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Journal Article
EMBO reports, ISSN 1469-221X, 09/2016, Volume 17, Issue 9, pp. 1326 - 1342
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2005, Volume 280, Issue 11, pp. 9887 - 9894
Insulin resistance and increased cytochrome P450 2E1 (CYP2E1) expression are both associated with and mechanistically implicated in the development of... 
DIABETES-MELLITUS | NONALCOHOLIC FATTY LIVER | METABOLIC SYNDROME | OXIDATIVE STRESS | EXPRESSION SENSITIZES HEPATOCYTES | CYTOCHROME-P450 2E1 | TRANSCRIPTION FACTOR FOXO1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-JUN | MICE LACKING | RECEPTOR SUBSTRATE-1 | Up-Regulation | Phosphorylation | Immunoprecipitation | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Hepatocytes - metabolism | Cytochrome P-450 CYP2E1 - biosynthesis | DNA-Binding Proteins - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Glutathione Peroxidase | MAP Kinase Kinase 4 | Time Factors | Hepatitis - metabolism | Adenoviridae - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytochrome P-450 CYP2E1 - chemistry | RNA - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Fatty Liver - metabolism | Signal Transduction | Down-Regulation | Mice, Inbred C57BL | Rats | Choline - chemistry | Glycogen Synthase Kinase 3 - metabolism | Serine - chemistry | Subcellular Fractions - metabolism | Blotting, Western | Proto-Oncogene Proteins c-akt | Transcription Factors - metabolism | Blotting, Northern | Insulin - metabolism | Tyrosine - metabolism | Animals | Proteins - metabolism | Methionine - chemistry | Glucose - metabolism | Forkhead Box Protein O1 | Mice | Forkhead Transcription Factors | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0166913 - e0166913
The aim of this study is to investigate whether the beneficial effect of exendin-4 on hepatic steatosis is mediated by beta-catenin signaling. After the HepG2... 
TCF7L2 | ACTIVATION | LIPID-METABOLISM | STEATOSIS | PATHWAY | FATTY LIVER-DISEASE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | PPAR-GAMMA | GENETIC-VARIANTS | ADIPOGENESIS | Fatty Acid Synthase, Type I - genetics | RNA, Small Interfering - genetics | Palmitic Acid - pharmacology | Humans | Cytosol - drug effects | Glycogen Synthase Kinase 3 beta - genetics | PPAR gamma - metabolism | Palmitic Acid - antagonists & inhibitors | Acetyl-CoA Carboxylase - genetics | Quinolines - pharmacology | Cell Nucleus - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Wnt Signaling Pathway | PPAR gamma - genetics | Imides - pharmacology | Transcription Factor 4 | beta Catenin - agonists | Gene Expression Regulation | Transcription Factors - genetics | Fatty Acid Synthase, Type I - metabolism | Glycogen Synthase Kinase 3 beta - metabolism | Stearoyl-CoA Desaturase - genetics | beta Catenin - metabolism | beta Catenin - genetics | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Peptides - pharmacology | Transcription Factors - metabolism | Diacylglycerol O-Acyltransferase - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | beta Catenin - antagonists & inhibitors | Lipogenesis - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Stearoyl-CoA Desaturase - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Cytosol - metabolism | Venoms - pharmacology | Cell Nucleus - drug effects | Diacylglycerol O-Acyltransferase - metabolism | Acetyl-CoA Carboxylase - metabolism | RNA, Small Interfering - metabolism | Transcription factors | Wnt protein | Genes | Liver | Diacylglycerol | Hepatoma | Palmitic acid | Desaturase | Proteins | β-catenin | Cell growth | Fatty liver | Sterols | Acetyl-CoA carboxylase | Rodents | Penicillin | Sterol regulatory element-binding protein | Inhibition | Lipogenesis | Medical research | Liver diseases | Internal medicine | Glycogen | Glycogen synthase kinase 3 | Triglycerides | Stearoyl-CoA desaturase | siRNA | Metabolism | Acyltransferase | Gene expression | Fatty acids | Fatty-acid synthase | Steatosis | Medicine | Musculoskeletal system | Signaling | Hospitals | Insulin resistance | Diabetes | Sterol regulatory element-binding protein 1c | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, pp. e37103 - e37103
Dioxins and dioxin-like compounds encompass a group of structurally related heterocyclic compounds that bind to and activate the aryl hydrocarbon receptor... 
RAT-LIVER | AROMATIC-HYDROCARBONS | GLUCONEOGENESIS | METABOLISM | PHOSPHOENOLPYRUVATE CARBOXYKINASE PEPCK | BIOLOGY | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD | PRIMARY HEPATOCYTES | AH RECEPTOR | TOXICITY | POLYCHLORINATED-BIPHENYLS | L-Lactate Dehydrogenase - metabolism | Gene Expression - drug effects | Gluconeogenesis - drug effects | Lactic Acid - metabolism | Liver - metabolism | Mice, Inbred C57BL | Male | Phosphoenolpyruvate Carboxylase - antagonists & inhibitors | Phosphoenolpyruvate Carboxylase - biosynthesis | Hepatocytes - metabolism | Phosphoenolpyruvate Carboxylase - genetics | Glucose-6-Phosphatase - metabolism | Dioxins - toxicity | Flavonoids - toxicity | Animals | Glycogen - metabolism | Liver - drug effects | Polychlorinated Biphenyls - toxicity | Adenosine Triphosphate - metabolism | Glucose - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Mice | Hepatocytes - drug effects | Glycerin | Glucose metabolism | Herbicides | Phosphatases | RNA | Glycogen | Heterocyclic compounds | Polychlorinated biphenyls | Physiological aspects | Glycerol | Glucose | Dextrose | Energy metabolism | Physiological effects | Toxicity | Liver | Dioxins | TCDD | Hydrocarbons | mRNA | PCB compounds | Aromatic compounds | Rodents | Lipid metabolism | Pollutants | Carbon sources | Gluconeogenesis | Lactate dehydrogenase | Gene expression | Metabolism | PCB | L-Lactate dehydrogenase | Hepatocytes | Dioxin | Forskolin | Lactic acid | Glucose-6-phosphatase | Acute toxicity | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2008, Volume 13, Issue 3, pp. 235 - 248
Invasion of surrounding brain tissue by isolated tumor cells represents one of the main obstacles to a curative therapy of glioblastoma multiforme. Here we... 
CELLBIO | FAS-INDUCED APOPTOSIS | IV COLLAGENASE | ACTIVATED PROTEIN-KINASE | ONCOLOGY | IN-VIVO | TRIMERIZATION DOMAIN | MEDIATED APOPTOSIS | SRC FAMILY KINASES | HUMAN GLIOMA-CELLS | NF-KAPPA-B | MOLECULAR-MECHANISMS | Neoplasm Transplantation | Fas Ligand Protein - metabolism | Glioblastoma - enzymology | Matrix Metalloproteinases - genetics | Humans | Brain Neoplasms - pathology | Glycogen Synthase Kinase 3 beta | Phosphatidylinositol 3-Kinases - metabolism | fas Receptor - metabolism | Recombinant Fusion Proteins - metabolism | Brain Neoplasms - metabolism | Brain Neoplasms - immunology | Transfection | Glioblastoma - genetics | RNA Interference | Proto-Oncogene Proteins c-yes - genetics | src-Family Kinases - metabolism | Glioblastoma - metabolism | Tumor Cells, Cultured | Brain Neoplasms - enzymology | Proto-Oncogene Proteins c-yes - metabolism | Signal Transduction | Neoplasm Invasiveness | Brain Neoplasms - genetics | Glycogen Synthase Kinase 3 - metabolism | Transplantation, Isogeneic | Animals | Glioblastoma - immunology | Glioblastoma - pathology | Cell Line, Tumor | Mice | Matrix Metalloproteinases - metabolism | Apoptosis | Cell Movement | Death Domain Receptor Signaling Adaptor Proteins - metabolism | RNA, Small Interfering - metabolism | Glucose metabolism | Synthesis | Glycogen | Glioblastoma multiforme | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2017, Volume 485, Issue 2, pp. 366 - 371
Dipeptidyl-peptidase 4 [DPP-4) has evolved into an important target in diabetes therapy due to its role in incretin hormone metabolism. In contrast to its... 
DPP4 | Insulin resistance | Lipid metabolism | Liver | Insulin signaling | PHOSPHORYLATION | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PATHOGENESIS | INHIBITION | BIOPHYSICS | GLUCAGON-LIKE PEPTIDE-1 | GLUCOSE-METABOLISM | PHARMACOLOGY | RESISTANCE | HEPATIC STEATOSIS | EXPRESSION | Glucose-6-Phosphatase - genetics | Carnitine O-Palmitoyltransferase - genetics | Dipeptidyl Peptidase 4 - metabolism | Phosphorylation | Humans | Gene Expression Regulation, Neoplastic | Hepatocytes - pathology | Hepatocytes - metabolism | Glycogen - metabolism | RNA Interference | Carnitine O-Palmitoyltransferase - metabolism | Lipid Metabolism - genetics | Proto-Oncogene Proteins c-akt - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Insulin Resistance | Dipeptidyl Peptidase 4 - genetics | PPAR alpha - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Glucose-6-Phosphatase - metabolism | Hep G2 Cells | Triglycerides - metabolism | Sterol Regulatory Element Binding Protein 1 - genetics | Glucose - metabolism | PPAR alpha - metabolism | Mitogen-Activated Protein Kinases - metabolism | Medical colleges | Liver diseases | Phosphatases | Glycogen | Triglycerides | Glucose | Insulin | Dextrose | Carnitine | Mitogens | Protein kinases | Protein binding | Fatty acids | Index Medicus | INSULIN | LIVER CELLS | SIGNALS | TRIGLYCERIDES | 60 APPLIED LIFE SCIENCES | CELL CULTURES
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 04/2015, Volume 308, Issue 7, pp. R614 - R626
To what extent hypoxia alters the adenosine (ADO) system and impacts on cardiac function during embryogenesis is not known. Ectonucleoside triphosphate... 
Adenosine signaling | Hypoxia | Anoxia-reoxygenation | Arrhythmias | Glycogen metabolism | hypoxia | glycogen metabolism | PHYSIOLOGY | OXIDANT STRESS | anoxia-reoxygenation | CARDIOMYOCYTES | DEVELOPING HEART | MEDIATED EMBRYO PROTECTION | RAT HEARTS | arrhythmias | ATRIOVENTRICULAR-CONDUCTION | LUNG EPITHELIAL-CELLS | CHICK-EMBRYO | RECEPTOR ACTIVATION | adenosine signaling | MOUSE HEARTS | Adaptation, Physiological | 5'-Nucleotidase - genetics | Equilibrative Nucleoside Transport Proteins - metabolism | Adenosine Kinase - metabolism | Glycogen Synthase - metabolism | Heart - embryology | Glycogen Synthase Kinase 3 beta | RNA, Messenger - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | Hypoxia - metabolism | Glycogen - metabolism | Time Factors | Gene Expression Regulation, Developmental | Membrane Transport Proteins - genetics | Myocardium - metabolism | Membrane Transport Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Heart - physiopathology | Receptors, Purinergic P1 - genetics | Signal Transduction | Apyrase - metabolism | Hypoxia - embryology | Glycogen Synthase Kinase 3 - metabolism | Chick Embryo | Adenosine Kinase - genetics | Organogenesis | Hypoxia - genetics | Animals | Energy Metabolism | Apyrase - genetics | Adenosine - metabolism | Hypoxia - physiopathology | Receptors, Purinergic P1 - metabolism | 5'-Nucleotidase - metabolism | Equilibrative Nucleoside Transport Proteins - genetics | Complications and side effects | Adenosine | Health aspects | Heart muscle | Embryonic development | RNA | Adenosine kinase | Glycogen | Cardiovascular system | Cell growth | Poultry | Genes | Kinases | Embryos | Index Medicus | Cardiovascular and Renal Integration
Journal Article
Journal Article
Journal Article