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Nature Structural and Molecular Biology, ISSN 1545-9993, 01/2012, Volume 19, Issue 1, pp. 117 - 122
The use of genetic mutations to study protein functions in vivo is a central paradigm of modern biology. Recent advances in reverse genetics such as RNA... 
TARGET | CELLS | SIGNALING PATHWAYS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAP | DROSOPHILA | NONMUSCLE MYOSIN | CELL BIOLOGY | UBIQUITINATION | BIOPHYSICS | GENE | CELLULAR-PROTEINS | EFFICIENT | Drosophila melanogaster - embryology | Cytoskeletal Proteins - genetics | Homeodomain Proteins - metabolism | Humans | Embryo, Nonmammalian - metabolism | Molecular Sequence Data | Embryo, Nonmammalian - embryology | Green Fluorescent Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Recombinant Fusion Proteins - metabolism | Drosophila melanogaster - metabolism | POU Domain Factors - genetics | Proteolysis | Base Sequence | Antibodies - immunology | Cytoskeletal Proteins - metabolism | POU Domain Factors - metabolism | Wings, Animal - embryology | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Animals, Genetically Modified | Gene Knockout Techniques | Blotting, Western | Homeodomain Proteins - genetics | Microscopy, Confocal | Wings, Animal - metabolism | Animals | Green Fluorescent Proteins - immunology | Histones - genetics | Models, Biological | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | Drosophila Proteins - genetics | HeLa Cells | Histones - metabolism | Luminescent Proteins - metabolism | Ubiquitin | Physiological aspects | Research | Structure | Green fluorescent protein | Proteins | Genetics | Eukaryotes | Mutation | Insects | Molecular biology | Index Medicus
Journal Article
Nature Methods, ISSN 1548-7091, 06/2012, Volume 9, Issue 6, pp. 582 - 584
Journal Article
Nature Methods, ISSN 1548-7091, 11/2014, Volume 11, Issue 12, pp. 1253 - 1260
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2012, Volume 122, Issue 11, pp. 4037 - 4047
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8577 - 8582
Immune responses can make protein therapeutics ineffective or even dangerous. We describe a general computational protein design method for reducing... 
T lymphocytes | Immune response | Immunodominant epitopes | Exotoxins | Medical treatment | Alleles | T lymphocyte epitopes | Epitopes | Genetic mutation | Epics | Biotherapeutics | Immunotoxin | Deimmunization | Machine learning | Rosetta | biotherapeutics | MULTIDISCIPLINARY SCIENCES | ANTIBODY | deimmunization | ALGORITHMS | machine learning | IDENTIFICATION | GREEN FLUORESCENT PROTEIN | REDUCED IMMUNOGENICITY | THERAPEUTIC PROTEINS | immunotoxin | OPTIMIZATION | PHASE-I | Virulence Factors - genetics | Protein Engineering - methods | Humans | Molecular Sequence Data | Epitopes, T-Lymphocyte - genetics | Green Fluorescent Proteins - genetics | Virulence Factors - immunology | HLA Antigens - genetics | Support Vector Machine | Flow Cytometry | Bacterial Toxins - genetics | Immunotoxins - chemistry | Epitopes, T-Lymphocyte - immunology | Green Fluorescent Proteins - chemistry | ADP Ribose Transferases - chemistry | Protein Structure, Tertiary | ADP Ribose Transferases - immunology | Immunization | Immunotoxins - immunology | Exotoxins - chemistry | Bacterial Toxins - immunology | Exotoxins - immunology | Mice, Inbred C57BL | HLA Antigens - immunology | Models, Molecular | Spectrometry, Fluorescence | Virulence Factors - chemistry | Bacterial Toxins - chemistry | Proteins - immunology | Proteins - genetics | Sequence Homology, Amino Acid | ADP Ribose Transferases - genetics | Immunotoxins - genetics | Animals | Green Fluorescent Proteins - immunology | Exotoxins - genetics | Cell Line, Tumor | Mice | Computer-Aided Design | Proteins - chemistry | Microbiological research | Protein research | Peptides | Research | Pseudomonas | T cells | Health aspects | Proteins | Bacteria | T cell receptors | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2007, Volume 179, Issue 4, pp. 2509 - 2519
Mycobacterium tuberculosis (Mtb) is thought to reside in macrophages, although infected dendritic cells (DCs) have been observed. Thus, although cellular... 
VITRO | IMMUNITY | MONOCYTE | INTERFERON-GAMMA | IFN-GAMMA | LYMPH-NODES | PULMONARY TUBERCULOSIS | CD4(+) T-CELLS | RECEPTOR | CHEMOKINE | IMMUNOLOGY | Lung - microbiology | Tuberculosis, Pulmonary - veterinary | Lymph Nodes - pathology | Dendritic Cells - immunology | Mycobacterium tuberculosis - immunology | Chemokine CCL21 | Dendritic Cells - pathology | Green Fluorescent Proteins - genetics | Biological Transport, Active - genetics | CD4-Positive T-Lymphocytes - pathology | Cell Movement - genetics | CD4-Positive T-Lymphocytes - immunology | Cell Movement - immunology | Biological Transport, Active - immunology | Receptors, Antigen, T-Cell - immunology | Chemokines, CC - immunology | Macrophages - immunology | Macrophages - microbiology | Chemokine CCL19 | Lung - pathology | CD4-Positive T-Lymphocytes - microbiology | Macrophages - pathology | Antigen Presentation - genetics | Mice, Transgenic | Lymph Nodes - immunology | Tuberculosis, Pulmonary - pathology | Antigen Presentation - immunology | Tuberculosis, Pulmonary - immunology | Animals | Green Fluorescent Proteins - immunology | Histocompatibility Antigens Class II - immunology | Dendritic Cells - microbiology | Mice | Receptors, Antigen, T-Cell - genetics | Histocompatibility Antigens Class II - genetics | Lung - immunology | Lymph Nodes - microbiology | Mycobacterium tuberculosis - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2016, Volume 55, Issue 38, pp. 11668 - 11672
Journal Article
Scientific Reports, ISSN 2045-2322, 2014, Volume 4, Issue 1, pp. 6881 - 6881
Ebola virus (EBOV) causes severe viral hemorrhagic fever in humans and non-human primates, with a case fatality rate of up to 88% in human outbreaks. Over the... 
NONHUMAN-PRIMATES | INFECTION | GLYCOPROTEIN | MULTIDISCIPLINARY SCIENCES | EPITOPES | TOOL | Ebola Vaccines - genetics | Recombinant Fusion Proteins - immunology | Hemorrhagic Fever, Ebola - prevention & control | Antibodies, Monoclonal - biosynthesis | Humans | Molecular Sequence Data | Green Fluorescent Proteins - genetics | Ebolavirus - genetics | Antigen-Antibody Reactions | Ebolavirus - immunology | Epitopes - immunology | Hemorrhagic Fever, Ebola - virology | Ebola Vaccines - chemistry | Vesiculovirus - genetics | Antigen-Antibody Complex - genetics | Ebola Vaccines - immunology | Hemorrhagic Fever, Ebola - immunology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Genes, Reporter | Antibodies, Viral - biosynthesis | Amino Acid Sequence | Gene Expression | Viral Envelope Proteins - genetics | Models, Molecular | Recombinant Fusion Proteins - chemistry | Epitopes - genetics | Antibodies, Monoclonal - genetics | Ebolavirus - chemistry | Sequence Alignment | Animals | Green Fluorescent Proteins - immunology | Immune Evasion | Antigen-Antibody Complex - chemistry | Viral Envelope Proteins - antagonists & inhibitors | Viral Envelope Proteins - chemistry | Antibodies, Viral - chemistry | Recombinant Fusion Proteins - genetics | Antibodies, Viral - immunology | Viral Envelope Proteins - immunology | Epitopes - chemistry | Mice | Mutation | Antigen-Antibody Complex - immunology | Antibodies, Viral - genetics | Ebola virus | Epidemics | Immunoglobulins | Hemorrhagic fever | Variable region | Monoclonal antibodies | Amino acids | Outbreaks | Surface plasmon resonance | Hemorrhage | Fever | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 07/2016, Volume 7, Issue 1, pp. 12057 - 12057
Journal Article
Journal Article