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PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 2, p. e14694
Natural products represent a significant reservoir of unexplored chemical diversity for early-stage drug discovery. The identification of lead compounds of... 
VASCULAR DEVELOPMENT | GENETIC APPROACH | TRANSGENIC ZEBRAFISH | CELLS | EMODIN | MULTIDISCIPLINARY SCIENCES | PROTEIN-KINASE CK2 | IN-VIVO | DRUG DISCOVERY | GROWTH | NEOVASCULARIZATION | Africa, Eastern | Neovascularization, Physiologic - drug effects | Plant Extracts - chemistry | Plant Extracts - pharmacology | Drug Discovery - methods | Biological Products - pharmacology | Green Fluorescent Proteins - genetics | Zebrafish - embryology | Embryo, Nonmammalian - drug effects | Green Fluorescent Proteins - metabolism | Plants, Medicinal - chemistry | Emodin - pharmacology | Animals, Genetically Modified | Embryo, Nonmammalian - blood supply | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | Biological Assay - methods | Chick Embryo | Biological Products - isolation & purification | Neovascularization, Physiologic - physiology | Diterpenes, Abietane - pharmacology | Animals | Models, Biological | Coleus - chemistry | Zebrafish - physiology | Angiogenesis Inhibitors - isolation & purification | Medicinal plants | Biological products | Medicine, Botanic | Genetic engineering | Medicine, Herbal | Drug discovery | Angiogenesis inhibitors | Product introduction | Mass spectrometry | Chromatography | Cell proliferation | Protein kinase C | Leukocyte migration | Laboratories | Identification methods | Genomics | Transgenic plants | Casein kinase II | Regulatory approval | FLI-1 protein | Angiogenesis | Inhibition | Pharmaceutical sciences | Plants (botany) | Medical research | Fractionation | Bioassay | Research & development--R&D | Bioassays | Cell division | Zebrafish | Mass spectroscopy | Lead compounds | Biological assays | Embryos | Biological activity | Endothelial cells | Plant extracts | Emodin | Herbal medicine | Screening | Thin layer chromatography | Flavonoids | Chorioallantoic membrane | Natural products | Thin-layer chromatography | Mutation | Cell migration | Cancer | Research & development | R&D
Journal Article
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 09/2013, Volume 59, pp. 96 - 103
Inhibitory effect of the -hexane, dichloromethane, ethyl acetate, and ethanol extracts from L. (dill) cultivated under organic (AG-O) and conventional (AG-C)... 
Enzyme inhibition | Anethum graveolens | Oil | Dill | Phenolic acid | Antioxidant activity | CHOLINESTERASE | BUTYRYLCHOLINESTERASE | ESSENTIAL OILS | TURKEY | FOOD SCIENCE & TECHNOLOGY | IN-VITRO | ACETYLCHOLINESTERASE | PLANTS | TOXICOLOGY | VEGETABLES | EXTRACTS | CONSTITUENTS | Oils, Volatile - chemistry | Plant Extracts - pharmacology | Solvents - chemistry | Anethum graveolens - chemistry | Antioxidants - metabolism | Oils, Volatile - pharmacology | Iron Chelating Agents - metabolism | Butyrylcholinesterase - chemistry | Cholinesterase Inhibitors - metabolism | Butyrylcholinesterase - metabolism | Cholinesterase Inhibitors - isolation & purification | Fish Proteins - antagonists & inhibitors | Enzyme Inhibitors - metabolism | Fruit - chemistry | Enzyme Inhibitors - pharmacology | Fish Proteins - metabolism | Cholinesterase Inhibitors - analysis | Electrophorus | Enzyme Inhibitors - analysis | Food, Organic - analysis | Plant Extracts - isolation & purification | Acetylcholinesterase - chemistry | Enzyme Inhibitors - isolation & purification | Iron Chelating Agents - analysis | Iron Chelating Agents - isolation & purification | Fruit - growth & development | Cholinesterase Inhibitors - pharmacology | Antioxidants - isolation & purification | Monoterpenes - metabolism | Monoterpenes - analysis | Acetylcholinesterase - metabolism | Plant Extracts - chemistry | Anethum graveolens - metabolism | Depsides - analysis | Fungal Proteins - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Monophenol Monooxygenase - metabolism | Cinnamates - metabolism | Antioxidants - analysis | Fruit - metabolism | Depsides - metabolism | Nitric Oxide - antagonists & inhibitors | Antioxidants - pharmacology | Oils, Volatile - isolation & purification | Drug Discovery | Animals | Iron Chelating Agents - pharmacology | Horses | Cinnamates - analysis | Anethum graveolens - growth & development | Fungal Proteins - metabolism | Antioxidants | Monounsaturated fatty acids | Analysis | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2018, Volume 160, pp. 193 - 206
Due to its important role in regulating angiogenesis, vascular homeostasis and remodeling, and arteriogenesis in blood vascular and lymphatic endothelial... 
Agonist | Therapeutic angiogenesis | Drug discovery | QSAR | Agnuside | Molecular modeling | CHEMISTRY, MEDICINAL | VASCULOGENESIS | VEGF | TRANSITION | CARDIAC-HYPERTROPHY | CARDIOVASCULAR-DISEASE | PHARMACOPHORE | GENE-TRANSFER | INHIBITORS | ENDOTHELIAL GROWTH-FACTOR | Small Molecule Libraries - pharmacology | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Biological Products - pharmacology | Dose-Response Relationship, Drug | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Vitex - chemistry | Glucosides - chemistry | Molecular Structure | Quantitative Structure-Activity Relationship | Glucosides - pharmacology | Human Umbilical Vein Endothelial Cells - drug effects | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Protein Kinase Inhibitors - isolation & purification | Biological Products - isolation & purification | Glucosides - isolation & purification | Small Molecule Libraries - chemistry | Biological Products - chemistry | Neovascularization, Pathologic - drug therapy | Least-Squares Analysis | Angiogenesis Inhibitors - isolation & purification | Cell Proliferation - drug effects | Molecular Docking Simulation | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Small Molecule Libraries - isolation & purification | Angiogenesis Inhibitors - chemistry | Medical screening | Hydrogen | Health aspects | Force and energy | Endothelium | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0127063 - e0127063
Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncology indications, including ulcerative colitis and colorectal... 
CELLS | TUMOR INVASION | INFLAMMATORY-BOWEL-DISEASE | MATRIX-METALLOPROTEINASE INHIBITORS | MATRIX-METALLOPROTEINASE-9 MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | GELATINASE-B | GROWTH | GENE-EXPRESSION | DOWN-REGULATION | TNF-ALPHA | Dextran Sulfate | Epitope Mapping | Colitis, Ulcerative - enzymology | Allosteric Regulation | Colorectal Neoplasms - genetics | Humans | Colitis, Ulcerative - genetics | Gene Expression Regulation, Neoplastic | Rats, Inbred Lew | Male | Antineoplastic Agents - metabolism | Matrix Metalloproteinase 9 - metabolism | Antineoplastic Agents - isolation & purification | Matrix Metalloproteinase 9 - genetics | Antibodies, Monoclonal, Humanized - biosynthesis | Antibodies, Monoclonal, Humanized - isolation & purification | Antibodies, Monoclonal, Humanized - pharmacology | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Colitis, Ulcerative - drug therapy | Drug Evaluation, Preclinical | Disease Models, Animal | Recombinant Proteins - metabolism | Colorectal Neoplasms - enzymology | Signal Transduction | Rats | Recombinant Proteins - genetics | Matrix Metalloproteinase Inhibitors - metabolism | Recombinant Proteins - administration & dosage | Xenograft Model Antitumor Assays | Matrix Metalloproteinase Inhibitors - pharmacology | Animals | Colitis, Ulcerative - chemically induced | Mice, Nude | Hybridomas - immunology | Mice | Colorectal Neoplasms - pathology | Matrix Metalloproteinase Inhibitors - isolation & purification | Matrix Metalloproteinase 9 - administration & dosage | Monoclonal antibodies | Inflammation | Metastasis | Health aspects | Colorectal cancer | Ulcerative colitis | Drugs | Animal models | Inflammatory bowel diseases | Matrix metalloproteinases | Disease | Toxicity | Colorectal carcinoma | Biology | Biochemistry | Matrix metalloproteinase | Drug development | Kinases | Metastases | Allosteric properties | Rodents | Surgery | Sodium sulfate | Xenografts | Tumorigenesis | Metalloproteinase | Inhibition | Drug therapy | Growth factors | Medical research | Cytokines | Neutrophils | Stroma | Metabolism | Patients | Gelatinase B | Inflammatory bowel disease | Dextran | Inhibitors | Sodium | Sulfate | Tumors | Cancer | Apoptosis | Index Medicus
Journal Article
Phytochemistry, ISSN 0031-9422, 2006, Volume 67, Issue 14, pp. 1539 - 1546
Four aldose reductase inhibitors were isolated from the ethanolic extract of the shoots of . These compounds were identified as 4,5-di- -caffeoylquinic acid,... 
Davidigenin | 4,5-Di- O-caffeoylquinic acid | Aldose reductase inhibitors | Aldose reductase | Artemisia dracunculus | Asteraceae | 2′,4′-Dihydroxy-4-methoxydihydrochalcone | 6-Demethoxycapillarisin | Dihydrochalcones | Russian tarragon | 4,5-Di-O-caffeoylquinic acid | dihydrochalcones | OXIDATIVE STRESS | NON-HYDANTOIN | CAFFEOYLQUINIC ACIDS | PHENOLIC-COMPOUNDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | davidigenin | aldose reductase | 2 ',4 '-dihydroxy-4-methoxydihydrochalcone | CYNARA-SCOLYMUS L | PLANT SCIENCES | aldose reductase inhibitors | NON-CARBOXYLIC ACID | IN-VITRO | 6-demethoxycapillarisin | 4,5-di-O-caffeoylquinic acid | FIBROBLAST GROWTH-FACTOR | POTENT ORAL ACTIVITY | DIABETIC-RAT MODELS | Chalcones - chemistry | Plant Extracts - chemistry | Quinic Acid - analogs & derivatives | Aldehyde Reductase - antagonists & inhibitors | Artemisia - chemistry | Enzyme Inhibitors - pharmacology | Quinic Acid - isolation & purification | Quinic Acid - chemistry | Chalcones - isolation & purification | Enzyme Inhibitors - isolation & purification | Chromones - chemistry | Enzyme Inhibitors - chemistry | Chalcones - pharmacology | Aldehyde Reductase - metabolism | Biological Assay | Chromones - isolation & purification | Monosaccharides - pharmacology | Molecular Structure | Quinic Acid - pharmacology | Chromones - pharmacology | Monosaccharides - chemistry | Monosaccharides - isolation & purification | Sugars | Monosaccharides
Journal Article
Glycobiology, ISSN 0959-6658, 05/2007, Volume 17, Issue 5, pp. 541 - 552
Journal Article
Marine Drugs, ISSN 1660-3397, 04/2015, Volume 13, Issue 4, pp. 2347 - 2375
Thirteen new and eighteen known natural products were isolated from a bloom material of an assembly of various Microcystis spp. collected in November, 2008,... 
Aeruginosin | Microphycin | Cyclic peptide | Anabaenopeptin | Nuclear magnetic resonance | Mass spectrometry | Microcystis | Micropeptin | Protease inhibitor | SECONDARY METABOLITES | CHEMISTRY, MEDICINAL | OSCILLATORIA-AGARDHII | DALTON RESERVOIR | AMINO-ACIDS | WATER BLOOM | DIVERSITY | CYANOBACTERIUM PLANKTOTHRIX-RUBESCENS | PROTEASE INHIBITORS | MASS-SPECTROMETRY | CYCLIC-PEPTIDES | Harmful Algal Bloom | Peptides, Cyclic - isolation & purification | Microcystis - chemistry | Chymotrypsin - metabolism | Stereoisomerism | Bacteriocins - chemistry | Microcystis - growth & development | Trypsin Inhibitors - pharmacology | Trypsin Inhibitors - isolation & purification | Guanidines - pharmacology | Peptides, Cyclic - pharmacology | Depsipeptides - pharmacology | Chromatography, High Pressure Liquid | Protein Prenylation | Peptides, Cyclic - chemistry | Ponds - microbiology | Serine Proteinase Inhibitors - isolation & purification | Urea - chemistry | Tandem Mass Spectrometry | Trypsin Inhibitors - chemistry | Serine Proteinase Inhibitors - chemistry | Spectrometry, Mass, Electrospray Ionization | Urea - analogs & derivatives | Nuclear Magnetic Resonance, Biomolecular | Molecular Structure | Oligopeptides - chemistry | Depsipeptides - chemistry | Serine Proteinase Inhibitors - pharmacology | Guanidines - isolation & purification | Marine Toxins - isolation & purification | Dipeptides - pharmacology | Depsipeptides - isolation & purification | Marine Toxins - pharmacology | Dipeptides - chemistry | Microcystis - isolation & purification | Guanidines - chemistry | Oligopeptides - isolation & purification | Marine Toxins - chemistry | Chymotrypsin - antagonists & inhibitors | Bacteriocins - pharmacology | Israel | Oligopeptides - pharmacology | Bacteriocins - isolation & purification | Urea - pharmacology | Aquaculture | Dipeptides - isolation & purification | Urea - isolation & purification | micropeptin | protease inhibitor | mass spectrometry | aeruginosin | microphycin | cyclic peptide | anabaenopeptin | nuclear magnetic resonance
Journal Article
Nature Cell Biology, ISSN 1465-7392, 06/2005, Volume 7, Issue 6, pp. 591 - 600
Journal Article