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Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 17 - 30
and mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate... 
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 12/2016, Volume 540, Issue 7632, pp. 236 - 241
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2166 - 2166
Isocitrate dehydrogenase (IDH) genes 1 and 2 are frequently mutated in acute myeloid leukaemia (AML), low-grade glioma, cholangiocarcinoma (CC) and... 
DNA METHYLATION | MAMMALIAN DNA | 5-METHYLCYTOSINE | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PHENOTYPE | RETINOIC ACID RECEPTORS | ACUTE MYELOID-LEUKEMIA | MUTATIONS | 5-CARBOXYLCYTOSINE | DISCOVERY | Neoplasms - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Regulation, Neoplastic | Cholangiocarcinoma - metabolism | Bone Neoplasms - pathology | Receptors, Retinoic Acid - genetics | Bone Neoplasms - metabolism | Glioma - metabolism | DNA-Binding Proteins - metabolism | Glioma - genetics | DNA Methylation | Neoplasms - genetics | Glioma - pathology | Trans-Activators - genetics | Chondrosarcoma - genetics | Chondrosarcoma - pathology | Bone Neoplasms - genetics | Bile Duct Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Central Nervous System Neoplasms - metabolism | Bile Duct Neoplasms - metabolism | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Central Nervous System Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Proto-Oncogene Proteins - genetics | Receptors, Retinoic Acid - metabolism | DNA-Binding Proteins - genetics | Central Nervous System Neoplasms - pathology | Cholangiocarcinoma - pathology | Chondrosarcoma - metabolism | Cholangiocarcinoma - genetics | Isocitrate Dehydrogenase - metabolism | Trans-Activators - metabolism | Glutarates - metabolism | Bile Duct Neoplasms - pathology | Mutation | Neoplasms - pathology | Leukemia, Myeloid, Acute - genetics | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7390, pp. 484 - 488
Journal Article
Scientific Reports, ISSN 2045-2322, 08/2016, Volume 6, Issue 1, pp. 32428 - 32428
Mutations of isocitrate dehydrogenase 1 (IDH1) and IDH2 in acute myeloid leukemia (AML) cells produce the oncometabolite R-2-hydroxyglutarate (R-2HG) to induce... 
AML | LOCATION | PROGENITORS | IDH2 MUTATIONS | INHIBITION | BONE-MARROW STROMA | MUTANT IDH2 | MULTIDISCIPLINARY SCIENCES | LEUKEMOGENESIS | DIFFERENTIATION | 2-HYDROXYGLUTARATE | Interleukin-8 - genetics | NIMA-Interacting Peptidylprolyl Isomerase - metabolism | Phosphorylation | Reactive Oxygen Species - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Complement C5a - metabolism | NF-kappa B - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Myeloid Cells - drug effects | Receptors, CXCR4 - genetics | Interleukin-8 - metabolism | Protein Stability | Interleukin-6 - metabolism | Mesenchymal Stromal Cells - drug effects | Interleukin-6 - genetics | Junctional Adhesion Molecule B - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Paracrine Communication - genetics | Mesenchymal Stromal Cells - metabolism | Isocitrate Dehydrogenase - genetics | Gene Expression Regulation, Leukemic | NIMA-Interacting Peptidylprolyl Isomerase - genetics | Receptors, CXCR4 - metabolism | Junctional Adhesion Molecule B - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | NF-kappa B - genetics | Paracrine Communication - drug effects | Myeloid Cells - metabolism | Complement C5a - genetics | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Glutarates - pharmacology | Mesenchymal Stromal Cells - pathology | Mutation | Myeloid Cells - pathology | Primary Cell Culture | Leukemia, Myeloid, Acute - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Cell proliferation | NF-κB protein | Reactive oxygen species | Peptidylprolyl isomerase | Transcription | Myeloid leukemia | Leukemia | Extracellular signal-regulated kinase | Paracrine signalling | Pin1 protein | CXCR4 protein | Hemopoiesis | Interleukin 6 | Chemotherapy | Stromal cells | Bone marrow | Isocitrate dehydrogenase | Acute myeloid leukemia | Interleukin 8 | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 12, pp. 6036 - 6058
Journal Article
Nature, ISSN 0028-0836, 12/2009, Volume 462, Issue 7274, pp. 739 - 744
Journal Article