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Journal of Neuroscience, ISSN 0270-6474, 03/2010, Volume 30, Issue 9, pp. 3326 - 3338
Journal Article
Cell Metabolism, ISSN 1550-4131, 2005, Volume 2, Issue 6, pp. 373 - 384
Defective glucose-stimulated insulin secretion is the main cause of hyperglycemia in type 2 diabetes mellitus. Mutations in HNF-1α cause a monogenic form of... 
DIABETES-MELLITUS | MEMBRANE-FUSION | HEPATOCYTE NUCLEAR FACTOR-1-ALPHA | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | FACTOR-I | MUTATIONS | SECRETION | TRANSCRIPTION FACTOR | MOLECULAR-MECHANISMS | ALPHA-GENE | CELL BIOLOGY | Immunohistochemistry | Immunoprecipitation | Membrane Glycoproteins - metabolism | Oligonucleotide Array Sequence Analysis | Calcium - metabolism | Humans | Insulinoma | Molecular Sequence Data | Immunoblotting | Diabetes Mellitus, Type 2 - metabolism | Exocytosis | RNA, Messenger - metabolism | Microscopy, Immunoelectron | Tissue Distribution | Insulin-Secreting Cells - metabolism | Time Factors | Base Sequence | Islets of Langerhans - cytology | Cloning, Molecular | Transcription, Genetic | Insulin Secretion | Genes, Reporter | Disease Models, Animal | Cell Line | Nucleic Acid Hybridization | Growth Hormone - metabolism | Hepatocyte Nuclear Factor 1 - metabolism | Glutathione Transferase - metabolism | Rats | Mice, Transgenic | Photons | Pancreas - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Two-Hybrid System Techniques | Blotting, Northern | Insulin - metabolism | Animals | Glucose - chemistry | Glucose - metabolism | Protein Binding | Mice | Models, Genetic | DNA, Complementary - metabolism | SNARE Proteins - metabolism | Microscopy, Fluorescence | RNA, Small Interfering - metabolism | Type 2 diabetes | Medical colleges | Pancreatic beta cells | Hyperglycemia | Molecular genetics | Insulin | Protein binding | Diabetes therapy
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 11/2016, Volume 53, Issue 9, pp. 6459 - 6475
We investigated the effects of an acute intrastriatal QUIN administration on cellular redox and bioenergetics homeostasis, as well as on important signaling... 
Signaling pathways | Neurology | Neurosciences | Energy metabolism | Biomedicine | Glutaric acidemia | Redox homeostasis | Neurobiology | Inflammatory response | Quinolinic acid | Cell Biology | PLASMA-MEMBRANES | 3-HYDROXYGLUTARIC ACID | NMDA RECEPTORS | NITRIC-OXIDE SYNTHASE | FACTOR-KAPPA-B | GLUTAMATE UPTAKE | NEUROSCIENCES | CEREBRAL-CORTEX | PRIMARY NEURONAL CULTURES | ANTIOXIDANT RESPONSE ELEMENT | CREATINE-KINASE | Brain Diseases, Metabolic - pathology | Glutaryl-CoA Dehydrogenase - metabolism | Glutathione - metabolism | Antioxidants - metabolism | Fluoresceins - metabolism | Nitrites - metabolism | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Electron Transport Complex IV - metabolism | Amino Acid Metabolism, Inborn Errors - metabolism | Sulfhydryl Compounds - metabolism | Neostriatum - drug effects | Lipid Peroxidation - drug effects | Neostriatum - metabolism | Quinolinic Acid - administration & dosage | Quinolinic Acid - toxicity | Amino Acid Metabolism, Inborn Errors - pathology | Brain Diseases, Metabolic - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Superoxide Dismutase - metabolism | Malondialdehyde - metabolism | Glutathione Peroxidase - metabolism | Neostriatum - pathology | Oxidation-Reduction | Brain Diseases, Metabolic - metabolism | Mice, Knockout | Nitrates - metabolism | Animals | Lactates - metabolism | Diet | Signal Transduction - drug effects | Models, Biological | NF-E2-Related Factor 2 - metabolism | Oxidative Stress - drug effects | Amino Acid Metabolism, Inborn Errors - enzymology | Energy Metabolism - drug effects | Glutaryl-CoA Dehydrogenase - deficiency | Antioxidants | Lysine | Creatine kinase | Glutathione transferase | Physiological aspects | Superoxide | Inflammation | Creatine | Homeostasis | Signal transduction | Oxidative stress | Bioenergetics | Index Medicus
Journal Article
Plant Physiology and Biochemistry, ISSN 0981-9428, 01/2017, Volume 110, pp. 167 - 177
Understanding the adverse impact of nanoparticles in crop plants has emerged as one of the most interesting fields of plant research. Therefore, this study has... 
Pea seedlings | Oxidative stress | Anatomical structures | Nitric oxide | Silver nanoparticles | ASSAY | TOXICITY | CHROMIUM | PLANT SCIENCES | RESPONSES | ANTIOXIDANT SYSTEMS | PROTECTIVE ROLE | GROWTH | PLANTS | Nitroprusside - metabolism | Reactive Oxygen Species - metabolism | Glutathione - metabolism | Glutathione Reductase - metabolism | Fluorescence | Nitroprusside - pharmacology | Ascorbic Acid - metabolism | Plant Roots - drug effects | Ascorbate Peroxidases - metabolism | X-Ray Diffraction | Plant Shoots - drug effects | Silver - toxicity | Plant Leaves - drug effects | Plant Proteins - metabolism | Nitric Oxide Donors - pharmacology | Peas - metabolism | Superoxide Dismutase - metabolism | Metal Nanoparticles - ultrastructure | Malondialdehyde - metabolism | Microscopy, Electron, Transmission | Plant Roots - metabolism | Metal Nanoparticles - chemistry | Nitric Oxide Donors - metabolism | Silver - chemistry | Peas - drug effects | Chlorophyll - metabolism | Seedlings - drug effects | Hydrogen Peroxide - metabolism | Chlorophyll - chemistry | Metal Nanoparticles - toxicity | Plant Leaves - metabolism | Photosynthesis - drug effects | Plant Shoots - metabolism | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Seedlings - metabolism | Nanoparticles | Chlorophyll | Silver | Peas | Phytochemistry | Superoxide | Photosynthesis | Nanotechnology
Journal Article
Ecotoxicology and Environmental Safety, ISSN 0147-6513, 01/2018, Volume 147, pp. 990 - 1001
Journal Article
Molecular systems biology, ISSN 1744-4292, 2017, Volume 13, Issue 3, pp. 916 - n/a
To elucidate the molecular mechanisms underlying non-alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis... 
serine | NAFLD | personalized genome‐scale metabolic modeling | glutathione | personalized genome-scale metabolic modeling | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE | DRUG TARGETS | CANCER | AMINO-ACID-METABOLISM | HEPATOCELLULAR-CARCINOMA | INSULIN-RESISTANCE | ADIPOSE-TISSUE | GENOME-SCALE | REVEALS | Glycine - blood | Liver - enzymology | Non-alcoholic Fatty Liver Disease - genetics | Glutathione - metabolism | Serine - blood | Humans | Liver - metabolism | Middle Aged | Male | Non-alcoholic Fatty Liver Disease - metabolism | Patient-Specific Modeling | Metabolomics - methods | Gene Expression Regulation, Enzymologic | Serine - administration & dosage | Animals | Lipoproteins - metabolism | Female | Mice | Non-alcoholic Fatty Liver Disease - diet therapy | Genome | NAD - metabolism | Serine - therapeutic use | Disease Models, Animal | Genomes | Metabolites | Metabolism | Liver | Rodents | Serine | Lipids | Biosynthesis | Glycine | Body mass index | Fatty liver | Precursors | Supplementation | Glutathione | Level (quantity) | Liver diseases | Fasting | Demand analysis | Dietary supplements | Triglycerides | Fluxes | Apolipoproteins | Gene expression | Cholesterol | Steatosis | NAD | Molecular modelling | Insulin resistance | Plasma levels | Laboratory animals | Life Sciences | Biochemistry, Molecular Biology | zefsky t | hepatocellular-carcinoma | british journal of nutrition | urenberg p | genome-scale | drug targets | adipose-tissue | 1976 | Biochemistry & Molecular Biology | muscle | 1991 | Biochemistry and Molecular Biology | v57 | obesity | amino-acid-metabolism | journal of clinical investigation | fatty liver-disease | tissue blood-flow | insulin-resistance | v65 | Biokemi och molekylärbiologi | p105 | p444
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 04/2016, Volume 310, Issue 8, pp. E624 - E632
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 23, pp. 5438 - 5458
Abstract Oxidative stress is a major component of harmful cascades activated in neurodegenerative disorders. We sought to elucidate possible effects of... 
Advanced Basic Science | Dentistry | Oxidative stress | Mitochondria | Caspase-dependent apoptosis | Endoplasmic reticulum | Alginate oligosaccharide | PC12 cells | LOCALIZATION | ACTIVATION | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | STABILIZATION | CHAPERONE | APOPTOSOME | CA2 | BAX | CYTOCHROME-C RELEASE | PROTEINS | MEMBRANE PERMEABILIZATION | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Calcium - metabolism | Glutathione - metabolism | Amyloid beta-Peptides - pharmacology | Oxidative Stress - physiology | Caspase 3 - metabolism | Endoplasmic Reticulum - metabolism | NF-kappa B - metabolism | Neurons - cytology | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | Oligosaccharides - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Apoptosis Inducing Factor - pharmacology | Cell Nucleus - metabolism | Endoplasmic Reticulum - drug effects | Oxidation-Reduction - drug effects | Neurons - metabolism | Phosphorylation - drug effects | Glucuronic Acid - chemistry | Neurons - drug effects | Polysaccharide-Lyases - chemistry | Apoptosis Inducing Factor - metabolism | Cell Survival - drug effects | Cytochromes c - metabolism | Hydrogen Peroxide - pharmacology | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Rats | Mitochondria - metabolism | Caspase 12 - metabolism | Hexuronic Acids - chemistry | Mitochondria - drug effects | HSP70 Heat-Shock Proteins - metabolism | Cell Shape - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Animals | Models, Biological | Alginates - chemistry | NF-E2-Related Factor 2 - metabolism | HSP90 Heat-Shock Proteins - metabolism | Apoptosis - physiology | Oxidative Stress - drug effects | Cell Nucleus - drug effects | Neurosciences | Nervous system diseases | Biological products | Hydrogen peroxide | Heat shock proteins | Nerve growth factor | Superoxide | Mitochondrial DNA | Biochemistry | Antioxidants | Tumor proteins | Protein kinases | Alzheimer's disease | Apoptosis | Stresses | Surgical implants | Biomedical materials | Cell death | Cascades | Blocking | Activation | Kinases
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 54, Issue 4, pp. 773 - 794
Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a... 
Gastroenterology and Hepatology | Drugs | Obesity | Oxidative stress | Mitochondria | Cell death | Lipids | Hepatotoxicity | Steatosis | TRIGLYCERIDE TRANSFER PROTEIN | DNA-POLYMERASE-GAMMA | PREGNANE X-RECEPTOR | PROLIFERATOR-ACTIVATED RECEPTOR | HEPATIC CYTOCHROME-P450 2E1 | ELEMENT-BINDING PROTEINS | FATTY-ACID OXIDATION | CONSTITUTIVE ANDROSTANE RECEPTOR | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RELATED PARAMETERS | GASTROENTEROLOGY & HEPATOLOGY | Carbohydrate Metabolism - drug effects | Reactive Oxygen Species - metabolism | Mitochondria, Liver - metabolism | Humans | Leptin - metabolism | Oxidative Phosphorylation - drug effects | Adipose Tissue - metabolism | Adiponectin - metabolism | Hepatitis C - complications | Cell Death - drug effects | Fatty Acids - metabolism | Chemical and Drug Induced Liver Injury - etiology | Diabetes Mellitus, Type 2 - complications | Genetic Predisposition to Disease | Fatty Liver - metabolism | Oxidation-Reduction | Obesity - complications | Insulin Resistance | Mitochondrial Membrane Transport Proteins - drug effects | Chemical and Drug Induced Liver Injury - genetics | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Models, Biological | Lipid Metabolism - drug effects | Alcoholic Intoxication - complications | Genome, Mitochondrial | Adipose Tissue - drug effects | Energy Metabolism - drug effects | Fatty Liver - etiology | Divalproex | Liver diseases | Thiols | Liver | Cytochrome P-450 | Mitochondrial DNA | Triglycerides | Stavudine | Permeability | Valproic acid | Fatty acids | Cells | Carnitine | Metabolites | Glutathione transferase | Acetaminophen | Physiological aspects | DNA polymerases | Health aspects | Zidovudine | Index Medicus | Reactive Oxygen Species | Fatty Acids | Adiponectin | Mitochondria, Liver | Life Sciences | Mitochondrial Membrane Transport Proteins | Cell Death | Diabetes Mellitus, Type 2 | Adipose Tissue | Alcoholic Intoxication | Hépatology and Gastroenterology | Oxidative Phosphorylation | Carbohydrate Metabolism | Lipid Metabolism | Drug-Induced Liver Injury | Fatty Liver | Human health and pathology | Energy Metabolism | Leptin | Hepatitis C
Journal Article