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Clinical Cancer Research, ISSN 1078-0432, 08/2003, Volume 9, Issue 9, pp. 3246 - 3253
Purpose: The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding... 
P-Glycoprotein/genetics | Multidrug Resistance-Associated Proteins/genetics | Cytochrome P-450 Enzyme System/genetics | Humans | Male | Carboxylesterase/genetics | Glucuronic Acids/chemistry | Middle aged | Neoplasm Proteins/genetics | Adult | Female | Gene Frequency | Genotype | Membrane Transport Proteins/genetics | Polymorphism, Genetic | Homozygote | Phenotype | DNA-Binding Proteins/genetics | Models, Biological | Alleles | Adenosine Triphosphate/genetics | Cell Line, Tumor | Protein Binding | ATP-Binding Cassette Transporters/genetics | Camptothecin/analogs & derivatives/pharmacokinetics/pharmacology | Aged | Research Support, U.S. Gov't, P.H.S | Glucuronosyltransferase/genetics | GILBERTS-SYNDROME | 7-ETHYL-10-HYDROXYCAMPTOTHECIN SN-38 | CANCER-PATIENTS | UDP-GLUCURONOSYLTRANSFERASE GENE | CPT-11 | METABOLISM | ONCOLOGY | IN-VIVO | RESISTANCE | PHARMACOGENETICS | CLINICAL PHARMACOKINETICS | Cytochrome P-450 CYP3A | Middle Aged | Adenosine Triphosphate - genetics | Glucuronosyltransferase - genetics | ATP-Binding Cassette Transporters - genetics | Membrane Transport Proteins - genetics | Multidrug Resistance-Associated Proteins - genetics | Glucuronates - chemistry | Neoplasm Proteins - genetics | Camptothecin - analogs & derivatives | Camptothecin - pharmacokinetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 | DNA-Binding Proteins - genetics | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | Irinotecan | Carboxylesterase - genetics | Cytochrome P-450 Enzyme System - genetics | X-ray Repair Cross Complementing Protein 1 | Camptothecin - pharmacology
Journal Article
PLoS Genetics, ISSN 1553-7390, 03/2011, Volume 7, Issue 3, p. e1001332
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2012, Volume 40, Issue 7, pp. 1366 - 1379
The transcription factors aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), peroxisome proliferator-activated... 
TRANSCRIPTION FACTORS | PRIMARY HUMAN HEPATOCYTES | ANTIOXIDANT RESPONSE ELEMENT | MESSENGER-RNA EXPRESSION | CONSTITUTIVE ANDROSTANE RECEPTOR | BILIARY-EXCRETION | PROLIFERATOR-ACTIVATED RECEPTOR | MOUSE-LIVER | PHARMACOLOGY & PHARMACY | MICROSOMAL-ENZYME INDUCERS | PREGNANE-X-RECEPTOR | Inactivation, Metabolic | Receptors, Steroid - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | NAD(P)H Dehydrogenase (Quinone) - genetics | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Organic Anion Transporters - genetics | Glutathione Transferase - genetics | Receptors, Aryl Hydrocarbon - metabolism | Female | NF-E2-Related Factor 2 - genetics | Sulfotransferases - metabolism | Aldehyde Dehydrogenase - metabolism | Sulfotransferases - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | Glutathione Transferase - metabolism | Aldehyde Dehydrogenase - genetics | PPAR alpha - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Mice, Knockout | Gene Expression Regulation, Enzymologic | Transcription Factors - metabolism | Animals | Glucuronosyltransferase - metabolism | Receptors, Steroid - genetics | NF-E2-Related Factor 2 - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | PPAR alpha - metabolism | Multidrug Resistance-Associated Proteins | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 13, pp. 20925 - 20938
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 22, pp. 19523 - 19532
Aberrant expression of the human hyaluronan synthase 2 (HAS2) gene has been implicated in the pathology of malignancy, pulmonary arterial hypertension,... 
FIBROSIS | ACID RECEPTOR | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | DISEASE | DIABETIC-NEPHROPATHY | PROLIFERATION | PROMOTER | CANCER | INSIGHTS | Epithelial Cells - metabolism | Nucleic Acid Heteroduplexes - genetics | Humans | Transforming Growth Factor beta1 - metabolism | Sp1 Transcription Factor - metabolism | Smad3 Protein - metabolism | Interleukin-1beta - genetics | Kidney Diseases - genetics | Gene Knockdown Techniques | Glucuronosyltransferase - genetics | RNA, Messenger - biosynthesis | Smad3 Protein - genetics | Hyaluronic Acid - biosynthesis | Interleukin-1beta - metabolism | Smad2 Protein - genetics | Transcription, Genetic | Hyaluronan Synthases | Response Elements - genetics | Sp3 Transcription Factor - metabolism | Kidney Diseases - metabolism | Kidney Tubules, Proximal - pathology | Kidney Diseases - pathology | RNA, Messenger - genetics | Sp3 Transcription Factor - genetics | Gene Expression Regulation | Smad2 Protein - metabolism | Epithelial Cells - pathology | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Transforming Growth Factor beta1 - genetics | Nucleic Acid Heteroduplexes - biosynthesis | RNA, Antisense - biosynthesis | Sp1 Transcription Factor - genetics | Fibrosis | Kidney Tubules, Proximal - metabolism | Cell Line, Tumor | Glucuronosyltransferase - biosynthesis | Hypertension, Pulmonary - pathology | RNA, Antisense - genetics | Gene Transcription | Natural Antisense HAS2-AS1 | Hyaluronan Synthase 2 | Noncoding RNA | Renal Fibrosis | Extracellular Matrix | Antisense RNA | Glycobiology and Extracellular Matrices | Hyaluronate | Kidney | Post-transcriptional Regulation
Journal Article
American journal of human genetics, ISSN 0002-9297, 2008, Volume 83, Issue 6, pp. 663 - 674
Journal Article
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 07/2014, Volume 11, Issue 7, pp. 2115 - 2125
Glioblastoma (GBM) is the most common and aggressive form of primary brain tumor with a median survival of 12–15 months, and the mechanisms underlying GBM... 
hydrogels | glioblastoma | three-dimensional | tumor microenvironment | tumor model | CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | PHENOTYPE | PROLIFERATION | METALLOPROTEINASES | MEDIATED MOTILITY RHAMM | HYALURONIC-ACID | OVEREXPRESSION | MALIGNANT GLIOMAS | PHARMACOLOGY & PHARMACY | EXTRACELLULAR-MATRIX | EXPRESSION | Biomimetics - methods | Gene Expression - drug effects | Gene Expression - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Brain Neoplasms - pathology | Spheroids, Cellular - pathology | Extracellular Matrix - metabolism | Hyaluronic Acid - pharmacology | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Brain Neoplasms - metabolism | Cell Movement - genetics | Brain - metabolism | Glucuronosyltransferase - genetics | Matrix Metalloproteinase 9 - metabolism | rho-Associated Kinases - metabolism | Matrix Metalloproteinase 9 - genetics | Glioblastoma - metabolism | Hyaluronan Synthases | Spheroids, Cellular - drug effects | Matrix Metalloproteinase 1 - genetics | Polyethylene Glycols - pharmacology | Proto-Oncogene Proteins p21(ras) - metabolism | Extracellular Matrix - drug effects | Spheroids, Cellular - metabolism | rho-Associated Kinases - genetics | Up-Regulation - genetics | Cell Communication - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | Brain - drug effects | Up-Regulation - drug effects | Cell Movement - drug effects | Glucuronosyltransferase - metabolism | Glioblastoma - pathology | Cell Communication - drug effects | Brain - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Hydrogels - pharmacology | Extracellular Matrix - pathology
Journal Article
American journal of hematology, ISSN 0361-8609, 2013, Volume 88, Issue 7, pp. 571 - 576
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2013, Volume 288, Issue 21, pp. 14824 - 14838
Journal Article