthesis | Saccharomyces cerevisiae - drug effects | Antifungal Agents - chemistry | Gene Expression Profiling | Candida albicans - growth & development | Candida albicans - genetics | Microbial Sensitivity Tests | Chitin - antagonists & inhibitors | Membrane Proteins - deficiency | Candida albicans - drug effects | Cell Wall - drug effects | Echinocandins - genetics | Glucosyltransferases - deficiency | Caspofungin - pharmacology | Echinocandins - antagonists & inhibitors | Glucosyltransferases - genetics | Antifungal Agents - pharmacology | Chitin Synthase - antagonists & inhibitors | Gene Expression Regulation, Fungal | Glucosyltransferases - antagonists & inhibitors | Benzothiazoles - pharmacology | Membrane Proteins - genetics | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Saccharomyces cerevisiae Proteins - genetics | Chitin Synthase - genetics | Drug Discovery | Drug Synergism | Small Molecule Libraries - chemistry | High-Throughput Screening Assays | Membrane Proteins - antagonists & inhibitors | Cell Wall - metabolism | Benzothiazoles - chemistry | Saccharomyces cerevisiae - enzymology | Chitin Synthase - deficiency | Echinocandins - deficiency | Drug Combinations | Saccharomyces cerevisiae - growth & development | Candida albicans - enzymology | Drugs | Yeasts | Yeast | Fungicides | Genes | Infections | Fungal infections | Chitin synthase | Proteins | Glucan | Cell cycle | Caspofungin | Chemical synthesis | Enzymes | Nikkomycin | Antifungal agents | Cell division | Chitin | Mutants | Organic chemistry | Inhibitors | Minimum inhibitory concentration | Echinocandins | Synergistic effect | Apoptosis | Index Medicus | Candida albicans | antifungal agents | glucan | Saccharomyces cerevisiae | chitin
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4. Full Text Efficacy of enzyme and substrate reduction therapy with a novel antagonist of glucosylceramide synthase for fabry disease
by Ashe, Karen M and Budman, Eva and Bangari, Dinesh S and Siegel, Craig S and Nietupski, Jennifer B and Wang, Bing and Desnick, Robert J and Scheule, Ronald K and Leonard, John P and Cheng, Seng H and Marshall, John
Molecular medicine (Cambridge, Mass.), ISSN 1076-1551, 04/2015, Volume 21, Issue 1, pp. 389 - 399
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Glucosyltransferases - antagonists & inhibitors | Trihexosylceramides - metabolism | Humans | Sphingolipids - metabolism | alpha-Galactosidase - metabolism | Carbamates - administration & dosage | alpha-Galactosidase - administration & dosage | Glycolipids - metabolism | Blood-Brain Barrier - drug effects | Quinuclidines - administration & dosage | Fabry Disease - pathology | Glucosyltransferases - metabolism | Animals | Fabry Disease - metabolism | Fabry Disease - drug therapy | Mice | Disease Models, Animal | Index Medicus
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5. Full Text Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants
by Gupta, Pulkit and Zhang, Zhifen and Sugiman-Marangos, Seiji N and Tam, John and Raman, Swetha and Julien, Jean-Phillipe and Kroh, Heather K and Lacy, D. Borden and Murgolo, Nicholas and Bekkari, Kavitha and Therien, Alex G and Hernandez, Lorraine D and Melnyk, Roman A
The Journal of biological chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 42, pp. 17290 - 17301
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Chondroitin Sulfate Proteoglycans - genetics | Cricetulus | Humans | Bacterial Toxins - antagonists & inhibitors | Glucosyltransferases - metabolism | HEK293 Cells | Clostridioides difficile - genetics | Protein Domains | Bacterial Toxins - genetics | Membrane Proteins - metabolism | Antibodies, Monoclonal - chemistry | CHO Cells | Glucosyltransferases - genetics | Caco-2 Cells | Glucosyltransferases - antagonists & inhibitors | Bacterial Proteins - antagonists & inhibitors | Clostridioides difficile - pathogenicity | Cricetinae | Chlorocebus aethiops | Membrane Proteins - genetics | Bacterial Proteins - genetics | Chondroitin Sulfate Proteoglycans - metabolism | Broadly Neutralizing Antibodies | Clostridioides difficile - enzymology | Bacterial Toxins - metabolism | Animals | Antibodies, Neutralizing - chemistry | Protein Binding | Bacterial Proteins - metabolism | Index Medicus | cell surface | antibody | receptor | Microbiology | toxin | trafficking
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6. Full Text Model-Assisted Analysis of Sugar Metabolism throughout Tomato Fruit Development Reveals Enzyme and Carrier Properties in Relation to Vacuole Expansion
by Bertrand P. Beauvoit and Sophie Colombié and Antoine Monier and Marie-Hélène Andrieu and Benoit Biais and Camille Bénard and Catherine Chéniclet and Martine Dieuaide-Noubhani and Christine Nazaret and Jean-Pierre Mazat and Yves Gibon
The Plant cell, ISSN 1040-4651, 8/2014, Volume 26, Issue 8, pp. 3224 - 3242
Enzymes | Cell walls | Cell division | Pericarp | LARGE-SCALE BIOLOGY ARTICLE | Kinetics | Plants | Parametric models | Vacuoles | Sugars | Fruits | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Cell Biology | Osmotic Pressure | Vacuoles - physiology | Lycopersicon esculentum - enzymology | Fruit - enzymology | Glucosyltransferases - physiology | Glucosyltransferases - metabolism | Lycopersicon esculentum - growth & development | Biological Transport | Cell Division | Plant Proteins - antagonists & inhibitors | Sucrose - metabolism | Plant Proteins - metabolism | Fruit - metabolism | Lycopersicon esculentum - metabolism | beta-Fructofuranosidase - metabolism | Carbohydrate Metabolism | Glucokinase - metabolism | Fruit - growth & development | Carrier Proteins - metabolism | Plants, Genetically Modified - metabolism | Glucokinase - antagonists & inhibitors | Models, Biological | Vacuoles - metabolism | beta-Fructofuranosidase - antagonists & inhibitors | Glucose metabolism | Carbohydrate metabolism | Analysis | Index Medicus | Life Sciences | Large-Scale Biology
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7. Full Text A role for CSLD3 during cell-wall synthesis in apical plasma membranes of tip-growing root-hair cells
by Park, Sungjin and Szumlanski, Amy L and Gu, Fangwei and Guo, Feng and Nielsen, Erik
Nature cell biology, ISSN 1465-7392, 08/2011, Volume 13, Issue 8, pp. 973 - 980
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Arabidopsis - growth & development | Genes, Plant | Genetic Complementation Test | Recombinant Fusion Proteins - metabolism | Plant Roots - drug effects | Arabidopsis Proteins - metabolism | Glucosyltransferases - metabolism | Recombinant Fusion Proteins - antagonists & inhibitors | Cell Wall - drug effects | Plants, Genetically Modified | Cell Membrane - metabolism | Plant Roots - growth & development | Glucosyltransferases - genetics | Glucosyltransferases - antagonists & inhibitors | Arabidopsis Proteins - genetics | Plant Roots - metabolism | Arabidopsis - cytology | Enzyme Inhibitors - pharmacology | Plant Roots - cytology | Arabidopsis - metabolism | Arabidopsis - genetics | Cell Wall - metabolism | Recombinant Fusion Proteins - genetics | Mutation | Arabidopsis Proteins - antagonists & inhibitors | Physiological aspects | Polysaccharides | Cell membranes | Research | Science/Life Science/Cells/Cell Parts/Wall/membrane | Plant cell walls | Index Medicus
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8. Full Text Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors
by Ghisaidoobe, Amar T and van den Berg, Richard J. B. H. N and Butt, Saleem S and Strijland, Anneke and Donker-Koopman, Wilma E and Scheij, Saskia and van den Nieuwendijk, Adrianus M. C. H and Koomen, Gerrit-Jan and van Loevezijn, Arnold and Leemhuis, Mark and Wennekes, Tom and van der Stelt, Mario and van der Marel, Gijsbert A and van Boeckel, Constant A. A and Aerts, Johannes M. F. G and Overkleeft, Herman S
Journal of medicinal chemistry, ISSN 0022-2623, 11/2014, Volume 57, Issue 21, pp. 9096 - 9104
Glucosyltransferases - antagonists & inhibitors | beta-Glucosidase - antagonists & inhibitors | Biphenyl Compounds - pharmacology | Biphenyl Compounds - chemical synthesis | Enzyme Inhibitors - chemistry | Humans | Imino Sugars - pharmacology | Enzyme Inhibitors - pharmacology | 1-Deoxynojirimycin - analogs & derivatives | Enzyme Inhibitors - chemical synthesis | Imino Sugars - chemical synthesis | Glucosylceramidase - antagonists & inhibitors | Index Medicus
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9. Full Text Prevention of cardiac hypertrophy by the use of a glycosphingolipid synthesis inhibitor in ApoE−/− mice
by Mishra, Sumita and Bedja, Djahida and Amuzie, Christine and Avolio, Alberto and Chatterjee, Subroto
Biochemical and biophysical research communications, ISSN 0006-291X, 09/2015, Volume 465, Issue 1, pp. 159 - 164
Cardiac hypertrophy | Lactosylceramide | Glycosphingolipids | Atherosclerotic heart disease | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Apolipoproteins E - deficiency | Natriuretic Peptide, Brain - metabolism | Cardiomegaly - etiology | Diet, High-Fat - adverse effects | Cardiomegaly - pathology | Male | Galactosyltransferases - genetics | Glucosyltransferases - metabolism | Atrial Natriuretic Factor - genetics | Galactosyltransferases - antagonists & inhibitors | Phosphorylation - drug effects | Heart Ventricles - pathology | Glucosyltransferases - genetics | Glucosyltransferases - antagonists & inhibitors | Gene Expression | Natriuretic Peptide, Brain - genetics | Atrial Natriuretic Factor - metabolism | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Cardiotonic Agents - pharmacology | Galactosyltransferases - metabolism | Mice, Knockout | Myocytes, Cardiac - pathology | Animals | Cardiomegaly - prevention & control | Myocytes, Cardiac - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Apolipoproteins E - genetics | Glycosphingolipids - antagonists & inhibitors | Glycosphingolipids - metabolism | Myocytes, Cardiac - metabolism | Mitogen-Activated Protein Kinases - genetics | Heart Ventricles - metabolism | Mice | Cardiomegaly - genetics | Cholesterol - adverse effects | Heart Ventricles - drug effects | Mitogen-Activated Protein Kinases - metabolism | Prevention | Heart | Heart enlargement | Diastereomers | Analysis | Apolipoproteins | Gene expression | Gangliosides | Index Medicus
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10. Full Text Glycosphingolipids-Nature, Function, and Pharmacological Modulation
by Wennekes, Tom and van den Berg, Richard J. B. H. N and Boot, Rolf G and van der Marel, Gijsbert A and Overkleeft, Herman S and Aerts, Johannes M. F. G
Angewandte Chemie (International ed.), ISSN 0570-0833, 2009, Volume 48, Issue 47, pp. 8848 - 8869
inhibitors | glycolipids | metabolism | drug design | sphingolipids | Drug design | Sphingolipids | Inhibitors | Glycolipids | Metabolism | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Glucosyltransferases - antagonists & inhibitors | Sphingolipids - biosynthesis | Cell Membrane | Glycosphingolipids - biosynthesis | Glycosphingolipids - pharmacology | Humans | Galactosylceramides - metabolism | Sphingolipids - metabolism | Glucosylceramidase - metabolism | Gaucher Disease - therapy | Glucosylceramidase - antagonists & inhibitors | Glucosyltransferases - metabolism | Glycosphingolipids - metabolism | Index Medicus
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