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Journal of Immunology, ISSN 0022-1767, 11/2013, Volume 191, Issue 10, pp. 5182 - 5195
The Wnt signaling network, an ancient signaling system governing ontogeny and homeostatic processes, has recently been identified to exert immunoregulatory... 
SIGNAL-TRANSDUCTION | TARGET | STEM-CELLS | ACTIVATION | PATHWAY | GLYCOGEN-SYNTHASE KINASE-3 | GENE-EXPRESSION | C-MYC | IMMUNOLOGY | BETA-CATENIN | INFLAMMATORY RESPONSE | Lung - microbiology | Tuberculosis, Pulmonary - metabolism | Cell Proliferation | Granuloma - metabolism | Toll-Like Receptor 2 - genetics | Tumor Necrosis Factor-alpha - genetics | Wnt Signaling Pathway - immunology | Mycobacterium tuberculosis - immunology | Arginase - biosynthesis | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Proto-Oncogene Proteins - biosynthesis | Wnt Proteins - metabolism | RNA, Messenger - biosynthesis | Wnt Proteins - genetics | Bone Marrow Cells - immunology | Lung - metabolism | Macrophages - immunology | Proto-Oncogene Proteins - metabolism | Lung - pathology | Mice, Inbred C57BL | Myeloid Differentiation Factor 88 - genetics | Pertussis Toxin - metabolism | Proto-Oncogene Proteins - genetics | Toll-Like Receptor 2 - metabolism | Proto-Oncogene Proteins c-myc - metabolism | beta Catenin - metabolism | Mice, Knockout | Cell Differentiation - immunology | Macrophages - metabolism | Tuberculosis, Pulmonary - immunology | Animals | Ki-67 Antigen - genetics | Ki-67 Antigen - biosynthesis | Mice | Wnt Proteins - biosynthesis | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Culture Media, Conditioned - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Cell and Tissue Research, ISSN 0302-766X, 10/2012, Volume 350, Issue 1, pp. 95 - 107
Epiprofin/Specificity Protein 6 (Epfn) is a Krüppel-like family (KLF) transcription factor that is critically involved in tooth morphogenesis and dental cell... 
Human Genetics | Mouse Epfn (+/−) | Biomedicine | Tooth development | Epiprofin/Sp6 | Wnt/β-catenin | Proteomics | Cell junction | Molecular Medicine | MDPC-23 | Epfn (−/−) | Mouse Epfn(+/-); Epfn(-/-) | TEETH | PROLIFERATION | BETA-CATENIN | CELL BIOLOGY | MORPHOGENESIS | EPITHELIUM | DENTIN | Wnt/beta-catenin | GROWTH | TRANSCRIPTION FACTOR | EXPRESSION | MOUSE INCISORS | Dental Pulp - embryology | Dental Pulp - metabolism | Wnt Proteins - metabolism | Incisor - cytology | Bone Morphogenetic Proteins - metabolism | Incisor - metabolism | Tooth - embryology | Tight Junctions - drug effects | Biomarkers - metabolism | Tight Junctions - metabolism | Dental Enamel - metabolism | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Dental Pulp - cytology | Dental Pulp - drug effects | Dental Papilla - embryology | beta Catenin - metabolism | Molar - embryology | Signal Transduction - drug effects | Adherens Junctions - drug effects | Mice | Dental Enamel - cytology | Dental Papilla - drug effects | Adherens Junctions - metabolism | Ameloblasts - metabolism | Kruppel-Like Transcription Factors - metabolism | Molar - cytology | Ameloblasts - drug effects | Tooth - cytology | Membrane Proteins - metabolism | Molar - drug effects | Kruppel-Like Transcription Factors - deficiency | Molar - metabolism | Odontoblasts - cytology | Recombinant Proteins - metabolism | Odontoblasts - metabolism | Incisor - drug effects | Ameloblasts - cytology | Intercellular Junctions - metabolism | Dental Papilla - metabolism | Glycogen Synthase Kinase 3 - metabolism | Dental Enamel - embryology | Dental Papilla - cytology | Animals | Intercellular Junctions - drug effects | Odontoblasts - drug effects | Morphogenesis - drug effects | Oximes - pharmacology | Cell Proliferation - drug effects | Incisor - embryology | Tooth - metabolism | Dental Enamel - drug effects | Developmental biology | Rodents | Teeth | Index Medicus | Cell proliferation | Bone morphogenetic protein 4 | Nestin | Transcription factors | Mesenchyme | Tight junctions | Wnt protein | catenin | Cell junctions | Morphogenesis | Signal transduction | Dental enamel | Ameloblasts | Developmental stages | Incisors | Bone morphogenetic proteins | Differentiation | Dental pulp
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 12/2015, Volume 107, Issue 12, pp. djv274 - djv274
Background: Cancer cachexia is a debilitating condition that impacts patient morbidity, mortality, and quality of life and for which effective therapies are... 
SKELETAL-MUSCLE ATROPHY | MURINE MODEL | FOXO | OXIDATIVE STRESS | TUMOR-BEARING MICE | ONCOLOGY | INSULIN-RESISTANCE | ADENOCARCINOMA | BIOCHEMISTRY | HDAC COMPLEXES | MECHANISMS | Cachexia - drug therapy | Histone Deacetylase Inhibitors - administration & dosage | Muscle, Skeletal - metabolism | Weight Loss - drug effects | Leukemia Inhibitory Factor - metabolism | Tripartite Motif Proteins | Carcinoma, Lewis Lung - complications | Forkhead Transcription Factors - metabolism | Mitochondrial Proteins - metabolism | Muscle, Skeletal - drug effects | Phenylbutyrates - administration & dosage | Cachexia - etiology | Muscle Proteins - metabolism | Phenylbutyrates - pharmacology | Cachexia - metabolism | Interleukin-6 - metabolism | Cytokines - metabolism | Neoplasms, Experimental - complications | Administration, Oral | Ubiquitin-Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | Lipase - metabolism | Adenocarcinoma - complications | Cachexia - prevention & control | Colonic Neoplasms - complications | Gene Expression Regulation - drug effects | Animals | Cytokines - drug effects | Ion Channels - metabolism | Survival Analysis | MEF2 Transcription Factors - metabolism | Histone Deacetylase Inhibitors - pharmacology | Forkhead Box Protein O1 | Mice | Muscle Strength - drug effects | Adipose Tissue - drug effects | Uncoupling Protein 3 | Cytokines - biosynthesis | Receptors, Interleukin-6 - metabolism | Care and treatment | Synthesis | Proteolysis | Glycogen | Patient outcomes | Colorectal cancer | Development and progression | Research | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0122373 - e0122373
Hepatitis B virus (HBV) pre-S2 mutant can induce hepatocellular carcinoma (HCC) via the induction of endoplasmic reticulum stress to activate mammalian target... 
HEPATOCELLULAR-CARCINOMA | S MUTANTS | X-PROTEIN | GROUND-GLASS HEPATOCYTES | MULTIDISCIPLINARY SCIENCES | C-MYC | TISSUE METABOLOMICS | CANCER-CELL METABOLISM | EXPRESSION | MTOR | TRANSGENIC MICE | Hepatitis B Surface Antigens - genetics | Immunohistochemistry | Hepatitis B - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Hepatitis B - virology | Glucose Transporter Type 1 - metabolism | YY1 Transcription Factor - metabolism | Phosphoproteins - metabolism | Liver Neoplasms - etiology | Glycogen - metabolism | Liver Neoplasms - pathology | Carcinoma, Hepatocellular - etiology | Cell Line | Protein Precursors - genetics | Signal Transduction | Hepatitis B Surface Antigens - metabolism | Mice, Transgenic | Proto-Oncogene Proteins c-myc - metabolism | Protein Precursors - metabolism | Mutant Proteins | Animals | Carcinoma, Hepatocellular - pathology | Hepatitis B virus - genetics | Liver Neoplasms - metabolism | Glycolysis | Mice | Hepatitis B virus - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Carcinoma, Hepatocellular - metabolism | Glycogen | Development and progression | Rapamycin | Glucose | Gene expression | Dextrose | Infection | Lactates | Glucose metabolism | Analysis | Resveratrol | Genetic engineering | Hepatitis B virus | Health aspects | Protein binding | Hepatitis B | TOR protein | Metabolic rate | Chronic infection | Viruses | Hepatocellular carcinoma | Activation | Myc protein | Hepatitis | Animal tissues | Tumorigenesis | Glucose transporter | Risk groups | Transgenic mice | Translation initiation | YY1 protein | Mammals | Metabolism | Signaling | Chemotherapy | Silymarin | Lactic acid | Aberration | Endoplasmic reticulum | Transporter | Metabolic disorders | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 03/2016, Volume 14, Issue 8, pp. 1979 - 1990
To identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse... 
CELLS | ACTIVATION | GENE | PANCREATIC-CANCER | NF1 | NATURAL ANTISENSE TRANSCRIPTS | BETA-CATENIN | TYPE-1 | NERVE SHEATH TUMORS | PROGRESSION | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Carcinogenesis - metabolism | Neurofibromatosis 1 - metabolism | Neurofibromin 1 - metabolism | DNA Helicases - genetics | STAT3 Transcription Factor - genetics | Disease Models, Animal | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | Carcinogenesis - genetics | Schwann Cells - pathology | Schwann Cells - metabolism | beta Catenin - metabolism | DNA Helicases - metabolism | Mice, Nude | Peripheral Nervous System Neoplasms - metabolism | Mice | Histones - metabolism | Neurofibromin 1 - genetics | RNA, Small Interfering - metabolism | Neoplasm Transplantation | Phosphorylation | Gene Expression Regulation, Neoplastic | Glycogen Synthase Kinase 3 beta - genetics | DNA-Binding Proteins - metabolism | Female | Neurofibromatosis 1 - genetics | Nuclear Proteins - genetics | Peripheral Nervous System Neoplasms - pathology | STAT3 Transcription Factor - metabolism | N-Terminal Acetyltransferase A - genetics | Glycogen Synthase Kinase 3 beta - antagonists & inhibitors | Nuclear Proteins - metabolism | N-Terminal Acetyltransferase A - antagonists & inhibitors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Glycogen Synthase Kinase 3 beta - metabolism | Neural Stem Cells - pathology | beta Catenin - genetics | Carcinogenesis - pathology | Transcription Factors - metabolism | Neurofibromatosis 1 - pathology | Animals | Histones - genetics | N-Terminal Acetyltransferase A - metabolism | Mutagenesis, Insertional | STAT3 Transcription Factor - antagonists & inhibitors | Neural Stem Cells - metabolism | Peripheral Nervous System Neoplasms - genetics | Index Medicus
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 05/2017, Volume 19, Issue 5, pp. 504 - 517
Adipocytes undergo considerable volumetric expansion in the setting of obesity. It has been proposed that such marked increases in adipocyte size may be sensed... 
ANION CHANNEL | ESSENTIAL COMPONENT | VOLUME REGULATION | GLUT4 TRANSLOCATION | GTPASE-ACTIVATING-PROTEIN | LEUCINE-RICH REPEAT | CHLORIDE CHANNEL | PLASMA-MEMBRANE | MICE LACKING | ADIPOSE-TISSUE | CELL BIOLOGY | Index Medicus
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 11/2013, Volume 27, Issue 11, pp. 1897 - 1917
Journal Article
STEM CELLS, ISSN 1066-5099, 06/2013, Volume 31, Issue 6, pp. 1086 - 1096
The studies of differentiation of mouse or human embryonic stem cells (hESCs) into specific cell types of the intestinal cells would provide insights to the... 
Embryonic stem cells | Endoderm | In vitro differentiation | Intestine differentiation | PROGENITOR CELLS | PROTEIN | CDX2 | BMP | MOUSE | DEFINITIVE ENDODERM | IDENTIFICATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | GENE | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MICE | HEMATOLOGY | EXPRESSION | Embryonic Stem Cells - metabolism | Intestinal Mucosa - metabolism | Embryonic Stem Cells - cytology | Endoderm - physiology | Enterocytes - metabolism | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Humans | Glycogen Synthase Kinase 3 beta | Intestines - metabolism | Wnt Proteins - metabolism | Intestinal Mucosa - cytology | Fibroblast Growth Factors - metabolism | Bone Morphogenetic Proteins - metabolism | Cell Differentiation - physiology | Pluripotent Stem Cells - cytology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Glycogen Synthase Kinase 3 - metabolism | Mice, Inbred ICR | Cell Lineage - physiology | Endoderm - metabolism | Pluripotent Stem Cells - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell Line, Tumor | Signal Transduction - physiology | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Enterocytes - physiology | Intestines - cytology | Glucose metabolism | Bone morphogenetic proteins | Fibroblast growth factors | Synthesis | Glycogen | Proteins | Cellular biology | Stem cells | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 12/2012, Volume 16, Issue 6, pp. 751 - 764
Journal Article
Journal Article