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ACS CHEMICAL NEUROSCIENCE, ISSN 1948-7193, 08/2019, Volume 10, Issue 8, pp. 3575 - 3589
Guanabenz (GBZ), an alpha(2)-adrenergic agonist, demonstrated off-target effects that restored protein homeostasis and ameliorated pathobiology in experimental... 
SELECTIVE-INHIBITION | POLYGLUTAMINE | CHEMISTRY, MEDICINAL | autophagy | PHOSPHORYLATION | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | Guanabenz | TRANSLATIONAL CONTROL | Phospho-eIF2 alpha | mRNA translation | UNFOLDED PROTEIN RESPONSE | MESSENGER-RNA | Huntingtin aggregation | integrated stress response (ISR) | EIF2-ALPHA | EXPRESSION
Journal Article
Science, ISSN 0036-8075, 04/2015, Volume 348, Issue 6231, pp. 239 - 242
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2013, Volume 55, pp. 64 - 75
Abstract C. elegans and D. rerio expressing mutant TAR DNA Binding Protein 43 (TDP-43) are powerful in vivo animal models for the genetics and pharmacology of... 
Neurology | C. elegans | Genetic models | Neurodegeneration | TDP-43 | ALS | ER stress | Small molecules | Zebrafish | SURVIVAL | METHYLENE-BLUE | OXIDATIVE STRESS | RNA | AMYOTROPHIC-LATERAL-SCLEROSIS | ENDOPLASMIC-RETICULUM STRESS | NEUROSCIENCES | CAENORHABDITIS-ELEGANS | INHIBITION | HEXANUCLEOTIDE REPEAT | Guanabenz - therapeutic use | Neurons - pathology | Thiourea - therapeutic use | Reactive Oxygen Species - metabolism | Neurotoxicity Syndromes - genetics | Humans | Green Fluorescent Proteins - genetics | Thiourea - pharmacology | Endoplasmic Reticulum Stress - genetics | RNA, Messenger - metabolism | Neurotoxicity Syndromes - drug therapy | DNA-Binding Proteins - metabolism | Neurotoxicity Syndromes - pathology | Time Factors | Escape Reaction - drug effects | Neurons - drug effects | Disease Models, Animal | Green Fluorescent Proteins - metabolism | Endoplasmic Reticulum Stress - drug effects | Microinjections | Animals, Genetically Modified | DNA-Binding Proteins - genetics | Mutation - genetics | Cinnamates - pharmacology | Escape Reaction - physiology | Caenorhabditis elegans | Guanabenz - pharmacology | Animals | Analysis of Variance | Movement Disorders - etiology | Neurotoxicity Syndromes - physiopathology | Touch - physiology | Zebrafish Proteins - genetics | Caenorhabditis elegans Proteins - genetics | Cinnamates - therapeutic use | Phenazines | Thiourea - analogs & derivatives | Movement Disorders - drug therapy | Amyotrophic lateral sclerosis | Neurons | Analysis | Protein binding | Index Medicus
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 08/2000, Volume 23, Issue 2, pp. 138 - 150
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5119 - 5134
A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human... 
MEDICINE, RESEARCH & EXPERIMENTAL | VISUAL CYCLE | PHAGOCYTOSIS | OPTICAL COHERENCE TOMOGRAPHY | ABCA4 | RHODOPSIN | MECHANISMS | MICE | DOXAZOSIN | LONG-TERM TREATMENT | CLINICAL-EXPERIENCE | Receptors, Adrenergic, alpha-2 - genetics | Guanabenz - therapeutic use | Reactive Oxygen Species | Receptor, Serotonin, 5-HT2A - genetics | Doxazosin - pharmacology | Humans | Photoreceptor Cells, Vertebrate - drug effects | Adrenergic alpha-Antagonists - therapeutic use | Macaca fascicularis | Adrenergic alpha-Antagonists - pharmacology | Molecular Targeted Therapy | Photoreceptor Cells, Vertebrate - physiology | Macular Degeneration - drug therapy | Adenylyl Cyclase Inhibitors | Adrenergic alpha-Agonists - therapeutic use | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - deficiency | Photoreceptor Cells, Vertebrate - radiation effects | ATP-Binding Cassette Transporters - genetics | Adenine - therapeutic use | Doxazosin - therapeutic use | Nerve Tissue Proteins - biosynthesis | Receptors, Adrenergic, alpha-2 - biosynthesis | Drug Evaluation, Preclinical | Disease Models, Animal | Macular Degeneration - prevention & control | Receptor, Serotonin, 5-HT2A - biosynthesis | Adenine - analogs & derivatives | Signal Transduction | Cell Survival | Light - adverse effects | Serotonin Antagonists - therapeutic use | Receptors, G-Protein-Coupled - biosynthesis | Adenine - pharmacology | Serotonin Antagonists - pharmacology | Nerve Tissue Proteins - genetics | Mice, Knockout | Guanabenz - pharmacology | Animals | Macular Degeneration - congenital | Macular Degeneration - genetics | Adrenergic alpha-Agonists - pharmacology | Mice | Mice, Inbred BALB C | Receptors, G-Protein-Coupled - genetics | Photoreceptor Cells, Vertebrate - pathology | Alcohol Oxidoreductases - deficiency | Macular degeneration | Retinal degeneration | Research | Studies | Pathology | Signal transduction | Disease | Genes | Retina | Photoreceptors | Pharmacology
Journal Article