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1. Full Text Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine
by Duan, Yanwei and Liu, Tian and Zhou, Yong and Dou, Tongyi and Yang, Qing
The Journal of biological chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 40, pp. 15429 - 15438
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | Substrate Specificity | Crystallography, X-Ray | Chitinases - metabolism | Isoenzymes - chemistry | beta-N-Acetylhexosaminidases - chemistry | Berberine - metabolism | Chitinases - genetics | Isoenzymes - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | beta-N-Acetylhexosaminidases - genetics | Binding Sites | Moths - chemistry | Chitinases - chemistry | Berberine - chemistry | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Chitinases - antagonists & inhibitors | Gene Expression | Genetic Vectors - chemistry | Isoenzymes - genetics | beta-N-Acetylhexosaminidases - metabolism | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | beta-N-Acetylhexosaminidases - antagonists & inhibitors | Recombinant Proteins - genetics | Medicine, Chinese Traditional - methods | Glycoside Hydrolase Inhibitors - chemistry | Static Electricity | Saccharomyces cerevisiae - chemistry | Animals | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | Saccharomyces cerevisiae - enzymology | Quinazolinones - chemistry | Kinetics | Quinazolinones - metabolism | Moths - enzymology | Isoenzymes - antagonists & inhibitors | Index Medicus | glycoside hydrolase | chitinase | β-N-acetyl-D-hexosaminidase | inhibitor | protein crystallization | insect | Enzymology | human | berberine
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2. Full Text Structure of MurNAc 6‑Phosphate Hydrolase (MurQ) from Haemophilus influenzae with a Bound Inhibitor
by Hadi, Timin and Hazra, Saugata and Tanner, Martin E and Blanchard, John S
Biochemistry (Easton), ISSN 0006-2960, 12/2013, Volume 52, Issue 51, pp. 9358 - 9366
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Catalytic Domain - drug effects | Phosphorylation | Hydrolysis - drug effects | Glycoside Hydrolases - genetics | Bacterial Proteins - chemistry | Crystallography, X-Ray | Muramic Acids - chemistry | Enzyme Inhibitors - chemistry | Haemophilus influenzae - enzymology | Conserved Sequence | Glycoside Hydrolases - chemistry | Escherichia coli Proteins - antagonists & inhibitors | Glycoside Hydrolases - antagonists & inhibitors | Binding, Competitive | Molecular Conformation - drug effects | Recombinant Proteins - metabolism | Amino Acid Sequence | Bacterial Proteins - antagonists & inhibitors | Biocatalysis | Enzyme Inhibitors - metabolism | Bacterial Proteins - genetics | Enzyme Inhibitors - pharmacology | Models, Molecular | Recombinant Proteins - chemistry | Escherichia coli Proteins - metabolism | Hydrogen Bonding | Escherichia coli Proteins - genetics | Bacterial Proteins - metabolism | Glycoside Hydrolases - metabolism | Escherichia coli Proteins - chemistry | Lysine - chemistry | Muramic Acids - metabolism | Glutamic Acid - chemistry | Physiological aspects | Enzymes | Hydrolases | Hemophilus infections | Research | Chemical properties | Index Medicus | peptidoglycan | recycling | MurQ | etherase | MurNAc 6P hydrolase | YfeU
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3. Full Text Fully deacetylated chitooligosaccharides act as efficient glycoside hydrolase family 18 chitinase inhibitors
by Chen, Lei and Zhou, Yong and Qu, Mingbo and Zhao, Yong and Yang, Qing
The Journal of biological chemistry, ISSN 0021-9258, 06/2014, Volume 289, Issue 25, pp. 17932 - 19740
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Catalytic Domain | Chitinases - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | Insect Proteins - genetics | Chitin - chemistry | Chitinases - metabolism | Chitin - pharmacology | Insect Proteins - antagonists & inhibitors | Chitinases - genetics | Moths - genetics | Oligosaccharides - pharmacology | Animals | Enzyme Inhibitors - chemistry | Insect Proteins - chemistry | Oligosaccharides - chemistry | Larva - enzymology | Larva - genetics | Insect Proteins - metabolism | Moths - enzymology | Chitinases - chemistry | Index Medicus | Chitinase | Protein Structure and Folding | Crystal Structure | Thermodynamics | Insect Molting | Deacetylated Chitooligosaccharides | Glycoside Hydrolase | Enzyme Inhibitor
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4. Full Text Revisiting glycoside hydrolase family 20 β-N-acetyl-d-hexosaminidases: Crystal structures, physiological substrates and specific inhibitors
by Liu, Tian and Duan, Yanwei and Yang, Qing
Biotechnology advances, ISSN 0734-9750, 07/2018, Volume 36, Issue 4, pp. 1127 - 1138
Substrate | Drug | Pesticide | Inhibitor | β-N-acetyl-d-hexosaminidase | Glycoside hydrolase | Catalytic mechanism | Crystal structure | β-N-acetyl-D-hexosaminidase | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Animals | beta-N-Acetylhexosaminidases - physiology | beta-N-Acetylhexosaminidases - metabolism | Humans | Crystallization | Fungal Proteins | beta-N-Acetylhexosaminidases - antagonists & inhibitors | Plant Proteins | beta-N-Acetylhexosaminidases - chemistry | Bacterial Proteins | Index Medicus
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5. Full Text The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors
by Sato, Mayo and Liebschner, Dorothee and Yamada, Yusuke and Matsugaki, Naohiro and Arakawa, Takatoshi and Wills, Siobhán S and Hattie, Mitchell and Stubbs, Keith A and Ito, Tasuku and Senda, Toshiya and Ashida, Hisashi and Fushinobu, Shinya
The Journal of biological chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12126 - 12138
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Glycoside Hydrolases - genetics | Bacterial Proteins - chemistry | Crystallography, X-Ray | alpha-N-Acetylgalactosaminidase - chemistry | Recombinant Fusion Proteins - metabolism | Acetylgalactosamine - metabolism | Coenzymes - metabolism | alpha-N-Acetylgalactosaminidase - metabolism | Metals - chemistry | Bifidobacterium bifidum - enzymology | Enzyme Inhibitors - chemistry | alpha-N-Acetylgalactosaminidase - antagonists & inhibitors | Conserved Sequence | Glycoside Hydrolases - chemistry | Coenzymes - chemistry | Binding Sites | Glycoside Hydrolases - antagonists & inhibitors | Amino Acid Sequence | Bacterial Proteins - antagonists & inhibitors | Catalytic Domain | Mutagenesis, Site-Directed | Enzyme Inhibitors - metabolism | Bacterial Proteins - genetics | Enzyme Inhibitors - pharmacology | Models, Molecular | Recombinant Fusion Proteins - chemistry | Acetylgalactosamine - chemistry | Probiotics | Metals - metabolism | Sequence Alignment | Bacterial Proteins - metabolism | Ligands | Protein Conformation | Structural Homology, Protein | Glycoside Hydrolases - metabolism | Mutation | alpha-N-Acetylgalactosaminidase - genetics | Amino Acid Substitution | Index Medicus | X-ray crystallography | glycoside hydrolase | Enzymology | Bifidobacterium bifidum | mucin | metal ion-protein interaction
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6. Full Text Discovery of Selective Small‐Molecule Activators of a Bacterial Glycoside Hydrolase
by Darby, John F and Landström, Jens and Roth, Christian and He, Yuan and Davies, Gideon J and Hubbard, Roderick E
Angewandte Chemie (International ed.), ISSN 1433-7851, 12/2014, Volume 53, Issue 49, pp. 13419 - 13423
protein structures | inhibitors | enzyme catalysis | glycosylation | glycoside hydrolase | Glycosylation | Inhibitors | Enzyme catalysis | Protein structures | Glycoside hydrolase | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Yuan (China) | Enzymes | Hydrolases | Enzyme inhibitors | Catalysis | Analysis | Bacteriology | Index Medicus | Catalysts | Exact solutions | Glycosides | Bacteria | Activation | Fragmentation | Communications
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7. Full Text (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition
by Rack, Johannes Gregor Matthias and Ariza, Antonio and Drown, Bryon S and Henfrey, Callum and Bartlett, Edward and Shirai, Tomohiro and Hergenrother, Paul J and Ahel, Ivan
Cell chemical biology, ISSN 2451-9456, 12/2018, Volume 25, Issue 12, pp. 1533 - 1546.e12
PARG | ADPRHL2 | DNA damage | ADPRH | PARP | metalloenzyme | ADP-ribosylation | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Adaptor Proteins, Signal Transducing - chemistry | Humans | Enzyme Inhibitors - pharmacology | Models, Molecular | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Dose-Response Relationship, Drug | Substrate Specificity - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Glycoside Hydrolases - chemistry | Protein Conformation | Glycoside Hydrolases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Glycoside Hydrolases - antagonists & inhibitors
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8. Full Text Crystal structures of glycoside hydrolase family 3 β-glucosidase 1 from Aspergillus aculeatus
by Suzuki, Kentaro and Sumitani, Jun-Ichi and Nam, Young-Woo and Nishimaki, Toru and Tani, Shuji and Wakagi, Takayoshi and Kawaguchi, Takashi and Fushinobu, Shinya
Biochemical journal, ISSN 0264-6021, 06/2013, Volume 452, Issue 2, pp. 211 - 221
Biorefinery | N-glycan | Protein glycosylation | β-glucosidase | Cellulase | Glycoside hydrolase family 3 | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Carbohydrate Sequence | Fungal Proteins - chemistry | Catalytic Domain | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Fungal Proteins - antagonists & inhibitors | Glycosylation | beta-Glucosidase - chemistry | beta-Glucosidase - antagonists & inhibitors | Polysaccharides - chemistry | beta-Glucosidase - metabolism | Ligands | Protein Conformation | Aspergillus - enzymology | Carbohydrate Conformation | Fungal Proteins - metabolism | Index Medicus
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9. Full Text Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack
by Ghani, Usman
European journal of medicinal chemistry, ISSN 0223-5234, 10/2015, Volume 103, pp. 133 - 162
α-glucosidase inhibitors | Synthetic | Anti-diabetic drugs | Natural | Drug development | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Diabetes Mellitus - enzymology | Hypoglycemic Agents - administration & dosage | Administration, Oral | Humans | Diabetes Mellitus - drug therapy | Diabetes Mellitus - metabolism | Hypoglycemic Agents - chemistry | Glycoside Hydrolase Inhibitors - chemistry | Glycoside Hydrolase Inhibitors - pharmacology | alpha-Glucosidases - metabolism | Glycoside Hydrolase Inhibitors - administration & dosage | Hypoglycemic Agents - pharmacology | Index Medicus
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