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The Journal of biological chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12220 - 12231
First messenger-dependent activation of MAP kinases in neuronal and endocrine cells is critical for cell differentiation and function and requires guanine nucleotide exchange factor (GEF... 
R-RAS | CYCLIC-AMP | COCAINE ADDICTION | SPECIFICITY | PATHWAY | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | P38 MAPK | PC12 CELLS | SIGNAL-REGULATED KINASE | RECEPTOR TYROSINE KINASE | rap GTP-Binding Proteins - antagonists & inhibitors | ras Proteins - genetics | Phosphorylation | ras Proteins - metabolism | Green Fluorescent Proteins - genetics | GTP-Binding Proteins - genetics | Neurogenesis | Protein Prenylation | MAP Kinase Signaling System | rap GTP-Binding Proteins - agonists | Neuroendocrine Cells - cytology | RNA Interference | Guanine Nucleotide Exchange Factors - metabolism | rap GTP-Binding Proteins - genetics | Neuroendocrine Cells - metabolism | Cyclic AMP - metabolism | Recombinant Proteins - metabolism | Green Fluorescent Proteins - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | GTP-Binding Proteins - chemistry | Nerve Tissue Proteins - agonists | ras Proteins - antagonists & inhibitors | Rats | Neurites - metabolism | Monomeric GTP-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Monomeric GTP-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Animals | Monomeric GTP-Binding Proteins - metabolism | Cell Line, Tumor | Ligands | Protein Processing, Post-Translational | Enzyme Activation | rap GTP-Binding Proteins - metabolism | GTP-Binding Proteins - metabolism | Signal Transduction | p38 | cAMP | p38 MAPK | small GTPase | ERK | guanine nucleotide exchange factor (GEF)
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23197
Journal Article
Journal Article
Nature structural & molecular biology, ISSN 1545-9985, 2014, Volume 21, Issue 7, pp. 617 - 625
...). We show that, in addition to the Ran G-nucleotide exchange factor RCC1, ELYS, the initiator of NPC formation, fails to associate with naked... 
MITOSIS | XENOPUS EGG EXTRACTS | DNA INTERACTIONS | BIOPHYSICS | MITOTIC CHROMOSOME | KINASE AURORA-B | BIOCHEMISTRY & MOLECULAR BIOLOGY | RAN GTPASE | ENVELOPE | AUTOINTEGRATION FACTOR BAF | CHROMOSOMAL PASSENGER COMPLEX | CELL BIOLOGY | Guanine Nucleotide Exchange Factors - physiology | Xenopus Proteins - genetics | DNA-Binding Proteins - metabolism | Spindle Apparatus - metabolism | Guanine Nucleotide Exchange Factors - metabolism | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | DNA-Binding Proteins - physiology | Guanine Nucleotide Exchange Factors - genetics | Transcription Factors - physiology | Xenopus laevis | Cell Cycle Proteins - metabolism | Chromatin Assembly and Disassembly | Nucleosomes - metabolism | Nuclear Proteins - metabolism | Nucleosomes - physiology | DNA - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Pore - metabolism | Transcription Factors - metabolism | Nuclear Envelope - metabolism | Animals | Proteomics | Xenopus Proteins - physiology | Xenopus Proteins - metabolism | Models, Genetic | Nuclear Proteins - physiology | Histones - metabolism | Cell Cycle Proteins - physiology | Chromatin | DNA replication | DNA damage | Physiological aspects | Genetic aspects | Research | Amphibians | Gene expression | Molecular biology | Deoxyribonucleic acid--DNA
Journal Article
Molecular cell, ISSN 1097-2765, 2009, Volume 35, Issue 5, pp. 563 - 573
.... We also show that the nucleotide-binding status of Gtr1 is regulated by the conserved... 
CELLBIO | PROTEINS | SIGNALING | YEAST SACCHAROMYCES-CEREVISIAE | CELL-GROWTH CONTROL | SIGNALING PATHWAYS | FUNCTIONAL HOMOLOG | RAG GTPASES | VACUOLE FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMINO-ACID PERMEASE | COMPONENT | GTP-BINDING PROTEINS | GAP1 PERMEASE | CELL BIOLOGY | Vacuoles - enzymology | Intracellular Membranes - enzymology | Saccharomyces cerevisiae - genetics | Multiprotein Complexes | Adaptor Proteins, Vesicular Transport - genetics | Saccharomyces cerevisiae - drug effects | Guanosine Triphosphate - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Vacuoles - drug effects | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Guanosine Diphosphate - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Monomeric GTP-Binding Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Transport Systems - metabolism | Sirolimus - pharmacology | Cycloheximide - pharmacology | Protein Transport | Transcription Factors - metabolism | Monomeric GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Endosomes - enzymology | Intracellular Membranes - drug effects | Mutation | Saccharomyces cerevisiae - growth & development | Proteins | Purines | Amino acids | Gross domestic product | Guanosine
Journal Article
International journal of molecular sciences, ISSN 1661-6596, 11/2016, Volume 17, Issue 11, pp. 1869 - 1869
.... However, the regulatory mechanisms of TRAF2 are not fully understood. Here we show evidence that TRAF2 requires brefeldin A-inhibited guanine nucleotide-exchange factor 1 (BIG1... 
TRAF2 | JNK | Tumor necrosis factor-α (TNF-α) | BIG1 | Apoptosis | APOPTOSIS | LOCALIZATION | ACTIVATION | PROTEIN | NECROPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | tumor necrosis factor-alpha (TNF-alpha); apoptosis | CHEMISTRY, MULTIDISCIPLINARY | CELL-DEATH | ADP-RIBOSYLATION FACTORS | RECYCLING ENDOSOMES | ARF-FAMILY | NF-KAPPA-B | RNA, Small Interfering - genetics | Luciferases - metabolism | Apoptosis - drug effects | Humans | TNF Receptor-Associated Factor 2 - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Luciferases - genetics | Proteolysis - drug effects | Ubiquitination - drug effects | Guanine Nucleotide Exchange Factors - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Genes, Reporter | Guanine Nucleotide Exchange Factors - genetics | NF-kappa B - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Gene Expression Regulation | TNF Receptor-Associated Factor 2 - metabolism | Signal Transduction - genetics | Receptors, Tumor Necrosis Factor, Type I - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type I - genetics | Protein Transport | TNF Receptor-Associated Factor 2 - antagonists & inhibitors | Tumor Necrosis Factor-alpha - pharmacology | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | NF-kappa B - genetics | Cell Line, Tumor | Protein Binding | HeLa Cells | RNA, Small Interfering - metabolism | Signal transduction | Tumor necrosis factor-TNF | Adenosine triphosphatase | apoptosis | tumor necrosis factor-α (TNF-α)
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2009, Volume 284, Issue 8, pp. 4846 - 4856
Journal Article