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European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 144, pp. 444 - 492
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, pp. e0171476 - e0171476
Seven metabolites were obtained from the microbial transformation of anabolic-androgenic steroid mibolerone (1) with Cunninghamella blakesleeana, C.... 
COLON-CANCER | BIOCATALYSTS | SURVIVAL | CELLS | CISPLATIN-INDUCED CYTOTOXICITY | PRODUCTS | MULTIDISCIPLINARY SCIENCES | HYDROXYLATION | ANDROGEN | MICROBIAL TRANSFORMATION | CERVICAL-CANCER | NIH 3T3 Cells | Antiprotozoal Agents - metabolism | Humans | 17-Ketosteroids - pharmacology | Chromatography, High Pressure Liquid | Carbonic Anhydrases - chemistry | Nandrolone - metabolism | Testosterone Congeners - chemistry | Antineoplastic Agents - metabolism | Testosterone Congeners - isolation & purification | 17-Ketosteroids - chemistry | Saccharomycetales - chemistry | Cunninghamella - metabolism | Antineoplastic Agents - isolation & purification | Biotransformation | Leishmania major - growth & development | Glucuronidase - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Monophenol Monooxygenase - chemistry | Cell Survival - drug effects | Saccharomycetales - drug effects | 17-Ketosteroids - metabolism | Cunninghamella - drug effects | Hydroxylation | Leishmania major - drug effects | 17-Ketosteroids - isolation & purification | Nandrolone - analogs & derivatives | Antiprotozoal Agents - chemistry | Glucuronidase - chemistry | Antineoplastic Agents - chemistry | Testosterone Congeners - pharmacology | Antiprotozoal Agents - pharmacology | Cunninghamella - chemistry | Antiprotozoal Agents - isolation & purification | Animals | Nandrolone - pharmacology | Testosterone Congeners - metabolism | Mice | HeLa Cells | Saccharomycetales - metabolism | Nandrolone - chemistry | alpha-Glucosidases - chemistry | Anabolic steroids | Research | Metabolites | Transformation | Promastigotes | Toxicity | Colorectal cancer | Cytotoxicity | Biocatalysts | Cancer therapies | Tropical diseases | Microorganisms | Parasitic diseases | Cervical carcinoma | Enzymes | Glucosidase | Breast cancer | Cervix | Substrates | Biological activity | Chromatography | Chemistry | Carbonic anhydrase | Tyrosinase | Cervical cancer | Cancer | Steroids | Index Medicus
Journal Article
Carbohydrate Polymers, ISSN 0144-8617, 01/2019, Volume 204, pp. 142 - 151
The present work investigated the antioxidative, anti-inflammatory and pulmonary protective effects of enzymatic- and acid- hydrolysed mycelia polysaccharides... 
Oudemansiella radicata | Acute lung injury | Antioxidant | Pulmonary protective | Anti-inflammatory | Enzymatic- acid- hydrolysed mycelia polysaccharide | FRUITING BODY | SIGNALING PATHWAYS | POLYMER SCIENCE | CHEMISTRY, ORGANIC | ANTITUMOR-ACTIVITY | ANTIAGING ACTIVITIES | ZINC POLYSACCHARIDES | IN-VITRO | LIPOPOLYSACCHARIDE | MICE | PLEUROTUS-DJAMOR | CHEMISTRY, APPLIED | NF-KAPPA-B | Cellulase - chemistry | Tumor Necrosis Factor-alpha - metabolism | Lung Injury - pathology | Antioxidants - chemistry | Polygalacturonase - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Interleukin-1alpha - metabolism | Male | Protective Agents - chemistry | Protective Agents - therapeutic use | Polysaccharides - toxicity | Polysaccharides - chemistry | Lung Injury - drug therapy | Interleukin-6 - metabolism | Polysaccharides - therapeutic use | Lung - pathology | Glucuronidase - chemistry | Anti-Inflammatory Agents, Non-Steroidal - toxicity | Multienzyme Complexes - chemistry | Antioxidants - toxicity | Hydrolysis | Antioxidants - therapeutic use | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Mice | Mycelium - chemistry | Protective Agents - toxicity | Agaricales - chemistry | Antioxidants | Acute respiratory distress syndrome | Prevention | Enzymes | Polysaccharides | C-reactive protein | Interleukins | Anti-inflammatory drugs | Analysis | Superoxide | Mitogens | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 124 - 169
The presence of -heterocycles as an essential structural motif in a variety of biologically active substances has stimulated the development of new strategies... 
Bioactive heterocycles | Enzymes | Biological potential | Synthetic methods | Inhibitors | Cross-coupling reactions | CHEMISTRY, MEDICINAL | ONE-POT SYNTHESIS | CRYSTAL-STRUCTURE | EFFICIENT SYNTHESIS | CELL LINES | NATIONAL-CANCER-INSTITUTE | C-H BONDS | ACRIDONE ALKALOIDS | ANTIINFLAMMATORY AGENTS | BIOLOGICAL EVALUATION | PROTEIN-KINASE INHIBITORS | Phosphotransferases - metabolism | Quinazolines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Glucuronidase - metabolism | Phosphotransferases - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Anticonvulsants - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Glucuronidase - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Quinazolines - chemistry | Angiogenesis Inhibitors - chemical synthesis | Quinazolinones - pharmacology | Anticonvulsants - chemical synthesis | Enzyme Inhibitors - pharmacology | Angiogenesis Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Tetrahydrofolate Dehydrogenase - metabolism | Anti-Bacterial Agents - chemical synthesis | Quinazolinones - chemical synthesis | Anticonvulsants - chemistry | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Quinazolinones - chemistry | Quinazolines - pharmacology | Angiogenesis Inhibitors - chemistry
Journal Article
Molecules, ISSN 1420-3049, 01/2017, Volume 22, Issue 1, pp. 125 - 125
Anti-inflammatory compounds were investigated from the ethanol extract of the roots and rhizomes of Asarum heterotropoides var. mandshuricum, a traditional... 
8-O-40 neolignan | Lignans | Amide | Asarum heterotropoides var. mandshuricum | Monoterpene | Anti-inflammatory | Aristolochiaceae | GLYCOSIDES | BIOACTIVE LIGNANS | PLANT | monoterpene | SIEBOLDII | RADIX | BIOCHEMISTRY & MOLECULAR BIOLOGY | ASIASARUM-HETEROTROPOIDES | COMPONENTS | NEOLIGNANS | CHEMISTRY, MULTIDISCIPLINARY | lignans | amide | anti-inflammatory | 8-O-4 ' neolignan | CHALCONE | HYDROXYBENZOIC ACIDS | Neutrophils - cytology | Plant Extracts - chemistry | Solvents - chemistry | Humans | Drugs, Chinese Herbal - pharmacology | Structure-Activity Relationship | Lignans - pharmacology | 1-Alkyl-2-acetylglycerophosphocholine Esterase - pharmacology | Monoterpenes - pharmacology | Rhizome - chemistry | 1-Alkyl-2-acetylglycerophosphocholine Esterase - antagonists & inhibitors | Glucuronidase - antagonists & inhibitors | Glucuronidase - secretion | Anti-Inflammatory Agents - isolation & purification | Molecular Structure | Drugs, Chinese Herbal - isolation & purification | Amides - pharmacology | Monoterpenes - isolation & purification | Chloroform | Ethanol | Anti-Inflammatory Agents - pharmacology | Lignans - chemistry | Neutrophils - drug effects | Rats | Lignans - isolation & purification | Amides - isolation & purification | Animals | Anti-Inflammatory Agents - chemistry | Drugs, Chinese Herbal - chemistry | Plant Roots - chemistry | Amides - chemistry | Monoterpenes - chemistry | Asarum - chemistry | Primary Cell Culture | Antiinflammatory agents | Platelet-activating factor | Roots | Traditional Chinese medicine | Amides | Inflammation | Leukocytes | Chinese medicine | Rhizomes | Pain | Absolute configuration | Leukocytes (polymorphonuclear) | In vitro methods and tests | 8-O-4′ neolignan
Journal Article