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Free Radical Biology and Medicine, ISSN 0891-5849, 02/2018, Volume 115, pp. 202 - 218
( ) is a disease gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease of proven genetic origin affecting 0.3–0.5% of... 
Oxidative stress | Heme oxygenase-1 (HO-1) | Argpyrimidine-modified heat-shock proteins | Redox signaling | Cerebral Cavernous Malformations | Antioxidant defense | Glyoxalase 1 (Glo1) | c-Jun | Oxidative DNA damage and apoptosis | Nuclear factor erythroid 2-related factor 2 (Nrf2) | Adaptive redox homeostasis | CCM1/KRIT1 | Cerebrovascular disease | GLYCATION END-PRODUCT | GLYOXALASE I | METHYLGLYOXAL MODIFICATION | ARGPYRIMIDINE-MODIFIED HSP70 | ENDOCRINOLOGY & METABOLISM | NF-KAPPA-B | AORTIC ENDOTHELIAL-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTALLINE SILICA | DEFENSE PATHWAY | SIGNALING PATHWAY | VASCULAR INTEGRITY | Antioxidants | Proteins | Brain | Heme | Homeostasis | Heat shock proteins | PTM, post-translational modification | hBMEC, human brain microvascular endothelial cells | Casp-3, Caspase-3 | COX-2, cycloxygenase-2 | BBB, blood-brain barrier | NVU, neurovascular unit | Cyt c, cytochrome c | ICH, intracerebral hemorrhage | MG, methylglyoxal | HO-1, Heme oxygenase-1 | CCM, Cerebral Cavernous Malformation | AP, argpyrimidine (Nẟ-(5-hydroxy-4,6-dimethylpyrimidine-2-yl)-l-ornithine) | Glo1, Glyoxalase 1 | ARE, antioxidant-response element | KRIT1 | ROS, reactive oxygen species | KRIT1, Krev interaction trapped 1 | AGEs, advanced glycation end-products | TUNEL, TdT-mediated dUTP nick-end labeling | EndMT, endothelial-to-mesenchymal transition | Nrf2, nuclear factor erythroid 2-related factor 2 | Keap1, Kelch-like ECH-associated protein 1 | SOD, superoxide dismutase | Hsp, heat-shock protein | CNS, central nervous system | JNK, c-Jun NH2-terminal kinase | MEF, mouse embryonic fibroblast | CCM1
Journal Article
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 10/2001, Volume 39, Issue 10, pp. 989 - 997
There is a growing interest in understanding the biological effect of time-tested folk medicinal plants. In the present work, the effect of dietary... 
glyoxalase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2001, Volume 276, Issue 3, pp. 1845 - 1849
The tertiary structure of the monomeric yeast glyoxalase I has been modeled based on the crystal structure of the dimeric human glyoxalase I and a sequence... 
glyoxalase I
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 5, pp. 869 - 873
Human glyoxalase I (hGLO I) is a rate-limiting enzyme in the pathway for detoxification of apoptosis-inducible methylglyoxal (MG), which is the side product of... 
Journal Article
PARASITOLOGY INTERNATIONAL, ISSN 1383-5769, 08/2017, Volume 66, Issue 4, pp. 453 - 457
Infection with the fish borne liver fluke Opisthorchis felineus is common in the Eastern Europe (Ukraine, European part of Russia), Northern Asia (Siberia) and... 
CHOLANGIOCARCINOMA | RECEPTOR | ALPHA-OXOALDEHYDES | RAGE | DICARBONYL STRESS | Opisthorchis felineus | Advanced glycation end products | Glycation RAGE | LIVER | Glyoxalase 1 | Glyoxalase 2 | EXPRESSION | PARASITOLOGY | Glutathione | GLYCATION END-PRODUCTS | GLYOXALASE-I
Journal Article
Molecular Metabolism, ISSN 2212-8778, 12/2018, Volume 18, pp. 143 - 152
The deficit of Glyoxalase I ( ) and the subsequent increase in methylglyoxal (MG) has been reported to be one the five mechanisms by which hyperglycemia causes... 
Glyoxalase 1 | Reactive metabolites | Methylglyoxal | Diabetic complications | Advanced glycation end products | Aldo-keto reductases | INCREASES | GLYCATION | DICARBONYL STRESS | HYPERGLYCEMIA | METABOLISM | DEGRADATION-PRODUCTS | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | TYPE-1 | ALDOSE REDUCTASE | GLYOXALASE-I
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 2003, Volume 31, Issue 6, pp. 1406 - 1408
Journal Article
Brain Research Bulletin, ISSN 0361-9230, 01/2019, Volume 144, pp. 164 - 170
Methylglyoxal (MG) is an α-dicarbonyl compound that is naturally produced in vivo through glucose metabolism. In general, MG is metabolized by the glyoxalase... 
Glyoxalase 1 | Carbonyl stress | Methylglyoxal | Aldose reductase | Ageing | REDOX STATE | PROTEIN OXIDATION | ANXIETY | ALZHEIMERS-DISEASE | SUSCEPTIBILITY | GLYCATION | RECEPTOR | NEUROSCIENCES | GLUTATHIONE | EXPRESSION | GLYOXALASE-I
Journal Article
Critical Reviews in Plant Sciences, ISSN 0735-2689, 11/2014, Volume 33, Issue 6, pp. 429 - 456
Glyoxalases are known to play a very important role in abiotic stress tolerance. This two-step pathway detoxifies ubiquitously present cytotoxic metabolite... 
glyoxalase I (GLYI) | glyoxalase II (GLYII) | methylglyoxal (MG) | biotic stress | abiotic stress | ARABIDOPSIS-THALIANA | ACTIVATED PROTEIN-KINASE | ESCHERICHIA-COLI | COMPARATIVE PROTEOMIC ANALYSIS | SACCHAROMYCES-CEREVISIAE | TRANSGENIC TOBACCO PLANTS | PLANT SCIENCES | RESPONSIVE GENES | TUMOR-NECROSIS-FACTOR | ORYZA-SATIVA | EXTRACELLULAR-MATRIX
Journal Article
Tree physiology, ISSN 0829-318X, 10/2018, Volume 38, Issue 10, pp. 1548 - 1565
Citrus are mainly grown in low pH soils with high active aluminum (Al). 'Xuegan' (Citrus sinensis (L.) Osbeck) and 'Shatian pummelo' (Citrus grandis (L.)... 
Citrus grandis | Reactive oxygen species | Citrus sinensis | Photosynthesis | Aluminum | Glyoxalase | LIPID-PEROXIDATION | CHLOROPHYLL FLUORESCENCE | HIGH-TEMPERATURE | aluminum | PHOTOPROTECTIVE SYSTEMS | HYDROGEN-SULFIDE | GLYOXALASE PATHWAY | photosynthesis | ANTIOXIDANT DEFENSE | glyoxalase | reactive oxygen species | CYSTEINE SYNTHASE | GAS-EXCHANGE | FORESTRY | ELECTRON-TRANSPORT
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 06/2012, Volume 18, Issue 6, pp. 926 - 926
This study establishes a mechanism for metabolic hyperalgesia based on the glycolytic metabolite methylglyoxal. We found that concentrations of plasma... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | FOREBRAIN | SENSITIVE METHOD | RAT | ROOT GANGLION NEURONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOOD-FLOW | CELL BIOLOGY | PERIPHERAL NEUROPATHY | RESISTANT SODIUM-CHANNELS | EXPRESSION | GLYOXALASE-I
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2019, Volume 24, Issue 18, p. 3210
Glyoxalase-I (Glo-I) enzyme was established to be a valid target for anticancer drug design. It performs the essential detoxification step of harmful... 
1,2,3-Selenadiazole | Glyoxalase-I | Inhibition | 1,2,3-Thiadiazole | Zinc Binding Feature
Journal Article
Journal of Functional Foods, ISSN 1756-4646, 10/2018, Volume 49, pp. 258 - 266
We investigated the effect of cyanidin-3-rutinoside (C3R) against methylglyoxal (MG)-advanced glycation end products (AGEs) mediated cardio-vascular... 
Glyoxalase I | Methylglyoxal | Arrhythmia | Cyanidin-3-rutinoside | Vascular dysfunctions | Glycation
Journal Article