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Cellular and Molecular Life Sciences, ISSN 1420-682X, 1/2014, Volume 71, Issue 2, pp. 331 - 348
Programmed necrosis is important in many (patho)physiological settings. For specific therapeutic intervention, however, a better knowledge is required whether... 
Life Sciences | Biochemistry, general | Life Sciences, general | Necroptosis | TNF | PARP-1 | Biomedicine general | Programmed necrosis | Cell Biology | APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | PARP | CELL BIOLOGY | INHIBITION | RECEPTOR-INTERACTING PROTEIN | POLYMERASE-1 | CASPASES | EXPRESSION | Free Radical Scavengers - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Calpain - metabolism | Apoptosis - drug effects | Humans | Antineoplastic Agents, Alkylating - pharmacology | Guanidines - pharmacology | JNK Mitogen-Activated Protein Kinases - metabolism | Necrosis | MCF-7 Cells | RNA Interference | HEK293 Cells | Benzamides - pharmacology | Cell Line | Ceramides - metabolism | Jurkat Cells | Nuclear Pore Complex Proteins - metabolism | Piperazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | HT29 Cells | Phthalazines - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Cathepsins - metabolism | Mice | HeLa Cells | Methyl Methanesulfonate - pharmacology | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Proteases | Tumor necrosis factor | Cell death | Biochemistry | Phosphotransferases | Sugars | Monosaccharides | Proteins | Gangrene | Signal transduction | Apoptosis
Journal Article
American Journal of Kidney Diseases, ISSN 0272-6386, 2010, Volume 55, Issue 5, pp. 928 - 940
Diabetic nephropathy is the leading cause of end-stage renal disease, and both the incidence and prevalence of diabetic nephropathy continue to increase.... 
Nephrology | advanced glycation | Diabetic nephropathy | therapy | CONTROLLED-TRIAL | DB/DB MICE | PKC-BETA INHIBITOR | KINASE-C-ALPHA | CONVERTING ENZYME-INHIBITORS | TISSUE GROWTH-FACTOR | EARLY RENAL-DISEASE | UROLOGY & NEPHROLOGY | CROSS-LINK BREAKER | GLYCATION END-PRODUCTS | NADPH OXIDASE INHIBITOR | Receptors, Immunologic - physiology | Humans | Diabetic Nephropathies - drug therapy | Nitric Oxide Synthase - antagonists & inhibitors | Guanidines - pharmacology | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Diabetic Nephropathies - physiopathology | Transforming Growth Factor beta - antagonists & inhibitors | Pyridoxamine - pharmacology | Pentoxifylline - pharmacology | Diabetic Nephropathies - prevention & control | Receptor for Advanced Glycation End Products | Endothelin Receptor Antagonists | Glycosaminoglycans - pharmacology | Amides - pharmacology | Hydrazines - pharmacology | Kidney - drug effects | Connective Tissue Growth Factor - antagonists & inhibitors | Diabetic Nephropathies - metabolism | NADPH Oxidases - antagonists & inhibitors | Phosphodiesterase Inhibitors - pharmacology | Clinical Trials as Topic | Pyrimidines - pharmacology | Vitamin B Complex - pharmacology | Disease Progression | Animals | Glycation End Products, Advanced - pharmacology | Glycation End Products, Advanced - blood | Pyridines - pharmacology
Journal Article
Apoptosis, ISSN 1360-8185, 4/2013, Volume 18, Issue 4, pp. 393 - 408
Journal Article
Nephrology Dialysis Transplantation, ISSN 0931-0509, 5/2009, Volume 24, Issue 5, pp. 1429 - 1435
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2008, Volume 587, Issue 1, pp. 129 - 134
The present study was performed to examine the involvement of nitric oxide (NO) signaling pathway in the anti-convulsant effect of adenosine against... 
Sodium nitroprusside | Adenosine | L-NAME | Aminoguanidine | Pentylenetetrazol | 7-NI | Seizure threshold | Sildenafil | L-arginine | Methylene blue | pentylenetetrazol | seizure threshold | RAT | POSSIBLE INVOLVEMENT | aminoguanidine | RELEASE | FORCED SWIMMING TEST | sildenafil | GUANYLATE-CYCLASE | adenosine | methylene blue | sodium nitroprusside | CONVULSIVE BEHAVIOR | ARGININE | PHARMACOLOGY & PHARMACY | CGMP PATHWAY | BRAIN | Seizures - prevention & control | Phosphodiesterase 5 Inhibitors | Guanidines - pharmacology | Male | Nitroprusside - pharmacology | Sulfones - pharmacology | Anticonvulsants - pharmacology | Seizures - chemically induced | Cyclic AMP - physiology | Sildenafil Citrate | Cyclic Nucleotide Phosphodiesterases, Type 5 - physiology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Nitric Oxide Donors - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Nitric Oxide - physiology | Adenosine - pharmacology | Methylene Blue - pharmacology | Piperazines - pharmacology | Indazoles - pharmacology | Animals | Signal Transduction - drug effects | Arginine - pharmacology | Convulsants | Mice | Pentylenetetrazole | Sodium nitroferricyanide | Cyanides | Seizures (Medicine) | Nitric oxide | Index Medicus
Journal Article
Neuroscience, ISSN 0306-4522, 2014, Volume 268, pp. 236 - 246
Highlights • l -NAME, aminoguanidine and sildenafil prevent LPS-induced depressive-like behavior. • l -Arginine, a NO precursor, did not prevent LPS-induced... 
Neurology | nitric oxide | depressive-like behavior | neuroinflammation | BDNF | LPS | oxidative stress | Depressive-like behavior | Oxidative stress | Neuroinflammation | Nitric oxide | ACTIVATION | GUANOSINE-MONOPHOSPHATE PATHWAY | PREPULSE INHIBITION | NITROSATIVE STRESS | MAJOR DEPRESSION | KAPPA-B | NEUROSCIENCES | L-TRYPTOPHAN | ANIMAL-MODEL | ACOUSTIC STARTLE | PITUITARY-ADRENAL AXIS | Oxidative Stress - physiology | Nitric Oxide Synthase - antagonists & inhibitors | Depressive Disorder - drug therapy | Guanidines - pharmacology | Male | Sulfones - pharmacology | Lipopolysaccharides | Brain - metabolism | Sildenafil Citrate | Interleukin-1beta - metabolism | Behavior, Animal - drug effects | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | Disease Models, Animal | NG-Nitroarginine Methyl Ester - pharmacology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Behavior, Animal - physiology | Depressive Disorder - metabolism | Piperazines - pharmacology | Brain - drug effects | Animals | Cyclic GMP - metabolism | Signal Transduction - drug effects | Arginine - pharmacology | Depressive Disorder - prevention & control | Signal Transduction - physiology | Mice | Nitric Oxide Synthase - metabolism | Oxidative Stress - drug effects | Imipramine - pharmacology | Nitric Oxide - metabolism | Antidepressants | Mitogens | Depression, Mental | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 05/2012, Volume 341, Issue 2, pp. 326 - 339
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 40, pp. 28641 - 28655
Journal Article
Pure and Applied Chemistry, ISSN 0033-4545, 07/2017, Volume 89, Issue 8, pp. 1007 - 1016
Guanidine derivatives are widely used antidiabetic drugs. Metformin (biguanide) is the first-line therapy for the type 2 diabetes mellitus due to its... 
computer-aided molecular design | heterocyclic chemistry | diabetes | Mendeleev XX | medicinal chemistry | structure-activity | Clinical trials | Hypoglycemic agents | Chemical properties | Methods
Journal Article