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Nature Medicine, ISSN 1078-8956, 12/2014, Volume 20, Issue 12, pp. 1410 - 1416
The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice.... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | CLINICAL-PICTURE | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | AUTOIMMUNITY | REGULATORY T-CELLS | GERMLINE MUTATIONS | MICE | BLOCKADE | IMMUNODEFICIENCY | ABATACEPT | Recurrence | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | Purpura, Thrombocytopenic, Idiopathic - genetics | Exons | Immune System Diseases - genetics | Humans | Middle Aged | Male | Anemia, Hemolytic, Autoimmune - genetics | Mutation, Missense | Respiratory Tract Infections - genetics | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | Young Adult | Purpura, Thrombocytopenic, Idiopathic - immunology | Adult | Female | Endocytosis - genetics | Polyendocrinopathies, Autoimmune - genetics | Child | Endocytosis - immunology | Granuloma - genetics | Autoimmune Diseases - immunology | CTLA-4 Antigen - genetics | B7-1 Antigen - metabolism | Codon, Nonsense | CTLA-4 Antigen - immunology | Syndrome | Polyendocrinopathies, Autoimmune - immunology | Lung Diseases, Interstitial - immunology | Animals | B-Lymphocytes - immunology | Lung Diseases, Interstitial - genetics | Pedigree | Anemia, Hemolytic, Autoimmune - immunology | Adolescent | Respiratory Tract Infections - immunology | Granuloma - immunology | Heterozygote | Mice | Antigens | Gene mutations | Physiological aspects | Genetic aspects | Immunologic diseases | Research | Risk factors | Proteins | Homeostasis | Cytotoxicity | Ligands | T cell receptors | Mutation | Immune system | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e33891 - e33891
Background: Langerhans cell histiocytosis (LCH) features inflammatory granuloma characterised by the presence of CD1a+ dendritic cells or 'LCH cells'.... 
ACTIVATION | MELANOMA | MULTIDISCIPLINARY SCIENCES | DYNAMICS | BRAF | PROLIFERATION | MUTATIONS | MULTIPLE SEQUENCE ALIGNMENT | EXPRESSION | CHILDHOOD | LESIONS | Granuloma - metabolism | Histiocytosis, Langerhans-Cell - genetics | Humans | Transcriptional Activation | Child, Preschool | Molecular Sequence Data | Infant | Male | Monocytes - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Histiocytosis, Langerhans-Cell - metabolism | Young Adult | Phosphorylation - genetics | HEK293 Cells | Female | Child | Proto-Oncogene Proteins B-raf - metabolism | Lymphocytes - metabolism | Amino Acid Sequence | Genetic Predisposition to Disease | Granuloma - genetics | Proto-Oncogene Proteins c-raf - genetics | Proto-Oncogene Proteins c-raf - metabolism | Polymorphism, Genetic | Sequence Homology, Amino Acid | Proto-Oncogene Proteins B-raf - genetics | Alleles | Histiocytosis, Langerhans-Cell - enzymology | Mutation | Pediatrics | RNA | Gene mutations | Dendritic cells | Genetic aspects | Children | Histiocytosis | T cells | Diseases | Granuloma | Phosphorylation | Senescence | Identification methods | Lymphocytes T | mRNA | Metastasis | Kinases | Paraffin | Blood | Cell activation | Cell growth | Lymphocytes | Cell cycle | Deoxyribonucleic acid--DNA | Hematology | Melanoma | Extracellular signal-regulated kinase | Abundance | Inflammation | Biophysics | Patients | Mutants | Medicine | Monocytes | Cellular biology | Diabetes | Conformation | Tumors | Cancer | Structure-function relationships | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 10/2014, Volume 34, Issue 7, pp. 871 - 890
Coronin-1A deficiency is a recently recognized autosomal recessive primary immunodeficiency caused by mutations in CORO1A (OMIM 605000) that results in T-cell... 
leprosy | Medical Microbiology | molluscum | CORO1A (Coronin-1A deficiency) | telomere | Internal Medicine | Biomedicine | Immunology | SCID-CID | Infectious Diseases | mucocutaneous | WES (whole exome sequencing) | HPV-epidermodysplasia verruciformis | CORONIN 1A | JAK-STAT | IMMUNOLOGY | DEFICIENCY | HYPOMORPHIC RAG1 MUTATIONS | DYSKERATOSIS-CONGENITA | WHIM SYNDROME | HUMAN PAPILLOMAVIRUSES | STEM-CELL TRANSPLANTATION | DNA-SEQUENCING DATA | T-CELLS | Humans | Male | CD4-Positive T-Lymphocytes - physiology | Telomere Shortening - genetics | Granuloma - complications | Leprosy, Tuberculoid - complications | DNA Mutational Analysis | Female | Papillomavirus Infections - etiology | Child | Microfilament Proteins - genetics | Skin - virology | Immunologic Memory - genetics | Skin - pathology | Siblings | Genetic Predisposition to Disease | Granuloma - genetics | Mucous Membrane - virology | B-Lymphocytes - physiology | Epidermodysplasia Verruciformis - genetics | Mutation - genetics | Killer Cells, Natural - physiology | Leprosy, Tuberculoid - genetics | Papillomavirus Infections - genetics | Polymorphism, Genetic | Severe Combined Immunodeficiency - complications | Severe Combined Immunodeficiency - genetics | Mucous Membrane - pathology | Molluscum Contagiosum - genetics | Adolescent | Heterozygote | Epidermodysplasia Verruciformis - etiology | Molluscum contagiosum | Analysis | Genomics | Immunodeficiency | Genetic research | Leprosy | Genetic aspects | B cells | T cells | Papillomavirus infections | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 04/2012, Volume 8, Issue 4, pp. e1002614 - e1002614
Trehalose 6,6'-dimycolate (TDM), a cord factor of Mycobacterium tuberculosis (Mtb), is an important regulator of immune responses during Mtb infections.... 
BACILLUS-CALMETTE-GUERIN | C-TYPE LECTIN | PERIPHERAL-BLOOD NEUTROPHILS | TUBERCULOSIS INFECTION | MICROBIOLOGY | CORD FACTOR TREHALOSE-6,6'-DIMYCOLATE | NECROSIS-FACTOR-ALPHA | ACTIVATING RECEPTOR | P38 MAP KINASE | TOLL-LIKE RECEPTOR-2 | GRANULOMA-FORMATION | VIROLOGY | PARASITOLOGY | Granuloma, Respiratory Tract - pathology | Protein Kinases - genetics | Toll-Like Receptor 2 - genetics | CD18 Antigens - immunology | Granuloma, Respiratory Tract - chemically induced | Lectins, C-Type - metabolism | Pneumonia - immunology | Neutrophils - metabolism | Neutrophil Infiltration - drug effects | Neutrophil Infiltration - immunology | Pneumonia - genetics | Granuloma, Respiratory Tract - immunology | CD18 Antigens - genetics | Membrane Proteins - genetics | Signal Transduction - genetics | Toll-Like Receptor 2 - metabolism | Tuberculosis, Pulmonary - pathology | Neutrophil Infiltration - genetics | Mice, Knockout | CD18 Antigens - metabolism | Signal Transduction - drug effects | Toll-Like Receptor 2 - immunology | Mice | Pneumonia - metabolism | Protein Kinases - metabolism | Tuberculosis, Pulmonary - metabolism | Adjuvants, Immunologic - pharmacology | Cord Factors - adverse effects | Lectins, C-Type - immunology | Pneumonia - pathology | Lectins, C-Type - genetics | Tuberculosis, Pulmonary - genetics | Adjuvants, Immunologic - adverse effects | Signal Transduction - immunology | CD11b Antigen - genetics | Adjuvants, Immunologic - chemistry | Pneumonia - chemically induced | Mycobacterium tuberculosis - chemistry | Lung - metabolism | Membrane Proteins - metabolism | Cord Factors - pharmacology | Mycobacterium tuberculosis - metabolism | Neutrophils - pathology | Granuloma, Respiratory Tract - genetics | Lung - pathology | CD11b Antigen - immunology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Cord Factors - chemistry | Neutrophils - immunology | Membrane Proteins - immunology | Gene Expression Regulation - drug effects | Tuberculosis, Pulmonary - immunology | Animals | Protein Kinases - immunology | Granuloma, Respiratory Tract - metabolism | CD11b Antigen - metabolism | Lung - immunology | Proteins | Flow cytometry | Tuberculosis | Microscopy | Rodents | Lipids | Ligands | Experiments | Immune system | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 2, pp. e14652 - e14652
Background: Chemokine (C-C motif) ligand 2 CCL2/MCP-1 is among the key signaling molecules of innate immunity; in particular, it is involved in recruitment of... 
NERVOUS-SYSTEM | MENINGITIS | CONFERS PROTECTION | PROTEIN | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | PULMONARY TUBERCULOSIS | CHEMOKINE RECEPTORS | GENE POLYMORPHISMS | EXPRESSION | CHILDREN | China - ethnology | Tuberculosis, Meningeal - genetics | Humans | Asian Continental Ancestry Group - genetics | Child, Preschool | Linkage Disequilibrium - genetics | Chemokine CCL2 - genetics | Male | Sex Characteristics | Tuberculosis, Pulmonary - genetics | Case-Control Studies | Tuberculosis, Pulmonary - cerebrospinal fluid | Tuberculosis, Pulmonary - complications | Asian Continental Ancestry Group - ethnology | Haplotypes - genetics | Phenotype | Ethnic Groups - genetics | Adolescent | Polymorphism, Single Nucleotide - genetics | Female | Child | Pediatrics | Tuberculosis | Antitubercular agents | Genetic aspects | Single nucleotide polymorphisms | Children | Health aspects | Risk factors | Diseases | Haplotypes | Granuloma | Vaccination | Genes | Amino acids | Nervous system | Innate immunity | Infections | Single-nucleotide polymorphism | Cerebrospinal fluid | Males | Immunity | Population genetics | Gene polymorphism | Recruitment | Proteins | Meningitis | Genotypes | Carbon-carbon composites | Family planning | Cytokines | Risk groups | BCG | Health risks | Gene expression | Children & youth | White blood cells | Signaling | Hospitals | Insects | Alleles | Adults | Mutation | Chemokines | Monocyte chemoattractant protein 1 | Polymorphism | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2014, Volume 192, Issue 10, pp. 4655 - 4665
In murine schistosomiasis, immunopathology and cytokine production in response to parasite eggs are uneven and strain dependent. CBA/J (CBA) mice develop... 
MANSONI EGG ANTIGENS | TH2 RESPONSES | CYTOKINE PRODUCTION | C-TYPE LECTIN | DC-SIGN | HOST-DEFENSE | IMMUNOLOGY | ADAPTIVE IMMUNE-RESPONSES | NF-KAPPA-B | T-CELLS | INNATE IMMUNITY | Proto-Oncogene Proteins pp60(c-src) - immunology | Spleen - immunology | Dendritic Cells - immunology | Humans | Lectins, C-Type - biosynthesis | Interleukin-1beta - genetics | Interleukin-23 - genetics | Th17 Cells - metabolism | Interleukin-1beta - metabolism | Mice, Inbred CBA | Schistosoma - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Schistosomiasis - metabolism | Proto-Oncogene Proteins c-raf - immunology | Receptors, Cell Surface - immunology | Interleukin-23 - immunology | Granuloma - pathology | Mitogen-Activated Protein Kinase 3 - metabolism | Schistosoma - immunology | Schistosomiasis - genetics | Th17 Cells - immunology | Granuloma - immunology | Mice | Enzyme Activation - genetics | Receptors, Cell Surface - genetics | Cell Adhesion Molecules - genetics | Lectins, C-Type - immunology | Dendritic Cells - pathology | Cell Adhesion Molecules - immunology | Lectins, C-Type - genetics | MAP Kinase Signaling System - immunology | Enzyme Activation - immunology | Interleukin-23 - metabolism | MAP Kinase Signaling System - genetics | Female | Receptors, Cell Surface - biosynthesis | Spleen - pathology | Schistosomiasis - immunology | Dendritic Cells - metabolism | Th17 Cells - pathology | Cell Line | Mitogen-Activated Protein Kinase 3 - immunology | Granuloma - genetics | Proto-Oncogene Proteins c-raf - genetics | Cell Adhesion Molecules - biosynthesis | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Interleukin-1beta - immunology | Gene Silencing - immunology | Proto-Oncogene Proteins c-raf - metabolism | Schistosoma - genetics | Animals | Spleen - metabolism | Proto-Oncogene Proteins pp60(c-src) - genetics | Proto-Oncogene Proteins pp60(c-src) - metabolism | Schistosomiasis - pathology | Index Medicus | Abridged Index Medicus
Journal Article
Experimental and Molecular Pathology, ISSN 0014-4800, 06/2014, Volume 96, Issue 3, pp. 393 - 399
Sarcoidosis is an immune-mediated multisystem disease characterized by the formation of non-caseating granulomas. The pathogenesis of sarcoidosis is unclear,... 
Granuloma | Reactive oxygen species | Formalin-fixed paraffin embedded tissue | Sarcoidosis | Cytokines | RT-PCR | Gene expression | Transcription factor | Pathology autoimmunity | INTERLEUKIN-2 | ACTIVATION | ACTIVE PULMONARY SARCOIDOSIS | MULTIPLE-SCLEROSIS PATIENTS | LYMPH-NODES | QUANTITATIVE PCR | PATHOLOGY | DISEASE-ACTIVITY | SPONTANEOUS RELEASE | MYCOBACTERIAL | LYMPHOCYTES | Up-Regulation | Membrane Glycoproteins - metabolism | Humans | Middle Aged | NADPH Oxidases - metabolism | Sarcoidosis - genetics | Transcriptome | Male | NF-kappa B - metabolism | Interferon-gamma - metabolism | Interleukins - metabolism | Young Adult | Interleukins - genetics | Specimen Handling | STAT1 Transcription Factor - metabolism | Cyclooxygenase 2 - genetics | Sarcoidosis - immunology | Aged, 80 and over | NADPH Oxidases - genetics | Adult | Female | Chemokine CCL2 - metabolism | Interferon-gamma - genetics | Child | Interleukin-6 - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Sarcoidosis - diagnosis | Gene Expression | Granuloma - genetics | Interleukin-6 - genetics | Chemokine CCL11 - metabolism | Interleukin-33 | Chemokine CCL11 - genetics | Chemokine CCL2 - genetics | Genetic Markers | STAT1 Transcription Factor - genetics | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Granuloma - pathology | NF-kappa B - genetics | Adolescent | Cyclooxygenase 2 - metabolism | Granuloma - immunology | Aged | Sarcoidosis - pathology | Genetic research | Diagnosis | Analysis | Genes | Index Medicus | transcription factor | formalin-fixed paraffin embedded tissue | pathology autoimmunity | reactive oxygen species | granuloma | sarcoidosis | cytokines | gene expression
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 09/2017, Volume 16, Issue 9, pp. 3266 - 3276
We hypothesized that distinct protein expression features of benign and malignant pulmonary nodules may reveal novel candidate biomarkers for the early... 
lung cancer | adenocarcinoma | indeterminate pulmonary nodule | parallel reaction monitoring | granuloma | CLASSIFIER | MANAGEMENT | PEPTIDE IDENTIFICATION | SEARCH | BIOCHEMICAL RESEARCH METHODS | RISK | CANCER | PRETEST PROBABILITY | ACCURACY | Solitary Pulmonary Nodule - genetics | Cell Adhesion Molecules - genetics | Adenocarcinoma - pathology | Adenocarcinoma of Lung | 5-Lipoxygenase-Activating Proteins - metabolism | Arachidonate 5-Lipoxygenase - genetics | Tissue Array Analysis | Humans | Lung Neoplasms - metabolism | Middle Aged | Gene Expression Regulation, Neoplastic | Transcriptome | Lung Neoplasms - pathology | Male | Glucose Transporter Type 3 - metabolism | CD11 Antigens - metabolism | Neoplasm Proteins - metabolism | Antigens, CD - genetics | Solitary Pulmonary Nodule - diagnosis | Antigens, CD - metabolism | CD11 Antigens - genetics | Respiratory Mucosa - pathology | Glucose Transporter Type 3 - genetics | Tandem Mass Spectrometry | Adenocarcinoma - metabolism | Biomarkers, Tumor - metabolism | Adult | Female | Solitary Pulmonary Nodule - metabolism | Adenocarcinoma - genetics | 5-Lipoxygenase-Activating Proteins - genetics | Proteomics - methods | Neoplasm Proteins - genetics | Solitary Pulmonary Nodule - pathology | Lung Neoplasms - genetics | Diagnosis, Differential | Arachidonate 5-Lipoxygenase - metabolism | Integrin alpha Chains - metabolism | Cell Adhesion Molecules - metabolism | GPI-Linked Proteins - metabolism | Adenocarcinoma - diagnosis | Aged | Biomarkers, Tumor - genetics | Respiratory Mucosa - metabolism | Lung Neoplasms - diagnosis | Integrin alpha Chains - genetics | GPI-Linked Proteins - genetics | Index Medicus
Journal Article
Journal of Oral Pathology & Medicine, ISSN 0904-2512, 03/2016, Volume 45, Issue 3, pp. 224 - 230
Journal Article
Gut, ISSN 0017-5749, 06/2017, Volume 66, Issue 6, pp. 1060 - 1073
ObjectivePatients with Niemann–Pick disease type C1 (NPC1), a lysosomal lipid storage disorder that causes neurodegeneration and liver damage, can present with... 
IBD-GENETICS | IBD CLINICAL | IMMUNODEFICIENCY | IBD BASIC RESEARCH | Crohn'S DISEASE | MIGLUSTAT THERAPY | PATHOGENESIS | APOPTOSIS | DENDRITIC CELLS | MACROPHAGES | SUSCEPTIBILITY | ILEAL MUCOSA | PHAGOSOME PROTEOME | GASTROENTEROLOGY & HEPATOLOGY | BOWEL-DISEASE | INNATE IMMUNITY | Tumor Necrosis Factor-alpha - metabolism | Crohn Disease - genetics | X-Linked Inhibitor of Apoptosis Protein - deficiency | Humans | Child, Preschool | Lysosomes | Male | Nod2 Signaling Adaptor Protein - genetics | Leukocytes, Mononuclear | Pyridazines - pharmacology | Niemann-Pick Disease, Type C - physiopathology | Autophagy - drug effects | Crohn Disease - complications | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Young Adult | Gentamicins - pharmacology | Adult | Bacteria | Female | Genetic Diseases, X-Linked - genetics | Autophagy - genetics | Child | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Macrophages - physiology | Granuloma - genetics | Cells, Cultured | Chlorpromazine - pharmacology | Imidazoles - pharmacology | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Granuloma - pathology | Nod2 Signaling Adaptor Protein - metabolism | Crohn Disease - pathology | Dopamine Antagonists - pharmacology | Adolescent | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Anti-Bacterial Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Mutation | Niemann-Pick Disease, Type C - complications | Niemann-Pick Disease, Type C - genetics | Autophagy (Cytology) | Inflammatory bowel diseases | Gastrointestinal diseases | Causes of | Colorectal diseases | Crohn's disease | Research | Niemann-Pick disease | Salmonella | Granuloma | Muramyl dipeptide | Liver | XIAP protein | Kinases | Macrophages | Autophagy | Defects | Genotype & phenotype | Cell activation | Intestine | Neurodegeneration | Npc1 protein | Age | NOD2 protein | Oligomerization | Dendritic cells | Cytokines | Blood & organ donations | Inflammation | Patients | Crohns disease | Studies | Inflammatory bowel disease | Monocytes | Proteomics | Colitis | Adapter proteins | Phagocytosis | Apoptosis | Index Medicus | Abridged Index Medicus | IBD - GENETICS | CROHN'S DISEASE | Inflammatory Bowel Disease | 1506
Journal Article