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Nature Medicine, ISSN 1078-8956, 02/2016, Volume 22, Issue 2, pp. 146 - 153
Journal Article
Journal of clinical investigation, ISSN 0021-9738, 2015, Volume 125, Issue 11, pp. 4135 - 4148
Patients with mutations of the recombination-activating genes (RAG) present with diverse clinical phenotypes, including severe combined immune deficiency... 
MEDICINE, RESEARCH & EXPERIMENTAL | MYASTHENIA-GRAVIS PATIENTS | GRANULOMATOUS-DISEASE | SYSTEMIC-LUPUS-ERYTHEMATOSUS | SEVERE COMBINED IMMUNODEFICIENCY | SYNDROME TYPE-I | OMENN-SYNDROME | CHRONIC MUCOCUTANEOUS CANDIDIASIS | AUTOIMMUNE-DISEASE | IMMUNOGLOBULIN-SECRETING CELLS | ACTIVATING GENE-1 DEFICIENCY | Antibody Specificity | Autoantibodies - blood | Humans | Granulomatous Disease, Chronic - genetics | Child, Preschool | Infant | Male | Homeodomain Proteins - immunology | Granulomatous Disease, Chronic - immunology | DNA-Binding Proteins - deficiency | Interferon-Induced Helicase, IFIH1 | Autoimmune Diseases - genetics | Young Adult | Antibodies, Neutralizing - immunology | Nuclear Proteins - deficiency | Adult | Female | Nuclear Proteins - genetics | Child | Cytokines - immunology | Disease Models, Animal | Virus Diseases - immunology | Toll-Like Receptors - immunology | Autoimmune Diseases - immunology | Severe Combined Immunodeficiency - therapy | Granulomatous Disease, Chronic - therapy | Severe Combined Immunodeficiency - immunology | DNA-Binding Proteins - genetics | Mice, Inbred Strains | Homeodomain Proteins - genetics | Toll-Like Receptors - agonists | Severe Combined Immunodeficiency - genetics | Autoantibodies - immunology | Animals | Autoantigens - immunology | Adolescent | DEAD-box RNA Helicases - immunology | Mice | Antibodies, Neutralizing - blood | Phenotype | Autoantibodies | Gene mutations | Genetic aspects | Health aspects | Identification and classification | Immune system | Immunoglobulins | Vitiligo | Psoriasis | Lymphocytes | Adenoviruses | Infections | Autoimmune diseases | Patients | Age | Viral infections | Methods | Children & youth | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 3, pp. 655 - 662.e8
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 127, Issue 5, pp. 1243 - 1252.e7
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2014, Volume 111, Issue 9, pp. 3526 - 3531
Patients with chronic granulomatous disease (CGD) have a mutated NADPH complex resulting in defective production of reactive oxygen species; these patients can... 
Aspergillus | Crohn disease | Chronic granulomatous disease | Monocytes | Lungs | Mice | Infections | Inflammation | Colitis | Macrophages | Interleukin-1 | S. aureus | Autoinflammatory disease | LPS | CELLS | ACTIVATION | INFECTIONS | CONTRIBUTE | interleukin-1 | CROHNS-DISEASE | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | COLITIS | autoinflammatory disease | COMPLICATIONS | DYSFUNCTION | Microtubule-Associated Proteins - metabolism | Humans | Autophagy - physiology | Granulomatous Disease, Chronic - complications | Granulomatous Disease, Chronic - immunology | NADPH Oxidases - deficiency | Interleukin-1beta - metabolism | Mice, Mutant Strains | Statistics, Nonparametric | Anti-Inflammatory Agents - therapeutic use | NADPH Oxidases - genetics | Colitis - drug therapy | Interleukin 1 Receptor Antagonist Protein - pharmacology | Colitis - immunology | Real-Time Polymerase Chain Reaction | Enzyme-Linked Immunosorbent Assay | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Phagosomes - metabolism | Colitis - etiology | Animals | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Aspergillus fumigatus | Granulomatous Disease, Chronic - drug therapy | Receptors, Interleukin-1 - antagonists & inhibitors | Proteins | Antagonist drugs | Rodents | Gene expression | Autophagy | Inflammatory diseases | Chronic illnesses | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2012, Volume 122, Issue 5, pp. 1816 - 1831
Aspergillus fumigatus is a model fungal pathogen and a common cause of infection in individuals with the primary immunodeficiency chronic granulomatous disease... 
ASPERGILLUS-FUMIGATUS ANTIGENS | MEDICINE, RESEARCH & EXPERIMENTAL | NADPH OXIDASE | RESPONSES | CD8(+) | DENDRITIC CELLS | IN-VIVO | INDUCED PROTECTION | INFECTION | AUTOPHAGY | CONTROLS PHAGOSOMAL PH | Lung - microbiology | Membrane Glycoproteins - metabolism | Dendritic Cells - immunology | Vaccination | NADPH Oxidases - metabolism | Dendritic Cells - physiology | Granulomatous Disease, Chronic - immunology | CD4-Positive T-Lymphocytes - physiology | CD4-Positive T-Lymphocytes - immunology | Granulomatous Disease, Chronic - microbiology | CD8-Positive T-Lymphocytes - metabolism | Female | Toll-Like Receptors - metabolism | Adjuvants, Immunologic - therapeutic use | DNA Helicases - genetics | Granulomatous Disease, Chronic - pathology | Dendritic Cells - metabolism | Oligodeoxyribonucleotides - therapeutic use | Spores, Fungal - immunology | Adaptive Immunity | ATPases Associated with Diverse Cellular Activities | Lung - pathology | Signal Transduction | Lymphocyte Activation | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Mice, Transgenic | Antigens, Fungal - immunology | DNA Helicases - deficiency | Granulomatous Disease, Chronic - therapy | NADPH Oxidase 2 | CD8-Positive T-Lymphocytes - physiology | Animals | Aspergillus fumigatus - immunology | Cross-Priming | Mice | CD8-Positive T-Lymphocytes - immunology | Lung - immunology | Phagocytosis | Aspergillosis - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 12/2014, Volume 21, Issue 16, pp. 2231 - 2245
Journal Article
Circulation, ISSN 0009-7322, 12/2014, Volume 130, Issue 23, pp. 2031 - 2039
BACKGROUND—Patients with chronic granulomatous disease (CGD) experience immunodeficiency because of defects in the phagocyte NADPH oxidase and the concomitant... 
Inflammation | Coronary vessels | Carotid arteries | Atherosclerosis | Immune system | atherosclerosis | INTIMA-MEDIA THICKNESS | NADPH OXIDASE | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | SUPEROXIDE-PRODUCTION | CARDIOVASCULAR EVENTS | carotid arteries | coronary vessels | inflammation | HIGH-RESOLUTION | immune system | CAROTID PLAQUE | PERIPHERAL VASCULAR DISEASE | APOE(-/-) MICE | EXPRESSION | CORONARY-ARTERY-DISEASE | Prevalence | Membrane Glycoproteins - metabolism | Humans | NADPH Oxidases - metabolism | NADPH Oxidases - immunology | Male | Granulomatous Disease, Chronic - immunology | Granulomatous Disease, Chronic - epidemiology | Young Adult | NADPH Oxidases - deficiency | Carotid Artery Diseases - pathology | Coronary Artery Disease - pathology | NADPH Oxidases - genetics | Adult | Female | Membrane Glycoproteins - immunology | Granulomatous Disease, Chronic - pathology | Carotid Artery Diseases - immunology | Cross-Sectional Studies | Vascular Calcification - immunology | Risk Factors | Carotid Artery Diseases - epidemiology | Phagocytes - immunology | Vascular Calcification - pathology | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Magnetic Resonance Imaging | Vascular Calcification - epidemiology | Coronary Artery Disease - epidemiology | Coronary Artery Disease - immunology | Complications and side effects | Chronic granulomatous disease | Usage | Magnetic resonance imaging | Immunodeficiency | Research | Risk factors | Index Medicus | Abridged Index Medicus | coronary arteries
Journal Article