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Lipids in Health and Disease, ISSN 1476-511X, 04/2017, Volume 16, Issue 1, pp. 77 - 10
Background: Atherosclerosis is a common cardiovascular disease that causes myocardial infarction, heart failure, and stroke. Increased oxidized low density... 
Oxidative stress | Oxidized low density lipoprotein | Human umbilical vein endothelial cells | Klotho | Lectin-like ox-LDL receptor | APOPTOSIS | ATHEROGENESIS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTECTS ENDOTHELIAL-CELLS | ATHEROSCLEROSIS | MECHANISMS | NUTRITION & DIETETICS | DISEASE | REQUIRES | DYSFUNCTION | SUPEROXIDE-DISMUTASE | Endothelium, Vascular - cytology | Reactive Oxygen Species - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Oxidative Stress | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Glucuronidase - metabolism | Superoxide Dismutase - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Reactive Oxygen Species - agonists | Nitric Oxide Synthase Type III - chemistry | Malondialdehyde - agonists | Human Umbilical Vein Endothelial Cells - cytology | Lipoproteins, LDL - metabolism | Nitric Oxide Synthase Type III - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Second Messenger Systems | Superoxide Dismutase - metabolism | Malondialdehyde - metabolism | Recombinant Proteins - metabolism | Atherosclerosis - pathology | Scavenger Receptors, Class E - agonists | Cell Survival | Nitric Oxide - antagonists & inhibitors | Cells, Cultured | Scavenger Receptors, Class E - antagonists & inhibitors | Nitric Oxide Synthase Type III - genetics | Atherosclerosis - metabolism | Nitric Oxide - agonists | Phosphatidylinositol 3-Kinase - chemistry | Superoxide Dismutase - chemistry | Scavenger Receptors, Class E - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Human Umbilical Vein Endothelial Cells - enzymology | Glucuronidase - genetics | Lipoproteins, LDL - antagonists & inhibitors | Phosphatidylinositol 3-Kinase - genetics | Endothelium, Vascular - metabolism | Proto-Oncogene Proteins c-akt - agonists | Endothelium, Vascular - pathology | Lipid Peroxidation | Malondialdehyde - antagonists & inhibitors | Nitric Oxide - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Myocardial infarction | Lipoproteins (low density) | Atherogenesis | Superoxide dismutase | Cardiovascular disease | AKT protein | Cell adhesion & migration | Proteins | Lysates | Cell growth | Atherosclerosis | Aging | Tumor necrosis factor-TNF | Heart diseases | Cerebral infarction | Stroke | Inositol | Cytokines | LOX-1 protein | Low density lipoprotein | Nitric-oxide synthase | Malondialdehyde | Endothelial cells | 1-Phosphatidylinositol 3-kinase | Endothelium | Polymerase chain reaction | Klotho protein | Arteriosclerosis | Nitric oxide | Calcification | Diabetes | Umbilical vein | Apoptosis
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 4003 - 4008
Phosphate homeostasis is maintained by a counterbalance between efflux from the kidney and influx from intestine and bone. FGF23 is a bone-derived phosphaturic... 
PHOSPHATE | MEDICINE, RESEARCH & EXPERIMENTAL | HORMONE GENE-EXPRESSION | IN-VIVO | CALCIUM | GROWTH | KLOTHO PROTEIN | SECONDARY HYPERPARATHYROIDISM | VITAMIN-D-RECEPTOR | DOMINANT HYPOPHOSPHATEMIC RICKETS | MICE | MAP Kinase Signaling System - physiology | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Fibroblast Growth Factors - genetics | Intestines - metabolism | Parathyroid Hormone - genetics | Fibroblast Growth Factors - metabolism | Parathyroid Glands - cytology | RNA, Messenger - biosynthesis | Kidney - metabolism | Parathyroid Hormone - biosynthesis | Bone and Bones - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Early Growth Response Protein 1 - genetics | Receptors, Fibroblast Growth Factor - genetics | Homeostasis - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | RNA, Messenger - genetics | Cells, Cultured | Gene Expression Regulation - physiology | Rats | Fibroblast Growth Factors - pharmacology | Gene Expression Regulation - drug effects | Phosphates - metabolism | Animals | Glucuronidase - biosynthesis | MAP Kinase Signaling System - drug effects | Early Growth Response Protein 1 - biosynthesis | Glucuronidase - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Homeostasis - physiology | Receptors, Fibroblast Growth Factor - metabolism | Vitamin D - metabolism | Protein Kinase Inhibitors - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Parathyroid Glands - metabolism | Homeostasis | Parathyroid glands | Fibroblast growth factors | Dosage and administration | Genetic aspects | Research | Health aspects
Journal Article
Journal Article
Science, ISSN 0036-8075, 11/2010, Volume 330, Issue 6005, pp. 831 - 835
The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial β-glucuronidases that... 
Enzymes | Anaerobic bacteria | Toxicity | REPORTS | Colorectal cancer | Diarrhea | Anaerobic conditions | Bacteria | Mice | Monomers | Crystal structure | IRINOTECAN CPT-11 | DIARRHEA | METABOLISM | COLITIS | MULTIDISCIPLINARY SCIENCES | BETA-GLUCURONIDASE | CAMPTOTHECINS | TOPOISOMERASE-I | PHARMACOGENETICS | GUT FLORA | CARCINOMA | Camptothecin - toxicity | Humans | Colon - drug effects | Glucuronidase - metabolism | Crystallography, X-Ray | Diarrhea - prevention & control | Intestinal Mucosa - drug effects | Prodrugs - metabolism | Enzyme Inhibitors - chemistry | Female | Glucuronidase - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - metabolism | Escherichia coli Proteins - antagonists & inhibitors | Bacteria, Anaerobic - drug effects | Drug Evaluation, Preclinical | Camptothecin - analogs & derivatives | Camptothecin - metabolism | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Colon - pathology | Glucuronidase - isolation & purification | Enzyme Inhibitors - pharmacology | Models, Molecular | Escherichia coli Proteins - metabolism | Glucuronidase - chemistry | Intestinal Mucosa - microbiology | Escherichia coli Proteins - isolation & purification | Antineoplastic Agents, Phytogenic - toxicity | Animals | Prodrugs - toxicity | Cell Line, Tumor | Protein Conformation | Colon - microbiology | Mice, Inbred BALB C | Glucuronidase - pharmacology | Escherichia coli Proteins - chemistry | Intestinal Mucosa - pathology | Antimitotic agents | Drugs | Prevention | Complications and side effects | Care and treatment | Dosage and administration | Antineoplastic agents | Health aspects | Cancer | Chemotherapy | Side effects | Index Medicus | Microorganisms | Inhibitors | LARGE INTESTINE | BACTERIA | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | CRYSTAL STRUCTURE | TOXICITY | 60 APPLIED LIFE SCIENCES | ENZYMES | ORAL ADMINISTRATION | TARGETS | MICE | SIDE EFFECTS
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 124 - 169
The presence of -heterocycles as an essential structural motif in a variety of biologically active substances has stimulated the development of new strategies... 
Bioactive heterocycles | Enzymes | Biological potential | Synthetic methods | Inhibitors | Cross-coupling reactions | CHEMISTRY, MEDICINAL | ONE-POT SYNTHESIS | CRYSTAL-STRUCTURE | EFFICIENT SYNTHESIS | CELL LINES | NATIONAL-CANCER-INSTITUTE | C-H BONDS | ACRIDONE ALKALOIDS | ANTIINFLAMMATORY AGENTS | BIOLOGICAL EVALUATION | PROTEIN-KINASE INHIBITORS | Phosphotransferases - metabolism | Quinazolines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Glucuronidase - metabolism | Phosphotransferases - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Anticonvulsants - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Glucuronidase - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Quinazolines - chemistry | Angiogenesis Inhibitors - chemical synthesis | Quinazolinones - pharmacology | Anticonvulsants - chemical synthesis | Enzyme Inhibitors - pharmacology | Angiogenesis Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Tetrahydrofolate Dehydrogenase - metabolism | Anti-Bacterial Agents - chemical synthesis | Quinazolinones - chemical synthesis | Anticonvulsants - chemistry | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Quinazolinones - chemistry | Quinazolines - pharmacology | Angiogenesis Inhibitors - chemistry
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2015, Volume 5, Issue 1, p. 7645
Journal Article
Human Reproduction, ISSN 0268-1161, 07/2017, Volume 32, Issue 7, pp. 1465 - 1473
Abstract STUDY QUESTION Are bisphenol A (BPA) and BPA analogs (BPA-A) safe for male human reproductive function? SUMMARY ANSWER The endocrine function of human... 
anti-androgenic compounds | bisphenols | insulin-like factor 3 | testosterone | Leydig cells | endocrine disruptor | human testis | inhibin B | Sertoli cells | reproductive function | UNITED-STATES | SERUM TESTOSTERONE CONCENTRATION | MASS-SPECTROMETRY METHOD | DIGLYCIDYL ETHER BADGE | SEMEN QUALITY | OBSTETRICS & GYNECOLOGY | REPRODUCTIVE BIOLOGY | HORMONE CONCENTRATIONS | WIDESPREAD OCCURRENCE | REPRODUCTIVE HORMONES | MANUFACTURING PLANT | HUMAN URINE | Gene Expression Regulation, Enzymologic - drug effects | Leydig Cells - cytology | Testis - metabolism | Apoptosis - drug effects | Benzhydryl Compounds - toxicity | Phenols - toxicity | Humans | Glucuronidase - metabolism | Male | Leydig Cells - drug effects | Testis - secretion | Nonsteroidal Anti-Androgens - chemistry | Benzhydryl Compounds - chemistry | Sertoli Cells - drug effects | Testis - drug effects | Glucuronosyltransferase - genetics | Testosterone - metabolism | Leydig Cells - metabolism | Sertoli Cells - cytology | Adult | Steryl-Sulfatase - metabolism | Sertoli Cells - metabolism | Steryl-Sulfatase - genetics | Nonsteroidal Anti-Androgens - toxicity | Reproducibility of Results | Sertoli Cells - secretion | Testosterone - secretion | Insulin - agonists | Sulfones - toxicity | Testis - cytology | Endocrine Disruptors - chemistry | Tissue Culture Techniques | Arylsulfotransferase - genetics | Epoxy Compounds - toxicity | Endocrine Disruptors - toxicity | Leydig Cells - secretion | Insulin - metabolism | Proteins - agonists | Proteins - metabolism | Glucuronidase - genetics | Glucuronosyltransferase - metabolism | Testosterone - antagonists & inhibitors | Phenols - chemistry | Arylsulfotransferase - metabolism | Proteins - antagonists & inhibitors | Life Sciences | Santé publique et épidémiologie
Journal Article