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1. Full Text Insights into the biological functions of Dock family guanine nucleotide exchange factors
by Laurin, Mélanie and Côté, Jean-François
Genes and Development, ISSN 0890-9369, 03/2014, Volume 28, Issue 6, pp. 533 - 547
Rho GTPases play key regulatory roles in many aspects of embryonic development, regulating processes such as differentiation, proliferation, morphogenesis, and... 
Dock180 | Elmo | Myoblast fusion | Mouse models | Neurogenesis | Migration | mouse models | HUMAN-BREAST-CANCER | MEMBRANE RECRUITMENT | NEUTROPHIL CHEMOTAXIS | DEVELOPMENTAL BIOLOGY | RAC ACTIVATOR | myoblast fusion | CELL BIOLOGY | LINKED MENTAL-RETARDATION | CELL-MIGRATION | IN-VIVO | GENETICS & HEREDITY | neurogenesis | migration | ADAMS-OLIVER SYNDROME | RHO GTPASES | Neurogenesis - genetics | Guanine Nucleotide Exchange Factors - genetics | Animals | Disease - genetics | Guanine Nucleotide Exchange Factors - metabolism | rho GTP-Binding Proteins - genetics | Humans | rho GTP-Binding Proteins - metabolism | Signal Transduction - genetics | Enzyme Activation | Growth and Development - genetics | Cell proliferation | Usage | Genetic disorders | Therapeutics | Mice | Genetic aspects | Research | Risk factors | Guanine | Homeopathy | Materia medica and therapeutics | Index Medicus | Review
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2. Full Text Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells
by Abiko, Hiyori and Fujiwara, Sachiko and Ohashi, Kazumasa and Hiatari, Ryuichi and Mashiko, Toshiya and Sakamoto, Naoya and Sato, Masaaki and Mizuno, Kensaku
Journal of Cell Science, ISSN 0021-9533, 2015, Volume 128, Issue 9, pp. 1683 - 1695
Cyclic stretch is an artificial model of mechanical force loading, which induces the reorientation of vascular endothelial cells and their stress fibers in a... 
Mechanotransduction | Solo/ARHGEF40 | Rho-GEF | Endothelial cells | Cyclic stretch | VE-cadherin | MIGRATION | PP125(FAK) | ACTIVATION | PHOSPHORYLATION | CELL BIOLOGY | ORGANIZATION | FORCE | SHEAR-STRESS | SMALL GTPASES | EXPRESSION | Actin Cytoskeleton - metabolism | Human Umbilical Vein Endothelial Cells - drug effects | Cadherins - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Stress Fibers - drug effects | Cell Count | Humans | Actins - metabolism | Stress, Mechanical | Tensile Strength - drug effects | rhoA GTP-Binding Protein - metabolism | Cell Adhesion - drug effects | Enzyme Activation - drug effects | Antigens, CD - metabolism | Gene Knockdown Techniques | Stress Fibers - metabolism | Egtazic Acid - pharmacology | Actin Cytoskeleton - drug effects | Guanine Nucleotide Exchange Factors - metabolism | Rho Guanine Nucleotide Exchange Factors - metabolism | RNA, Small Interfering - metabolism | Index Medicus
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3. Full Text Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors
by Xun Shang and Fillipo Marchioni and Chris R. Evelyn and Nisha Sipes and Xuan Zhou and William Seibel and Matthew Wortman and Yi Zheng
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 8, pp. 3155 - 3160
The G-protein-mediated Rho guanine nucleotide exchange factor (GEF)-Rho GTPase signaling axis has been implicated in human pathophysiology and is a potential... 
Proteins | Molecules | 3T3 cells | NIH 3T3 cells | Drug interactions | Stress fibers | Actins | Biochemistry | Breast cancer | Focal adhesions | TRANSFORMATION | HETEROTRIMERIC G-PROTEINS | GTPASES | LEUKEMIA-ASSOCIATED RHO | MULTIDISCIPLINARY SCIENCES | BIOLOGY | DBL ONCOGENE PRODUCT | FAMILY PROTEINS | CANCER | DRUGGABLE GENOME | RATIONAL DESIGN | Sequence Homology, Amino Acid | Amino Acid Sequence | Cell Movement - drug effects | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | Humans | Neoplasm Invasiveness - prevention & control | Cell Line, Tumor | Cell Division - drug effects | Chemical inhibitors | Pharmacology | Research | G proteins | Properties | Guanosine triphosphatase | Guanine | Signal transduction | Enzymes | Glycoproteins | Cells | Index Medicus | Biological Sciences
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4. Full Text Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
by Marei, Hadir and Carpy, Alejandro and Woroniuk, Anna and Vennin, Claire and White, Gavin and Timpson, Paul and Macek, Boris and Malliri, Angeliki
Nature Communications, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, pp. 10664 - 10664
The small GTPase Rac1 has been implicated in the formation and dissemination of tumours. Upon activation by guanine nucleotide exchange factors (GEFs), Rac1... 
CDC42 | TIAM1 | COMPLEX-FORMATION | INVASION | PROTEIN FLIGHTLESS-I | MULTIDISCIPLINARY SCIENCES | LEUCINE-RICH REPEAT | FAMILY PROTEINS | RHO-GTPASES | SMALL GTPASES | FOCAL ADHESIONS | Cell Line | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Humans | Actins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Guanine Nucleotide Exchange Factors - metabolism | Mice | T-Lymphoma Invasion and Metastasis-inducing Protein 1 | rac1 GTP-Binding Protein - metabolism | Cell Movement | rac1 GTP-Binding Protein - genetics | Index Medicus
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5. Full Text BLOC-3 Mutated in Hermansky-Pudlak Syndrome Is a Rab32/38 Guanine Nucleotide Exchange Factor
by Gerondopoulos, Andreas and Langemeyer, Lars and Liang, Jin-Rui and Linford, Andrea and Barr, Francis A
Current Biology, ISSN 0960-9822, 11/2012, Volume 22, Issue 22, pp. 2135 - 2139
Hermansky-Pudlak syndrome (HPS) is a human disease characterized by partial loss of pigmentation and impaired blood clotting [ ]. These symptoms are caused by... 
MELANOSOME BIOGENESIS | TRANSPORT | PROTEIN | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEX-3 BLOC-3 | HPS1 | TRAFFICKING | EARLY ENDOSOMES | LYSOSOME-RELATED ORGANELLES | PIGMENT | CELL BIOLOGY | rab GTP-Binding Proteins - metabolism | Amino Acid Sequence | Guanine Nucleotide Exchange Factors - genetics | Hermanski-Pudlak Syndrome - metabolism | Melanosomes | Membrane Proteins - genetics | Humans | Molecular Sequence Data | rab GTP-Binding Proteins - genetics | Proteins - genetics | Hermanski-Pudlak Syndrome - genetics | Proteins - metabolism | Guanine Nucleotide Exchange Factors - metabolism | Membrane Proteins - metabolism | Mutation | Index Medicus | Blood coagulation | Enzymes | Clathrin | endosomes | Hermansky-Pudlak syndrome | Organelles | Pigmentation | Recruitment | guanine nucleotide exchange factor | Granules | Platelets | Melanin | Guanosinetriphosphatase | Report
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6. Full Text Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors
by Yeh, Brian J and Lim, Wendell A and Deb, Anrica and Rutigliano, Robert J and Bar-Sagi, Dafna
Nature, ISSN 0028-0836, 05/2007, Volume 447, Issue 7144, pp. 596 - 600
Eukaryotic cells mobilize the actin cytoskeleton to generate a remarkable diversity of morphological behaviours, including motility, phagocytosis and... 
CIRCUITS | ACTIVATION | COMPLEX | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | RHO GTPASES | SIGNALS | CASCADE | N-WASP | MECHANISMS | DOMAINS | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | Fibroblasts - enzymology | Signal Transduction | Rats | cdc42 GTP-Binding Protein - metabolism | Animals | Guanine Nucleotide Exchange Factors - metabolism | rho GTP-Binding Proteins - metabolism | Fibroblasts - cytology | Pseudopodia - physiology | Cell Shape - physiology | Fibroblasts - metabolism | Hypothesis testing | Proteins | Eukaryotes | Catalysis | Cellular biology | Genomics | Index Medicus
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7. Full Text Phosphorylation-dependent regulation of connecdenn/DENND1 guanine nucleotide exchange factors
by Kulasekaran, Gopinath and Nossova, Nadya and Marat, Andrea L and Lund, Ingrid and Cremer, Christopher and Ioannou, Maria S and McPherson, Peter S
Journal of Biological Chemistry, ISSN 0021-9258, 07/2015, Volume 290, Issue 29, pp. 17999 - 18008
Connecdenn 1/2 are DENN (differentially expressed in normal and neoplastic cells) domain-bearing proteins that function as GEFs (guanine nucleotide exchange... 
PATHWAYS | CELLS | RAB | PROTEIN | GTPASES | GLUT4 TRANSLOCATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | DENN DOMAIN | BINDING | FAMILY | Protein Structure, Tertiary | rab GTP-Binding Proteins - metabolism | Phosphorylation | Death Domain Receptor Signaling Adaptor Proteins - chemistry | Signal Transduction | Humans | 3T3-L1 Cells | Protein Interaction Maps | 14-3-3 Proteins - metabolism | Insulin - metabolism | Animals | Guanine Nucleotide Exchange Factors - metabolism | HEK293 Cells | Mice | Proto-Oncogene Proteins c-akt - metabolism | Death Domain Receptor Signaling Adaptor Proteins - metabolism | Guanine Nucleotide Exchange Factors - chemistry | Index Medicus | endosome | Rab | Rab35 | connecdenn | DENN domain | endocytosis | intracellular trafficking | membrane trafficking | Cell Biology | guanine nucleotide exchange factor (GEF)
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8. Full Text Chlamydial entry involves TARP binding of guanine nucleotide exchange factors
by Lane, B. Josh and Mutchler, Charla and Al Khodor, Souhaila and Grieshaber, Scott S and Carabeo, Rey A
PLoS Pathogens, ISSN 1553-7366, 03/2008, Volume 4, Issue 3, pp. e1000014 - e1000014
Chlamydia trachomatis attachment to cells induces the secretion of the elementary body-associated protein TARP (Translocated Actin Recruiting Protein). TARP... 
HOST-CELLS | ACTIN | PHOSPHATIDYLINOSITOL 3-KINASE | TRACHOMATIS | PH DOMAIN | MICROBIOLOGY | BRUTONS TYROSINE KINASE | INVASION | VIROLOGY | HELA-CELLS | RAC | PLECKSTRIN HOMOLOGY DOMAIN | PARASITOLOGY | Phosphorylation | Signal Transduction | Humans | Actins - metabolism | Nuclear Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | HeLa Cells - microbiology | Endocytosis - physiology | Tyrosine - metabolism | Transfection | Bacterial Adhesion - physiology | Guanine Nucleotide Exchange Factors - metabolism | Chlamydia trachomatis - pathogenicity | Protein Binding | Cytoskeletal Proteins - metabolism | Chlamydia trachomatis - physiology | Proto-Oncogene Proteins c-akt - metabolism | Host-Pathogen Interactions - physiology | Index Medicus | Proteins | Heparan sulfate | Sexually transmitted diseases | STD | Disease | Ligands | Infections | Kinases | Experiments
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9. Full Text Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration
by Zaritsky, Assaf and Tseng, Yun Yu and Rabadán, M. Angeles and Krishna, Shefali and Overholtzer, Michael and Danuser, Gaudenz and Hall, Alan
Journal of Cell Biology, ISSN 0021-9525, 06/2017, Volume 216, Issue 6, pp. 1543 - 1556
Efficient collective migration depends on a balance between contractility and cytoskeletal rearrangements, adhesion, and mechanical cell-cell communication,... 
P114RHOGEF | JUNCTION FORMATION | ACTIVATION | EPITHELIAL-CELLS | PATHWAY | MECHANICAL FORCES | NOTCH | GUIDANCE | RHO-GTPASES | MYOSIN-II | CELL BIOLOGY | Cell Line | Guanine Nucleotide Exchange Factors - genetics | Bronchi - enzymology | Signal Transduction | rho GTP-Binding Proteins - genetics | Humans | SOS1 Protein - metabolism | rhoA GTP-Binding Protein - metabolism | rhoC GTP-Binding Protein | Rho Guanine Nucleotide Exchange Factors - genetics | Wound Healing | rhoA GTP-Binding Protein - genetics | Actomyosin - metabolism | Phenotype | Transfection | RNA Interference | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | rho GTP-Binding Proteins - metabolism | Epithelial Cells - enzymology | SOS1 Protein - genetics | Rho Guanine Nucleotide Exchange Factors - metabolism | Bronchi - cytology | Cell Movement | Cues | Exchanging | Intercellular signalling | Leukocyte migration | Actomyosin | Contractility | Back propagation | RhoA protein | Gene expression | Clustering | Cell interactions | Guanine | Cell adhesion & migration | Genotype & phenotype | Molecules | Myosin | Monolayers | Clusters | Cytoskeleton | Guanine nucleotide exchange factor | Cell migration | Index Medicus
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10. Full Text The Guanine Nucleotide Exchange Factors Trio, Ect2, and Vav3 Mediate the Invasive Behavior of Glioblastoma
by Salhia, Bodour and Tran, Nhan L and Chan, Amanda and Wolf, Amparo and Nakada, Mitsutoshi and Rutka, Fiona and Ennis, Matthew and McDonough, Wendy S and Berens, Michael E and Symons, Marc and Rutka, James T
American Journal of Pathology, The, ISSN 0002-9440, 2008, Volume 173, Issue 6, pp. 1828 - 1838
Malignant gliomas are characterized by their ability to invade normal brain tissue. We have previously shown that the small GTPase Rac1 plays a role in both... 
Pathology | NEUROLOGICAL TUMORS | ASTROCYTOMA | GENETIC-BASIS | ACTIVATION | MALIGNANT-TRANSFORMATION | RAC | CELL-MIGRATION | PKC-ZETA | AXON GUIDANCE | PATHOLOGY | RHO-GTPASES | RNA, Small Interfering - genetics | Cell Proliferation | Proto-Oncogene Proteins c-vav - genetics | Rats, Wistar | Humans | Gene Expression Profiling | Brain - physiology | Cell Movement - physiology | Guanine Nucleotide Exchange Factors - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Reproducibility of Results | Neoplasm Invasiveness | Protein-Serine-Threonine Kinases - genetics | Rats | Proto-Oncogene Proteins - genetics | Animals | Glioblastoma - pathology | Cell Line, Tumor | Databases, Nucleic Acid | Glioblastoma - physiopathology | Proto-Oncogene Proteins c-vav - metabolism | rac1 GTP-Binding Protein - metabolism | RNA, Small Interfering - metabolism | rac1 GTP-Binding Protein - genetics | Index Medicus | Abridged Index Medicus | Regular
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11. Full Text Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB
by Guo, Zhong and Hou, Xiaomin and Goody, Roger S and Itzen, Aymelt
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 45, pp. 32466 - 32474
Small G-proteins of the Ras superfamily control the temporal and spatial coordination of intracellular signaling networks by acting as molecular on/off... 
COMPLEX | ACTIVATION | LEGIONELLA | DOMAIN | Guanine Nucleotide Exchange Factor (GEF) | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Rab Proteins | Small GTPases | Intracellular Trafficking | Enzyme Mechanisms | REGULATOR | GDP | STRUCTURAL BASIS | POLARIZED MEMBRANE-TRANSPORT | GTPASE | Recombinant Proteins - metabolism | rab GTP-Binding Proteins - metabolism | Humans | rab3A GTP-Binding Protein - metabolism | Protein-Serine-Threonine Kinases - genetics | Multienzyme Complexes - metabolism | Recombinant Proteins - chemistry | rab GTP-Binding Proteins - genetics | rab3A GTP-Binding Protein - chemistry | Guanosine Triphosphate - metabolism | Multienzyme Complexes - genetics | Recombinant Proteins - genetics | rab3A GTP-Binding Protein - genetics | Multienzyme Complexes - chemistry | Guanosine Triphosphate - genetics | rab GTP-Binding Proteins - chemistry | Guanosine Triphosphate - chemistry | Protein-Serine-Threonine Kinases - chemistry | Catalysis | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | Membrane Biology
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12. Full Text SH3-class Ras guanine nucleotide exchange factors are essential for Aspergillus fumigatus invasive growth
by Martin-Vicente, Adela and Souza, Ana Camila Oliveira and Al Abdallah, Qusai and Ge, Wenbo and Fortwendel, Jarrod R
Cellular Microbiology, ISSN 1462-5814, 2019, Volume 21, Issue 6, pp. e13013 - e13013
Proper hyphal morphogenesis is essential for the establishment and progression of invasive disease caused by filamentous fungi. In the human pathogen... 
germination | guanine nucleotide exchange factor | virulence | Ras | aspergillosis | Aspergillus fumigatus | polarity | BUD-SITE-SELECTION | HIGH-TEMPERATURE | MICROBIOLOGY | MEMBRANE LOCALIZATION | CELL BIOLOGY | CANDIDA-ALBICANS | CDC25 | ROLES | DIFFERENTIATION | GTPASE | HYPHAL GROWTH | Proteins | Mycoses | Development and progression | Growth | Guanine | Exchanging | Phenotypes | Cell walls | Virulence | Ras protein | Morphogenesis | Fungi | Signaling | Cascades | Aspergillosis | Polarity | Guanine nucleotide exchange factor
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13. Full Text Rho-specific Guanine nucleotide exchange factors (Rho-GEFs) inhibition affects macrophage phenotype and disrupts Golgi complex
by Chen, Wei and Zhao, Yue and Li, Xian C and Kubiak, Jacek Z and Ghobrial, Rafik M and Kloc, Malgorzata
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 12/2017, Volume 93, pp. 12 - 24
Macrophages play crucial role in tissue homeostasis and the innate and adaptive immune response. Depending on the state of activation macrophages acquire... 
Cytoskeleton | Actin | Golgi complex | RhoA | Macrophage | POLARITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | G-PROTEINS | MONOCYTES | RECEPTOR | CELL-SHAPE | CELL BIOLOGY | ELEMENTS | PATHWAY | ARCHITECTURE | MODULATION | rho GTP-Binding Proteins - genetics | rho-Associated Kinases - genetics | Mice, Transgenic | Rho Guanine Nucleotide Exchange Factors - genetics | Animals | rho-Associated Kinases - metabolism | Macrophages, Peritoneal - ultrastructure | rho GTP-Binding Proteins - metabolism | Organic Chemicals - pharmacology | Golgi Apparatus - metabolism | Mice | Rho Guanine Nucleotide Exchange Factors - metabolism | Macrophages, Peritoneal - metabolism | Golgi Apparatus - ultrastructure | Phagocytosis | Golgi Apparatus - genetics | Index Medicus | Life Sciences | Genetics
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14. Full Text Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule
by Tsai, Jordan C and Miller-Vedam, Lakshmi E and Anand, Aditya A and Jaishankar, Priyadarshini and Nguyen, Henry C and Renslo, Adam R and Frost, Adam and Walter, Peter
Science, ISSN 0036-8075, 03/2018, Volume 359, Issue 6383, pp. 1483 - 1483
Regulation by the integrated stress response (ISR) converges on the phosphorylation of translation initiation factor eIF2 in response to a variety of stresses.... 
EUKARYOTIC TRANSLATION INITIATION | INHIBITION | ALPHA-SUBUNIT | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | REGULATORY SUBCOMPLEX | CRYO-EM | FACTOR 2B | EIF2-ALPHA | INTEGRATED STRESS-RESPONSE | MAMMALIAN-CELLS | Memory - drug effects | Phosphorylation | Recombinant Proteins - ultrastructure | Escherichia coli | Humans | Cyclohexylamines - chemistry | Recombinant Proteins - chemistry | Acetamides - pharmacology | Recombinant Proteins - genetics | Nootropic Agents - chemistry | Protein Folding | Cryoelectron Microscopy | Eukaryotic Initiation Factor-2B - chemistry | Acetamides - chemistry | Cyclohexylamines - pharmacology | Protein Stability - drug effects | Eukaryotic Initiation Factor-2B - genetics | Protein Conformation | Eukaryotic Initiation Factor-2B - ultrastructure | Mutation | Nootropic Agents - pharmacology | Protein Multimerization - drug effects | Neuroimaging | Exchanging | Brain | Regulations | Atomic force microscopy | Traumatic brain injury | Target recognition | Disorders | Cognitive ability | Nervous system | Cognition | Ultracentrifugation | Guanine | Convergence | Analogs | Proteins | Head injuries | Synthesis | Rodents | Atomic structure | Guanine nucleotide exchange factor | Stress response | Dimerization | Assembly | Symmetry | Stresses | Enzymes | Translation | Translation initiation | Pharmacology | Electron microscopy | Sedimentation | Chemical compounds | Substrates | Mutants | Neurological diseases | Transmission electron microscopy | Composite materials | Inhibitors | Cognition & reasoning | Microscopy | Ionic strength | Dismantling | Binding sites | Index Medicus
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