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Neuroscience Letters, ISSN 0304-3940, 02/2018, Volume 666, pp. 32 - 37
It is well established that healthy aging, mild cognitive impairment (MCI), and Alzheimer's disease (AD) are associated with substantial declines in episodic... 
MCI | GPX1 | Alzheimer’s disease | GPX4 | Episodic memory
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 04/2020, Volume 235, Issue 4, pp. 3425 - 3437
Glutathione peroxidase 4 (GPX4) has been confirmed to inhibit ferroptosis in cancer cells, however, whether GPX4 serves as an oncogene is not clear. In this... 
lung cancer | ferroptosis | GPX4 | cisplatin | pan‐cancer | authphagy
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 01/2020, Volume 26, Issue 1, pp. 3 - 6
Using an unbiased genetic screen, map genes that enhance or suppress growth defects in response to different mitochondrial inhibitors to model mitochondrial... 
CRISPR screen | complex I | mitochondrial toxins | GPX4
Journal Article
Trends in Cell Biology, ISSN 0962-8924, 2015, Volume 26, Issue 3, pp. 165 - 176
Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation... 
Pathology | system xc | ferroptosis | GPX4 | cell death | lipid peroxides | ROS | Ferroptosis | System x | Cell death | Lipid peroxides | Animals | Iron - physiology | Reactive Oxygen Species - metabolism | Cell Death - physiology | Humans | Glutathione Peroxidase - physiology | Neurons - physiology | Glutamic Acid - physiology | Lipid Peroxidation | Physiological aspects | Lipid peroxidation | Enzymes | Peroxidase
Journal Article
Chemico-biological interactions, ISSN 0009-2797, 12/2019, p. 108930
Ferroptosis is recently identified form of regulated cell death which differs from previously identified cell death in a way that it is driven by... 
Journal Article
Experimental Cell Research, ISSN 0014-4827, 08/2019, Volume 381, Issue 1, pp. 139 - 149
Guanine-rich RNA sequence binding factor 1 (GRSF1) is a member of the RNA-binding protein (RBP) family. GRSF1 regulates RNA metabolism through RNA processing,... 
Myoblast/ myo-differentiation | GPX4 | GRSF1 | Differentiation | ROS | Purines | Forests and forestry | RNA | Protein binding
Journal Article
Redox Biology, ISSN 2213-2317, 02/2020, Volume 30, p. 101413
Drug resistance is the main obstacle in the improvement of chemotherapeutic efficacy in glioblastoma. Previously, we showed that dehydroepiandrosterone (DHEA),... 
GPX4 | ALZ003 | Glioblastoma
Journal Article
NATURE, ISSN 0028-0836, 11/2019, Volume 575, Issue 7784, pp. 693 - 693
Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids(1,2). To date, ferroptosis has been thought to be... 
CANCER-CELLS | PROTEIN | GPX4 | ANTIOXIDANT | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | MECHANISMS | UBIQUINONE | STRESS | AIF | CELL-DEATH
Journal Article
CELL, ISSN 0092-8674, 11/2017, Volume 171, Issue 6, pp. 1226 - 1227
Journal Article
The American Journal of Pathology, ISSN 0002-9440, 01/2020, Volume 190, Issue 1, pp. 68 - 81
Oxidative stress and its associated lipid peroxidation play a key role in nonalcoholic steatohepatitis (NASH). Ferroptosis is a recently recognized type of... 
PATHOGENESIS | OXIDATIVE STRESS | FATTY LIVER-DISEASE | ABLATION | RISK | MODEL | PATHOLOGY | SELENOPROTEIN GPX4 | PROTECTS
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 07/2015, Volume 10, Issue 7, pp. 1604 - 1609
Little is known about the regulation of nonapoptotic cell death. Using massive insertional mutagenesis of haploid KBM7 cells we identified nine genes involved... 
MECHANISM | GPX4 | BIOCHEMISTRY & MOLECULAR BIOLOGY | FERROPTOSIS | MICE | IDENTIFICATION | FAILURE | DAMAGE | Haploidy | Small Molecule Libraries - pharmacology | Apoptosis - drug effects | Humans | Gene Expression Regulation | Cell Line, Tumor | Lipid Metabolism | Mutagenesis, Insertional | Index Medicus | Letters
Journal Article
ACS Nano, ISSN 1936-0851, 12/2018, Volume 12, Issue 12, pp. 12380 - 12392
Ferroptosis, an iron-based cell-death pathway, has recently attracted great attention owing to its effectiveness in killing cancer cells. Previous... 
theranostics | ferroptosis | GPX4 | nanobubbles | glutathione | CANCER-CELLS | ACTIVATION | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | DEATH | GLUTATHIONE LEVELS | CHEMISTRY, MULTIDISCIPLINARY | THERAPY | OXIDE NANOPARTICLES | PATHWAY | BIOLOGY | CONTRAST | GENERATION
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2016, Volume 59, Issue 5, pp. 2041 - 2053
Ferroptosis is a nonapoptotic, iron-catalyzed form of regulated necrosis that is critically dependent on glutathione peroxidase 4 (GPX4). It has been shown to... 
GPX4 | CHEMISTRY, MEDICINAL | CELL-DEATH | Animals | Cyclohexylamines - pharmacology | Humans | Cell Line, Tumor | Cyclohexylamines - chemistry | Phenylenediamines - pharmacology | Mice | Molecular Structure | Cell Death - drug effects | Phenylenediamines - chemistry
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2016, Volume 113, Issue 34, pp. E4966 - E4975
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 2018, Volume 314, Issue 5, pp. F702 - F714
Ferroptosis is an iron-dependent form of regulated nonapoptotic cell death, which contributes to damage in models of acute kidney injury (AKI). Herne... 
Proximal tubule | Erastin | Iron | Ferrostatin-1 | Acute kidney injury | PHYSIOLOGY | GPX4 | RAT | REPERFUSION INJURY | DEATH | DAMAGE | erastin | DISEASE | LIVER | UROLOGY & NEPHROLOGY | iron | ferrostatin-1 | acute kidney injury | proximal tubule | Kidneys | Health aspects | Heme | Apoptosis
Journal Article
Cell, ISSN 0092-8674, 10/2017, Volume 171, Issue 3, pp. 628 - 641.e26
Journal Article