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American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 05/2015, Volume 308, Issue 9, pp. F993 - F1003
IL-1 beta-secreting nucleotide-binding oligomerization domain protein 3 (NLRP3) inflammasomes play a pivotal role in triggering innate immune responses in... 
Diabetic nephropathy | Uric acid | NLRP3 inflammasome | Macrophage | PHYSIOLOGY | INJURY | macrophage | CELL-PROLIFERATION | MECHANISMS | ALLOPURINOL | PATHOGENESIS | KIDNEY-FUNCTION | INFLAMMASOME | DISEASE | UROLOGY & NEPHROLOGY | uric acid | NF-KAPPA-B | diabetic nephropathy | URIC-ACID | Inflammasomes - metabolism | Diabetic Nephropathies - etiology | NLR Family, Pyrin Domain-Containing 3 Protein | Coculture Techniques | Diabetes Mellitus, Type 2 - genetics | Humans | Male | NF-kappa B - metabolism | Hyperuricemia - metabolism | Diabetes Mellitus, Type 2 - metabolism | Diabetic Nephropathies - immunology | Hyperuricemia - immunology | Inflammation - metabolism | Transfection | RNA Interference | Time Factors | Interleukin-1beta - metabolism | Diabetes Mellitus, Type 2 - immunology | HMGB1 Protein - metabolism | Inflammation Mediators - metabolism | Diabetic Nephropathies - prevention & control | Hyperuricemia - complications | Diabetes Mellitus, Type 2 - complications | Macrophages - immunology | Disease Models, Animal | Cell Line | Kidney Tubules, Proximal - immunology | Uric Acid - metabolism | Signal Transduction | Diabetic Nephropathies - metabolism | Diabetic Nephropathies - genetics | Inflammation - immunology | Inflammation - etiology | Disease Progression | Inflammasomes - genetics | Hyperuricemia - drug therapy | Carrier Proteins - genetics | Rats, Inbred OLETF | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Chemokine CXCL12 - metabolism | Kidney Tubules, Proximal - metabolism | Gout Suppressants - pharmacology | Macrophages - drug effects | Kidney Tubules, Proximal - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Type 2 diabetes | Cellular proteins | Kidneys | Immune response | Physiological aspects | Genetic aspects | Properties | Injuries
Journal Article
Nature, ISSN 0028-0836, 03/2006, Volume 440, Issue 7081, pp. 237 - 241
Journal Article
The Journal of Immunology, ISSN 0022-1767, 04/2005, Volume 174, Issue 8, pp. 5016 - 5023
Microcrystals of calcium pyrophosphate dihydrate (CPPD) and monosodium urate (MSU) deposited in synovium and articular cartilage initiate joint inflammation... 
REGULATED KINASE | ACTIVATION | PROTEIN | PHOSPHATIDYLINOSITOL 3-KINASE | TOLL-LIKE RECEPTORS | MICROBIAL LIPOPROTEINS | INDUCED INFLAMMATION | IL-1 RECEPTOR | IMMUNOLOGY | EXPRESSION | CUTTING EDGE | Protein Kinases - metabolism | Calcium Pyrophosphate - toxicity | Toll-Like Receptor 2 | Membrane Glycoproteins - metabolism | Chondrocytes - immunology | Humans | Calcium Pyrophosphate - metabolism | DNA, Complementary - genetics | Chondrocalcinosis - immunology | Interleukin-1 Receptor-Associated Kinases | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | Receptors, Cell Surface - antagonists & inhibitors | Chondrocytes - drug effects | Toll-Like Receptors | Membrane Glycoproteins - antagonists & inhibitors | Cattle | Base Sequence | Antigens, Differentiation - metabolism | Gout - immunology | Chondrocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Nitric Oxide - biosynthesis | Gene Expression | Uric Acid - metabolism | Signal Transduction | Uric Acid - toxicity | RNA, Messenger - genetics | Cells, Cultured | Crystallization | Receptors, Cell Surface - metabolism | Myeloid Differentiation Factor 88 | I-kappa B Kinase | Immunity, Innate | Gout - etiology | Membrane Glycoproteins - genetics | Proto-Oncogene Proteins c-akt | Adaptor Proteins, Signal Transducing | Gout - metabolism | Animals | Models, Biological | Chondrocalcinosis - etiology | TNF Receptor-Associated Factor 6 - metabolism | Chondrocalcinosis - metabolism | Receptors, Immunologic - metabolism | rac1 GTP-Binding Protein - metabolism | Receptors, Cell Surface - genetics
Journal Article
Clinical Immunology, ISSN 1521-6616, 2012, Volume 147, Issue 3, pp. 223 - 228
Abstract Blocking the cytokines Interleukin-1beta (IL-1β) and Interleukin-18 (IL-18) benefits a diverse range of inflammatory pathologies. In each of these... 
Allergy and Immunology | NLRP3 | Interleukin-1 | Inflammasome | Autoinflammation | JUVENILE IDIOPATHIC ARTHRITIS | CONTACT HYPERSENSITIVITY | THIOREDOXIN-INTERACTING PROTEIN | NLRP3 INFLAMMASOME | BEHCETS-DISEASE | IMMUNOLOGY | NALP3 INFLAMMASOME | INTESTINAL INFLAMMATION | RECEPTOR ANTAGONIST GENE | INTERLEUKIN-1-BETA INHIBITION | AUTOIMMUNE ADDISONS-DISEASE | Neoplasms - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Obesity - immunology | Atherosclerosis - genetics | Humans | Inflammatory Bowel Diseases - immunology | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Diabetes Mellitus, Type 2 - metabolism | Inflammatory Bowel Diseases - metabolism | Obesity - genetics | Neoplasms - genetics | Interleukin-1beta - metabolism | Diabetes Mellitus, Type 2 - immunology | Inflammatory Bowel Diseases - genetics | Alzheimer Disease - immunology | Nuclear Proteins - genetics | Gout - immunology | DNA-Binding Proteins | Atherosclerosis - immunology | Nuclear Proteins - immunology | Atherosclerosis - metabolism | Apoptosis Regulatory Proteins - metabolism | Obesity - metabolism | Gout - metabolism | Animals | Carrier Proteins - metabolism | Neoplasms - immunology | Inflammasomes - immunology | Alzheimer Disease - metabolism | Gout - genetics | Adaptor Proteins, Signal Transducing - metabolism | Alzheimer Disease - genetics | Interleukin-18 - metabolism | Autoimmunity
Journal Article
1977, Advances in experimental medicine and biology, Volume 76, 2 v. ill.
Book
PLoS ONE, ISSN 1932-6203, 2017, Volume 12, Issue 8, p. e0182751
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 2015, Volume 67, Issue 12, pp. 3303 - 3313
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2008, Volume 45, Issue 11, pp. 1542 - 1550
Journal Article
Frontiers in Bioscience, ISSN 1093-9946, 01/2012, Volume 17, Issue 2, pp. 656 - 669
Uric acid is the product of purine metabolism. It is known that hyperuricemia, defined as high levels of blood uric acid, is the major etiological factor of... 
Cardiovascular disease | Hyperuricemia | Inflammasome | Review | Uric acid | URATE OXIDASE | METABOLIC SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOW-DENSITY-LIPOPROTEIN | BLOOD-PRESSURE | NALP3 INFLAMMASOME | CELL BIOLOGY | MIDDLE-AGED MEN | CARDIOVASCULAR-DISEASE | CORONARY-HEART-DISEASE | INDUCED NEUTROPHIL ACTIVATION | PARKINSONS-DISEASE
Journal Article