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Journal Article
eBook
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 06/2013, Volume 53, Issue 6, pp. 601 - 610
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2009, Volume 27, Issue 16, pp. 2604 - 2614
Purpose We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in irinotecan (CPT-11)... 
CELL LUNG-CANCER | GENETIC POLYMORPHISMS | MESSENGER-RNA | ONCOLOGY | SLCO1B1 POLYMORPHISM | RESISTANCE | HUMAN LIVER | EXPRESSION | METASTATIC COLORECTAL-CANCER | FUNCTIONAL-SIGNIFICANCE | JAPANESE SUBJECTS | Multivariate Analysis | Glucuronides - pharmacokinetics | Hepatocyte Nuclear Factor 1-alpha - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Biotransformation - genetics | Male | Organic Anion Transporters - metabolism | Patient Selection | Glucuronosyltransferase - genetics | Antineoplastic Agents, Phytogenic - administration & dosage | Organic Anion Transporters - genetics | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Camptothecin - administration & dosage | Female | Multidrug Resistance-Associated Proteins - genetics | Neutropenia - chemically induced | Neutropenia - genetics | Antineoplastic Agents, Phytogenic - pharmacokinetics | Colorectal Neoplasms - metabolism | Antineoplastic Agents, Phytogenic - adverse effects | Camptothecin - analogs & derivatives | Camptothecin - pharmacokinetics | Camptothecin - adverse effects | Genetic Predisposition to Disease | Drug Administration Schedule | Risk Assessment | Risk Factors | Treatment Outcome | Polymorphism, Genetic | Bilirubin - blood | Phenotype | Glucuronosyltransferase - metabolism | Aged | Solute Carrier Organic Anion Transporter Family Member 1b1 | Multidrug Resistance-Associated Proteins - metabolism | Index Medicus | Original Reports | Gic7 | Faze
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Xenobiotica, ISSN 0049-8254, 12/2017, Volume 47, Issue 12, pp. 1064 - 1076
1. The metabolism, excretion and pharmacokinetics of glasdegib (PF-04449913) were investigated following administration of a single oral dose of 100 mg/100 μCi... 
smoothened inhibitor | mass balance, PF-04449913 | Glasdegib | ADME | mass balance | SAFETY | PF-04449913 | MALIGNANCIES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INHIBITOR | CANCER | HEDGEHOG | Young Adult | Glucuronides - metabolism | Administration, Oral | Biotransformation | Humans | Benzimidazoles - pharmacokinetics | Adult | Male | Phenylurea Compounds - pharmacokinetics | Healthy Volunteers | Index Medicus
Journal Article
Journal Article
15.