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1. Full Text Fluorescent nucleic acid base analogues
by Wilhelmsson, L. Marcus
Quarterly Reviews of Biophysics, ISSN 0033-5835, 5/2010, Volume 43, Issue 2, pp. 159 - 183
The use of fluorescent nucleic acid base analogues is becoming increasingly important in the fields of biology, biochemistry and biophysical chemistry as well... 
GUANOSINE-ANALOG | BIOPHYSICS | DYNAMICS | RESONANCE ENERGY-TRANSFER | ENZYMATIC INCORPORATION | CYTOSINE ANALOGS | 2-AMINOPURINE | DOUBLE-STRANDED DNA | PYRROLO-DC | PTERIDINE NUCLEOSIDE ANALOGS | PAIR | Fluorescence Resonance Energy Transfer | Fluorescent Dyes - chemistry | Nucleic Acids - chemistry | Humans | Staining and Labeling | Fluorescence | Scientific method | Biophysics | Molecular biology | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA | reca | hybridization properties | enzymatic incorporation | resonance energy-transfer | Chemical Sciences | pteridine nucleoside analogs | klenow fragment | Kemi | guanosine-analog | double-stranded dna | pyrrolo-dc | t7 rna-polymerase | nucleoprotein filament
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2. Full Text Supramolecular gels made from nucleobase, nucleoside and nucleotide analogs
by Peters, Gretchen Marie and Davis, Jeffery T
Chemical Society Reviews, ISSN 0306-0012, 5/2016, Volume 45, Issue 11, pp. 3188 - 326
Supramolecular or molecular gels are attractive for various applications, including diagnostics, tissue scaffolding and targeted drug release. Gelators derived... 
G-RIBBON | GCENTER-DOT-K+ HYDROGEL | PHYSICOCHEMICAL PROPERTIES | REVERSIBLE ORGANOGELS | WATER GELATION | ORGANIC-SOLVENTS | GUANOSINE 5'-MONOPHOSPHATE | G-QUARTET | SELF-COMPLEMENTARY | CHEMISTRY, MULTIDISCIPLINARY | OLIGONUCLEOTIDE ANALOGS | Gels | Guanosines | Gelation | Nucleosides | Derivatives | Nucleotides | Guanines | Assembly
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3. Full Text Supramolecular gels made from nucleobase, nucleoside and nucleotide analogs
by Peters, Gretchen Marie and Davis, Jeffery T
Chemical Society reviews, ISSN 0306-0012, 06/2016, Volume 45, Issue 11, pp. 3188 - 3206
Supramolecular or molecular gels are attractive for various applications, including diagnostics, tissue scaffolding and targeted drug release. Gelators derived... 
Animals | Pyrimidine Nucleosides - chemistry | Drug Stability | Humans | Purine Nucleosides - chemistry | Hydrogels - chemistry | Nucleotides - chemistry
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4. Full Text Molybdopterin Biosynthesis: Trapping of Intermediates for the MoaA-Catalyzed Reaction Using 2′-DeoxyGTP and 2′-ChloroGTP as Substrate Analogues
by Mehta, Angad P and Abdelwahed, Sameh H and Xu, Hui and Begley, Tadhg P
Journal of the American Chemical Society, ISSN 0002-7863, 07/2014, Volume 136, Issue 30, pp. 10609 - 10614
MoaA is a radical S-adenosylmethionine (AdoMet) enzyme that catalyzes a complex rearrangement of guanosine-5'-triphosphate (GTP) in the first step of... 
MOLYBDENUM COFACTOR | ENZYME MOAA | PRECURSOR | REDUCTASE | IDENTIFICATION | CLUSTER | CHEMISTRY, MULTIDISCIPLINARY | Coenzymes - metabolism | Metalloproteins - metabolism | Escherichia coli - enzymology | Escherichia coli - metabolism | Guanosine Triphosphate - analogs & derivatives | Halogenation | Substrate Specificity | Escherichia coli Proteins - metabolism | Guanosine Triphosphate - metabolism | Isomerases - metabolism | Pteridines - metabolism | Phosphates | Chemical properties | Guanosine triphosphatase | Analysis | Guanosine
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5. Full Text How to find the optimal partner—studies of snurportin 1 interactions with U snRNA 5′ TMG-cap analogues containing modified 2-amino group of 7-methylguanosine
by Piecyk, Karolina and Niedzwiecka, Anna and Ferenc-Mrozek, Aleksandra and Lukaszewicz, Maciej and Darzynkiewicz, Edward and Jankowska-Anyszka, Marzena
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2015, Volume 23, Issue 15, pp. 4660 - 4668
Snurportin 1 is an adaptor protein that mediates the active nuclear import of uridine-rich small nuclear RNAs (U snRNA) by the importin-β receptor pathway. Its... 
Molecular recognition | U snRNA | Snurportin 1 | TMG-cap | Protein–ligand binding | Protein-ligand binding | NUCLEAR IMPORT | CHEMISTRY, MEDICINAL | RNA | RECOGNITION | NEMATODE TRANSLATION | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | TRIMETHYLGUANOSINE CAP | STRUCTURAL BASIS | EUKARYOTIC TRANSLATION | EIF4E | BINDING | Guanosine - analogs & derivatives | RNA Cap-Binding Proteins - metabolism | Humans | Spectrometry, Fluorescence | RNA, Small Nuclear - metabolism | Guanosine - metabolism | Spectrophotometry, Ultraviolet | Receptors, Cytoplasmic and Nuclear - metabolism
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6. Full Text Sphingosine 1-Phosphate Analogs as Receptor Antagonists
by Michael D. Davis and Jeremy J. Clemens and Timothy L. Macdonald and Kevin R. Lynch
Journal of Biological Chemistry, ISSN 0021-9258, 03/2005, Volume 280, Issue 11, pp. 9833 - 9841
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator that evokes a variety of cell and tissue responses via a set of cell surface receptors. The recent... 
MIGRATION | SURVIVAL | SUBTYPES | FTY720 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPHINGOSINE-1-PHOSPHATE | TRAFFICKING | RATS | IMMUNOSUPPRESSANT | DISCOVERY | Receptors, Lysosphingolipid - antagonists & inhibitors | Models, Chemical | Calcium - metabolism | Humans | Guanosine Triphosphate - metabolism | Structure-Activity Relationship | Dose-Response Relationship, Drug | Lipids - chemistry | Transfection | Phosphoserine - analogs & derivatives | Phosphoserine - pharmacology | Drug Design | Lysophospholipids - pharmacology | Inhibitory Concentration 50 | Cell Membrane - metabolism | Guanosine Triphosphate - chemistry | Lymphocytes - metabolism | Propylene Glycols - pharmacology | Cell Line | Signal Transduction | Lysophospholipids - chemistry | Fingolimod Hydrochloride | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Protein Binding | Ligands | Kinetics | Phosphoserine - chemistry | Sphingosine - chemistry | Cell Movement
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7. Full Text Synthesis of acyclic nucleoside analogues based on 1,2,4-triazolo[1,5-a]pyrimidin-7-ones by one-step Vorbrüggen glycosylation
by Khalymbadzha, Igor A and Shestakova, Tatyana S and Subbotina, Julia O and Eltsov, Oleg S and Musikhina, Alexandra A and Rusinov, Vladimir L and Chupakhin, Oleg N and Karpenko, Inna L and Jasko, Maxim V and Kukhanova, Marina K and Deev, Sergey L
Tetrahedron, ISSN 0040-4020, 02/2014, Volume 70, Issue 6, pp. 1298 - 1305
New acyclovir analogues were obtained by reaction of 1,2,4-triazolo[1,5- ]pyrimidin-7-ones – with (2-acetoxyethoxy)methyl acetate in the presence of... 
Transglycosylation | Vorbrüggen glycosylation | Regioselectivity | Acyclovir analogues | 1,2,4-Triazolo[1,5-a]pyrimidine-7-one | TMSOTf | Herpes simplex virus | DESIGN | VIRUS | CHEMISTRY, ORGANIC | CONVENIENT | GUANOSINE | ACYCLONUCLEOSIDES | FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | POTENT | Vorbruggen glycosylation | DRUGS | INHIBITORS | DERIVATIVES | Nucleosides | Thermodynamics | Purines | Acyclovir | Isomerization
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8. Full Text Efficiency of incorporation and chain termination determines the inhibition potency of 2′-modified nucleotide analogs against hepatitis C virus polymerase
by Fung, Amy and Jin, Zhinan and Dyatkina, Natalia and Wang, Guangyi and Beigelman, Leo and Deval, Jerome
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 2014, Volume 58, Issue 7, pp. 3636 - 3645
Ribonucleotide analog inhibitors of the RNA-dependent RNA polymerase of hepatitis C virus (HCV) represent one of the most exciting recent developments in HCV... 
COMPLEX | BETA-D-2'-DEOXY-2'-FLUORO-2'-C-METHYLCYTIDINE | ACTIVATION | DEPENDENT RNA-POLYMERASE | REPLICATION | NUCLEOSIDE ANALOGS | MECHANISM | ACTIVE-SITE | CRYSTAL-STRUCTURE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | REPLICON | Hepacivirus - drug effects | Antiviral Agents - pharmacology | Hepacivirus - enzymology | Algorithms | Humans | Uridine Triphosphate - pharmacology | Enzyme Inhibitors - pharmacology | RNA Replicase - antagonists & inhibitors | Guanosine Triphosphate - metabolism | Kinetics | Uridine Triphosphate - analogs & derivatives | Antiviral Agents
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9. Full Text Diastereoselective Synthesis of 6″‑(Z)- and 6″‑(E)‑Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers
by Kumamoto, Hiroki and Fukano, Misato and Nakano, Tomohiko and Iwagami, Keito and Takeyama, Chiaki and Kohgo, Satoru and Imoto, Shuhei and Amano, Masayuki and Kuwata-Higashi, Nobuyo and Aoki, Manabu and Abe, Hiroshi and Mitsuya, Hiroaki and Fukuhara, Kiyoshi and Haraguchi, Kazuhiro
The Journal of Organic Chemistry, ISSN 0022-3263, 04/2016, Volume 81, Issue 7, pp. 2827 - 2836
A method for the diastereoselective synthesis of 6″-(Z)- and 6″‑(E)-fluorinated analogues of the anti-HBV agent entecavir has been developed. Construction of... 
ROUTE | REDUCING AGENT | STANNYLATION | CHEMISTRY, ORGANIC | INTERMEDIATE | OLEFINS | POTENTIAL INHIBITORS | HYDROLASE | ACCESS | Antiviral Agents - pharmacology | Guanine - analogs & derivatives | HIV-1 - drug effects | Stereoisomerism | Humans | Structure-Activity Relationship | Hepatitis B virus - drug effects | Guanosine - chemistry | Antiviral Agents - chemistry | Guanine - pharmacology | Antiviral Agents - chemical synthesis | Guanine - chemistry | Hep G2 Cells - chemistry | Guanine - chemical synthesis | Hepatitis B virus | Research | Chemical properties | Chemical synthesis | Diastereomers | Analysis | Index Medicus
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10. Full Text Design, Synthesis, and Biological Evaluation of (3R)‑1,2,3,4-Tetrahydro-7-hydroxy‑N‑[(1S)‑1-[[(3R,4R)‑4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) Analogues: In Vitro Pharmacology and ADME Profile
by Kormos, Chad M and Gichinga, Moses G and Maitra, Rangan and Runyon, Scott P and Thomas, James B and Brieaddy, Lawrence E and Mascarella, S. Wayne and Navarro, Hernán A and Carroll, F. Ivy
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2014, Volume 57, Issue 17, pp. 7367 - 7381
JDTic analogues 4–15 which have the hydroxyl groups replaced with other groups were synthesized and their in vitro efficacy at the μ, δ, and κ opioid receptors... 
CHEMISTRY, MEDICINAL | ANTAGONIST | INHIBITION | PERMEABILITY | LY2456302 | COCAINE-SEEKING | REINSTATEMENT | KAPPA-OPIOID RECEPTOR | IDENTIFICATION | 2-METHYL-N-((2'-(PYRROLIDIN-1-YLSULFONYL)BIPHENYL-4-YL)METHYL)PROPAN-1-AMINE | DISCOVERY | Binding, Competitive | Tetrahydroisoquinolines - pharmacology | Receptors, Opioid, kappa - antagonists & inhibitors | Models, Chemical | Piperidines - metabolism | Humans | Receptors, Opioid, kappa - metabolism | Models, Molecular | Tetrahydroisoquinolines - chemical synthesis | Piperidines - chemical synthesis | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Hydrogen Bonding | Piperidines - pharmacology | Tetrahydroisoquinolines - metabolism | Drug Design | Molecular Docking Simulation | Molecular Structure | Receptors, Opioid, kappa - chemistry | Kinetics | Radioligand Assay
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11. Full Text Cap analogs containing 6-thioguanosine-reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules
by Nowakowska, Monika and Kowalska, Joanna and Martin, Franck and D'Orchymont, Arnaud and Zuberek, Joanna and Lukaszewicz, Maciej and Darzynkiewicz, Edward and Jemielity, Jacek
Organic and Biomolecular Chemistry, ISSN 1477-0520, 07/2014, Volume 12, Issue 27, pp. 4841 - 4847
Numerous biomolecules recognize the 7-methylguanosine cap structure present at the 5' ends of eukaryotic mRNAs. Photo-crosslinking is a valuable technique to... 
SITE | LINKING | COMPLEX | PROTEIN | RECOGNITION | DECAPPING ENZYME | STABILITY | CHEMISTRY, ORGANIC | EIF4E | DUPLEX DNA | TRANSLATIONAL-EFFICIENCY | Guanosine - analogs & derivatives | Protein Biosynthesis | Cross-Linking Reagents - chemistry | Ultraviolet Rays | Guanosine - chemistry | RNA Cap Analogs - chemical synthesis | RNA, Messenger - chemistry | Thionucleosides - chemistry
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12. Full Text Thiophene-expanded guanosine analogues of Gemcitabine
by Chen, Zhe and Ku, Therese C and Seley-Radtke, Katherine L
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2015, Volume 25, Issue 19, pp. 4274 - 4276
The chemotherapeutic drug Gemcitabine, 2′,2′-difluoro-2′-deoxycytidine, has long been the standard of care for a number of cancers. Gemcitabine’s... 
Nucleosides | 2′,2′-Difluoro-2′-deoxycytidine | Expanded guanosine | Tricyclic | Cancer | 2',2'-Difluoro-2'-deoxycytidine | CHEMISTRY, MEDICINAL | SERIES | CHEMISTRY, ORGANIC | FLUORINATED NUCLEOSIDES | MECHANISMS | HEPATITIS-C VIRUS | 2 ',2 '-Difluoro-2 '-deoxycytidine | INACTIVE NUCLEOSIDE | DIMENSIONAL PROBES | TRIESTERS | BINDING-SITES | DERIVATIVES | PROTIDE TECHNOLOGY | Guanosine - analogs & derivatives | Deoxycytidine - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Molecular Conformation | Thiophenes - pharmacology | Deoxycytidine - pharmacology | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Guanosine - chemistry | Cell Line, Tumor | Guanosine - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Thiophenes - chemistry | Deoxycytidine - analogs & derivatives | Drug Screening Assays, Antitumor | Gemcitabine | Thiophene | 2′-Difluoro-2′-deoxycytidine
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13. Full Text Manipulating DNA G‐Quadruplex Structures by Using Guanosine Analogues
by Haase, Linn and Karg, Beatrice and Weisz, Klaus
ChemBioChem, ISSN 1439-4227, 04/2019, Volume 20, Issue 8, pp. 985 - 993
The ability to control the folding topology of DNA G‐quadruplexes allows for rational design of quadruplex‐based scaffolds for potential use in various... 
conformation analysis | oligonucleotides | G-quadruplexes | guanosine | aptamers | topology | VISUALIZATION | CHEMISTRY, MEDICINAL | BASE STACKING | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | G-TETRAD | NMR SOLUTION STRUCTURE | SUBSTITUTIONS | HUMAN TELOMERE | SELECTION | FOLDING TOPOLOGY | LNA | DNA | Analysis | Organic chemistry | Sequences | Stability | Guanosine | Design modifications | Inversions | Polarity | Topology | Scaffolds | Deoxyribonucleic acid--DNA | Sugar
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14. Full Text A sequential direct arylation/Suzuki-Miyaura cross-coupling transformation of unprotected 2′-deoxyadenosine affords a novel class of fluorescent analogues
by Storr, Thomas E and Strohmeier, Johanna A and Baumann, Christoph G and Fairlamb, Ian J. S
Chemical Communications, ISSN 1359-7345, 09/2010, Volume 46, Issue 35, pp. 6470 - 6472
Novel rigid 8-biaryl-2'-deoxyadenosines with tuneable fluorescent properties can be accessed by an efficient sequential catalytic Pd-0-coupling approach. 
OLIGONUCLEOTIDE PROBES | POLYMERASE INCORPORATION | PURINE | DNA | CONSTRUCTION | 2'-DEOXYURIDINE | GUANOSINE | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | NUCLEOSIDE TRIPHOSPHATES | BASE ANALOGS | Fluorescent Dyes - chemistry | Crystallography, X-Ray | Deoxyadenosines - chemistry | Deoxyadenosines - chemical synthesis | Molecular Conformation
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15. Full Text EF-G Activation by Phosphate Analogs
by Salsi, Enea and Farah, Elie and Ermolenko, Dmitri N
Journal of Molecular Biology, ISSN 0022-2836, 05/2016, Volume 428, Issue 10, pp. 2248 - 2258
Elongation factor G (EF-G) is a universally conserved translational GTPase that promotes the translocation of tRNA and mRNA through the ribosome. EF-G binds to... 
mRNA translocation | Beryllium fluoride | Ribosome | EF-G | GTP hydrolysis | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELONGATION-FACTOR-G | MESSENGER-RNA TRANSLOCATION | RIBOSOMAL-SUBUNIT | CONFORMATIONAL-CHANGES | HYBRID-STATE | DOMAIN IV | MOVEMENT | BINDING | GTP Phosphohydrolases - metabolism | Hydrolysis - drug effects | RNA, Transfer - metabolism | Ribosomes - drug effects | Peptide Elongation Factor G - metabolism | Protein Biosynthesis - drug effects | Aluminum Compounds - pharmacology | Boranes - pharmacology | Guanosine Triphosphate - metabolism | RNA, Messenger - metabolism | Phosphates - pharmacology | Fluorides - pharmacology | Phosphates | Hydrolysis | Analysis | Transfer RNA
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16. Full Text Synthesis and application of 2′-fluoro-substituted cap analogs
by Kore, Anilkumar R and Shanmugasundaram, Muthian and Charles, Irudaya and Cheng, Angie M and Barta, Timothy J
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 19, pp. 5295 - 5299
Design, synthesis, and biological evaluation of 2′-fluoro-substituted cap analogs i.e., m G[5′]ppp[5′]G and m G[5′]ppp[5′]m G are reported. Design, synthesis,... 
Translation efficiency | In vitro transcription | 2′-Fluoro-substituted cap analogs | 5′ Capped RNA | HeLa cells | Luciferase activity | Capping efficiency | CHEMISTRY, MEDICINAL | capping efficiency | MESSENGER-RNA | METHYLATED NUCLEOTIDES | translation efficiency | luciferase activity | in vitro transcription | 5 ' capped RNA | CHEMISTRY, ORGANIC | 2 '-fluoro-substituted cap analogs | Guanosine - analogs & derivatives | Actins - biosynthesis | DNA-Directed RNA Polymerases - antagonists & inhibitors | Humans | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | Genes, Reporter - genetics | Viral Proteins - antagonists & inhibitors | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Actins - genetics | Luciferases - genetics | Guanosine - chemical synthesis | RNA, Messenger - biosynthesis | Guanosine - chemistry | Drug Design | Plasmids - genetics | Guanosine - pharmacology | Protein Biosynthesis - drug effects | HeLa Cells | 2′-Fluoro substituted cap analogs
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