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Arthritis & rheumatology (Hoboken, N.J.), ISSN 2326-5191, 2016, Volume 68, Issue 10, pp. 2492 - 2502
Objective Antinuclear antibodies (ANAs) are detected in ∼18% of females, yet autoimmune disease develops in only 5–8%. Immunologic differences between... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON | CYTOKINE PRODUCTION | RISK-FACTORS | DENDRITIC CELLS | ANTINUCLEAR ANTIBODIES | RHEUMATOLOGY | EXPRESSION | SLE | IG-LIKE RECEPTOR-1 | T-CELLS | Interferon-alpha - pharmacology | Multivariate Analysis | Phosphoproteins - drug effects | Interferon-beta - immunology | Antibodies, Antinuclear - immunology | Humans | Middle Aged | Interleukin-17 - immunology | STAT1 Transcription Factor - drug effects | Centromere Protein B - immunology | Male | Monocytes - immunology | Ribosomal Proteins - immunology | Healthy Volunteers | Case-Control Studies | Leukocytes - immunology | Young Adult | Flow Cytometry | Autoimmunity - immunology | Lupus Erythematosus, Systemic - immunology | Ribonucleoproteins - immunology | Tumor Necrosis Factor-alpha - immunology | Aged, 80 and over | Adult | B-Lymphocyte Subsets - immunology | Female | Interleukin-12 Subunit p40 - immunology | Cytokines - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Immunophenotyping | Logistic Models | Nuclear Proteins - immunology | STAT1 Transcription Factor - immunology | Stem Cell Factor - immunology | Interferon-alpha - immunology | Autoantibodies - immunology | Interferon-gamma - immunology | STAT3 Transcription Factor - drug effects | Sex Factors | Aged | Granulocyte Colony-Stimulating Factor - immunology | STAT3 Transcription Factor - immunology | Plasma Cells - immunology | Systemic Lupus Erythematosus
Journal Article
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2015, Volume 43, Issue 3, pp. 502 - 514
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine produced by auto-reactive T helper (Th) cells that initiate tissue... 
EFFECTOR PHASE | COLONY-STIMULATING FACTOR | DENDRITIC CELLS | MULTIPLE-SCLEROSIS | MACROPHAGES | IN-VIVO | LYMPH-NODES | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | T-CELLS | ENCEPHALOMYELITIS EAE | Receptors, CCR2 - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Receptors, CCR2 - immunology | Dendritic Cells - immunology | Humans | Antigens, Ly - genetics | STAT5 Transcription Factor - immunology | Autoimmunity - genetics | Monocytes - metabolism | Monocytes - immunology | Transcriptome - immunology | Interleukin-1beta - genetics | STAT5 Transcription Factor - metabolism | Signal Transduction - immunology | Inflammation - metabolism | Flow Cytometry | Autoimmunity - immunology | Interleukin-1beta - metabolism | Myeloid Cells - immunology | Antigens, Ly - metabolism | Dendritic Cells - drug effects | Myeloid Cells - drug effects | Cytokine Receptor Common beta Subunit - metabolism | Phosphorylation - immunology | Phosphorylation - drug effects | Dendritic Cells - metabolism | Cytokine Receptor Common beta Subunit - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Interleukin-1beta - immunology | Mice, Transgenic | Inflammation - immunology | Signal Transduction - genetics | Transcriptome - drug effects | Transcriptome - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Monocytes - drug effects | Encephalomyelitis, Autoimmune, Experimental | Receptors, CCR2 - metabolism | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Antigens, Ly - immunology | Signal Transduction - drug effects | Inflammation - genetics | Myeloid Cells - metabolism | Cytokine Receptor Common beta Subunit - genetics | Flow cytometry | Phosphorylation | Disease | Cytokines | Bone marrow | Software | Inflammation | Autoimmune diseases
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2013, Volume 38, Issue 3, pp. 514 - 527
Interleukin-21 (IL-21) has broad actions on T and B cells, but its actions in innate immunity are poorly understood. Here we show that IL-21 induced apoptosis... 
NKT CELLS | HOMEOSTASIS | FOLLICULAR-HELPER-CELLS | HUMAN B-CELLS | STEADY-STATE | INTERLEUKIN-21 | DIFFERENTIATION | IMMUNOLOGY | IMMUNE TOLERANCE | T-CELLS | NEGATIVE REGULATOR | Natural Killer T-Cells - drug effects | Oligonucleotide Array Sequence Analysis | Apoptosis - drug effects | Dendritic Cells - immunology | STAT5 Transcription Factor - immunology | Receptors, Interleukin-21 - genetics | Interferon-gamma - metabolism | CD4-Positive T-Lymphocytes - immunology | Interleukins - genetics | Gene Expression - immunology | STAT3 Transcription Factor - genetics | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | DNA, Intergenic - genetics | Protein Binding - immunology | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Galactosylceramides - immunology | Mice | STAT3 Transcription Factor - immunology | Gene Expression - drug effects | Galactosylceramides - pharmacology | DNA-Binding Proteins - deficiency | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Receptors, Interleukin-21 - deficiency | Flow Cytometry | Bcl-2-Like Protein 11 | Natural Killer T-Cells - metabolism | DNA, Intergenic - metabolism | Interleukins - immunology | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Dendritic Cells - drug effects | Membrane Proteins - metabolism | Interleukins - pharmacology | Dendritic Cells - metabolism | STAT3 Transcription Factor - metabolism | Proto-Oncogene Proteins - metabolism | Receptors, Interleukin-21 - immunology | Mice, Inbred C57BL | Cells, Cultured | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Membrane Proteins - immunology | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Animals | Apoptosis - immunology | Interferon-gamma - immunology | CD4-Positive T-Lymphocytes - drug effects | DNA, Intergenic - immunology | Natural Killer T-Cells - immunology | Interleukins | Dendritic cells | Analysis | Genomics | Macrophage colony stimulating factor | Biological response modifiers | T cells | Apoptosis | Cytokines | Genes | Genomes | Kinases | Binding sites | Deoxyribonucleic acid--DNA | apoptosis | dendritic cells | GM-CSF | IL-21
Journal Article
Journal Article
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2002, Volume 169, Issue 1, pp. 443 - 453
We have biologically characterized two new members of the IL-17 cytokine family: IL-17F and IL-25. In contrast to conventional in vitro screening approaches,... 
RECEPTOR-GAMMA CHAIN | LYMPHOID DEVELOPMENT | ANTIBODY | ASTHMA | GENE-THERAPY | AIRWAY HYPERRESPONSIVENESS | DEFICIENT MICE | IMMUNOLOGY | IDENTIFICATION | CELL | EXPRESSION | Interleukin-13 - physiology | Bronchial Hyperreactivity - immunology | Humans | Pulmonary Eosinophilia - genetics | Pulmonary Eosinophilia - virology | Interleukin-17 - physiology | Male | Th2 Cells - immunology | Lymphocyte Subsets - immunology | Leukocytosis - virology | Cell Movement - immunology | Th1 Cells - metabolism | RNA, Messenger - biosynthesis | Growth Substances - genetics | Interleukins | Adenoviridae - immunology | Growth Substances - administration & dosage | Amino Acid Sequence | Leukocytosis - immunology | Interleukin-17 - genetics | Neutrophils - virology | Intestinal Diseases, Parasitic - immunology | Mice, Knockout | Mice | Mice, Inbred BALB C | Amino Acid Motifs - genetics | Strongylida Infections - genetics | Molecular Sequence Data | Interleukin-5 - biosynthesis | Th1 Cells - immunology | Hematopoietic Stem Cells - immunology | Interleukin-17 - chemistry | Intestinal Diseases, Parasitic - genetics | Growth Substances - chemistry | Strongylida Infections - immunology | Basophils - immunology | Adenoviridae - genetics | Killer Cells, Natural - immunology | Female | Mucus - metabolism | Interleukin-5 - physiology | Lung - metabolism | Pulmonary Eosinophilia - immunology | Mast Cells - immunology | Lung - pathology | Mice, Inbred C57BL | Aspergillosis - genetics | Neutrophils - immunology | Hematopoietic Stem Cells - metabolism | Inflammation - immunology | Interleukin-17 - biosynthesis | Administration, Intranasal | Th2 Cells - metabolism | Sequence Homology, Amino Acid | Animals | Amino Acid Motifs - immunology | Growth Substances - physiology | Inflammation - genetics | Genetic Vectors | Leukocytosis - genetics | Granulocytes - immunology | Lung - immunology | Aspergillosis - immunology
Journal Article