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PLoS Genetics, ISSN 1553-7390, 03/2011, Volume 7, Issue 3, pp. e1001332 - e1001332
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2003, Volume 9, Issue 9, pp. 3246 - 3253
Purpose: The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding... 
GILBERTS-SYNDROME | 7-ETHYL-10-HYDROXYCAMPTOTHECIN SN-38 | CANCER-PATIENTS | UDP-GLUCURONOSYLTRANSFERASE GENE | CPT-11 | METABOLISM | ONCOLOGY | IN-VIVO | RESISTANCE | PHARMACOGENETICS | CLINICAL PHARMACOKINETICS | Cytochrome P-450 CYP3A | Humans | Middle Aged | Adenosine Triphosphate - genetics | Male | Glucuronosyltransferase - genetics | ATP-Binding Cassette Transporters - genetics | Membrane Transport Proteins - genetics | Adult | Female | Multidrug Resistance-Associated Proteins - genetics | Glucuronates - chemistry | Neoplasm Proteins - genetics | Camptothecin - analogs & derivatives | Camptothecin - pharmacokinetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 | Gene Frequency | Genotype | DNA-Binding Proteins - genetics | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | Polymorphism, Genetic | Homozygote | Irinotecan | Phenotype | Models, Biological | Alleles | Carboxylesterase - genetics | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Protein Binding | Aged | X-ray Repair Cross Complementing Protein 1 | Camptothecin - pharmacology | Index Medicus | P-Glycoprotein/genetics | Research Support; U.S. Gov't; P.H.S | Multidrug Resistance-Associated Proteins/genetics | Cytochrome P-450 Enzyme System/genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Carboxylesterase/genetics | MEDICINE | Glucuronic Acids/chemistry | Neoplasm Proteins/genetics | Polymorphism; Genetic | Models; Biological | Membrane Transport Proteins/genetics | DNA-Binding Proteins/genetics | MEDICIN | Cell Line; Tumor | Adenosine Triphosphate/genetics | ATP-Binding Cassette Transporters/genetics | Camptothecin/analogs & derivatives/pharmacokinetics/pharmacology | Glucuronosyltransferase/genetics
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2012, Volume 40, Issue 7, pp. 1366 - 1379
The transcription factors aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), peroxisome proliferator-activated... 
TRANSCRIPTION FACTORS | PRIMARY HUMAN HEPATOCYTES | ANTIOXIDANT RESPONSE ELEMENT | MESSENGER-RNA EXPRESSION | CONSTITUTIVE ANDROSTANE RECEPTOR | BILIARY-EXCRETION | PROLIFERATOR-ACTIVATED RECEPTOR | MOUSE-LIVER | PHARMACOLOGY & PHARMACY | MICROSOMAL-ENZYME INDUCERS | PREGNANE-X-RECEPTOR | Inactivation, Metabolic | Receptors, Steroid - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | NAD(P)H Dehydrogenase (Quinone) - genetics | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Organic Anion Transporters - genetics | Glutathione Transferase - genetics | Receptors, Aryl Hydrocarbon - metabolism | Female | NF-E2-Related Factor 2 - genetics | Sulfotransferases - metabolism | Aldehyde Dehydrogenase - metabolism | Sulfotransferases - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | Glutathione Transferase - metabolism | Aldehyde Dehydrogenase - genetics | PPAR alpha - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Mice, Knockout | Gene Expression Regulation, Enzymologic | Transcription Factors - metabolism | Animals | Glucuronosyltransferase - metabolism | Receptors, Steroid - genetics | NF-E2-Related Factor 2 - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | PPAR alpha - metabolism | Multidrug Resistance-Associated Proteins | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Journal Article
BMC Gastroenterology, ISSN 1471-230X, 01/2017, Volume 17, Issue 1, pp. 2 - 2
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 13, pp. 20925 - 20938
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 12/2008, Volume 83, Issue 6, pp. 663 - 674
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 22, pp. 19523 - 19532
Aberrant expression of the human hyaluronan synthase 2 (HAS2) gene has been implicated in the pathology of malignancy, pulmonary arterial hypertension,... 
FIBROSIS | ACID RECEPTOR | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | DISEASE | DIABETIC-NEPHROPATHY | PROLIFERATION | PROMOTER | CANCER | INSIGHTS | Epithelial Cells - metabolism | Nucleic Acid Heteroduplexes - genetics | Humans | Transforming Growth Factor beta1 - metabolism | Sp1 Transcription Factor - metabolism | Smad3 Protein - metabolism | Interleukin-1beta - genetics | Kidney Diseases - genetics | Gene Knockdown Techniques | Glucuronosyltransferase - genetics | RNA, Messenger - biosynthesis | Smad3 Protein - genetics | Hyaluronic Acid - biosynthesis | Interleukin-1beta - metabolism | Smad2 Protein - genetics | Transcription, Genetic | Hyaluronan Synthases | Response Elements - genetics | Sp3 Transcription Factor - metabolism | Kidney Diseases - metabolism | Kidney Tubules, Proximal - pathology | Kidney Diseases - pathology | RNA, Messenger - genetics | Sp3 Transcription Factor - genetics | Gene Expression Regulation | Smad2 Protein - metabolism | Epithelial Cells - pathology | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Transforming Growth Factor beta1 - genetics | Nucleic Acid Heteroduplexes - biosynthesis | RNA, Antisense - biosynthesis | Sp1 Transcription Factor - genetics | Fibrosis | Kidney Tubules, Proximal - metabolism | Cell Line, Tumor | Glucuronosyltransferase - biosynthesis | Hypertension, Pulmonary - pathology | RNA, Antisense - genetics | Index Medicus | Gene Transcription | Natural Antisense HAS2-AS1 | Hyaluronan Synthase 2 | Noncoding RNA | Renal Fibrosis | Extracellular Matrix | Antisense RNA | Glycobiology and Extracellular Matrices | Hyaluronate | Kidney | Post-transcriptional Regulation
Journal Article
Comparative Biochemistry and Physiology, Part C, ISSN 1532-0456, 01/2019, Volume 215, pp. 18 - 24
While it has been known for a while that some snake species are extremely sensitive to acetaminophen, the underlying mechanism for this toxicity has not been... 
UDP‑glucuronosyltransferase | Mammalia | Acetaminophen | Toxicity | Snake | Biotransformation | N‑acetyltransferase | Reptilia | Phylogeny | ASSAY | UDP-glucuronosyltransferase | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLUCURONIDATION | PARACETAMOL | N-acetyltransferase | ZOOLOGY | METABOLISM | DEACETYLATION | ENDOCRINOLOGY & METABOLISM | TOXICOLOGY | Acetaminophen - adverse effects | Acetaminophen - metabolism | Acetyltransferases - metabolism | Liver - enzymology | Reptilian Proteins - genetics | Species Specificity | Snakes - physiology | Databases, Genetic | Environmental Pollutants - metabolism | Acetyltransferases - genetics | Agkistrodon - genetics | Glucuronosyltransferase - genetics | Glutathione Transferase - genetics | Isoenzymes - metabolism | Analgesics, Non-Narcotic - adverse effects | Colubridae - genetics | Crotalus - physiology | Sulfotransferases - metabolism | Colubridae - physiology | Boidae - physiology | Environmental Pollutants - toxicity | Boidae - genetics | Agkistrodon - physiology | Drug Resistance | Sulfotransferases - genetics | Acetaminophen - toxicity | Isoenzymes - genetics | Glutathione Transferase - metabolism | Analgesics, Non-Narcotic - metabolism | Toxicokinetics | Snakes - genetics | Animals | Glucuronosyltransferase - metabolism | Crotalus - genetics | Reptilian Proteins - metabolism | Animal genetics | Aromatic amines | Metabolites | Gene mutations | Glutathione transferase | Genomics | Turtles | Alligators | Comparative analysis | Snakes | Index Medicus
Journal Article
American Journal of Hematology, ISSN 0361-8609, 07/2013, Volume 88, Issue 7, pp. 571 - 576
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 08/2016, Volume 119, Issue 2, pp. 173 - 183
Sunitinib ( SUN ) is a multi‐targeted tyrosine kinase inhibitor that was recently approved for the treatment of gastrointestinal tract and renal cancers. To... 
BREAST-CANCER | DIACYLGLYCEROL ACYLTRANSFERASE | TYROSINE KINASE INHIBITOR | RECEPTOR | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INDUCTION | CYTOCHROME-P450 3A4 | DRUG TRANSPORT | PHASE-I | RENAL-CELL CARCINOMA | HEPATITIS-E | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Liver - enzymology | Rats, Wistar | Kidney - enzymology | Aryl Hydrocarbon Hydroxylases - genetics | Transcriptome | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 CYP1B1 - metabolism | Male | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Steroid 16-alpha-Hydroxylase - metabolism | RNA, Messenger - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Glucuronosyltransferase - genetics | Glutathione Transferase - genetics | ATP-Binding Cassette Transporters - genetics | Liver - drug effects | Isoenzymes - metabolism | Cytochrome P-450 CYP1A2 - genetics | Lipid Peroxidation - drug effects | ATP-Binding Cassette Transporters - metabolism | Cytochrome P450 Family 2 - genetics | Indoles - pharmacology | Xenobiotics - metabolism | Steroid 16-alpha-Hydroxylase - antagonists & inhibitors | Cytochrome P450 Family 2 - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Kidney - drug effects | Isoenzymes - genetics | RNA, Messenger - genetics | Glutathione Transferase - metabolism | Rats | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Cytochrome P450 Family 4 - metabolism | Pyrroles - pharmacology | Animals | Cytochrome P450 Family 2 - metabolism | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Steroid 16-alpha-Hydroxylase - genetics | Cytochrome P450 Family 4 - genetics | Antimitotic agents | Enzymes | Antineoplastic agents | Liver | Proteins | Protein expression | Rodents | Index Medicus
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 07/2014, Volume 11, Issue 7, pp. 2115 - 2125
Glioblastoma (GBM) is the most common and aggressive form of primary brain tumor with a median survival of 12-15 months, and the mechanisms underlying GBM... 
hydrogels | glioblastoma | three-dimensional | tumor microenvironment | tumor model | CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | PHENOTYPE | PROLIFERATION | METALLOPROTEINASES | MEDIATED MOTILITY RHAMM | HYALURONIC-ACID | OVEREXPRESSION | MALIGNANT GLIOMAS | PHARMACOLOGY & PHARMACY | EXTRACELLULAR-MATRIX | EXPRESSION | Biomimetics - methods | Gene Expression - drug effects | Gene Expression - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Brain Neoplasms - pathology | Spheroids, Cellular - pathology | Extracellular Matrix - metabolism | Hyaluronic Acid - pharmacology | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Brain Neoplasms - metabolism | Cell Movement - genetics | Brain - metabolism | Glucuronosyltransferase - genetics | Matrix Metalloproteinase 9 - metabolism | rho-Associated Kinases - metabolism | Matrix Metalloproteinase 9 - genetics | Glioblastoma - metabolism | Hyaluronan Synthases | Spheroids, Cellular - drug effects | Matrix Metalloproteinase 1 - genetics | Polyethylene Glycols - pharmacology | Proto-Oncogene Proteins p21(ras) - metabolism | Extracellular Matrix - drug effects | Spheroids, Cellular - metabolism | rho-Associated Kinases - genetics | Up-Regulation - genetics | Cell Communication - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | Brain - drug effects | Up-Regulation - drug effects | Cell Movement - drug effects | Glucuronosyltransferase - metabolism | Glioblastoma - pathology | Cell Communication - drug effects | Brain - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Hydrogels - pharmacology | Extracellular Matrix - pathology | Index Medicus
Journal Article
Aquatic Toxicology, ISSN 0166-445X, 07/2017, Volume 188, pp. 43 - 53
Diclofenac (DCF) is one of widely used non-steroidal anti-inflammatory drugs. Recently, this drug has been universally detected in aquatic environment.... 
Mosquito fish | Oxidative stress | Nrf2 | Diclofenac | DANIO-RERIO | ENZYME-ACTIVITIES | TILAPIA OREOCHROMIS-NILOTICUS | ANTIOXIDANT RESPONSE ELEMENT | CARP CYPRINUS-CARPIO | UDP-GLUCURONOSYLTRANSFERASES | CLOFIBRIC ACID | GLUTATHIONE | MARINE & FRESHWATER BIOLOGY | LIVER | TOXICOLOGY | Malondialdehyde - metabolism | Fishes - genetics | Superoxide Dismutase - genetics | Catalase - genetics | Isoenzymes - genetics | Gene Expression Regulation | Glutathione Transferase - metabolism | Diclofenac - toxicity | NAD(P)H Dehydrogenase (Quinone) - genetics | Phylogeny | Anti-Inflammatory Agents, Non-Steroidal - toxicity | Catalase - metabolism | Fish Proteins - genetics | Glucuronosyltransferase - genetics | Animals | Glutathione Transferase - genetics | Water Pollutants, Chemical - toxicity | Isoenzymes - metabolism | Female | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Oxidative Stress - drug effects | Superoxide Dismutase - metabolism | Enzymes | Mosquitoes | Genes | Genetic research | Animal genetic engineering | Genetic aspects | Goods and services tax | Toiletries | Cysteine | Biological products | RNA | Superoxide | Genetic transcription | Glutamate | Antioxidants | Zinc compounds | Anopheles | Fluocinolone acetonide | Glutathione transferase | Ligases | Analysis | Personal care industry | Nonsteroidal anti-inflammatory drugs | Index Medicus
Journal Article