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Annals of the Rheumatic Diseases, ISSN 0003-4967, 02/2017, Volume 76, Issue 2, pp. 377 - 385
Journal Article
Cell, ISSN 0092-8674, 2003, Volume 112, Issue 5, pp. 659 - 672
Granzyme A (GzmA) induces a caspase-independent cell death pathway characterized by single-stranded DNA nicks and other features of apoptosis. A GzmA-activated... 
TARGET | REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | TRANSCRIPTION | DEGRADATION | FRAGMENTATION | CLEAVAGE | HISTONE ACETYLATION | NUCLEAR TRANSLOCATION | DIPHOSPHATE KINASE | CELL BIOLOGY | HMGB2 Protein - genetics | Nucleoside-Diphosphate Kinase | HMGB2 Protein - metabolism | Histone Chaperones | Humans | Apoptosis - genetics | Phosphoproteins - metabolism | Deoxyribonucleases - metabolism | DNA, Single-Stranded - genetics | DNA-(Apurinic or Apyrimidinic Site) Lyase | Genes, Tumor Suppressor - physiology | Serine Endopeptidases - genetics | Nuclear Proteins - genetics | Active Transport, Cell Nucleus - genetics | Immunity, Cellular - genetics | Chromosomal Proteins, Non-Histone - metabolism | Gene Expression Regulation - genetics | Jurkat Cells | DNA Fragmentation - genetics | DNA, Single-Stranded - metabolism | Granzymes | Nucleosomes - metabolism | Nuclear Proteins - metabolism | Monomeric GTP-Binding Proteins - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Chromosomal Proteins, Non-Histone - genetics | Transcription Factors - metabolism | Deoxyribonucleases - genetics | Monomeric GTP-Binding Proteins - metabolism | T-Lymphocytes, Cytotoxic - metabolism | Models, Biological | Carbon-Oxygen Lyases - genetics | K562 Cells | Carbon-Oxygen Lyases - metabolism | NM23 Nucleoside Diphosphate Kinases | Serine Endopeptidases - metabolism | HeLa Cells | Gene Silencing - physiology | Physiological aspects | Enzyme inhibitors | Metastasis | Lymphocytes | DNA damage | Apoptosis
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 06/2013, Volume 210, Issue 6, pp. 1189 - 1200
The forkhead O transcription factors (FOXO) integrate a range of extracellular signals, including growth factor signaling, inflammation, oxidative stress, and... 
TRANSCRIPTION FACTORS | EFFECTOR | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | L-SELECTIN | IN-VIVO | INFECTION | IMMUNOLOGY | BETA-CATENIN | NAIVE | EXPRESSION | CUTTING EDGE | Forkhead Transcription Factors - immunology | Lymphocytic choriomeningitis virus - immunology | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - cytology | Granzymes - metabolism | Lectins, C-Type - immunology | Cell Survival - genetics | T-Box Domain Proteins - immunology | Granzymes - genetics | Lectins, C-Type - genetics | Lymphocytic Choriomeningitis - immunology | Antigens, CD - genetics | Antigens, CD - metabolism | Cell Differentiation - genetics | Lectins, C-Type - metabolism | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Forkhead Transcription Factors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Granzymes - immunology | T Cell Transcription Factor 1 - metabolism | Immunologic Memory - genetics | Immunologic Memory - immunology | Antigens, Differentiation, T-Lymphocyte - immunology | Mice, Inbred C57BL | Hepatocyte Nuclear Factor 1-alpha | Antigens, Differentiation, T-Lymphocyte - metabolism | Mice, Transgenic | Cell Survival - immunology | Forkhead Transcription Factors - genetics | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | T Cell Transcription Factor 1 - genetics | Cell Differentiation - immunology | Animals | Up-Regulation - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | T Cell Transcription Factor 1 - immunology | Forkhead Box Protein O1 | Mice | CD8-Positive T-Lymphocytes - immunology | 309
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e62778
Current influenza vaccines stimulate neutralising antibody to the haemagglutinin antigen but as there is antigenic drift in HA it is difficult to prepare a... 
EFFECTOR | CROSS-REACT | INFECTIONS | PROTECTION | RECOGNITION | MULTIDISCIPLINARY SCIENCES | HUMANS | PHENOTYPE | A-VIRUS | RECIPIENTS | LYMPHOCYTES | HLA-A2 Antigen - genetics | Influenza Vaccines - administration & dosage | Viral Matrix Proteins - genetics | Perforin - genetics | Humans | Middle Aged | Nucleoproteins - genetics | Vaccination | Viral Vaccines - genetics | Antigens, Viral - genetics | Epitopes, T-Lymphocyte - genetics | Granzymes - genetics | Hemagglutinins - immunology | Orthomyxoviridae - immunology | Adult | Granzymes - immunology | Orthomyxoviridae - drug effects | Perforin - immunology | Epitopes, T-Lymphocyte - immunology | Nucleoproteins - immunology | CD57 Antigens - immunology | HLA-A2 Antigen - immunology | Recombinant Proteins - genetics | Viral Vaccines - administration & dosage | Hemagglutinins - genetics | Antigens, Viral - immunology | Influenza Vaccines - immunology | Influenza Vaccines - genetics | Recombinant Proteins - immunology | CD8-Positive T-Lymphocytes - virology | Influenza, Human - genetics | Viral Core Proteins - genetics | Adolescent | CD57 Antigens - genetics | Vaccines, Synthetic | Viral Core Proteins - immunology | Viral Matrix Proteins - immunology | CD8-Positive T-Lymphocytes - immunology | Influenza, Human - prevention & control | Viral Vaccines - immunology | Influenza, Human - immunology | Influenza viruses | Influenza vaccines | Proteins | Medical research | Influenza | Medicine, Experimental | T cells | Antigenic determinants | CD57 antigen | Flow cytometry | CD8 antigen | Cytotoxicity | Viruses | Infections | Lymphocytes T | Vaccines | Avian flu | Genotype & phenotype | Hepatitis | Immunology | Lymphocytes | Perforin | Antigens | Immunization | Antigenic drift | T cell receptors | Epitopes | CD4 antigen | Medicine | Studies | Swine flu | Histocompatibility antigen HLA | Drift
Journal Article
Science, ISSN 0036-8075, 12/1999, Volume 286, Issue 5446, pp. 1957 - 1959
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 4, pp. 373 - 383
Journal Article
Journal Article
Human Gene Therapy, ISSN 1043-0342, 08/2017, Volume 28, Issue 8, pp. 667 - 680
In advanced and metastatic stages of colorectal cancer (CRC), reduced sensitivity to conventional strategies is still a major obstacle to successful... 
Research Articles | oncolytic adenovirus | colorectal cancer | immune | decorin | GM-CSF | MEDICINE, RESEARCH & EXPERIMENTAL | SYSTEMIC DELIVERY | CELLS | FACTOR-BETA | TGF-BETA | CANCER | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | MEDIATED INHIBITION | PHASE-I | EXPRESSION | T-Lymphocyte Subsets - immunology | Genetic Therapy | Genetic Vectors - administration & dosage | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Colorectal Neoplasms - genetics | Humans | Cytopathogenic Effect, Viral | Carcinogenesis - metabolism | Colorectal Neoplasms - therapy | Epithelial-Mesenchymal Transition | Adenoviridae - genetics | Transgenes | Gene Order | Colorectal Neoplasms - metabolism | Decorin - genetics | Disease Models, Animal | Gene Expression | Transduction, Genetic | Cytokines - metabolism | Signal Transduction | Immunomodulation | Carcinogenesis - genetics | Oncolytic Viruses - genetics | Genetic Vectors - genetics | Oncolytic Virotherapy | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Xenograft Model Antitumor Assays | Animals | Colorectal Neoplasms - immunology | Virus Replication | T-Lymphocyte Subsets - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Decorin - metabolism | Decorin | Mesenchyme | Toxicity | CD8 antigen | Transforming growth factor-b | Colorectal carcinoma | Colorectal cancer | Clinical trials | Cytotoxicity | Lymphocytes T | Infections | Metastasis | Tissues | Macrophages | Blood | Metastases | Angiogenesis | Granzyme B | Granulocytes | Lymphocytes | Coding | Xenografts | Oncolysis | Colony-stimulating factor | Inhibition | Perforin | Vascular endothelial growth factor | Growth factors | Activation analysis | Spleen | Medical research | Immune response | Granulocyte-macrophage colony-stimulating factor | Colonies | Gene expression | Patients | Lungs | Adenoviruses | Antitumor activity | Leukocytes (granulocytic) | Tumors | Apoptosis | Cancer
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2015, Volume 194, Issue 8, pp. 3768 - 3777
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2008, Volume 181, Issue 11, pp. 7660 - 7669
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e108554
Latency-associated peptide (LAP) - expressing regulatory T cells (Tregs) are important for immunological self-tolerance and immune homeostasis. In order to... 
ENCEPHALOMYELITIS | TGF-BETA | BETA-DEPENDENT MANNER | IMMUNOTHERAPY | TOLERANCE | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION FACTOR FOXP3 | EFFECTOR/MEMORY | INDUCTION | VERSUS-HOST-DISEASE | PROGRESSION | Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | Perforin - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Peptides - genetics | Receptors, CCR5 - genetics | Male | Granzymes - genetics | Receptors, Tumor Necrosis Factor, Type II - immunology | Case-Control Studies | Colorectal Neoplasms - diagnosis | Receptors, CCR5 - immunology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Ki-67 Antigen - immunology | Aged, 80 and over | Female | Granzymes - immunology | Perforin - immunology | Transforming Growth Factor beta - immunology | Protein Precursors - genetics | Peptides - immunology | Immune Tolerance | Protein Precursors - immunology | Lymphatic Metastasis | Forkhead Transcription Factors - genetics | Receptors, Tumor Necrosis Factor, Type II - genetics | Colorectal Neoplasms - immunology | Transforming Growth Factor beta - genetics | Ki-67 Antigen - genetics | Immunologic Memory | Aged | Biomarkers, Tumor - genetics | Colorectal Neoplasms - pathology | Biomarkers, Tumor - immunology | Peptides | Physicians | Colorectal carcinoma | Transforming growth factor-a | Colorectal cancer | Homeostasis | Leukocytes (mononuclear) | Oncology | Lymphocytes T | Tissues | Blood | Immunosuppressive agents | Metastases | Granzyme B | Immunology | Lymphocytes | Immunotherapy | Hepatology | Surgery | Gastroenterology | Peripheral blood mononuclear cells | Population | Foxp3 protein | Perforin | Growth factors | Immune system | Antigens | CCR5 protein | Immune response | Hematology | Immunoregulation | T cell receptors | Patients | Immunological tolerance | Latency | CD4 antigen | Medicine | Hospitals | Cancer
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2010, Volume 207, Issue 8, pp. 1687 - 1699
CD8(+) T lymphocytes mediate the immune response to viruses, intracellular bacteria, protozoan parasites, and tumors. We provide evidence that the... 
BET | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | CD4 | SELECTIVE EXPRESSION | POSITIVE SELECTION | NURD COMPLEX | DISTAL PROMOTER | GENE-EXPRESSION | CELL DIFFERENTIATION | IMMUNOLOGY | THYMOCYTES | CD8-Positive T-Lymphocytes - cytology | Protein Binding - genetics | Cell Proliferation | Ovalbumin - immunology | CD8-Positive T-Lymphocytes - transplantation | Granzymes - genetics | Lymphocyte Activation - immunology | Peptide Fragments - immunology | CD8-Positive T-Lymphocytes - metabolism | Receptors, Antigen, T-Cell - immunology | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Receptors, Antigen, T-Cell - metabolism | CD4-Positive T-Lymphocytes - metabolism | Repressor Proteins - genetics | Mice, Transgenic | Antigen Presentation - immunology | T-Lymphocyte Subsets - transplantation | Clone Cells - metabolism | CD8 Antigens - metabolism | T-Lymphocytes, Cytotoxic - metabolism | CD8 Antigens - genetics | Mice | Receptors, Antigen, T-Cell - genetics | CD8-Positive T-Lymphocytes - immunology | Cytotoxicity, Immunologic - immunology | T-Lymphocyte Subsets - immunology | Clone Cells - cytology | Pore Forming Cytotoxic Proteins - genetics | T-Lymphocyte Subsets - cytology | Granzymes - metabolism | Adoptive Transfer | Listeria monocytogenes - immunology | Signal Transduction - immunology | Tumor Suppressor Proteins - genetics | Clone Cells - immunology | Listeriosis - immunology | Phospholipase C gamma - genetics | ZAP-70 Protein-Tyrosine Kinase - metabolism | Ovalbumin - genetics | T-Lymphocytes, Cytotoxic - immunology | Pore Forming Cytotoxic Proteins - metabolism | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Gene Expression Regulation - physiology | Enhancer Elements, Genetic - immunology | Animals | Apoptosis - immunology | T-Lymphocyte Subsets - metabolism | Listeria monocytogenes - genetics | Listeriosis - microbiology | Enhancer Elements, Genetic - genetics | Orthomyxoviridae Infections - immunology
Journal Article