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Drug Metabolism and Disposition, ISSN 0090-9556, 07/2012, Volume 40, Issue 7, pp. 1366 - 1379
The transcription factors aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), peroxisome proliferator-activated... 
TRANSCRIPTION FACTORS | PRIMARY HUMAN HEPATOCYTES | ANTIOXIDANT RESPONSE ELEMENT | MESSENGER-RNA EXPRESSION | CONSTITUTIVE ANDROSTANE RECEPTOR | BILIARY-EXCRETION | PROLIFERATOR-ACTIVATED RECEPTOR | MOUSE-LIVER | PHARMACOLOGY & PHARMACY | MICROSOMAL-ENZYME INDUCERS | PREGNANE-X-RECEPTOR | Inactivation, Metabolic | Receptors, Steroid - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | NAD(P)H Dehydrogenase (Quinone) - genetics | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Organic Anion Transporters - genetics | Glutathione Transferase - genetics | Receptors, Aryl Hydrocarbon - metabolism | Female | NF-E2-Related Factor 2 - genetics | Sulfotransferases - metabolism | Aldehyde Dehydrogenase - metabolism | Sulfotransferases - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | Glutathione Transferase - metabolism | Aldehyde Dehydrogenase - genetics | PPAR alpha - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Mice, Knockout | Gene Expression Regulation, Enzymologic | Transcription Factors - metabolism | Animals | Glucuronosyltransferase - metabolism | Receptors, Steroid - genetics | NF-E2-Related Factor 2 - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | PPAR alpha - metabolism | Multidrug Resistance-Associated Proteins | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2009, Volume 329, Issue 3, pp. 1023 - 1031
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2013, Volume 41, Issue 2, pp. 256 - 262
There is increasing evidence that pregnancy alters the function of drug-metabolizing enzymes and drug transporters in a gestational-stage and tissue-specific... 
WOMEN | METFORMIN | CLEARANCE | IN-VITRO | PHARMACOKINETICS | PLASMA-CONCENTRATIONS | 3RD TRIMESTER | ZIDOVUDINE | PHARMACOLOGY & PHARMACY | HUMAN-IMMUNODEFICIENCY-VIRUS | EXPRESSION | Smoking - adverse effects | Estrogens - pharmacology | Liver - enzymology | Cholestasis - metabolism | Minor Histocompatibility Antigens | Taurocholic Acid - metabolism | Humans | Kidney - enzymology | Cytochrome P-450 Enzyme System - metabolism | Male | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Intestine, Small - enzymology | Lung - enzymology | Glucuronosyltransferase - genetics | RNA, Messenger - biosynthesis | Kidney - metabolism | Estrogen Receptor alpha - agonists | Liver - drug effects | Cotinine - metabolism | Maternal Behavior | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Pesticides - metabolism | Adrenal Glands - enzymology | Progesterone - pharmacology | Estradiol - pharmacology | Hepatocytes - drug effects | Retinoic Acid 4-Hydroxylase | Multidrug Resistance-Associated Proteins - drug effects | Gene Expression Regulation, Developmental - drug effects | Placenta - enzymology | Ethinyl Estradiol - pharmacology | Aryldialkylphosphatase - metabolism | Carboxylesterase - metabolism | Fetus - drug effects | Placenta - drug effects | Pregnancy | Animals | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Hydroxyprogesterones - metabolism | Index Medicus | Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Journal Article
FEBS Journal, ISSN 1742-464X, 05/2016, Volume 283, Issue 9, pp. 1689 - 1700
Intervertebral discs ( IVD s) provide stability and flexibility to the spinal column; however, IVD s, and in particular the nucleus pulposus ( NP ), undergo a... 
intervertebral disc degeneration | Smad | BMP | mesenchymal stem cells | nucleus pulposus | BMP7 | REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MESENCHYMAL STEM-CELLS | TRANSPLANTATION | CROSS-TALK | LUMBAR-SPINE | IN-VITRO | NUCLEUS PULPOSUS CELLS | DISEASE | GROWTH | DIFFERENTIATION | RNA, Small Interfering - genetics | Bone Morphogenetic Protein 7 - genetics | Humans | Extracellular Matrix - metabolism | Intervertebral Disc Degeneration - metabolism | Intervertebral Disc Degeneration - therapy | Collagen Type II - metabolism | Intervertebral Disc Degeneration - pathology | Lentivirus - metabolism | Glucuronosyltransferase - genetics | Mesenchymal Stromal Cells - cytology | Smad1 Protein - genetics | Lentivirus - genetics | Intervertebral Disc - pathology | Chondrocytes - metabolism | Disease Models, Animal | Intervertebral Disc Degeneration - genetics | SOX9 Transcription Factor - metabolism | Chondrocytes - pathology | Rabbits | Genetic Vectors - chemistry | Signal Transduction | Bone Marrow Cells - cytology | Glycosaminoglycans - metabolism | Keratin-8 - genetics | Gene Expression Regulation | Genetic Vectors - metabolism | Mesenchymal Stromal Cells - metabolism | Intervertebral Disc - metabolism | Aggrecans - metabolism | Smad1 Protein - antagonists & inhibitors | Aggrecans - genetics | Collagen Type II - genetics | Keratin-19 - genetics | Animals | Glucuronosyltransferase - metabolism | Keratin-8 - metabolism | Bone Morphogenetic Protein 7 - metabolism | Smad1 Protein - metabolism | Keratin-19 - metabolism | Extracellular Matrix - pathology | SOX9 Transcription Factor - genetics | Bone Marrow Cells - metabolism | Mesenchymal Stem Cell Transplantation | RNA, Small Interfering - metabolism | Physiological aspects | Bone morphogenetic proteins | Cell differentiation | Analysis | Stem cells | Extracellular matrix | Spine | Rodents | Keratins | Therapy | Surgical implants | Smad protein | Mesenchyme | Collagen (type II) | Sox9 protein | Medical services | Differentiation (biology) | Electrochemical machining | Homeostasis | Nucleus pulposus | Remodeling | Intervertebral discs | Nuclei | Flexibility | Bone marrow | Degeneration | Effectiveness | Stability | Markers | Feasibility studies | Implantation | Columns (process) | Survival | Diseases | Overexpression | Disks | Feasibility | Chondroitin sulfate | Sulfate | Aggrecan | Viability | Bone morphogenetic protein 7 | Index Medicus
Journal Article
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 08/2016, Volume 13, Issue 8, pp. 2631 - 2640
Journal Article
Life Sciences, ISSN 0024-3205, 07/2011, Volume 89, Issue 1-2, pp. 57 - 64
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 08/2016, Volume 119, Issue 2, pp. 173 - 183
Sunitinib ( SUN ) is a multi‐targeted tyrosine kinase inhibitor that was recently approved for the treatment of gastrointestinal tract and renal cancers. To... 
BREAST-CANCER | DIACYLGLYCEROL ACYLTRANSFERASE | TYROSINE KINASE INHIBITOR | RECEPTOR | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INDUCTION | CYTOCHROME-P450 3A4 | DRUG TRANSPORT | PHASE-I | RENAL-CELL CARCINOMA | HEPATITIS-E | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Liver - enzymology | Rats, Wistar | Kidney - enzymology | Aryl Hydrocarbon Hydroxylases - genetics | Transcriptome | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 CYP1B1 - metabolism | Male | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Steroid 16-alpha-Hydroxylase - metabolism | RNA, Messenger - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Glucuronosyltransferase - genetics | Glutathione Transferase - genetics | ATP-Binding Cassette Transporters - genetics | Liver - drug effects | Isoenzymes - metabolism | Cytochrome P-450 CYP1A2 - genetics | Lipid Peroxidation - drug effects | ATP-Binding Cassette Transporters - metabolism | Cytochrome P450 Family 2 - genetics | Indoles - pharmacology | Xenobiotics - metabolism | Steroid 16-alpha-Hydroxylase - antagonists & inhibitors | Cytochrome P450 Family 2 - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Kidney - drug effects | Isoenzymes - genetics | RNA, Messenger - genetics | Glutathione Transferase - metabolism | Rats | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Cytochrome P450 Family 4 - metabolism | Pyrroles - pharmacology | Animals | Cytochrome P450 Family 2 - metabolism | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Steroid 16-alpha-Hydroxylase - genetics | Cytochrome P450 Family 4 - genetics | Antimitotic agents | Enzymes | Antineoplastic agents | Liver | Proteins | Protein expression | Rodents | Index Medicus
Journal Article
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 04/2015, Volume 29, Issue 4, pp. 1290 - 1298
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2017, Volume 45, Issue 7, pp. 755 - 764
To assess drug-drug interaction (DDI) potential for the three directacting antiviral (3D) regimen of ombitasvir, dasabuvir, and paritaprevir, in vitro studies... 
METABOLISM | PHARMACOKINETICS | INTERACTION PROFILE | TRANSPORTERS | DIGOXIN | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | INHIBITOR | DISPOSITION | P-GLYCOPROTEIN | RITONAVIR | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 Enzyme Inhibitors - metabolism | Male | Antiviral Agents - metabolism | Macrocyclic Compounds - pharmacology | Carbamates - metabolism | Uracil - pharmacology | HEK293 Cells | Female | Membrane Transport Proteins - metabolism | Ritonavir - pharmacology | Carbamates - pharmacology | Hepacivirus - drug effects | Cell Line | Antiviral Agents - pharmacology | Anilides - metabolism | Macrocyclic Compounds - metabolism | Sulfonamides - pharmacology | Ritonavir - metabolism | Anilides - pharmacology | Drug Interactions - physiology | Sulfonamides - metabolism | Uracil - metabolism | Uracil - analogs & derivatives | Plasma | Ritonavir | Viruses | Hepatitis | Dynamic models | Drug interaction | P-Glycoprotein | Static models | Inducers | Glucuronosyltransferase | Antiviral agents | UDP-glucuronosyltransferase | Drug interactions | Glycoprotein | Substrate inhibition | Breast cancer | Pharmacology | Exposure | Substrates | Organic anion transporting polypeptide | Liability | Inhibitors | Predictions | Hepatitis C virus | Hepatitis C | Transporter | Cancer | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2013, Volume 41, Issue 2, pp. 353 - 361
Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require... 
SERUM CREATININE LEVELS | IMMUNODEFICIENCY-VIRUS-INFECTION | HUMAN HEPATOCYTES | HEALTHY-SUBJECTS | CYTOCHROME-P450 ENZYMES | GLOMERULAR-FILTRATION | PHARMACOLOGY & PHARMACY | GASTROINTESTINAL PH | MULTIDRUG-RESISTANCE | BOOSTED PROTEASE INHIBITORS | P-GLYCOPROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | HIV Integrase Inhibitors - pharmacology | Heterocyclic Compounds, 3-Ring - metabolism | Cricetulus | Cytochrome P-450 Enzyme Inhibitors | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cytochrome P-450 Enzyme System - metabolism | Membrane Transport Proteins - drug effects | Male | Neoplasm Proteins - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Drug Interactions | Transfection | Membrane Transport Proteins - genetics | Microsomes, Liver - drug effects | Madin Darby Canine Kidney Cells | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Microsomes, Liver - enzymology | Hepatocytes - drug effects | CHO Cells | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Isoenzymes | Enzyme Induction | HIV Integrase Inhibitors - metabolism | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Animals | Glucuronosyltransferase - metabolism | Dogs | Cytochrome P-450 Enzyme System - genetics | Glucuronosyltransferase - antagonists & inhibitors | ATP Binding Cassette Transporter, Sub-Family B | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Hepatocytes - enzymology | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 09/2014, Volume 5, Issue 1, pp. 4573 - 4573
Journal Article