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Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 4774 - 10
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from... 
CUTANEOUS MALIGNANT-MELANOMA | METAANALYSIS | SUN EXPOSURE | VARIANTS | MULTIDISCIPLINARY SCIENCES | GENETIC INFLUENCES | PREVALENCE | MELANOCYTIC NEVI | CANCER | TANNING RESPONSE | GENOME-WIDE ASSOCIATION | Cytochrome P-450 CYP1B1 - genetics | Humans | Stem Cell Factor - genetics | RNA-Binding Proteins | RNA - genetics | Telomere-Binding Proteins - genetics | Telomerase - genetics | Nevus, Pigmented - genetics | Group VI Phospholipases A2 - genetics | Melanoma - genetics | Genetic Pleiotropy - genetics | Nuclear Proteins - genetics | Microfilament Proteins - genetics | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Guanine Nucleotide Exchange Factors - genetics | Histone Deacetylases - genetics | Interferon Regulatory Factors - genetics | Repressor Proteins - genetics | Nerve Tissue Proteins - genetics | Carrier Proteins - genetics | Skin Neoplasms - genetics | MicroRNAs - genetics | Polymorphism, Single Nucleotide | Receptors, G-Protein-Coupled - genetics | Bivariate analysis | Pathways | Interferon regulatory factor 4 | Genes | Melanoma | Nevus | Risk | Skin | Single-nucleotide polymorphism | Loci | PLA2G6 protein, human | risk assessment | cutaneous melanoma | Interferon Regulatory Factors | RNA | Medical and Health Sciences | KITLG protein, human | single nucleotide polymorphism | Repressor Proteins | carrier protein | repressor protein | Group VI Phospholipases A2 | Stn1 protein, human | pigmented nevus | G protein coupled receptor | genetic risk | genetic predisposition | skin tumor | PPARGC1B protein, human | telomerase RNA | Carrier Proteins | Basic Medicine | peroxisome proliferator activated receptor gamma coactivator 1beta | nerve protein | biology | gene | HDAC4 protein, human | Receptors, G-Protein-Coupled | Caucasian | melanoma | European Continental Ancestry Group | Genetic Pleiotropy | Nerve Tissue Proteins | histone deacetylase 4 | Guanine Nucleotide Exchange Factors | Nuclear Proteins | Clinical Medicine | Skin Neoplasms | Cytochrome P-450 CYP1B1 | interferon regulatory factor | DOCK8 protein, human | gene expression | cytochrome P450 1B1 | United States | meta analysis | Medicin och hälsovetenskap | Article | skin | pleiotropy | Klinisk medicin | nuclear protein | Medicinsk genetik | Medical Genetics | Netherlands | telomerase | genetics | human | stem cell factor | GPRC5A protein, human | phospholipase A2 group VI | telomere binding protein | meta-analysis | United Kingdom | Histone Deacetylases | interferon regulatory factor 4 | actin binding protein | SYNE2 protein, human | histone deacetylase | Telomere-Binding Proteins | gene locus | guanine nucleotide exchange factor | Microfilament Proteins | MicroRNAs | Nevus, Pigmented | genome-wide association study | Medicinska och farmaceutiska grundvetenskaper | microRNA | meta analysis (topic) | MIRN146 microRNA, human | cancer | Australia | Cancer and Oncology | CYP1B1 protein, human | interferon regulatory factor-4 | telomere homeostasis | Cancer och onkologi
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 11/2016, Volume 17, Issue 11, pp. 1869 - 1869
.... However, the regulatory mechanisms of TRAF2 are not fully understood. Here we show evidence that TRAF2 requires brefeldin A-inhibited guanine nucleotide-exchange factor 1 (BIG1... 
TRAF2 | JNK | Tumor necrosis factor-α (TNF-α) | BIG1 | Apoptosis | APOPTOSIS | LOCALIZATION | ACTIVATION | PROTEIN | NECROPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | tumor necrosis factor-alpha (TNF-alpha); apoptosis | CHEMISTRY, MULTIDISCIPLINARY | CELL-DEATH | ADP-RIBOSYLATION FACTORS | RECYCLING ENDOSOMES | ARF-FAMILY | NF-KAPPA-B | RNA, Small Interfering - genetics | Luciferases - metabolism | Apoptosis - drug effects | Humans | TNF Receptor-Associated Factor 2 - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Luciferases - genetics | Proteolysis - drug effects | Ubiquitination - drug effects | Guanine Nucleotide Exchange Factors - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Genes, Reporter | Guanine Nucleotide Exchange Factors - genetics | NF-kappa B - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Gene Expression Regulation | TNF Receptor-Associated Factor 2 - metabolism | Signal Transduction - genetics | Receptors, Tumor Necrosis Factor, Type I - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type I - genetics | Protein Transport | TNF Receptor-Associated Factor 2 - antagonists & inhibitors | Tumor Necrosis Factor-alpha - pharmacology | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | NF-kappa B - genetics | Cell Line, Tumor | Protein Binding | HeLa Cells | RNA, Small Interfering - metabolism | Signal transduction | Tumor necrosis factor-TNF | Adenosine triphosphatase | apoptosis | tumor necrosis factor-α (TNF-α)
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12220 - 12231
First messenger-dependent activation of MAP kinases in neuronal and endocrine cells is critical for cell differentiation and function and requires guanine nucleotide exchange factor (GEF... 
R-RAS | CYCLIC-AMP | COCAINE ADDICTION | SPECIFICITY | PATHWAY | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | P38 MAPK | PC12 CELLS | SIGNAL-REGULATED KINASE | RECEPTOR TYROSINE KINASE | rap GTP-Binding Proteins - antagonists & inhibitors | ras Proteins - genetics | Phosphorylation | ras Proteins - metabolism | Green Fluorescent Proteins - genetics | GTP-Binding Proteins - genetics | Neurogenesis | Protein Prenylation | MAP Kinase Signaling System | rap GTP-Binding Proteins - agonists | Neuroendocrine Cells - cytology | RNA Interference | Guanine Nucleotide Exchange Factors - metabolism | rap GTP-Binding Proteins - genetics | Neuroendocrine Cells - metabolism | Cyclic AMP - metabolism | Recombinant Proteins - metabolism | Green Fluorescent Proteins - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | GTP-Binding Proteins - chemistry | Nerve Tissue Proteins - agonists | ras Proteins - antagonists & inhibitors | Rats | Neurites - metabolism | Monomeric GTP-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Monomeric GTP-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Animals | Monomeric GTP-Binding Proteins - metabolism | Cell Line, Tumor | Ligands | Protein Processing, Post-Translational | Enzyme Activation | rap GTP-Binding Proteins - metabolism | GTP-Binding Proteins - metabolism | Signal Transduction | p38 | cAMP | p38 MAPK | small GTPase | ERK | guanine nucleotide exchange factor (GEF)
Journal Article
The Plant Journal, ISSN 0960-7412, 05/2012, Volume 70, Issue 3, pp. 389 - 397
...)‐bound active forms, in which guanine nucleotide exchange factors (GEFs) predominantly function to promote activation of the GTPases... 
Dbl homology | Rho GEF | immunity | Rac | Rho GTPase | SWAP-70 | NADPH OXIDASE | COMPLEX | PROTEIN | CRYSTAL-STRUCTURE | SMALL GTPASE RAC | FAMILY | PLANT SCIENCES | RHO-GTPASES | DISEASE RESISTANCE | INNATE IMMUNITY | Reactive Oxygen Species - metabolism | Gene Expression - genetics | Oryza - metabolism | Molecular Sequence Data | rac GTP-Binding Proteins - metabolism | Phylogeny | Oryza - genetics | RNA Interference | Guanine Nucleotide Exchange Factors - metabolism | rac GTP-Binding Proteins - genetics | Plant Proteins - metabolism | Oryza - immunology | Protein Structure, Tertiary | Amino Acid Sequence | Guanine Nucleotide Exchange Factors - genetics | Plant Immunity - genetics | Signal Transduction | Tobacco - metabolism | rho GTP-Binding Proteins - genetics | RNA, Messenger - genetics | RNA, Plant - genetics | Reactive Oxygen Species - analysis | Plant Leaves - immunology | Protein Interaction Mapping | Sequence Homology, Amino Acid | Plant Proteins - genetics | Sequence Alignment | Plant Leaves - genetics | Plant Leaves - metabolism | Tobacco - genetics | rho GTP-Binding Proteins - metabolism | RNA | Molecular genetics | Genes | Plant genetics | Chitin | Gene expression | Gross domestic product | Guanine | Proteins | Purines | Messenger RNA | Lymphomas | G proteins | Plant biology | Signal transduction | Enzymes | Rice | Immune system | Reactive oxygen species | Immune response | Guanosine | RNA-mediated interference | Homology | Immunity | guanine nucleotide exchange factor | Development | B-cell lymphoma | Guanosinetriphosphatase
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2018, Volume 359, Issue 6383, pp. 1533 - 1536
Journal Article