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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 2, pp. 402 - 412
Background Mutations in dedicator of cytokinesis 8 (DOCK8) cause a combined immunodeficiency (CID) also classified as autosomal recessive (AR) hyper-IgE... 
Allergy and Immunology | Primary combined immunodeficiency | autosomal recessive hyper-IgE syndrome | signal transducer and activator of transcription 3 | Molluscum contagiosum | hyper-IgE syndrome | dedicator of cytokinesis 8 | SURVIVAL | BONE-MARROW-TRANSPLANTATION | STAT3 | GLYCOSYLATION | IMMUNOLOGY | ALLERGY | DOCK8 DEFICIENCY | DISORDER | MUTATIONS | STEM-CELL TRANSPLANTATION | IMMUNODEFICIENCY | Job Syndrome - genetics | Job Syndrome - mortality | Humans | Middle Aged | Child, Preschool | Male | Support Vector Machine | Virus Diseases - complications | Eosinophils - immunology | Immunoglobulin E - blood | CD4-Positive T-Lymphocytes - immunology | Bacterial Infections - genetics | Eosinophils - pathology | Virus Diseases - genetics | Child | Guanine Nucleotide Exchange Factors - deficiency | STAT3 Transcription Factor - genetics | Skin Diseases - mortality | Immunoglobulin M - genetics | Guanine Nucleotide Exchange Factors - genetics | Virus Diseases - immunology | Skin Diseases - immunology | Antigens, Viral - immunology | Phenotype | Skin Diseases - complications | Job Syndrome - complications | Adolescent | Survival Analysis | Virus Diseases - mortality | Mutation | STAT3 Transcription Factor - immunology | CD8-Positive T-Lymphocytes - immunology | Bacterial Infections - mortality | Job Syndrome - immunology | CD8-Positive T-Lymphocytes - pathology | Skin Diseases - genetics | Antigens, Bacterial - immunology | Infant | Antigens, Bacterial - blood | CD4-Positive T-Lymphocytes - pathology | Antigens, Viral - blood | Bacterial Infections - complications | Immunoglobulin E - genetics | Bacterial Infections - immunology | Adult | Female | Immunoglobulin M - blood | Guanine Nucleotide Exchange Factors - immunology | Lymphocyte Count | Genotype & phenotype | Immunoglobulins | Laboratories | Lymphocytes | Families & family life | Lymphomas | Viral infections | Deoxyribonucleic acid--DNA | Immunoglobulin M | Immunoglobulin E | CD8-Positive T-Lymphocytes | Life Sciences | Antigens, Viral | Bacterial Infections | Job Syndrome | CD4-Positive T-Lymphocytes | Virus Diseases | Skin Diseases | Antigens, Bacterial | Guanine Nucleotide Exchange Factors | STAT3 Transcription Factor | Eosinophils
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2014, Volume 192, Issue 7, pp. 3390 - 3398
Journal Article
Nature Immunology, ISSN 1529-2908, 2009, Volume 10, Issue 12, pp. 1283 - 1291
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2017, Volume 198, Issue 5, pp. 1887 - 1899
In myelodysplastic syndromes (MDS), functional defects of neutrophils result in high mortality because of infections; however, the molecular basis remains... 
INHIBITS MIGRATION | TOOTH TYPE 4H | SUPEROXIDE-PRODUCTION | PEPTIDE-STIMULATED NEUTROPHILS | DOCK8 DEFICIENCY | IMMUNOLOGY | RHO-GTPASES | OXIDASE COMPONENTS | SIGNAL-REGULATED KINASE | PHOSPHOLIPASE-D ACTIVATION | NUCLEOTIDE EXCHANGE FACTORS | Chemotaxis, Leukocyte | Cell Proliferation | Humans | Middle Aged | Male | rac1 GTP-Binding Protein - immunology | cdc42 GTP-Binding Protein - immunology | Guanine Nucleotide Exchange Factors - metabolism | Aged, 80 and over | Female | Microfilament Proteins - metabolism | Chemotaxis - immunology | Microfilament Proteins - genetics | Guanine Nucleotide Exchange Factors - deficiency | Guanine Nucleotide Exchange Factors - genetics | Microfilament Proteins - deficiency | Neutrophil Activation | Neutrophils - immunology | Neutrophils - physiology | MicroRNAs - immunology | cdc42 GTP-Binding Protein - genetics | Guanine Nucleotide Exchange Factors - immunology | HL-60 Cells | Aged | MicroRNAs - genetics | RNA, Small Interfering | MicroRNAs - physiology | Interleukin-8 - immunology | Myelodysplastic Syndromes - immunology | rac1 GTP-Binding Protein - genetics | Cdc42 protein | Chemotactic factors | Leukocyte migration | Neutrophils | MiRNA | Disorders | Rac1 protein | Activation | Leukocytes (neutrophilic) | siRNA | Cytokinesis | Ribonucleic acid--RNA | Myelodysplastic syndrome | Guanine | Proteins | Cell activation | MicroRNAs | Degranulation | Attenuation | Aberration | Guanine nucleotide exchange factor | Cell migration | Interleukin 8
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2016, Volume 126, Issue 12, pp. 4497 - 4515
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 04/2013, Volume 13, Issue 4, pp. 465 - 476
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2012, Volume 13, Issue 6, pp. 612 - 620
Journal Article
Nature Communications, ISSN 2041-1723, 01/2017, Volume 8, Issue 1, p. 13946
Mutations of DOCK8 in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. However, the molecular link... 
COMBINED IMMUNODEFICIENCY | INHIBITION | T-CELL SURVIVAL | MST1 DEFICIENCY | DERMATITIS | MULTIDISCIPLINARY SCIENCES | RECEPTOR | HYPER-IGE SYNDROMES | MICE | CYTOKINESIS 8 DEFICIENCY | HYPOXIA-INDUCIBLE FACTORS | Cell Nucleus - immunology | Dermatitis, Atopic - genetics | Cytosol - immunology | Male | Sp1 Transcription Factor - immunology | CD4-Positive T-Lymphocytes - pathology | CD4-Positive T-Lymphocytes - immunology | Interleukins - genetics | Cell Nucleus - metabolism | Immunoglobulin E - immunology | Immunoglobulin E - genetics | Interleukins - immunology | Dermatitis, Atopic - immunology | Female | Active Transport, Cell Nucleus | Basic Helix-Loop-Helix Transcription Factors - deficiency | Guanine Nucleotide Exchange Factors - deficiency | Disease Models, Animal | Promoter Regions, Genetic | Guanine Nucleotide Exchange Factors - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Aryl Hydrocarbon Receptor Nuclear Translocator - immunology | Gene Expression Regulation | Dermatitis, Atopic - pathology | Mice, Knockout | Protein Transport | Animals | Sp1 Transcription Factor - genetics | Guanine Nucleotide Exchange Factors - immunology | Basic Helix-Loop-Helix Transcription Factors - immunology | Cytosol - metabolism | Heterozygote | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Mice
Journal Article
Nature Immunology, ISSN 1529-2908, 04/2018, Volume 19, Issue 4, pp. 407 - 419
Journal Article