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Nature, ISSN 0028-0836, 08/2010, Volume 466, Issue 7308, pp. 829 - 834
The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial... 
PROGENITOR CELLS | OSTEOBLAST | OSTEOPONTIN | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | RECEPTOR | DIFFERENTIATION | NEURAL CREST | COOPERATION | EXPRESSION | Chondrocytes - cytology | Nestin | Multipotent Stem Cells - metabolism | Parathyroid Hormone - pharmacology | Cell Lineage - drug effects | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Multipotent Stem Cells - drug effects | Sympathetic Nervous System - physiology | Cell Division | Stromal Cells - drug effects | Osteoblasts - cytology | Hematopoietic Stem Cells - drug effects | Mesenchymal Stromal Cells - drug effects | Gene Expression Regulation - genetics | Osteoblasts - drug effects | Stromal Cells - metabolism | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Mice, Transgenic | Hematopoietic Stem Cells - metabolism | Stem Cell Niche - cytology | Nerve Tissue Proteins - metabolism | Granulocyte Colony-Stimulating Factor - pharmacology | Animals | Chemokine CXCL12 - metabolism | Cell Differentiation - drug effects | Multipotent Stem Cells - cytology | Hematopoietic Stem Cells - cytology | Stem Cell Niche - metabolism | Mice | Stem Cell Niche - drug effects | Osteoblasts - metabolism | Intermediate Filament Proteins - metabolism | Mesenchymal Stem Cell Transplantation | Stromal Cells - cytology | Cell Movement | Physiological aspects | Genetic aspects | Research | Bone marrow cells | Gene expression | Osteoblasts | Hematopoietic stem cells | Studies | Proteins | Bone marrow | Rodents | Stem cells
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2013, Volume 210, Issue 9, pp. 1695 - 1710
Treatment with monoclonal antibody specific for cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), an inhibitory receptor expressed by T lymphocytes, has... 
EFFECTOR | MEDICINE, RESEARCH & EXPERIMENTAL | CTLA-4 BLOCKADE | LYMPHOCYTE-ASSOCIATED ANTIGEN-4 | CANCER-PATIENTS | IN-VIVO | COMBINATION IMMUNOTHERAPY | MONOCLONAL-ANTIBODY | IMMUNOLOGY | LARGE ESTABLISHED MELANOMA | GAMMA-RIV | ANTITUMOR-ACTIVITY | Fas Ligand Protein - metabolism | Lymph Nodes - pathology | Antibodies, Blocking - pharmacology | Lymphocyte Depletion | Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use | Receptors, IgG - metabolism | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Melanoma - prevention & control | Lymph Nodes - drug effects | Cell Membrane - metabolism | Clone Cells | Cell Membrane - drug effects | Tumor Microenvironment - drug effects | Phagocytes - drug effects | Mice, Inbred C57BL | Treatment Outcome | Lymph Nodes - immunology | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | Phagocytes - immunology | TNF-Related Apoptosis-Inducing Ligand - metabolism | Tumor Microenvironment - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Lymphocytes, Tumor-Infiltrating - pathology | Signal Transduction - drug effects | Melanoma - immunology | CD8-Positive T-Lymphocytes - drug effects | Antibodies, Blocking - therapeutic use | Lymphocyte Count | Mice | CD11b Antigen - metabolism | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Melanoma - therapy | CD4 Antigens - metabolism | Lymphocytes, Tumor-Infiltrating - immunology
Journal Article
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7578, pp. 323 - 328
Journal Article
Blood, ISSN 0006-4971, 02/2017, Volume 129, Issue 6, pp. 729 - 739
Bone marrow suppression is an adverse effect associated with many antibiotics, especially when administered for prolonged treatment courses. Recent advances in... 
GRANULOPOIESIS | STEM-CELLS | HEMATOLOGY | NEUTROPENIA | T-CELLS | DISEASE | CD8-Positive T-Lymphocytes - pathology | STAT1 Transcription Factor - deficiency | Hematopoietic Stem Cells - pathology | Anemia - pathology | Gastrointestinal Microbiome - physiology | Leukopenia - therapy | Hematopoiesis - drug effects | Granulocytes - drug effects | Leukopenia - chemically induced | CD8-Positive T-Lymphocytes - metabolism | Thrombocytosis - microbiology | Bone Marrow Cells - drug effects | Granulocytes - pathology | Anti-Bacterial Agents - adverse effects | B-Lymphocytes - pathology | Granulocytes - metabolism | Thrombocytosis - pathology | B-Lymphocytes - metabolism | Hematopoietic Stem Cells - drug effects | Gene Expression | Leukopenia - microbiology | Macrophages - pathology | Signal Transduction | Germ-Free Life - genetics | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Anemia - chemically induced | Anemia - therapy | Hematopoiesis - genetics | Hematopoietic Stem Cells - metabolism | Germ-Free Life - drug effects | STAT1 Transcription Factor - genetics | Leukopenia - pathology | Fecal Microbiota Transplantation | Thrombocytosis - chemically induced | Mice, Knockout | B-Lymphocytes - drug effects | Macrophages - metabolism | Animals | Gastrointestinal Microbiome - drug effects | CD8-Positive T-Lymphocytes - drug effects | Macrophages - drug effects | Mice | Anemia - microbiology | Thrombocytosis - therapy | Bone Marrow Cells - metabolism | Hematopoiesis and Stem Cells
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0170814
Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a debilitating adverse effect of cancer treatment. Current understanding... 
MACROPHAGE INFILTRATION | PAIN | INDUCED MECHANICAL ALLODYNIA | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | DORSAL-ROOT GANGLIA | SPINAL-CORD | NERVE INJURY | SENSORY NEURONS | SATELLITE GLIAL-CELLS | PACLITAXEL | Hyperalgesia - chemically induced | Neuralgia - genetics | Spleen - immunology | Chemokine CCL2 - immunology | Male | Spleen - drug effects | Activating Transcription Factor 3 - immunology | T-Lymphocytes, Regulatory - pathology | Hyperalgesia - pathology | T-Lymphocytes, Regulatory - immunology | Neurofilament Proteins - genetics | Neuralgia - immunology | Chemokine CCL3 - genetics | Microglia - pathology | Lymph Nodes - drug effects | Activating Transcription Factor 3 - genetics | Receptors, Purinergic P2Y12 - genetics | Gene Expression | Receptors, Purinergic P2Y12 - immunology | Mice, Transgenic | Lymph Nodes - immunology | Spinal Cord - immunology | Hyperalgesia - immunology | T-Lymphocytes, Regulatory - drug effects | Hyperalgesia - genetics | Ganglia, Spinal - pathology | Mice | CD8-Positive T-Lymphocytes - immunology | Ganglia, Spinal - drug effects | CD8-Positive T-Lymphocytes - pathology | Lymph Nodes - pathology | Spinal Cord - drug effects | Chemokine CCL3 - immunology | Sensory Receptor Cells - immunology | Neuralgia - pathology | Microglia - immunology | Antineoplastic Agents - adverse effects | Spinal Cord - pathology | Neuralgia - chemically induced | Neurofilament Proteins - immunology | Spleen - pathology | Ganglia, Spinal - immunology | Sensory Receptor Cells - pathology | Microglia - drug effects | Mice, Inbred C57BL | Paclitaxel - adverse effects | Chemokine CCL2 - genetics | Animals | Sensory Receptor Cells - drug effects | CD8-Positive T-Lymphocytes - drug effects | Organoplatinum Compounds - adverse effects | Usage | Chemotherapy | Care and treatment | Oxalic acid | Polyneuropathies | Research | Diagnosis | T cells | Cancer | Spinal cord | Neurosciences | CD8 antigen | Carbon tetrachloride | Interleukin | Central nervous system | Transgenic | Nervous system | Diabetic neuropathy | Lymphocytes T | Cerebrospinal fluid | Peripheral neuropathy | Macrophages | Lymph nodes | Proteins | Neurotoxicity | Interleukin 4 | Pain | Dorsal root ganglia | Lymphocytes | Rodents | Sensory neurons | Tumor necrosis factor-TNF | Horns | Dorsal horn | Peripheral nervous system | Pain sensitivity | Spleen | Pain perception | Immune response | Cytokines | Granulocyte-macrophage colony-stimulating factor | Hypersensitivity | CCL3 protein | Interleukin 12 | Inflammation | CCL4 protein | Microglia | CD4 antigen | Studies | White blood cells | TNF inhibitors | Infiltration | Chemokines | Monocyte chemoattractant protein 1
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2013, Volume 368, Issue 15, pp. 1408 - 1416
A dose-intense infusional chemotherapy program plus rituximab had a high degree of efficacy in patients with primary mediastinal B-cell lymphoma, which is... 
MEDICINE, GENERAL & INTERNAL | AMPLIFICATION | MANAGEMENT | EFFICACY | DOXORUBICIN | SCLEROSIS | CLASSICAL HODGKIN LYMPHOMA | RADIOTHERAPY | EXPRESSION | GERMINAL-CENTER | CHEMOTHERAPY | Cyclophosphamide - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Follow-Up Studies | Humans | Middle Aged | Antibodies, Monoclonal, Murine-Derived - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Cyclophosphamide - adverse effects | Filgrastim | Dose-Response Relationship, Drug | Young Adult | Vincristine - administration & dosage | Adult | Female | Retrospective Studies | Doxorubicin - administration & dosage | Prednisone - administration & dosage | Etoposide - adverse effects | Lymphoma, Large B-Cell, Diffuse - drug therapy | Prednisone - adverse effects | Kaplan-Meier Estimate | Rituximab | Stroke Volume - drug effects | Etoposide - administration & dosage | Recombinant Proteins - administration & dosage | Disease-Free Survival | Vincristine - adverse effects | Aged | Antibodies, Monoclonal, Murine-Derived - adverse effects | Doxorubicin - adverse effects | Granulocyte Colony-Stimulating Factor - administration & dosage | Drugs | Dose-response relationship (Biochemistry) | Usage | Cyclophosphamide | Patient outcomes | Dosage and administration | Lymphomas | Product/Service Evaluations | Drug therapy, Combination | Drug therapy | Doxorubicin | Medical research | Nuclear magnetic resonance--NMR | Disease | Review boards | Genes | Etoposide | Prednisone | Radiation therapy | Kinases | Vincristine | Patients | Morbidity | Chemotherapy | Lymphocytes B | Remission | Mutation | Hodgkin's disease | B-cell lymphoma
Journal Article
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 502 - 514
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine produced by auto-reactive T helper (Th) cells that initiate tissue... 
EFFECTOR PHASE | COLONY-STIMULATING FACTOR | DENDRITIC CELLS | MULTIPLE-SCLEROSIS | MACROPHAGES | IN-VIVO | LYMPH-NODES | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | T-CELLS | ENCEPHALOMYELITIS EAE | Receptors, CCR2 - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Receptors, CCR2 - immunology | Dendritic Cells - immunology | Humans | Antigens, Ly - genetics | STAT5 Transcription Factor - immunology | Autoimmunity - genetics | Monocytes - metabolism | Monocytes - immunology | Transcriptome - immunology | Interleukin-1beta - genetics | STAT5 Transcription Factor - metabolism | Signal Transduction - immunology | Inflammation - metabolism | Flow Cytometry | Autoimmunity - immunology | Interleukin-1beta - metabolism | Myeloid Cells - immunology | Antigens, Ly - metabolism | Dendritic Cells - drug effects | Myeloid Cells - drug effects | Cytokine Receptor Common beta Subunit - metabolism | Phosphorylation - immunology | Phosphorylation - drug effects | Dendritic Cells - metabolism | Cytokine Receptor Common beta Subunit - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Interleukin-1beta - immunology | Mice, Transgenic | Inflammation - immunology | Signal Transduction - genetics | Transcriptome - drug effects | Transcriptome - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Monocytes - drug effects | Encephalomyelitis, Autoimmune, Experimental | Receptors, CCR2 - metabolism | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Antigens, Ly - immunology | Signal Transduction - drug effects | Inflammation - genetics | Myeloid Cells - metabolism | Cytokine Receptor Common beta Subunit - genetics | Flow cytometry | Phosphorylation | Disease | Cytokines | Bone marrow | Software | Inflammation | Autoimmune diseases
Journal Article