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Kidney International, ISSN 0085-2538, 05/2017, Volume 91, Issue 5, pp. 1104 - 1114
Journal Article
Drug Resistance Updates, ISSN 1368-7646, 2016, Volume 29, pp. 54 - 75
Abstract Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, angiogenesis and... 
Infectious Disease | Hematology, Oncology and Palliative Medicine | Heparanase-inhibiting compounds | Chemoresistance | Heparanase | Clinical trials | Tumorigenesis | Inflammation | Exosomes | Autophagy | MULTIPLE-MYELOMA | MAMMALIAN HEPARANASE | FIBROBLAST-GROWTH-FACTOR | FACTOR-KAPPA-B | DRUG-RESISTANCE | SULFATE PROTEOGLYCANS | CELL-MIGRATION | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | EXTRACELLULAR-MATRIX | TUMOR MICROENVIRONMENT | Humans | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - immunology | Glycoside Hydrolase Inhibitors - therapeutic use | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Glucuronidase - immunology | Autophagy - drug effects | Neovascularization, Pathologic - pathology | Tumor Microenvironment - genetics | Neoplasms - genetics | Glucuronidase - antagonists & inhibitors | Neovascularization, Pathologic - prevention & control | Neovascularization, Pathologic - immunology | Autophagy - genetics | Neoplasm Proteins - genetics | Tumor Microenvironment - drug effects | Immunity, Innate - drug effects | Signal Transduction | Neoplasms - drug therapy | Tumor Microenvironment - immunology | Drug Resistance, Neoplasm - genetics | Glucuronidase - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoplasms - immunology | Neovascularization, Pathologic - genetics | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | Enzymes | Sarcoma | Oncology, Experimental | Development and progression | Metastasis | Research | Drug resistance | Sulfates | Gene expression | Chemotherapy | Immunotherapy | Monoclonal antibodies | Lymphomas | Cellular signal transduction | Heparin | Health aspects | Cancer | chemoresistance | autophagy | inflammation | exosomes | clinical trials | tumorigenesis | heparanase-inhibiting compounds
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 05/2013, Volume 85, Issue 10, pp. 1424 - 1432
The activity of heparanase is responsible for heparan sulfate cleavage, thus resulting in the release of heparan sulfate-bound growth factors. Since heparanase... 
SST0001 | Antitumor activity | Pediatric sarcomas | Heparanase inhibitor | Antiangiogenic agents | TARGETED THERAPY | MATRIX | STIMULATION | CELL-LINES | HEPARIN | CANCER | SULFATE | RHABDOMYOSARCOMA | PHARMACOLOGY & PHARMACY | TUMOR MICROENVIRONMENT | ENDOTHELIAL GROWTH-FACTOR | Osteosarcoma - drug therapy | Humans | Glucuronidase - metabolism | Rhabdomyosarcoma - pathology | Heparin - therapeutic use | Antineoplastic Agents - therapeutic use | Cell Line, Tumor - drug effects | Bone Neoplasms - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Bevacizumab | Rhabdomyosarcoma - blood supply | Bone Neoplasms - blood supply | Antibodies, Monoclonal, Humanized - pharmacology | Osteosarcoma - blood supply | Angiogenesis Inhibitors - therapeutic use | Female | Glucuronidase - antagonists & inhibitors | Indoles - pharmacology | Neovascularization, Pathologic - prevention & control | Rhabdomyosarcoma - drug therapy | Antineoplastic Agents - pharmacology | Bone Neoplasms - drug therapy | Pyrroles - therapeutic use | Child | Heparin - pharmacology | Antibodies, Monoclonal, Humanized - therapeutic use | Neoplasm Invasiveness | Angiogenesis Inhibitors - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Pyrroles - pharmacology | Animals | Heparin - analogs & derivatives | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Indoles - therapeutic use | Mice | Osteosarcoma - pathology | Antimitotic agents | Pediatrics | Sarcoma | Drug therapy | Antineoplastic agents
Journal Article
Leukemia, ISSN 0887-6924, 05/2014, Volume 28, Issue 10, pp. 1988 - 1992
Journal Article
Journal Article
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 11/2013, Volume 8, Issue 11, pp. 1899 - 1905
Background and objectivesSoluble Klotho is an anti-aging phosphaturic protein associated with vascular-renal protection. In vitro and in vivo studies have... 
PHOSPHATE | PROTEIN | THIAZIDE DIURETICS | GENE | ARTERIAL STIFFNESS | UROLOGY & NEPHROLOGY | EXPRESSION | VALSARTAN | ALDOSTERONE SYSTEM | HYDROCHLOROTHIAZIDE | Pulse Wave Analysis | Valsartan | Diabetic Nephropathies - etiology | Albuminuria - blood | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | Middle Aged | Calcium Channel Blockers - therapeutic use | Diabetic Nephropathies - drug therapy | Hypertension - drug therapy | Male | Diabetic Nephropathies - blood | Systole | Diabetic Nephropathies - diagnosis | Hypertension - etiology | Hypertension - blood | Albuminuria - physiopathology | Diabetic Nephropathies - physiopathology | Time Factors | Albuminuria - diagnosis | Phosphates - blood | Female | Blood Pressure - drug effects | Hypertension - diagnosis | Diabetes Mellitus, Type 2 - complications | Albuminuria - etiology | Valine - analogs & derivatives | Hospitals, University | Treatment Outcome | Biomarkers - blood | Glucuronidase - blood | Hypertension - physiopathology | Amlodipine - therapeutic use | Diabetes Mellitus, Type 2 - diagnosis | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 2 - physiopathology | Albuminuria - drug therapy | London | Diuretics - therapeutic use | Renin-Angiotensin System - drug effects | Tetrazoles - therapeutic use | Valine - therapeutic use | Aged | Hydrochlorothiazide - therapeutic use | Original
Journal Article