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Journal of Neuroscience, ISSN 0270-6474, 01/2009, Volume 29, Issue 2, pp. 393 - 401
Glucocorticoids exert an opposing rapid regulation of glutamate and GABA synaptic inputs to hypothalamic magnocellular neurons via the activation of... 
GABA | Magnocellular neuron | Endocannabinoid | Glucocorticoid | Nitric oxide | SUPRAOPTIC NUCLEUS | endocannabinoid | glucocorticoid | nitric oxide | ACTIVATION | magnocellular neuron | NITRIC-OXIDE SYNTHASE | NEUROSCIENCES | MEMBRANE ESTROGEN-RECEPTORS | ENDOCANNABINOID RELEASE | PARAVENTRICULAR NUCLEUS | G(alpha) | ADRENALECTOMIZED RATS | NEURONS | VASOPRESSIN | OXYTOCIN | G(beta)gamma | Cannabinoid Receptor Modulators - metabolism | Synaptic Transmission - physiology | gamma-Aminobutyric Acid - metabolism | GTP-Binding Proteins - antagonists & inhibitors | Male | Penicillamine - analogs & derivatives | Patch-Clamp Techniques - methods | Quinoxalines - pharmacology | Dexamethasone - pharmacology | Piperidines - pharmacology | Dronabinol - analogs & derivatives | Neurons - physiology | Nitric Oxide Donors - pharmacology | Dronabinol - pharmacology | Neurons - drug effects | Electric Stimulation - methods | Pyrans - pharmacology | Guanosine Diphosphate - pharmacology | Pyrazoles - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Synapses - drug effects | Synapses - physiology | Penicillamine - pharmacology | Valine - analogs & derivatives | Enzyme Inhibitors - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Thionucleotides - pharmacology | Rats, Sprague-Dawley | Animals | Guanosine Diphosphate - analogs & derivatives | Hypothalamus - cytology | Signal Transduction - drug effects | Arginine - pharmacology | Cannabinoid Receptor Modulators - antagonists & inhibitors | Glucocorticoids - pharmacology | Glutamic Acid - metabolism | Valine - pharmacology | In Vitro Techniques | Nitric Oxide - metabolism | GTP-Binding Proteins - metabolism | Gβγ
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 08/2013, Volume 305, Issue 3, pp. C276 - C289
Gain-of-function mutations in the transient receptor potential (TRP) cation channel subfamily C member 6 (TRPC6) gene and mutations in the NPHS2 gene encoding... 
Podocyte | Glomerular filtration | TRPC6 | Mechanosensitive | Slit diaphragm | glomerular filtration | BKCA CHANNELS | PHYSIOLOGY | PROTEIN | mechanosensitive | NEPHRIN | CAPILLARY WALL | SURFACE EXPRESSION | RECEPTOR | CELL BIOLOGY | GLOMERULAR SLIT DIAPHRAGM | CATION CHANNELS | podocyte | slit diaphragm | MUTATIONS | NEPHROTIC SYNDROME | ortho-Aminobenzoates - pharmacology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Spider Venoms - pharmacology | Cytochalasin D - pharmacology | Type C Phospholipases - antagonists & inhibitors | Nephrotic Syndrome | Diglycerides - pharmacology | RNA Interference | Estrenes - pharmacology | Pyrrolidinones - pharmacology | HEK293 Cells | Kidney Glomerulus - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | TRPC Cation Channels - genetics | Intracellular Signaling Peptides and Proteins - genetics | Phospholipase A2 Inhibitors | Guanosine Diphosphate - pharmacology | Cell Line | Podocytes - metabolism | Membrane Proteins - genetics | Phosphodiesterase Inhibitors - pharmacology | Rats | Imidazoles - pharmacology | Thionucleotides - pharmacology | Calcium Channel Blockers - pharmacology | Cinnamates - pharmacology | Peptides - pharmacology | Animals | Guanosine Diphosphate - analogs & derivatives | TRPC Cation Channels - metabolism | Chlorobenzoates - pharmacology | Mice | RNA, Small Interfering | Mutation | Ion Channel Gating
Journal Article
The Journal of Physiology, ISSN 0022-3751, 07/2010, Volume 588, Issue 14, pp. 2605 - 2619
In vertebrate retina, melatonin regulates various physiological functions. In this work we investigated the mechanisms underlying melatonin‐induced... 
CIRCADIAN CLOCK | XENOPUS-LAEVIS | BIPOLAR CELLS | PROTEIN-KINASE-C | PHYSIOLOGY | FISH RETINA | PHOSPHOLIPASE-C | VISUAL PATHWAY | FUNCTIONAL-ROLE | MT2 MELATONIN | RECEPTORS | NEUROSCIENCES | Cyclic GMP - pharmacology | Receptor, Melatonin, MT2 - antagonists & inhibitors | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Male | Calcium - analysis | Melatonin - physiology | Type C Phospholipases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - physiology | Isoquinolines - pharmacology | Cyclic GMP - analogs & derivatives | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Bridged-Ring Compounds - pharmacology | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Guanosine Diphosphate - pharmacology | Pertussis Toxin - pharmacology | Retinal Ganglion Cells - physiology | Protein Kinase C - physiology | Retinal Ganglion Cells - enzymology | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Rats | Protein Kinase C - antagonists & inhibitors | Receptor, Melatonin, MT2 - physiology | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Animals | Egtazic Acid - pharmacology | Glycine - physiology | Guanosine Diphosphate - analogs & derivatives | Signal Transduction - drug effects | Tetrahydronaphthalenes - pharmacology | Thiones - pharmacology | Carbazoles - pharmacology | Type C Phospholipases - physiology | Melatonin | Phospholipids | Glycine | Ganglion | Gross domestic product | Protein kinases | Kinases | Retina | Physiology | Neuroscience
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2007, Volume 150, Issue 5, pp. 613 - 623
Background and purpose: A nonpsychoactive constituent of the cannabis plant, cannabidiol has been demonstrated to have low affinity for both cannabinoid CB1... 
cannabidiol | CB2 receptor | CP55940 | O‐2654 | GTPγS assay | CB1 receptor | mouse brain | inverse agonism | neutral antagonism | O-2654 | GTP gamma S assay | INHIBITION | LIGANDS | SELECTIVE INVERSE AGONIST | MOUSE VAS-DEFERENS | PERIPHERAL CANNABINOID RECEPTOR | PHARMACOLOGY & PHARMACY | BINDING | BRAIN | Cricetulus | Cyclohexanols | Receptor, Cannabinoid, CB2 - agonists | Cannabinoid Receptor Antagonists | Cyclohexanes - pharmacology | Humans | Bornanes - pharmacology | Anti-Inflammatory Agents - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Receptors, Cannabinoid - metabolism | Receptor, Cannabinoid, CB1 - agonists | Transfection | Piperidines - pharmacology | Morpholines - antagonists & inhibitors | Phenols - antagonists & inhibitors | Cyclohexanes - antagonists & inhibitors | Benzoxazines - antagonists & inhibitors | Cell Membrane - metabolism | Cell Membrane - drug effects | Receptors, Cannabinoid - genetics | CHO Cells | Phenols - pharmacology | Pyrazoles - pharmacology | Cricetinae | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Morpholines - pharmacology | Cannabidiol - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Brain - drug effects | Cannabinoid Receptor Agonists | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Benzoxazines - pharmacology | Protein Binding | Mice | Cannabidiol - metabolism | In Vitro Techniques | Naphthalenes - antagonists & inhibitors | Research Papers
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 01/2005, Volume 21, Issue 1, pp. 151 - 160
The mechanisms by which uridine triphosphate (UTP) stimulates ATP release from Schwann cells cultured from the sciatic nerve were investigated using online... 
purinergic receptors | exocytosis | bioluminescence | protein kinase C | Bioluminescence | Protein kinase C | Purinergic receptors | Exocytosis | NERVE | MECHANISMS | RELEASE | ASTROCYTES | NEUROSCIENCES | UTP | NUCLEOTIDE RECEPTORS | GLUTAMATE | CALCIUM | NEURONS | SMOOTH-MUSCLE-CELLS | Guanosine Triphosphate - pharmacology | Nucleic Acid Synthesis Inhibitors - pharmacology | Calcium - metabolism | Adenosine Triphosphate - secretion | Brefeldin A - pharmacology | Phorbol 12,13-Dibutyrate - pharmacology | Receptors, Purinergic P2Y2 | Cytochalasin D - pharmacology | Phenanthridines - pharmacology | Type C Phospholipases - antagonists & inhibitors | Diagnostic Imaging - methods | Dose-Response Relationship, Drug | Alkaloids | Botulinum Toxins - pharmacology | Glycyrrhetinic Acid - pharmacology | Drug Interactions | Isoquinolines - pharmacology | Glyburide - pharmacology | Time Factors | Botulinum Toxins, Type A | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Sciatic Nerve - cytology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Protein Synthesis Inhibitors - pharmacology | Pyridoxal Phosphate - analogs & derivatives | Schwann Cells - secretion | Suramin - pharmacology | Schwann Cells - drug effects | Animals, Newborn | Pyridoxal Phosphate - pharmacology | Uridine Triphosphate - pharmacology | Purinergic P2 Receptor Antagonists | Rats | Protein Kinase C - antagonists & inhibitors | Purinergic P2 Receptor Agonists | Sulfonamides - pharmacology | Microscopy, Confocal - methods | Rats, Sprague-Dawley | Immunohistochemistry - methods | Animals | Benzophenanthridines | Receptors, Purinergic P2 - metabolism | Thapsigargin - pharmacology | Furosemide - pharmacology
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2012, Volume 679, Issue 1-3, pp. 68 - 74
Journal Article
Pain, ISSN 0304-3959, 01/2011, Volume 152, Issue 1, pp. 95 - 105
To elucidate the mechanisms of antinociception mediated by the dopaminergic descending pathway in the spinal cord, we investigated the actions of dopamine (DA)... 
D2-like receptor | Inhibitory descending pathway | A11 | Spinal cord | Dopamine | In vivo patch-clamp | POTASSIUM CHANNELS | NEUROSCIENCES | DORSAL-HORN | CLINICAL NEUROLOGY | C-AFFERENT-FIBERS | CARRAGEENAN HYPERALGESIA | NUCLEUS-ACCUMBENS | ORGANIZATION | D2 RECEPTORS | PAIN | RAT LACTOTROPHS | ANESTHESIOLOGY | LONG-TERM NOCICEPTION | Male | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Drug Interactions | Dopamine Agents - pharmacology | Pain - drug therapy | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Pain - etiology | Tetrodotoxin - pharmacology | Action Potentials - drug effects | Guanosine Diphosphate - pharmacology | Chlorides - pharmacology | Dopamine - pharmacology | Rats | Sodium Channel Blockers - pharmacology | Spinal Cord - anatomy & histology | Excitatory Amino Acid Antagonists - pharmacology | Substantia Gelatinosa - cytology | Thionucleotides - pharmacology | Rats, Sprague-Dawley | Barium Compounds - pharmacology | Animals | Guanosine Diphosphate - analogs & derivatives | Afferent Pathways - physiology | 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology | Skin - innervation | Quinpirole - pharmacology | Physical Stimulation - adverse effects | Nociceptors - drug effects | Marine toxins | Neurons | Analysis | Biological apparatus and supplies | Universities and colleges | Gross domestic product
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 04/2010, Volume 113, Issue 2, pp. 530 - 542
J. Neurochem. (2010) 113, 530–542. Adenosine produces cardiovascular depressor effects in various brain regions. However, the cellular mechanisms underlying... 
KATP | synaptic transmission | G proteins | sympathetic nervous system | hypothalamus | adenosine receptors | Adenosine receptors | Hypothalamus | Sympathetic nervous system | Synaptic transmission | SUPRAOPTIC NUCLEUS | PRESYNAPTIC INHIBITION | SPONTANEOUSLY HYPERTENSIVE-RATS | SENSITIVE K+ CHANNELS | RECEPTOR AGONISTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPINAL-CORD | K-ATP | NEUROSCIENCES | SIGNALING PATHWAY | ENDOGENOUS ADENOSINE | CENTRAL-NERVOUS-SYSTEM | SYNAPTIC GABA RELEASE | Analgesics - pharmacology | Tolbutamide - pharmacology | KATP Channels - physiology | Male | Xanthines - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Dose-Response Relationship, Drug | Paraventricular Hypothalamic Nucleus - cytology | Glyburide - pharmacology | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Tetrodotoxin - pharmacology | Neurons - drug effects | Action Potentials - drug effects | Potassium Channel Blockers - pharmacology | Guanosine Diphosphate - pharmacology | Membrane Potentials - drug effects | Triazines - pharmacology | Rats | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Adenosine - pharmacology | Bicuculline - pharmacology | Thionucleotides - pharmacology | Membrane Potentials - physiology | Rats, Sprague-Dawley | Receptor, Adenosine A1 - metabolism | GABA Antagonists - pharmacology | Triazoles - pharmacology | Animals | Guanosine Diphosphate - analogs & derivatives | In Vitro Techniques | Cell research | Adenosine | Neurons | Tolbutamide | GABA | Glibenclamide | Cytochemistry | Membrane proteins | Cardiovascular disease | Potassium | Adenosine triphosphatase
Journal Article
Journal Article
Molecular and Cellular Neuroscience, ISSN 1044-7431, 2008, Volume 39, Issue 2, pp. 273 - 284
Whereas the entorhinal cortex (EC) receives profuse serotonergic innervations from the raphe nuclei in the brain stem and is critically involved in the... 
G-Protein | Synapse | Inhibition | Receptor | Transmission | Channel | COMPLEX PARTIAL SEIZURES | TEMPORAL-LOBE EPILEPSY | GABAERGIC TRANSMISSION | NEURONS IN-VITRO | BACKGROUND POTASSIUM CHANNELS | INTRINSIC CONNECTIONS | NEUROSCIENCES | SYNAPTIC INHIBITION | PARAHIPPOCAMPAL REGION | FUNCTIONAL EXPRESSION | SUPERFICIAL LAYERS | Interneurons - physiology | Entorhinal Cortex - metabolism | gamma-Aminobutyric Acid - metabolism | Serotonin - pharmacology | Patch-Clamp Techniques - methods | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Neural Inhibition - physiology | Potassium Channels, Tandem Pore Domain - immunology | Estrenes - pharmacology | Pyramidal Cells - physiology | Pyrrolidinones - pharmacology | Platelet Aggregation Inhibitors - pharmacology | Pyramidal Cells - drug effects | Action Potentials - drug effects | Potassium Channel Blockers - pharmacology | Suramin - pharmacology | Guanosine Diphosphate - pharmacology | Animals, Newborn | Interneurons - drug effects | Inhibitory Postsynaptic Potentials - physiology | Rats | Entorhinal Cortex - drug effects | Thionucleotides - pharmacology | Magnesium - pharmacology | Rats, Sprague-Dawley | Arachidonic Acids - pharmacology | Phospholipid Ethers - pharmacology | Action Potentials - physiology | Antibodies - pharmacology | Animals | Serotonin Agents - pharmacology | Guanosine Diphosphate - analogs & derivatives | Ruthenium Red - pharmacology | Potassium Channels, Tandem Pore Domain - physiology | In Vitro Techniques | Neural Inhibition - drug effects | Inhibitory Postsynaptic Potentials - drug effects | channel | inhibition | transmission | receptor | synapse | G protein
Journal Article
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 2003, Volume 144, Issue 1, pp. 87 - 93
This study investigated the involvement of NMDA receptors and the L-arginine-nitric oxide (NO) pathway in the antidepressant-like effects of zinc in the forced... 
Antidepressant | Nitric oxide | l-NNA | NMDA | Depression | l-arginine | Zinc | L-NNA | L-arginine | nitric oxide | TAIL SUSPENSION TEST | antidepressant | MAJOR DEPRESSION | FORCED SWIMMING TEST | NEUROSCIENCES | ASCORBATE | QUINOLINIC ACID | MODELS | REDOX | BEHAVIORAL SCIENCES | depression | LOWER SERUM ZINC | zinc | BRAIN | MODULATION | Free Radical Scavengers - pharmacology | Receptors, N-Methyl-D-Aspartate - metabolism | Motor Activity - drug effects | Male | Hindlimb Suspension - physiology | Dose-Response Relationship, Drug | Depression - drug therapy | Depression - metabolism | Drug Interactions | Time Factors | Zinc Compounds - pharmacology | Immobilization - physiology | Behavior, Animal - drug effects | Female | Antidepressive Agents - pharmacology | Swimming | Nitric Oxide Donors - pharmacology | Zinc Compounds - therapeutic use | Fluoxetine - pharmacology | Guanosine Monophosphate - pharmacology | Chlorides - pharmacology | Pain Measurement - drug effects | Excitatory Amino Acid Antagonists - pharmacology | Chlorides - therapeutic use | Antidepressive Agents - therapeutic use | Animals | Ascorbic Acid - pharmacology | Mice | Dizocilpine Maleate - pharmacology | Imipramine - pharmacology | Ketamine - pharmacology | Nitric Oxide - metabolism | S-Nitroso-N-Acetylpenicillamine - pharmacology | Arginine - metabolism | Drug Combinations
Journal Article