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European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 144, pp. 444 - 492
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 124 - 169
The presence of -heterocycles as an essential structural motif in a variety of biologically active substances has stimulated the development of new strategies... 
Bioactive heterocycles | Enzymes | Biological potential | Synthetic methods | Inhibitors | Cross-coupling reactions | CHEMISTRY, MEDICINAL | ONE-POT SYNTHESIS | CRYSTAL-STRUCTURE | EFFICIENT SYNTHESIS | CELL LINES | NATIONAL-CANCER-INSTITUTE | C-H BONDS | ACRIDONE ALKALOIDS | ANTIINFLAMMATORY AGENTS | BIOLOGICAL EVALUATION | PROTEIN-KINASE INHIBITORS | Phosphotransferases - metabolism | Quinazolines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Glucuronidase - metabolism | Phosphotransferases - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Anticonvulsants - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Glucuronidase - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Quinazolines - chemistry | Angiogenesis Inhibitors - chemical synthesis | Quinazolinones - pharmacology | Anticonvulsants - chemical synthesis | Enzyme Inhibitors - pharmacology | Angiogenesis Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Tetrahydrofolate Dehydrogenase - metabolism | Anti-Bacterial Agents - chemical synthesis | Quinazolinones - chemical synthesis | Anticonvulsants - chemistry | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Quinazolinones - chemistry | Quinazolines - pharmacology | Angiogenesis Inhibitors - chemistry
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 05/2013, Volume 85, Issue 10, pp. 1424 - 1432
The activity of heparanase is responsible for heparan sulfate cleavage, thus resulting in the release of heparan sulfate-bound growth factors. Since heparanase... 
SST0001 | Antitumor activity | Pediatric sarcomas | Heparanase inhibitor | Antiangiogenic agents | TARGETED THERAPY | MATRIX | STIMULATION | CELL-LINES | HEPARIN | CANCER | SULFATE | RHABDOMYOSARCOMA | PHARMACOLOGY & PHARMACY | TUMOR MICROENVIRONMENT | ENDOTHELIAL GROWTH-FACTOR | Osteosarcoma - drug therapy | Humans | Glucuronidase - metabolism | Rhabdomyosarcoma - pathology | Heparin - therapeutic use | Antineoplastic Agents - therapeutic use | Cell Line, Tumor - drug effects | Bone Neoplasms - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Bevacizumab | Rhabdomyosarcoma - blood supply | Bone Neoplasms - blood supply | Antibodies, Monoclonal, Humanized - pharmacology | Osteosarcoma - blood supply | Angiogenesis Inhibitors - therapeutic use | Female | Glucuronidase - antagonists & inhibitors | Indoles - pharmacology | Neovascularization, Pathologic - prevention & control | Rhabdomyosarcoma - drug therapy | Antineoplastic Agents - pharmacology | Bone Neoplasms - drug therapy | Pyrroles - therapeutic use | Child | Heparin - pharmacology | Antibodies, Monoclonal, Humanized - therapeutic use | Neoplasm Invasiveness | Angiogenesis Inhibitors - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Pyrroles - pharmacology | Animals | Heparin - analogs & derivatives | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Indoles - therapeutic use | Mice | Osteosarcoma - pathology | Antimitotic agents | Pediatrics | Sarcoma | Drug therapy | Antineoplastic agents
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, p. e0149081
The administration of fructooligosaccharides (FOS) beneficially modulates gastrointestinal functions and may enhance the metabolism of polyphenols. However,... 
METABOLITES | PROANTHOCYANIDINS | CHAIN FATTY-ACIDS | PHENOLIC-COMPOUNDS | MULTIDISCIPLINARY SCIENCES | HUMAN HEALTH | COMPONENTS | ELLAGIC ACID | ELLAGITANNINS | BIOAVAILABILITY | CONSUMPTION | Plant Extracts - chemistry | Anthocyanins - isolation & purification | Rats, Wistar | Plant Extracts - pharmacology | Glucuronidase - metabolism | Intestinal Absorption - drug effects | Polyphenols - pharmacology | Body Weight - drug effects | Male | Flavonols - isolation & purification | Fatty Acids, Volatile - metabolism | Cecum - physiology | Oligosaccharides - isolation & purification | Oligosaccharides - pharmacology | Proanthocyanidins - pharmacology | Cecum - metabolism | Hydrolyzable Tannins - pharmacology | Glucuronidase - antagonists & inhibitors | Diet - methods | Fragaria - chemistry | Fatty Acids, Volatile - antagonists & inhibitors | Hydrolyzable Tannins - isolation & purification | Intestinal Absorption - physiology | Digestion - drug effects | Polyphenols - isolation & purification | Anthocyanins - pharmacology | Fatty Acids, Volatile - biosynthesis | Rats | Cecum - drug effects | Digestion - physiology | Animals | Glucuronidase - biosynthesis | Flavonols - pharmacology | Proanthocyanidins - isolation & purification | Anthocyanin | Research | Oligosaccharides | Microbiota (Symbiotic organisms) | Gastrointestinal system | Laboratories | Cellulose | Acidification | Food science | Animal reproduction | Metabolites | Polyphenols | Digestive enzymes | Proanthocyanidins | Urine | Flavonols | Enzymes | Ethanol | Cecum | Fructooligosaccharides | Gastrointestinal tract | Bioavailability | Acid production | Metabolism | Fatty acids | Prebiotics | Nutrition research | Diet | Anthocyanins | Dietary fiber
Journal Article
Journal of Natural Products, ISSN 0163-3864, 12/2009, Volume 72, Issue 12, pp. 2145 - 2152
Journal Article
Journal Article
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 01/2018, Volume 51, pp. 8 - 15
Olive oil vascular benefits have been attributed to hydroxytyrosol (HT). However, HT biological actions are still debated because it is extensively metabolized... 
Hydroxytyrosol | Oxidative stress | β-Glucuronidase | Bilitranslocase | Endothelial function | Hydroxytyrosol glucuronides | BIOCHEMISTRY & MOLECULAR BIOLOGY | FLAVONOIDS | P-GLYCOPROTEIN | QUERCETIN | POLYPHENOLS | NUTRITION & DIETETICS | REACTIVE OXYGEN | OLIVE OIL | ENDOTHELIAL-CELLS | beta-Glucuronidase | ABSORPTION | MEMBRANE-TRANSPORT | EXPRESSION | Oxidants - pharmacology | Vascular Diseases - prevention & control | Antioxidants - chemistry | Rats, Wistar | Phenylethyl Alcohol - analogs & derivatives | Antioxidants - metabolism | Glucuronidase - metabolism | Endothelium, Vascular - drug effects | Male | Endothelium, Vascular - enzymology | Glucuronides - metabolism | Membrane Transport Modulators - pharmacology | Glucaric Acid - analogs & derivatives | Phenylmethylsulfonyl Fluoride - pharmacology | Glucuronidase - antagonists & inhibitors | tert-Butylhydroperoxide - pharmacology | Ceruloplasmin - antagonists & inhibitors | Glucuronides - chemistry | Biological Transport, Active - drug effects | Enzyme Inhibitors - pharmacology | Vascular Diseases - enzymology | Phenylethyl Alcohol - metabolism | Aorta, Thoracic | Glucaric Acid - pharmacology | Animals | Endothelium, Vascular - metabolism | Ceruloplasmin - metabolism | Oxidative Stress - drug effects | Vasodilation - drug effects | In Vitro Techniques | Vascular Diseases - metabolism | Dietary Supplements | Phenylethyl Alcohol - chemistry | Metabolites | Dilatation | Blood vessels | Polyphenols | Acetylcholine | High performance liquid chromatography | Endothelium | Life Sciences | Human health and pathology | Cardiology and cardiovascular system
Journal Article
Journal Article