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Journal of Endocrinology, ISSN 0022-0795, 2016, Volume 231, Issue 2, pp. 135 - 145
Somatostatin analogs (SSA) are the mainstay of pharmacological treatment for pituitary adenomas. However, some patients escape from therapy with octreotide, a... 
Somatostatin | Gene expression | Pituitary | Cell signaling | Pituitary adenoma | pituitary | SOMATOSTATIN ANALOG SOM230 | AGGRESSIVE FEATURES | MEDICAL-TREATMENT | CUSHINGS-DISEASE | QUANTITATIVE-ANALYSIS | pituitary adenoma | RECEPTOR SUBTYPES | GROWTH-HORMONE | somatostatin | cell signaling | ENDOCRINOLOGY & METABOLISM | ACTH RELEASE | gene expression | ADENOMAS | GENE-EXPRESSION LEVELS | ACTH-Secreting Pituitary Adenoma - drug therapy | Humans | Drug Resistance, Neoplasm | Male | Pituitary Gland - secretion | Somatostatin - pharmacology | Prolactinoma - metabolism | Receptors, Somatostatin - genetics | Antineoplastic Agents, Hormonal - adverse effects | Growth Hormone-Secreting Pituitary Adenoma - metabolism | Pituitary Neoplasms - secretion | Receptors, Somatostatin - metabolism | Neoplasm Proteins - genetics | Prolactinoma - pathology | Cell Survival - drug effects | Pituitary Neoplasms - drug therapy | ACTH-Secreting Pituitary Adenoma - secretion | Calcium Signaling - drug effects | Adenoma - secretion | Growth Hormone-Secreting Pituitary Adenoma - pathology | Pituitary Gland - metabolism | Somatostatin - adverse effects | Prolactinoma - secretion | Neoplasm Proteins - metabolism | Adenoma - metabolism | Receptors, Somatostatin - agonists | Protein Isoforms - metabolism | Protein Isoforms - agonists | Adenoma - drug therapy | Female | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Prolactinoma - drug therapy | Somatostatin - analogs & derivatives | Antineoplastic Agents, Hormonal - pharmacology | ACTH-Secreting Pituitary Adenoma - metabolism | Pituitary Gland - pathology | Cells, Cultured | Octreotide - adverse effects | Pituitary Neoplasms - pathology | Pituitary Neoplasms - metabolism | Octreotide - pharmacology | Growth Hormone-Secreting Pituitary Adenoma - drug therapy | Neoplasm Proteins - agonists | Adenoma - pathology | Growth Hormone-Secreting Pituitary Adenoma - secretion | ACTH-Secreting Pituitary Adenoma - pathology | Pituitary Gland - drug effects | Protein Isoforms - genetics
Journal Article
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2017, Volume 102, Issue 6, pp. 2009 - 2018
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1692 - 1702
Pituitary somatotroph adenomas result in dysregulated growth hormone (GH) hypersecretion and acromegaly; however, regulatory mechanisms that promote GH... 
CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | MEDICAL THERAPY | SMALL-MOLECULE | TARGETING STAT3 | PROOPIOMELANOCORTIN | TRANSSPHENOIDAL SURGERY | GENE-REGULATION | INHIBITOR | SIGNAL TRANSDUCER | Up-Regulation | Species Specificity | Adenoma - genetics | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Growth Hormone-Secreting Pituitary Adenoma - genetics | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Benzenesulfonates - therapeutic use | Adenoma - metabolism | Benzenesulfonates - pharmacology | Growth Hormone-Secreting Pituitary Adenoma - metabolism | STAT3 Transcription Factor - physiology | Female | Antineoplastic Agents - pharmacology | Active Transport, Cell Nucleus | Neoplasm Proteins - genetics | Binding Sites | Rats, Inbred WF | STAT3 Transcription Factor - genetics | Prolactin - secretion | Recombinant Fusion Proteins - biosynthesis | Promoter Regions, Genetic | Aminosalicylic Acids - pharmacology | Human Growth Hormone - genetics | Neoplasm Proteins - biosynthesis | Rats | Aminosalicylic Acids - therapeutic use | STAT3 Transcription Factor - biosynthesis | Feedback, Physiological | Growth Hormone - genetics | Animals | Signal Transduction - drug effects | Adenoma - secretion | Cell Line, Tumor | Growth Hormone-Secreting Pituitary Adenoma - secretion | Signal Transduction - physiology | STAT3 Transcription Factor - antagonists & inhibitors | Human Growth Hormone - secretion | Somatotropin | Transcription factors | Development and progression | Genetic aspects | Adenoma | Properties | Health aspects | Pituitary gland | Cell growth | Hospitals | Rodents | Tumors | Endocrinology
Journal Article
European Journal of Endocrinology, ISSN 0804-4643, 02/2012, Volume 166, Issue 2, pp. 223 - 234
Journal Article
Acta Neurochirurgica, ISSN 0001-6268, 2011, Volume 153, Issue 7, pp. 1391 - 1399
Journal Article
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2012, Volume 97, Issue 6, pp. 2093 - 2104
Context: Ectopic GHRH secretion is a rare cause of acromegaly, and case reports are mainly isolated. Setting: From the registry of the sole laboratory... 
CELL TUMOR | NEUROENDOCRINE TUMOR | ACTING SOMATOSTATIN ANALOG | IN-VITRO | PANCREATIC-ISLET TUMOR | BRONCHIAL CARCINOID-TUMOR | SOMATOTROPH HYPERPLASIA | OCTREOTIDE TREATMENT | ENDOCRINOLOGY & METABOLISM | MULTIPLE ENDOCRINE NEOPLASIA | BIOCHEMICAL REMISSION | Pituitary Neoplasms - surgery | Carcinoid Tumor - surgery | Prognosis | Follow-Up Studies | Carcinoid Tumor - complications | Humans | Middle Aged | Growth Hormone-Secreting Pituitary Adenoma - complications | Neuroendocrine Tumors - complications | Male | Multiple Endocrine Neoplasia Type 1 - complications | Growth Hormone-Releasing Hormone - blood | Pituitary Neoplasms - complications | Multiple Endocrine Neoplasia Type 1 - secretion | Acromegaly - etiology | Growth Hormone-Secreting Pituitary Adenoma - surgery | Pituitary Neoplasms - secretion | Adult | Bronchial Neoplasms - surgery | Female | Registries | France | Growth Hormone-Releasing Hormone - secretion | Pancreatic Neoplasms - secretion | Bronchial Neoplasms - complications | Pancreatic Neoplasms - surgery | Acromegaly - metabolism | Treatment Outcome | Bronchial Neoplasms - secretion | Acromegaly - surgery | Adolescent | Growth Hormone-Secreting Pituitary Adenoma - secretion | Neuroendocrine Tumors - surgery | Aged | Carcinoid Tumor - secretion | Neuroendocrine Tumors - secretion | Multiple Endocrine Neoplasia Type 1 - surgery | Pancreatic Neoplasms - complications | Neuroendocrine Tumors | Carcinoid Tumor | Multiple Endocrine Neoplasia Type 1 | Acromegaly | Bronchial Neoplasms | Growth Hormone-Releasing Hormone | Growth Hormone-Secreting Pituitary Adenoma | Pituitary Neoplasms | Life Sciences | Pancreatic Neoplasms | Cancer
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 12/2013, Volume 98, Issue 12, pp. E1918 - E1926
Context: Targeted secretion inhibitors (TSIs), a new class of recombinant biotherapeutic proteins engineered from botulinum toxin, represent a novel approach... 
SURGERY | GH SECRETION | CELLS | MECHANISM | ENDOCRINOLOGY & METABOLISM | BOTULINUM NEUROTOXIN | TRAFFICKING | HORMONE RECEPTOR ANTAGONIST | EXPRESSION | SNAP-25 | DISEASE-ACTIVITY | Botulinum Toxins - genetics | Recombinant Fusion Proteins - pharmacology | Humans | Neoplasm Proteins - antagonists & inhibitors | Pituitary Gland - secretion | Growth Hormone-Releasing Hormone - pharmacology | Botulinum Toxins - pharmacology | Growth Hormone-Secreting Pituitary Adenoma - metabolism | Human Growth Hormone - metabolism | Pituitary Neoplasms - secretion | Protein Engineering | Neoplasm Proteins - genetics | Human Growth Hormone - genetics | Recombinant Fusion Proteins - chemistry | Secretory Pathway - drug effects | Pituitary Neoplasms - drug therapy | Adenoma - secretion | Botulinum Toxins - chemistry | Recombinant Fusion Proteins - genetics | Ligands | Growth Hormone-Releasing Hormone - analogs & derivatives | Growth Hormone-Secreting Pituitary Adenoma - pathology | Receptors, LHRH - genetics | Pituitary Gland - metabolism | SNARE Proteins - genetics | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Adenoma - metabolism | Acromegaly - etiology | Adenoma - drug therapy | Drug Design | Acromegaly - prevention & control | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Receptors, LHRH - metabolism | Tumor Cells, Cultured | Protein Structure, Tertiary | Pituitary Gland - pathology | Pituitary Neoplasms - pathology | Antineoplastic Agents - chemistry | Growth Hormone-Releasing Hormone - genetics | Pituitary Neoplasms - metabolism | Growth Hormone-Secreting Pituitary Adenoma - drug therapy | Human Growth Hormone - antagonists & inhibitors | Growth Hormone-Releasing Hormone - metabolism | Adenoma - pathology | Growth Hormone-Secreting Pituitary Adenoma - secretion | Receptors, LHRH - antagonists & inhibitors | SNARE Proteins - antagonists & inhibitors | SNARE Proteins - metabolism | Human Growth Hormone - secretion | Pituitary Gland - drug effects
Journal Article
Acta Neurochirurgica, Supplementum, ISSN 0065-1419, 01/2017, Volume 124, pp. 101 - 106
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 08/2014, Volume 307, Issue 3, pp. E326 - E334
Klotho is a transmembranal protein highly expressed in the kidneys, choroid plexus, and anterior pituitary. Klotho can also be cleaved and shed and acts as a... 
Insulin-like growth factor I | Pituitary | Acromegaly | Extracellular signal-regulated kinase | Basic fibroblast growth factor | Growth hormone | Klotho | pituitary | extracellular signal-regulated kinase | SIGNALING PATHWAYS | PHYSIOLOGY | insulin-like growth factor I | RETENTION | basic fibroblast growth factor | FACTOR RECEPTORS | PITUITARY-ADENOMAS | klotho | SOMATOSTATIN | MUTATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | TUMOR-SUPPRESSOR | acromegaly | MICE | growth hormone | BINDING | Insulin-Like Growth Factor Binding Protein 3 - genetics | Somatotrophs - metabolism | Somatotrophs - pathology | Humans | Glucuronidase - metabolism | Male | Neoplasm Proteins - antagonists & inhibitors | Somatotrophs - cytology | Insulin-Like Growth Factor I - genetics | Neoplasm Proteins - metabolism | Adenoma - metabolism | Growth Hormone-Secreting Pituitary Adenoma - metabolism | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Neoplasm Proteins - secretion | Aging | Growth Hormone - secretion | Nerve Tissue Proteins - administration & dosage | Tumor Cells, Cultured | Recombinant Proteins - metabolism | Cell Line | Growth Hormone - blood | Liver - metabolism | Cells, Cultured | Gene Expression Regulation | Rats | Somatotrophs - secretion | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Glucuronidase - genetics | Mice, Nude | Adenoma - secretion | Adenoma - pathology | Growth Hormone-Secreting Pituitary Adenoma - secretion | Mice | Growth Hormone-Secreting Pituitary Adenoma - pathology | Insulin-Like Growth Factor I - antagonists & inhibitors | Insulin-Like Growth Factor I - metabolism
Journal Article