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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a... 
ACYL GLUCURONIDES | CHEMISTRY, MEDICINAL | PROTEIN | RAT | REACTIVE METABOLITES | TIENILIC ACID | HEPATIC-NECROSIS | BIOACTIVATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | TOXICOLOGY | HUMAN URINE | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
Journal Article
Nutrition, Metabolism and Cardiovascular Diseases, ISSN 0939-4753, 2013, Volume 23, Issue 11, pp. 1086 - 1092
Abstract Background and aims Resveratrol, the most investigated dietary compound in studies aimed at linking wine consumption to human health, is an extremely... 
Cardiovascular | Phytoestrogen | Red wine | Resveratrol metabolism | Resveratrol | ESTROGEN-RECEPTORS | CARDIAC & CARDIOVASCULAR SYSTEMS | ASSAY | ALPHA | BETA | BREAST-CANCER CELLS | NUTRITION & DIETETICS | IN-VIVO | ENDOCRINOLOGY & METABOLISM | HEALTH | Nuclear Receptor Coactivator 2 - agonists | Humans | Neoplasm Proteins - antagonists & inhibitors | Stilbenes - chemistry | Stilbenes - pharmacology | Estrogen Receptor beta - metabolism | Adenocarcinoma - metabolism | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - genetics | Glucuronides - metabolism | Glucuronides - pharmacology | MCF-7 Cells | Sulfates - chemistry | Estrogen Antagonists - chemistry | Glucosides - chemistry | Antineoplastic Agents, Phytogenic - metabolism | Clone Cells | Neoplasm Proteins - genetics | Binding Sites | Estrogen Receptor beta - antagonists & inhibitors | Peptide Fragments - genetics | Phytoestrogens - pharmacology | Glucuronides - chemistry | Recombinant Proteins - chemistry | Estrogen Receptor alpha - antagonists & inhibitors | Sulfates - pharmacology | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Glucosides - metabolism | Estrogen Receptor alpha - genetics | Peptide Fragments - agonists | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Phytoestrogens - metabolism | Stereoisomerism | Phytoestrogens - chemistry | Estrogen Antagonists - pharmacology | Stilbenes - metabolism | Nuclear Receptor Coactivator 2 - metabolism | Neoplasm Proteins - metabolism | Breast Neoplasms - metabolism | Estrogen Receptor beta - agonists | Estrogen Receptor alpha - metabolism | Female | Recombinant Proteins - metabolism | Glucosides - pharmacology | Peptide Fragments - metabolism | Sulfates - metabolism | Antineoplastic Agents, Phytogenic - chemistry | Estrogen Antagonists - metabolism | Nuclear Receptor Coactivator 2 - antagonists & inhibitors | Neoplasm Proteins - agonists | Antineoplastic Agents, Phytogenic - pharmacology | Nuclear Receptor Coactivator 2 - genetics | Metabolites | Beverages
Journal Article
Toxicological Sciences, ISSN 1096-6080, 2012, Volume 125, Issue 2, pp. 359 - 367
The flame retardant tetrabromobisphenol A (TBBPA) is a high production flame retardant that interferes with thyroid hormone (TH) signaling. Despite its rapid... 
Vertebrate model | Biotransformation | Endocrine disruption | Thyroid hormone | Phase II metabolism | TBBPA | Metabolism | TADPOLE METAMORPHOSIS | thyroid hormone | EXPOSURE ASSESSMENT | ENVIRONMENT | RATS | POLYBROMINATED DIPHENYL ETHERS | endocrine disruption | phase II metabolism | ORGANOHALOGENS | biotransformation | vertebrate model | BROMINATED FLAME RETARDANTS | THYROID-HORMONE DISRUPTION | metabolism | BISPHENOL-A | TOXICOLOGY | Humans | Transcriptional Activation - drug effects | Dose-Response Relationship, Drug | Flame Retardants - toxicity | Glucuronides - metabolism | Spectrometry, Mass, Electrospray Ionization | Transfection | Triiodothyronine - metabolism | Thyroid Hormone Receptors alpha - genetics | Larva - drug effects | Chromatography, Liquid | Toxicity Tests - methods | Polybrominated Biphenyls - toxicity | Xenopus laevis - genetics | Genes, Reporter | Binding, Competitive | Endocrine Disruptors - metabolism | Sulfates - metabolism | Xenopus laevis - embryology | Larva - metabolism | Antithyroid Agents - toxicity | Thyroid Hormone Receptors alpha - drug effects | Endocrine Disruptors - toxicity | Animals | Xenopus laevis - metabolism | Flame Retardants - metabolism | Polybrominated Biphenyls - metabolism | Thyroid Hormone Receptors alpha - metabolism | Kinetics | Zebrafish Proteins - genetics | Zebrafish Proteins - drug effects | Antithyroid Agents - metabolism
Journal Article
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 10/2016, Volume 36, pp. 21 - 30
The bioactivity of -resveratrol (RSV), an important wine polyphenol, and of its metabolites was investigated in a more relevant setup comprising an coculture... 
Coculture | Cardiovascular disease | ICAM-1 | Intestine | Nitric oxide | Resveratrol | OXIDATIVE STRESS | METABOLITES | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR-KAPPA-B | CANCER | BIOAVAILABILITY | NUTRITION & DIETETICS | GROWTH-FACTOR | ABSORPTION | NEOVASCULARIZATION | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Reactive Oxygen Species - metabolism | Antioxidants - chemistry | Oxidative Stress | Enterocytes - metabolism | Vascular Endothelial Growth Factors - antagonists & inhibitors | Antioxidants - metabolism | Coculture Techniques | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Stilbenes - metabolism | Stilbenes - chemistry | Interleukin-8 - agonists | Intestinal Absorption | Reactive Oxygen Species - agonists | Inflammation Mediators - agonists | Glucuronides - metabolism | Inflammation Mediators - metabolism | Vascular Endothelial Growth Factors - agonists | Inflammation Mediators - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Interleukin-8 - metabolism | Endothelium, Vascular - immunology | Biomarkers - metabolism | Caco-2 Cells | Cell Line | Sulfates - metabolism | Nitric Oxide - antagonists & inhibitors | Cell Communication | Interleukin-8 - antagonists & inhibitors | Nitric Oxide - agonists | Enterocytes - immunology | Intercellular Adhesion Molecule-1 - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Intercellular Adhesion Molecule-1 - chemistry | Endothelium, Vascular - metabolism | Vascular Endothelial Growth Factors - metabolism | Nitric Oxide - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Molecular Nutrition & Food Research, ISSN 1613-4125, 03/2010, Volume 54, Issue 3, pp. 311 - 322
Epidemiology supports the important role of nutrition in prostate cancer (PCa) prevention. Pomegranate juice (PJ) exerts protective effects against PCa, mainly... 
Polyphenol | Ellagitannins | Bioavailability | Gene expression | Cancer | APOPTOSIS | CANCER CELLS | FOOD SCIENCE & TECHNOLOGY | CELL-CYCLE ARREST | CHEMOPREVENTION | HYPERPLASIA | P21 | GROWTH | GENE-EXPRESSION | CACO-2 CELLS | Coumarins - metabolism | Plant Extracts - chemistry | Prostatic Hyperplasia - urine | Prostatic Neoplasms - metabolism | Ellagic Acid - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Coumarins - chemistry | Male | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | Prostate - metabolism | Plant Extracts - administration & dosage | Juglans - chemistry | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Glucuronides - metabolism | Prostatic Neoplasms - urine | Hydrolyzable Tannins - chemistry | Biomarkers, Tumor - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Glucuronides - administration & dosage | Prostatic Neoplasms - prevention & control | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Beverages - analysis | Glucuronides - chemistry | Punicaceae - chemistry | Prostatic Neoplasms - surgery | Fruit - chemistry | Coumarins - administration & dosage | Ellagic Acid - chemistry | Rats | Glucuronides - urine | Nuclear Proteins - metabolism | Ellagic Acid - urine | Hydrolyzable Tannins - metabolism | Coumarins - urine | Proto-Oncogene Proteins c-myc - metabolism | Rats, Sprague-Dawley | Prostatic Hyperplasia - metabolism | Prostatic Hyperplasia - surgery | Hydrolyzable Tannins - administration & dosage | Animals | Intestines - microbiology | Aged | Proto-Oncogene Proteins c-myc - genetics
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14728 - 14733
We provide a demonstration in humans of the principle of pharmacometabonomics by showing a dear connection between an individual's metabolic phenotype, in the... 
Urine | Metabolomics | Excretion | Pharmacogenetics | Metabolites | Metabolic diseases | Bacteria | Glucuronides | Sulfates | Metabolism | Sulfate | Acetaminophen | p-cresol | Glucuronide | DNA-ADDUCTS | sulfate | QUINONE METHIDE | bacteria | MULTIDISCIPLINARY SCIENCES | ACETAMINOPHEN HEPATOTOXICITY | MYELIN BASIC-PROTEIN | acetaminophen | AUTISTIC-CHILDREN | GUT MICROFLORA | glucuronide | LOW-DOSE PARACETAMOL | PHARMACOGENOMICS | P-CRESOL SULFATE | HUMAN SULFOTRANSFERASES | Acetaminophen - metabolism | Analgesics, Non-Narcotic - pharmacokinetics | Humans | Middle Aged | Male | Sulfuric Acid Esters - metabolism | Young Adult | Bacteria - growth & development | Cresols - urine | Adult | Bacteria - metabolism | Acetaminophen - analogs & derivatives | Sulfates - metabolism | Magnetic Resonance Spectroscopy | Administration, Oral | Gastrointestinal Tract - microbiology | Acetaminophen - urine | Analgesics, Non-Narcotic - administration & dosage | Analgesics, Non-Narcotic - metabolism | Cresols - metabolism | Gastrointestinal Tract - metabolism | Host-Pathogen Interactions | Sulfuric Acid Esters - urine | Adolescent | Acetaminophen - pharmacokinetics | Host-bacteria relationships | Drug metabolism | Metabonomic analysis | Research | Competition | Drugs | biomarkers | Cresol | Magnetic resonance spectroscopy | p-Cresol | Analgesics | Sulfonation | Xenobiotics | Digestive tract | Pharmaceuticals | Biological Sciences
Journal Article
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 01/2017, Volume 39, pp. 156 - 168
Dietary fiber-derived short-chain fatty acids (SCFA) and phenolics produced by the gut microbiome have multiple effects on health. We have tested the... 
Short-chain fatty acids | Polyphenol | Phase II metabolism | Transporter | Gut metabolism | HUMAN COLON | SULFOTRANSFERASES | HYDROXYCINNAMIC ACIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HESPERETIN | NUTRITION & DIETETICS | UDP-GLUCURONOSYLTRANSFERASES | FERULIC ACID | GENE-EXPRESSION | BUTYRATE | PHASE-II METABOLISM | CACO-2 CELLS | Fatty Acids, Volatile - pharmacology | Propionates - pharmacology | Butyrates - pharmacology | Humans | Hesperidin - metabolism | Neoplasm Proteins - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Intestinal Mucosa - drug effects | Polyphenols - metabolism | Intestinal Mucosa - cytology | Glucuronosyltransferase - genetics | Monocarboxylic Acid Transporters - metabolism | Biological Transport | Muscle Proteins - metabolism | Neoplasm Proteins - genetics | Caco-2 Cells | Lactates - pharmacology | Coumaric Acids - metabolism | Intestinal Mucosa - microbiology | Symporters - metabolism | Muscle Proteins - genetics | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Gastrointestinal Microbiome - drug effects | Glucuronosyltransferase - metabolism | Symporters - genetics | Acetates - pharmacology | Monocarboxylic Acid Transporters - genetics | Lactates | Enzymes | Metabolites | Microbiota (Symbiotic organisms) | RNA | Analysis | Physiological aspects | Phenols | Esters | Sulfates | Fatty acids | Resveratrol | HT-3′-glu, Hesperetin-3′-O-glucuronide | DMCA, 3,4-dimethoxycinnamic acid | ABCG2, ATP-binding cassette sub-family G member 2 (BCRP) | FA, Ferulic acid | FA-sul, Ferulic acid-4-O-sulfate | HT-7-sul, Hesperetin-7-O-sulfate | HT, Hesperetin | HT-7-glu, Hesperetin-7-O-glucuronide | HT-3′-sul, Hesperetin-3′-O-sulfate | ABCC, ATP-binding cassette sub-family C | SULT, Sulfotransferase | DHFA, Dihydroferulic acid | FA-glu, Ferulic acid-4-O-glucuronide | SA, Salicylic acid | UGT, Uridine diphosphate-glucuronosyl transferase | SCFA, Short-chain fatty acids
Journal Article
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 07/2015, Volume 104, Issue 7, pp. 2369 - 2377
In th is study, we aimed to determine the glucuronidation potential of psoralidin in humans and to perform validation on use of psoralidin-3- -glucuronidation... 
psoralidin | reaction phenotyping | functional marker | UGTs | glucuronidation | Functional marker |