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The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 07/2013, Volume 98, Issue 7, pp. 2783 - 2790
Context: Thyroid-associated ophthalmopathy (TAO) manifests as inflammation of orbital connective tissue. Bone marrow–derived CD34+ fibrocytes infiltrate the... 
CIGARETTE-SMOKING | PROTEIN | THYROTROPIN RECEPTOR | IFN-GAMMA | DISEASE | TISSUE | ENDOCRINOLOGY & METABOLISM | ENDOPEROXIDE H SYNTHASE-2 | IL-1-BETA | INDUCTION | GRAVES OPHTHALMOPATHY | Leukocytes - pathology | Fibroblasts - secretion | Antigens, CD34 - metabolism | Orbit - immunology | Graves Ophthalmopathy - surgery | Humans | Interleukin 1 Receptor Antagonist Protein - genetics | Interleukin-1alpha - metabolism | Orbit - surgery | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Cyclooxygenase 2 - biosynthesis | Leukocytes - immunology | Graves Ophthalmopathy - metabolism | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | Cell Transdifferentiation | Interleukin 1 Receptor Antagonist Protein - secretion | Interleukin-1alpha - genetics | Interleukin-1beta - biosynthesis | Orbit - pathology | Fibroblasts - metabolism | Recombinant Proteins - metabolism | Promoter Regions, Genetic | Disease Susceptibility | Cells, Cultured | Gene Expression Regulation | Fibroblasts - pathology | RNA Stability | Graves Ophthalmopathy - immunology | Orbit - metabolism | Cyclooxygenase 2 - metabolism | Fibroblasts - immunology | Interleukin-1alpha - biosynthesis | Leukocytes - secretion | Graves Ophthalmopathy - pathology | Leukocytes - metabolism | Index Medicus | Abridged Index Medicus | Endocrine Research
Journal Article
Journal Article
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 05/2013, Volume 98, Issue 5, pp. 2153 - 2159
Context: Graves ophthalmopathy (GO) is an autoimmune disorder characterized by increased adipogenesis and hyaluronan (HA) production by orbital fibroblasts.... 
AUTOIMMUNITY | DISEASE | ENDOCRINOLOGY & METABOLISM | STIMULATING HORMONE-RECEPTOR | UPDATE | CAMP PRODUCTION | PREADIPOCYTE FIBROBLASTS | AGONIST | Eye - pathology | Thyrotropin - agonists | Receptors, Thyrotropin - agonists | Adipose Tissue, White - immunology | Humans | Adipose Tissue, White - metabolism | Cell Dedifferentiation | Eye - immunology | Graves Ophthalmopathy - metabolism | Osmolar Concentration | Protein Processing, Post-Translational - drug effects | Thyrotropin - pharmacology | Immunoglobulins, Thyroid-Stimulating - metabolism | Thyrotropin - antagonists & inhibitors | Eye - drug effects | Phosphorylation - drug effects | Graves Ophthalmopathy - drug therapy | Proto-Oncogene Proteins c-akt - metabolism | Cyclic AMP - metabolism | Quinazolinones - pharmacology | Fibroblasts - metabolism | Eye - metabolism | Adipose Tissue, White - pathology | Receptors, Thyrotropin - metabolism | Cells, Cultured | Receptors, Thyrotropin - antagonists & inhibitors | Fibroblasts - pathology | Graves Ophthalmopathy - immunology | Signal Transduction - drug effects | Drug Inverse Agonism | Fibroblasts - drug effects | Hyaluronic Acid - metabolism | Fibroblasts - immunology | Graves Ophthalmopathy - pathology | Pyridines - pharmacology | Antibodies, Monoclonal - metabolism | Adipose Tissue, White - drug effects | Index Medicus | Abridged Index Medicus | Endocrine Research
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, pp. e0174260 - e0174260
Background Graves' disease is the most common form of autoimmune thyroid disorder, characterized by hyperthyroidism due to circulating autoantibodies. To... 
IN-VIVO ELECTROPORATION | THYROTROPIN RECEPTOR | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | DISEASE | ORBITAL FIBROBLASTS | HYALURONAN SYNTHESIS | MECHANISMS | ORBITOPATHY | EXPRESSION | SUBUNIT | Eye - pathology | Graves Disease - blood | Graves Ophthalmopathy - diagnostic imaging | Receptors, Thyrotropin - genetics | Autoantibodies - blood | Humans | Thyroxine - blood | Eye - diagnostic imaging | Female | Disease Models, Animal | Graves Disease - diagnostic imaging | Immunization | Enzyme-Linked Immunosorbent Assay | Electroporation | Injections, Intramuscular | Receptors, Thyrotropin - immunology | Magnetic Resonance Imaging | Animals | Thyroid Gland - pathology | Graves Ophthalmopathy - blood | Graves Ophthalmopathy - pathology | Mice | Mice, Inbred BALB C | Genetic Vectors | Graves Disease - pathology | 3T3 Cells | Autoimmunity | Genetic vectors | Thyrotropin releasing factor | Analysis | Hyperthyroidism | Physiological aspects | Genetic aspects | Research | Health aspects | Risk factors | Animal models | Disease | Laboratories | Hyperplasia | Antibodies | Staining | Animal diseases | Thyroid gland | Hormones | Kinases | Follicles | Medical schools | Goiter | Rodents | Animal tissues | Thyroxine | Fibroblasts | Physiology | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Recombinant | Thyroid | Enzymes | Autoantibodies | Injection | Metabolism | Gene expression | Medicine | Thyroid-stimulating hormone receptors | Hospitals | Magnetic resonance imaging | Plasmids | Hyaluronic acid | Endocrinology | Hypertrophy | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0143514 - e0143514
Graves' ophthalmopathy (GO) is a disfiguring and sometimes blinding disease, which is characterized by inflammation and swelling of orbital tissues, with... 
FIBROSIS | PATHOGENESIS | CELLS | THYROID-ASSOCIATED OPHTHALMOPATHY | OXIDATIVE STRESS | COLLAGEN | MULTIDISCIPLINARY SCIENCES | INDUCTION | INDUCER | INSIGHTS | Up-Regulation | Fibrosis - genetics | Gene Expression | Reactive Oxygen Species - metabolism | Antioxidants - metabolism | Humans | Middle Aged | RNA, Messenger - genetics | Cells, Cultured | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Male | Antioxidants - pharmacology | Graves Ophthalmopathy - genetics | RNA, Messenger - metabolism | Young Adult | Fibroblasts - drug effects | Adult | Female | Connective Tissue Growth Factor - genetics | Graves Ophthalmopathy - pathology | Connective Tissue Growth Factor - metabolism | Fibroblasts - metabolism | Antioxidants | Eye | Care and treatment | Oculomotor paralysis | Development and progression | Research | Paralysis | Apolipoproteins | Health aspects | Risk factors | Oxidative stress | Hydrogen peroxide | Ascorbic acid | Disease | Pathogenesis | Acetylcysteine | Biochemistry | Thyroid gland | Mitochondrial DNA | Fibronectin | Lethal dose | Proteins | Connective tissues | Surgery | Vitamin C | Fibroblasts | Extracellular matrix | Growth factors | Adipogenesis | Incubation | Connective tissue growth factor | Pharmacology | Gene expression | Chemical compounds | Patients | Fibrosis | Molecular biology | Index Medicus
Journal Article
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 11/2016, Volume 40, Issue 1-2, pp. 245 - 252
Journal Article