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Biochemical Journal, ISSN 0264-6021, 09/2007, Volume 406, Issue 3, pp. 407 - 414
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 10, pp. 3535 - 3545
Altered glycolytic flux in cancer cells (the "Warburg effect") causes their proliferation to rely upon elevated glutamine metabolism ("glutamine addiction").... 
DESIGN | KIDNEY-TYPE GLUTAMINASE | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | RENAL MITOCHONDRIAL GLUTAMINASE | EXPRESSION | Drug Resistance, Multiple | Humans | Molecular Conformation | Sulfides - chemistry | Glutamine - metabolism | Crystallography, X-Ray | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Triple Negative Breast Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Thiadiazoles - chemistry | Enzyme Inhibitors - chemistry | Triple Negative Breast Neoplasms - pathology | Antineoplastic Agents - pharmacology | Benzeneacetamides - chemistry | Glutamine - chemistry | Sulfides - metabolism | Thiadiazoles - metabolism | Neoplasm Proteins - genetics | Benzeneacetamides - pharmacology | Sulfides - pharmacology | Thiadiazoles - pharmacology | Binding, Competitive | Recombinant Proteins - metabolism | Enzyme Inhibitors - metabolism | Allosteric Site - drug effects | Enzyme Inhibitors - pharmacology | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Glutaminase - metabolism | Antineoplastic Agents - chemistry | Glutaminase - antagonists & inhibitors | Glutaminase - chemistry | Glutamine - antagonists & inhibitors | Hydrogen Bonding | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | Benzeneacetamides - metabolism | Cell Proliferation - drug effects | Mutation | Glutaminase - genetics | Amino Acid Substitution | anticancer drug | crystallography | BPTES | glutaminase | cancer | Metabolism | CB-839
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2015, Volume 125, Issue 6, pp. 2293 - 2306
Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a... 
CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | KIDNEY-TYPE GLUTAMINASE | PHOSPHATE-ACTIVATED GLUTAMINASE | MITOCHONDRIAL METABOLISM | AEROBIC GLYCOLYSIS | GROWTH | C-MYC | ACUTE MYELOID-LEUKEMIA | 2-HYDROXYGLUTARATE LEVELS | EXPRESSION | Neoplasm Transplantation | Humans | Gene Expression Regulation, Neoplastic | Mutation, Missense | Carcinoma, Hepatocellular - drug therapy | Heterografts | Cell Transformation, Neoplastic - genetics | Carcinoma, Hepatocellular - genetics | Liver Neoplasms, Experimental - genetics | Liver Neoplasms, Experimental - pathology | Sulfides - pharmacology | Thiadiazoles - pharmacology | Glutaminase - biosynthesis | Mice, Transgenic | Carcinoma, Hepatocellular - enzymology | Cell Transformation, Neoplastic - metabolism | Glutaminase - antagonists & inhibitors | Gene Expression Regulation, Enzymologic | Animals | Liver Neoplasms, Experimental - drug therapy | Carcinoma, Hepatocellular - pathology | Liver Neoplasms, Experimental - enzymology | Mice | Mice, Inbred BALB C | Cell Transformation, Neoplastic - pathology | Glutaminase - genetics | Amino Acid Substitution | Medical research | Enzymes | Colleges & universities | Grants | Glucose | Metabolism | Fatty acids | Proteins | Survival analysis | Cell growth | Software | Lymphomas | Tumorigenesis | Infrared imaging systems | Laboratory animals | Tumors | Cancer | Crystal structure | Index Medicus | Abridged Index Medicus | Oncology | Hepatology
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2005, Volume 386, Issue 3, pp. 535 - 542
The pattern of expression of glutaminase isoenzymes in tumour cells has been investigated to clarify its role in the malignant transformation and the prospect... 
Breast cancer cell | Reverse transcriptase PCR (RT-PCR) | Glutaminase | Hepatoma cancer cell | Glutamine | Leukaemia | LOCALIZATION | hepatoma cancer cell | KIDNEY-TYPE GLUTAMINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEPATOMA-CELLS | glutamine | reverse transcriptase PCR (RT-PCR) | MITOCHONDRIAL GLUTAMINASE | MESSENGER-RNA | METABOLISM | GENE | GROWTH | LIVER | glutaminase | leukaemia | breast cancer cell | EXPRESSION | Isoenzymes - blood | Leukemia - blood | Cell Proliferation | Leukemia - pathology | Liver - enzymology | Humans | Kidney - enzymology | Brain - enzymology | RNA, Messenger - analysis | Brain - abnormalities | Neoplasms - blood | Neoplasms - genetics | Tumor Cells, Cultured | Phosphates - pharmacology | Gene Expression Regulation, Neoplastic - genetics | Leukemia - genetics | Glutamic Acid - pharmacology | Isoenzymes - genetics | Leukemia - enzymology | RNA, Messenger - genetics | Biomarkers - analysis | Glutaminase - blood | Neoplasms - enzymology | Glutaminase - metabolism | Biomarkers - blood | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Gene Expression Regulation, Enzymologic - genetics | Kinetics | Transcription, Genetic - genetics | Neoplasms - pathology | Glutaminase - genetics | GS, glutamine synthetase | MBMNC, medullar blood mononuclear cell | LGA, liver-type glutaminase | GA, glutaminase | RT, reverse transcriptase | KGA, kidney-type glutaminase
Journal Article
Blood, ISSN 0006-4971, 09/2015, Volume 126, Issue 11, pp. 1346 - 1356
Journal Article
Biochemistry, ISSN 0006-2960, 12/2011, Volume 50, Issue 50, pp. 10764 - 10770
Journal Article