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1. Full Text Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
by Matsuoka, Ken-Ichi and Koreth, John and Kim, Haesook T and Bascug, Gregory and McDonough, Sean and Kawano, Yutaka and Murase, Kazuyuki and Cutler, Corey and Ho, Vincent T and Alyea, Edwin P and Armand, Philippe and Blazar, Bruce R and Antin, Joseph H and Soiffer, Robert J and Ritz, Jerome
Science Translational Medicine, ISSN 1946-6234, 04/2013, Volume 5, Issue 179, pp. 179ra43 - 179ra43
CD4(+)Foxp3(+) regulatory T cells (T-regs) play a central role in the maintenance of immune tolerance after allogeneic hematopoietic stem cell transplantation.... 
MEDICINE, RESEARCH & EXPERIMENTAL | MAINTENANCE | PLASMA-LEVELS | CHRONIC GVHD | IN-VIVO | EXPANSION | RECEPTOR | IL-2 | MECHANISMS | EXPRESSION | TRANSPLANTATION | CELL BIOLOGY | Apoptosis - drug effects | Humans | Middle Aged | Interleukin-2 - therapeutic use | Male | Graft vs Host Disease - immunology | T-Lymphocytes, Regulatory - immunology | Dose-Response Relationship, Drug | Young Adult | STAT5 Transcription Factor - metabolism | Signal Transduction - immunology | Lymphocyte Activation - immunology | Interleukin-2 - administration & dosage | Adult | Female | Homeostasis - drug effects | Homeostasis - immunology | Immunophenotyping | T-Lymphocytes, Regulatory - drug effects | Apoptosis - immunology | Graft vs Host Disease - drug therapy | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Cell Proliferation - drug effects | Chronic Disease | Index Medicus
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2. Full Text Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey
by Zeiser, F and Burchert, A and Lengerke, C and Verbeek, M.M and Maas-Bauer, K and Metzelder, S.K and Spoerl, S and Ditschkowski, M and Ecsedi, M and Sockel, K and Ayuk, F and Ajib, S and Fontbrune, F.S. de and Na, I.K and Penter, L and Holtick, U and Wolf, D and Schuler, E and Meyer, E and Apostolova, P and Bertz, H and Marks, R and Lubbert, M and Wasch, R and Scheid, C and Stolzel, F and Ordemann, R and Bug, G and Kobbe, G and Negrin, R and Brune, M and Spyridonidis, A and Schmitt-Graff, A and Velden, W.J. van der and Huls, G.A and Mielke, S and Grigoleit, G.U and Kuball, J and Flynn, R and Ihorst, G and Du, J and Blazar, B.R and Arnold, R and Kroger, N and Passweg, J and Halter, J and Socie, G and Beelen, D and Peschel, C and Neubauer, A and Finke, J and Duyster, J and Bubnoff, N. von and Sahlgrenska akademin and Institute of Medicine, Department of Internal Medicine and Clinical Nutrition and Göteborgs universitet and Gothenburg University and Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition and Sahlgrenska Academy
Leukemia, ISSN 0887-6924, 2015, Volume 29, Issue 10, pp. 2062 - 2068
Despite major improvements in allogeneic hematopoietic cell transplantation over the past decades, corticosteroid-refractory (SR) acute (a) and chronic (c)... 
ANTITHYMOCYTE GLOBULIN THERAPY | FACTOR-RECEPTOR | SURVIVAL | RESISTANT | ALEMTUZUMAB | ONCOLOGY | ACUTE GVHD | EXTRACORPOREAL PHOTOPHERESIS | CYTOKINE INHIBITION | SALVAGE THERAPY | HEMATOLOGY | MYCOPHENOLATE-MOFETIL | Hematologic Neoplasms - therapy | Recurrence | Pyrazoles - therapeutic use | Prognosis | Follow-Up Studies | Humans | Middle Aged | Salvage Therapy | Male | Transplantation, Homologous | Young Adult | Graft vs Host Disease - mortality | Hematopoietic Stem Cell Transplantation - adverse effects | Adult | Female | Retrospective Studies | Hematologic Neoplasms - complications | Graft vs Host Disease - etiology | Disease Models, Animal | Adrenal Cortex Hormones - pharmacology | Survival Rate | Janus Kinases - antagonists & inhibitors | Animals | Graft vs Host Disease - drug therapy | Aged | Mice | Neoplasm Staging | Drug Resistance, Neoplasm - drug effects | Complications and side effects | Oncology, Experimental | Stem cells | Graft versus host reaction | Transplantation | Research | Drug therapy | Cancer | Index Medicus | SALVAGE | THERAPY | EXTRACORPOREAL | PHOTOPHERESIS | Cancer and Oncology | Cancer och onkologi
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3. Full Text Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
by Koreth, John and Matsuoka, Ken-ichi and Kim, Haesook T and McDonough, Sean M and Bindra, Bhavjot and Alyea, Edwin P and Armand, Philippe and Cutler, Corey and Ho, Vincent T and Treister, Nathaniel S and Bienfang, Don C and Prasad, Sashank and Tzachanis, Dmitrios and Joyce, Robin M and Avigan, David E and Antin, Joseph H and Ritz, Jerome and Soiffer, Robert J
The New England Journal of Medicine, ISSN 0028-4793, 12/2011, Volume 365, Issue 22, pp. 2055 - 2066
A low daily dose of subcutaneous interleukin-2 increases the number and function of regulatory T cells and results in substantial improvement in about half of... 
MEDICINE, GENERAL & INTERNAL | THERAPY | BONE-MARROW-TRANSPLANTATION | WORKING GROUP-REPORT | TOLERANCE | CLINICAL-TRIALS | LOW-DOSE INTERLEUKIN-2 | INFUSION | IL-2 | EXPRESSION | CONSENSUS DEVELOPMENT PROJECT | Glucocorticoids - therapeutic use | Interleukin-2 - adverse effects | Humans | Middle Aged | Male | Graft vs Host Disease - immunology | Disease Progression | T-Lymphocytes, Regulatory - immunology | Dose-Response Relationship, Drug | Young Adult | Graft vs Host Disease - drug therapy | Forkhead Transcription Factors - metabolism | Interleukin-2 - administration & dosage | Observation | Adult | Female | Aged | Leukocyte Count | Chronic Disease | Drug Resistance | Cohort Studies | Autografts | Graft-versus-host reaction | Cell survival | Cytokines | Glucocorticoids | Immunoregulation | Mortality | Lymphocytes T | CD4 antigen | Immunology | Interleukin 2 | Foxp3 protein | Forkhead protein | Cancer | Index Medicus | Abridged Index Medicus
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4. Full Text Ibrutinib for chronic graft-versus-host disease after failure of prior therapy
by Miklos, David and Cutler, Corey S and Arora, Mukta and Waller, Edmund K and Jagasia, Madan and Pusic, Iskra and Flowers, Mary E and Logan, Aaron C and Nakamura, Ryotaro and Blazar, Bruce R and Li, Yunfeng and Chang, Stephen and Lal, Indu and Dubovsky, Jason and James, Danelle F and Styles, Lori and Jaglowski, Samantha
Blood, ISSN 0006-4971, 11/2017, Volume 130, Issue 21, pp. 2243 - 2250
Chronic graft-versus-host disease (cGVHD) is a serious complication of allogeneic stem cell transplantation with few effective options available after failure... 
B-CELLS | PREDNISONE | CHRONIC GVHD | WORKING GROUP-REPORT | CLINICAL-TRIALS | CELL TRANSPLANTATION | RANDOMIZED-TRIAL | MARROW-TRANSPLANTATION | HEMATOLOGY | CHILDRENS ONCOLOGY GROUP | CONSENSUS DEVELOPMENT PROJECT | Pyrazoles - therapeutic use | Demography | Protein-Tyrosine Kinases - metabolism | Humans | Middle Aged | Male | Adrenal Cortex Hormones - therapeutic use | Dose-Response Relationship, Drug | Young Adult | Treatment Failure | Adult | Female | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Biomarkers - metabolism | Severity of Illness Index | Graft vs Host Disease - blood | Pyrimidines - pharmacology | Protein-Tyrosine Kinases - blood | Graft vs Host Disease - drug therapy | Pyrimidines - therapeutic use | Pyrimidines - adverse effects | Aged | Chronic Disease | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus | Plenary Paper
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5. Full Text Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease
by Koreth, John and Kim, Haesook T and Jones, Kyle T and Lange, Paulina B and Reynolds, Carol G and Chammas, Marie J and Dusenbury, Katherine and Whangbo, Jennifer and Nikiforow, Sarah and Alyea, Edwin P and Armand, Philippe and Cutler, Corey S and Ho, Vincent T and Chen, Yi-Bin and Avigan, David and Blazar, Bruce R and Antin, Joseph H and Ritz, Jerome and Soiffer, Robert J
Blood, ISSN 0006-4971, 07/2016, Volume 128, Issue 1, pp. 130 - 137
Chronic graft-versus-host disease (cGVHD) is associated with inadequate reconstitution of tolerogenic CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs).... 
CRITERIA | CHRONIC GVHD | WORKING GROUP-REPORT | BONE-MARROW-TRANSPLANTATION | TOLERANCE | CLINICAL-TRIALS | REGULATORY T-CELLS | VALIDATION | IL-2 | HEMATOLOGY | CONSENSUS DEVELOPMENT PROJECT | Killer Cells, Natural | Follow-Up Studies | Humans | Middle Aged | Male | Graft vs Host Disease - blood | Graft vs Host Disease - drug therapy | Time Factors | Interleukin-2 - administration & dosage | Lymphocyte Count | T-Lymphocytes, Regulatory | Adult | Female | Aged | Chronic Disease | Index Medicus | Abridged Index Medicus | Transplantation
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6. Full Text Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: A study in children and young adults
by Jodele, Sonata and Davies, Stella M and Lane, Adam and Khoury, Jane and Dandoy, Christopher and Goebel, Jens and Myers, Kasiani and Grimley, Michael and Bleesing, Jack and El-Bietar, Javier and Wallace, Gregory and Chima, Ranjit S and Paff, Zachary and Laskin, Benjamin L
Blood, ISSN 0006-4971, 07/2014, Volume 124, Issue 4, pp. 645 - 653
Transplant-associated thrombotic microangiopathy (TMA) leads to generalized endothelial dysfunction that can progress to multiorgan injury, and severe cases... 
ECULIZUMAB | COMPLEMENT | HEMOLYTIC-UREMIC SYNDROME | RENAL PATHOLOGY | HAPTOGLOBIN | STEM-CELL TRANSPLANTATION | CHRONIC KIDNEY-DISEASE | HYPERTENSION | RECIPIENTS | HEMATOLOGY | VERSUS-HOST-DISEASE | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Immunosuppressive Agents - therapeutic use | Risk Factors | Child, Preschool | Thrombotic Microangiopathies - mortality | Male | Survival Rate | Transplantation, Homologous | Young Adult | Graft vs Host Disease - drug therapy | Graft vs Host Disease - mortality | Adolescent | Hematopoietic Stem Cell Transplantation - adverse effects | Adult | Female | Thrombotic Microangiopathies - diagnosis | Thrombotic Microangiopathies - etiology | Child | Graft vs Host Disease - diagnosis | Graft vs Host Disease - etiology | Thrombotic Microangiopathies - drug therapy | Index Medicus | Abridged Index Medicus | 100 | Transplantation
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7. Full Text Rituximab for steroid-refractory chronic graft-versus-host disease
by Cutler, Corey and Miklos, David and Kim, Haesook T and Treister, Nathaniel and Woo, Sook-Bin and Bienfang, Don and Klickstein, Lloyd B and Levin, Jesse and Miller, Katherine and Reynolds, Carol and Macdonell, Rebecca and Pasek, Mildred and Lee, Stephanie J and Ho, Vincent and Soiffer, Robert and Antin, Joseph H and Ritz, Jerome and Alyea, Edwin
Blood, ISSN 0006-4971, 07/2006, Volume 108, Issue 2, pp. 756 - 762
B cells may be implicated in the pathophysiology of chronic graft-versus-host disease (GVHD), as evidenced by antibody production against sex-mismatched, Y... 
B-CELLS | MONOCLONAL-ANTIBODY RITUXIMAB | BONE-MARROW-TRANSPLANTATION | LYMPHOPROLIFERATIVE DISEASE | RANDOMIZED CLINICAL-TRIAL | ANTI-CD20 | PREEMPTIVE THERAPY | LYMPHOMA | STEM-CELL TRANSPLANTATION | HEMATOLOGY | CYCLOSPORINE | Musculoskeletal Diseases - drug therapy | Musculoskeletal Diseases - etiology | Antibodies, Monoclonal, Murine-Derived | Humans | Middle Aged | Rituximab | Male | Skin Diseases - drug therapy | Graft vs Host Disease - pathology | Skin Diseases - etiology | B-Lymphocytes - drug effects | Graft vs Host Disease - drug therapy | Antibodies, Monoclonal - administration & dosage | Adult | Female | Prednisone - pharmacology | Steroids - pharmacology | B-Lymphocytes - pathology | Chronic Disease | Drug Resistance | Salvage Therapy - methods | Index Medicus | Abridged Index Medicus | Transplantation
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8. Full Text Consensus Conference on Clinical Practice in Chronic GVHD: Second-Line Treatment of Chronic Graft-versus-Host Disease
by Wolff, Daniel and Schleuning, Michael and von Harsdorf, Stephanie and Bacher, Ulrike and Gerbitz, Armin and Stadler, Michael and Ayuk, Francis and Kiani, Alexander and Schwerdtfeger, Rainer and Vogelsang, Georgia B and Kobbe, Guido and Gramatzki, Martin and Lawitschka, Anita and Mohty, Mohamad and Pavletic, Steven Z and Greinix, Hildegard and Holler, Ernst
Biology of Blood and Marrow Transplantation, ISSN 1083-8791, 2011, Volume 17, Issue 1, pp. 1 - 17
Steroid refractory chronic graft-versus-host disease (cGVHD) is associated with a significant morbidity and mortality. Although first-line treatment of cGVHD... 
Hematology, Oncology and Palliative Medicine | Bone marrow transplantation | Immunosuppressive therapy | Allogeneic hematopoietic stem cell transplantation | Chronic GVHD | MONOCLONAL-ANTIBODY TREATMENT | LOW-DOSE METHOTREXATE | BONE-MARROW-TRANSPLANTATION | RECEPTOR FUSION PROTEIN | RESISTANT CHRONIC GVHD | IMMUNOLOGY | STEROID-REFRACTORY ACUTE | TRANSPLANTATION | WORKING GROUP-REPORT | REGULATORY T-CELLS | STEM-CELL TRANSPLANTATION | HEMATOLOGY | MYCOPHENOLATE-MOFETIL | Fibrosis - drug therapy | Graft vs Host Disease - drug therapy | Drug Therapy - methods | Humans | Salvage Therapy | Chronic Disease | Precision Medicine - methods | Drug Therapy - trends | Graft vs Host Disease - pathology | Tyrosine | Medical colleges | Platelet-derived growth factor | Oncology, Experimental | Transplantation | Research | Vitamin A | Cyclophosphamide | Hydroxychloroquine | Conferences, meetings and seminars | Stem cells | Mycophenolate mofetil | Methotrexate | Cancer | Index Medicus
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9. Full Text PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy
by Asano, Takeru and Meguri, Yusuke and Yoshioka, Takanori and Kishi, Yuriko and Iwamoto, Miki and Nakamura, Makoto and Sando, Yasuhisa and Yagita, Hideo and Koreth, John and Kim, Haesook T and Alyea, Edwin P and Armand, Philippe and Cutler, Corey S and Ho, Vincent T and Antin, Joseph H and Soiffer, Robert J and Maeda, Yoshinobu and Tanimoto, Mitsune and Ritz, Jerome and Matsuoka, Ken-Ichi
Blood, ISSN 0006-4971, 04/2017, Volume 129, Issue 15, pp. 2186 - 2197
CD4(+) Foxp3(+) regulatory T cells (Tregs) play a central role in the maintenance of immune tolerance after hematopoietic stem cell transplantation. We... 
ALLOGRAFT-REJECTION | LUNG-CANCER | LIGANDS | CHRONIC GVHD | SAFETY | AUTOIMMUNE-DISEASES | TOLERANCE | BLOCKADE | HEMATOLOGY | VERSUS-HOST-DISEASE | TRANSPLANTATION | Antigens, CD - immunology | Proto-Oncogene Proteins c-bcl-2 - immunology | STAT5 Transcription Factor - immunology | Immunologic Memory - drug effects | Antigens, CD - genetics | Graft vs Host Disease - immunology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Graft vs Host Disease - genetics | STAT5 Transcription Factor - genetics | fas Receptor - immunology | Phosphorylation - genetics | fas Receptor - genetics | Phosphorylation - immunology | Phosphorylation - drug effects | Hepatitis A Virus Cellular Receptor 2 - immunology | Disease Models, Animal | CTLA-4 Antigen - genetics | CTLA-4 Antigen - immunology | Graft vs Host Disease - pathology | Mice, Knockout | Animals | Graft vs Host Disease - drug therapy | Interleukin-2 - pharmacology | Mice | Programmed Cell Death 1 Receptor - immunology | Hepatitis A Virus Cellular Receptor 2 - genetics | Chronic Disease | Programmed Cell Death 1 Receptor - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus | Abridged Index Medicus | Transplantation
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10. Full Text Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease
by Spoerl, Silvia and Mathew, Nimitha R and Bscheider, Michael and Schmitt-Graeff, Annette and Chen, Sophia and Mueller, Tony and Verbeek, Mareike and Fischer, Julius and Otten, Vera and Schmickl, Martina and Maas-Bauer, Kristina and Finke, Jürgen and Peschel, Christian and Duyster, Justus and Poeck, Hendrik and Zeiser, Robert and Von Bubnoff, Nikolas
Blood, ISSN 0006-4971, 06/2014, Volume 123, Issue 24, pp. 3832 - 3842
Graft-versus-host-disease (GVHD) is a severe complication of allogeneic hematopoietic cell transplantation (allo-HCT) characterized by the production of high... 
TARGET | INTERFERON-GAMMA | JANUS KINASE INHIBITOR | CD4(+) T-CELLS | TOFACITINIB | GVHD | GENERATION | MARROW-TRANSPLANTATION | HEMATOLOGY | PROMOTES | RUXOLITINIB | Severity of Illness Index | Pyrazoles - therapeutic use | Humans | Mice, Inbred C57BL | Cells, Cultured | Blood Group Incompatibility - complications | Male | Treatment Outcome | Molecular Targeted Therapy | Animals | Graft vs Host Disease - drug therapy | Protein Kinase Inhibitors - therapeutic use | Hematopoietic Stem Cell Transplantation - adverse effects | Female | Mice | Mice, Inbred BALB C | Drug Evaluation, Preclinical | Graft vs Host Disease - etiology | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Transplantation, Homologous - adverse effects | Index Medicus | Abridged Index Medicus
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11. Full Text Measuring Therapeutic Response in Chronic Graft-versus-Host Disease. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2014 Response Criteria Working Group Report
by Lee, Stephanie J and Wolff, Daniel and Kitko, Carrie and Koreth, John and Inamoto, Yoshihiro and Jagasia, Madan and Pidala, Joseph and Olivieri, Attilio and Martin, Paul J and Przepiorka, Donna and Pusic, Iskra and Dignan, Fiona and Mitchell, Sandra A and Lawitschka, Anita and Jacobsohn, David and Hall, Anne M and Flowers, Mary E.D and Schultz, Kirk R and Vogelsang, Georgia and Pavletic, Steven
Biology of Blood and Marrow Transplantation, ISSN 1083-8791, 2015, Volume 21, Issue 6, pp. 984 - 999
Abstract In 2005, the National Institutes of Health (NIH) Chronic Graft-versus-Host Disease (GVHD) Consensus Response Criteria Working Group recommended... 
Hematology, Oncology and Palliative Medicine | Chronic graft-versus-host disease | Allogeneic hematopoietic cell transplantation | Consensus | Response criteria | Guidelines | RHEUMATOID-ARTHRITIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | 6-MINUTE WALK TEST | BONE-MARROW-TRANSPLANTATION | FAILURE-FREE SURVIVAL | IMMUNOLOGY | HUMAN ACTIVITY PROFILE | TRANSPLANTATION | CHRONIC GVHD CONSORTIUM | OBLITERANS ORGANIZING PNEUMONIA | STEM-CELL TRANSPLANTATION | HEMATOLOGY | SLEEP QUALITY INDEX | United States | Hematologic Neoplasms - mortality | Humans | Immunosuppressive Agents - therapeutic use | Antineoplastic Agents - therapeutic use | Hematologic Neoplasms - pathology | Graft vs Host Disease - immunology | Transplantation, Homologous | National Institutes of Health (U.S.) | Graft vs Host Disease - mortality | Adult | Child | Biomarkers - analysis | Hematopoietic Stem Cell Transplantation | Terminology as Topic | Treatment Outcome | Clinical Trials as Topic | Remission Induction | Disease Progression | Graft vs Host Disease - pathology | Graft vs Host Disease - drug therapy | Survival Analysis | Hematologic Neoplasms - drug therapy | Hematologic Neoplasms - immunology | Chronic Disease | Measurement | Clinical trials | Political corruption | Health aspects | Index Medicus | consensus | guidelines | response criteria | allogeneic hematopoietic cell transplantation
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