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Scientific Reports, ISSN 2045-2322, 09/2016, Volume 6, Issue 1, p. 34138
The Goto-Kakizaki (GK) rat is an animal model of non-obese type 2 diabetes (T2D). The GK rat was generated through the introduction of various genetic... 
GOTO-KAKIZAKI RATS | METABOLISM | BAD | SENSITIVE K+ CHANNELS | GLUCOSE | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | ENVIRONMENT | RESISTANCE | RECEPTOR | EXPRESSION | Diabetes mellitus | Melanocortin | Homeostasis | Chemoreception | Hypothalamus | Gene expression | Ribonucleic acid--RNA | Energy balance | Rodents | Inbreeding | Diabetes | Mutation | Protein interaction
Journal Article
Acta Biochim Biophys Sin, ISSN 1672-9145, 6/2009, Volume 41, Issue 6, pp. 472 - 477
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e55925
Interleukin-1beta (IL-1 beta) is a major cause for induction of various inflammatory mechanisms that are decisively involved to provoke pathogenesis of type 2... 
IN-VITRO RELEASE | GOTO-KAKIZAKI RATS | HOMEOSTASIS MODEL ASSESSMENT | ISLET-ASSOCIATED MACROPHAGES | INTERLEUKIN-1 RECEPTOR ANTAGONIST | HIGH-FAT DIET | INSULIN-RESISTANCE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | BETA-CELL | TYPE-2 | Interleukin 1 Receptor Antagonist Protein - administration & dosage | Kidney - pathology | Skin - metabolism | Male | Insulin - blood | Hyperglycemia - drug therapy | Antigens, CD - metabolism | Kidney Function Tests | Kidney - metabolism | Islets of Langerhans - metabolism | Diabetes Mellitus, Type 2 - complications | Skin - pathology | Disease Models, Animal | Hyperglycemia - prevention & control | Glucose Tolerance Test | Kidney - drug effects | Gels | Insulin Resistance | Rats | Diabetes Mellitus, Type 2 - blood | Animals | Hyperglycemia - blood | Antigens, Differentiation, Myelomonocytic - metabolism | Poloxamer | Interleukin 1 Receptor Antagonist Protein - adverse effects | Hyperglycemia - etiology | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Hyperglycemia | Blood sugar monitoring | Interleukins | Physiological aspects | Skin | Glucose | Glucose tolerance tests | Dextrose | Drugs | Syngeneic grafts | Pathogenesis | Weaning | Interleukin | Drug delivery | Interleukin 1 receptors | Macrophages | Interleukin 6 | Toxicology | Rodents | Interleukin 1 | Histochemical analysis | Pancreas | Pharmaceutical sciences | Half life | Urine | Kidneys | Cytokines | Interleukin 1 receptor antagonist | Diabetes mellitus | Body temperature | Radioactive half-life | Inflammation | Pharmacology | FDA approval | Metabolism | Insulin | Studies | Glucose tolerance | Insulin resistance | Infiltration | Diabetes | Chemokines | Apoptosis
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2009, Volume 4, Issue 9, p. e6963
Background: Inflammation followed by fibrosis is a component of islet dysfunction in both rodent and human type 2 diabetes. Because islet inflammation may... 
NADPH OXIDASE | GOTO-KAKIZAKI RAT | PANCREATIC-ISLETS | RENIN-ANGIOTENSIN SYSTEM | INTERLEUKIN-1 RECEPTOR ANTAGONIST | NITRIC-OXIDE SYNTHASE | BIOLOGY | CARDIOVASCULAR-DISEASE | NECROSIS-FACTOR-ALPHA | BETA-CELL MASS | HEME OXYGENASE-1 | Interleukin-1 - metabolism | Oxidative Stress | Rats, Wistar | Antioxidants - metabolism | Gene Expression Regulation | Rats | Male | Inflammation | Diabetes Mellitus, Type 2 - metabolism | Animals | Endothelial Cells - cytology | Models, Biological | Interleukin 1 Receptor Antagonist Protein - metabolism | Islets of Langerhans - cytology | Diabetes Mellitus, Experimental - metabolism | Type 2 diabetes | Interleukins | RNA | Genes | Angiotensin | Genetic research | Gene expression | Vascular endothelial growth factor | Endothelium | Oxidative stress | Laboratories | Interleukin | Biology | Activation | Interleukin 1 receptors | Kinases | Epoxide hydrolase | Cell adhesion & migration | Vascularization | Proteins | Angiogenesis | Signal transduction | Cell activation | Hyperglycemia | Rodents | Atherosclerosis | Interleukin 1 | Angiotensinogen | Trends | Pancreas | Immune system | Cardiovascular system | Hypertension | Cytokines | Interleukin 1 receptor antagonist | Diabetes mellitus | Metabolism | Apolipoproteins | Fibrinolysis | Cholesterol | Endothelial cells | Polymerase chain reaction | Pathology | Arachidonate 12-lipoxygenase | Arteriosclerosis | Fibrosis | Insulin resistance | Islets of Langerhans | Diabetes | Lipoxygenase | Endocrinology
Journal Article
Journal Article
Neuroscience Letters, ISSN 0304-3940, 08/2017, Volume 655, pp. 41 - 45
Although both type 2 diabetes mellitus (T2DM) and aging are related with Alzheimer’s disease (AD), the effects of aging on the Alzheimer’s proteins and the... 
Goto-Kakizaki (GK) rat | Type 2 diabetes mellitus (T2DM) | Alzheimer’s protein | Synaptic proteins | Advanced-age
Journal Article
Neuropeptides, ISSN 0143-4179, 04/2018, Volume 68, pp. 49 - 56
Hyperphagia triggers and accelerates diabetes, and prevents proper dietary control of glycemia. Inversely, the impact of hyperglycemia on hyperphagia and... 
POMC | GK rat | Type 2 diabetes | Hyperglycemia | Weaning | Hyperphagia | Glucose sensing | LEPTIN | GOTO-KAKIZAKI RATS | HOMEOSTASIS | FOOD-INTAKE | NONOBESE | NEUROSCIENCES | OBESITY | MIGLITOL | HORMONE | NUCLEUS | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION
Journal Article