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1. Full Text Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling
by Hattersley, Gary and Dean, Thomas and Corbin, Braden A and Bahar, Hila and Gardella, Thomas J
Endocrinology, ISSN 0013-7227, 01/2016, Volume 157, Issue 1, pp. 141 - 149
The PTH receptor type 1 (PTHR1) mediates the actions of two endogenous polypeptide ligands, PTH and PTHrP, and thereby plays key roles in bone biology. Based... 
(PTH)/PTH-RELATED PROTEIN-RECEPTOR | PATHWAYS | STATES | LIGAND-BINDING | BIASED AGONISM | ENDOCRINOLOGY & METABOLISM | ERK1/2 ACTIVATION | PARATHYROID-HORMONE PTH | MECHANISMS | OSTEOPOROSIS | CAMP | Receptor, Parathyroid Hormone, Type 1 - chemistry | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Peptide Fragments - pharmacology | Guanosine 5'-O-(3-Thiotriphosphate) - chemistry | HEK293 Cells | Cell Membrane - metabolism | Bone Density Conservation Agents - metabolism | Cyclic AMP - metabolism | Binding Sites - drug effects | Cell Membrane - drug effects | Bone Density Conservation Agents - chemistry | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Second Messenger Systems - drug effects | Models, Molecular | Recombinant Proteins - chemistry | Parathyroid Hormone-Related Protein - chemistry | Parathyroid Hormone-Related Protein - metabolism | Bone Density Conservation Agents - pharmacology | Parathyroid Hormone-Related Protein - pharmacology | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Peptide Fragments - chemistry | MAP Kinase Signaling System - drug effects | Receptor, Parathyroid Hormone, Type 1 - genetics | Genes, Reporter - drug effects | Ligands | Protein Conformation | Kinetics | GTP-Binding Proteins - metabolism | Original Research
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2. Full Text Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6
by Keisuke Yanagida and Kayo Masago and Hiroki Nakanishi and Yasuyuki Kihara and Fumie Hamano and Yoko Tajima and Ryo Taguchi and Takao Shimizu and Satoshi Ishii
Journal of Biological Chemistry, ISSN 0021-9258, 06/2009, Volume 284, Issue 26, pp. 17731 - 17741
p2y5 is an orphan G protein-coupled receptor that is closely related to the fourth lysophosphatidic acid (LPA) receptor, LPA 4 . Here we report that p2y5 is a... 
Endothelium, Vascular - cytology | Lysophospholipids - metabolism | Calcium - metabolism | Humans | GTP-Binding Protein alpha Subunits, G12-G13 - metabolism | Liver Neoplasms, Experimental - metabolism | Receptors, Purinergic P2 - genetics | Cloning, Molecular | Cell Membrane - metabolism | Radioligand Assay | Liver Neoplasms, Experimental - pathology | Cyclic AMP - metabolism | Umbilical Veins - cytology | Neuroblastoma - pathology | Cells, Cultured | GTP-Binding Protein alpha Subunits, G12-G13 - genetics | Rats | Blotting, Western | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Endothelium, Vascular - metabolism | Receptors, Purinergic P2 - metabolism | Carcinoma, Hepatocellular - pathology | Neuroblastoma - metabolism | Carcinoma, Hepatocellular - metabolism | Umbilical Veins - metabolism | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling
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3. Full Text Allosteric Modulation of the Cannabinoid CB1 Receptor
by Martin R. Price and Gemma L. Baillie and Adèle Thomas and Lesley A. Stevenson and Morag Easson and Richard Goodwin and Adèle McLean and Lorraine McIntosh and Gillian Goodwin and Glenn Walker and Paul Westwood and Julia Marrs and Fiona Thomson and Phillip Cowley and Arthur Christopoulos and Roger G. Pertwee and Ruth A. Ross
Molecular Pharmacology, ISSN 0026-895X, 11/2005, Volume 68, Issue 5, pp. 1484 - 1495
We investigated the pharmacology of three novel compounds, Org 27569 (5-chloro-3-ethyl-1 H -indole-2-carboxylic acid... 
INTERNATIONAL UNION | PAIN | ANTAGONIST | LIGANDS | ACETYLCHOLINE | PHARMACOLOGY | ENDOCANNABINOID SYSTEM | PROTEIN-COUPLED RECEPTORS | CLASSIFICATION | PHARMACOLOGY & PHARMACY | BINDING | Piperidines - metabolism | Allosteric Regulation | Humans | Male | Pyrazoles - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Cyclohexanols - metabolism | Receptor, Cannabinoid, CB1 - drug effects | Receptor, Cannabinoid, CB1 - chemistry | Mice | Binding Sites | Vas Deferens - physiology | Vas Deferens - drug effects
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4. Full Text Use of the GTPγS ([35S]GTPγS and Eu‐GTPγS) binding assay for analysis of ligand potency and efficacy at G protein‐coupled receptors
by Strange, Philip G
British Journal of Pharmacology, ISSN 0007-1188, 11/2010, Volume 161, Issue 6, pp. 1238 - 1249
In this review I consider assays for G protein‐coupled receptor (GPCR) activity based on the binding of labelled analogues of GTPγS ([35S]GTPγS or Eu‐GTPγS) to... 
GTPγS binding assay | inverse agonist | drug screening | functional assay | agonist | antagonist | efficacy | Agonist | Functional assay | Inverse agonist | Efficacy | Antagonist | Drug screening | M-3 MUSCARINIC RECEPTORS | SCINTILLATION PROXIMITY ASSAY | PHARMACOLOGICAL CHARACTERIZATION | GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE) | GTP gamma S binding assay | CHO-CELLS | UNDERLYING AGONIST EFFICACY | HUMAN DOPAMINE-D-2 RECEPTOR | PHARMACOLOGY & PHARMACY | GUANINE-NUCLEOTIDES | RAT THALAMUS | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Radioligand Assay - utilization | Animals | Receptors, G-Protein-Coupled - metabolism | Sulfur Radioisotopes - metabolism | Drug Inverse Agonism | Humans | Radioligand Assay - methods | Ligands | Reviews | Themed Section
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5. Full Text High constitutive activity is an intrinsic feature of ghrelin receptor protein: A study with a functional monomeric GHS-R1a receptor reconstituted in lipid discs
by Damian, Marjorie and Marie, Jacky and Leyris, Jean-Philippe and Fehrentz, Jean-Alain and Verdié, Pascal and Martinez, Jean and Banères, Jean-Louis and Mary, Sophie
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 6, pp. 3630 - 3641
Despite its central role in signaling and the potential therapeutic applications of inverse agonists, the molecular mechanisms underlying G protein-coupled... 
MONOMERIC RHODOPSIN | STRUCTURAL INSIGHTS | GPCR DRUG DISCOVERY | INVERSE AGONISM | CONFORMATIONAL-CHANGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA(1B)-ADRENERGIC RECEPTOR | RESONANCE ENERGY-TRANSFER | COUPLED RECEPTORS | HORMONE SECRETAGOGUE RECEPTOR | BETA-ADRENERGIC RECEPTOR | Protein Structure, Tertiary | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Arrestins - chemistry | Fish Proteins - chemistry | Membrane Proteins - genetics | Humans | Fish Proteins - metabolism | Membranes, Artificial | Arrestins - genetics | Arrestins - metabolism | Receptors, Ghrelin - genetics | Fish Proteins - genetics | Guanosine 5'-O-(3-Thiotriphosphate) - chemistry | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Lipids - chemistry | Animals | GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry | Membrane Proteins - chemistry | Sepia | Receptors, Ghrelin - metabolism | Membrane Proteins - metabolism | Enzyme Activation | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Receptors, Ghrelin - chemistry | Membrane Proteins | Signal Transduction | Ghrelin | Internalization | Fluorescence | Constitutive Activity | 7-Helix Receptor | Arrestin
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6. Full Text The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors
by Volker Brinkmann and Michael D. Davis and Christopher E. Heise and Rainer Albert and Sylvain Cottens and Robert Hof and Christian Bruns and Eva Prieschl and Thomas Baumruker and Peter Hiestand and Carolyn A. Foster and Markus Zollinger and Kevin R. Lynch
Journal of Biological Chemistry, ISSN 0021-9258, 06/2002, Volume 277, Issue 24, pp. 21453 - 21457
Immunosuppressant drugs such as cyclosporin have allowed widespread organ transplantation, but their utility remains limited by toxicities, and they are... 
SEQUESTRATION | ACCELERATION | CIRCULATING MATURE LYMPHOCYTES | PROTEIN-COUPLED RECEPTOR | LYSOPHOSPHOLIPIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPHINGOSINE-1-PHOSPHATE | KINASE | IMMUNOSUPPRESSIVE ACTIVITY | MOLECULAR-CLONING | FUNCTIONAL-CHARACTERIZATION | Phosphorylation | Encephalomyelitis, Autoimmune, Experimental - metabolism | Kidney - pathology | Models, Chemical | Rats, Wistar | Insecta | Rats, Inbred Lew | Receptors, Lysophospholipid | Dose-Response Relationship, Drug | Time Factors | Lymphopenia - metabolism | Cell Membrane - metabolism | Sphingosine - metabolism | Lymphocytes - metabolism | Recombinant Proteins - metabolism | Cell Line | Signal Transduction | Propylene Glycols - metabolism | Receptors, G-Protein-Coupled | Fingolimod Hydrochloride | Rats | Receptors, Cell Surface - metabolism | Lipid Metabolism | Chemotaxis | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Mice | Apoptosis
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7. Full Text Structures of the Noncanonical RNA Ligase RtcB Reveal the Mechanism of Histidine Guanylylation
by Desai, Kevin K and Bingman, Craig A and Phillips, George N and Raines, Ronald T
Biochemistry, ISSN 0006-2960, 04/2013, Volume 52, Issue 15, pp. 2518 - 2525
RtcB is an atypical RNA ligase that joins either 2′,3′-cyclic phosphate or 3′-phosphate termini to 5′-hydroxyl termini. In contrast to typical RNA ligases,... 
PHOSPHATE | CATALYSIS | PROTEIN | CRYSTAL-STRUCTURE | DNA | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | 3'-PHOSPHATE | LIGATION | SEQUENTIAL 2',3'-CYCLIC PHOSPHODIESTERASE | Archaeal Proteins - metabolism | RNA Ligase (ATP) - metabolism | Archaeal Proteins - chemistry | Models, Molecular | Crystallography, X-Ray | Guanosine Triphosphate - metabolism | Histidine - metabolism | Guanosine 5'-O-(3-Thiotriphosphate) - analogs & derivatives | Pyrococcus horikoshii - enzymology | Guanosine 5'-O-(3-Thiotriphosphate) - chemistry | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Manganese - metabolism | Hydrogen Bonding | RNA Ligase (ATP) - chemistry | Protein Conformation | RNA sequencing | Histidine | Analysis | Enzyme binding | Research | Chemical properties | Enzyme kinetics | Structure
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8. Full Text Medium-chain Fatty Acids as Ligands for Orphan G Protein-coupled Receptor GPR84
by Jinghong Wang and Xiaosu Wu and Nicole Simonavicius and Hui Tian and Lei Ling
Journal of Biological Chemistry, ISSN 0021-9258, 11/2006, Volume 281, Issue 45, pp. 34457 - 34464
Free fatty acids (FFAs) play important physiological roles in many tissues as an energy source and as signaling molecules in various cellular processes.... 
IMMUNE | CELLS | RESPONSES | OBESITY | GPR120 | ASSAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SECRETION | GPR40 | IDENTIFICATION | IL-12 | Receptors, G-Protein-Coupled - metabolism | Calcium - metabolism | Humans | DNA, Complementary - genetics | Interleukin-12 Subunit p40 - secretion | Monocytes - metabolism | RNA, Messenger - metabolism | Aequorin - metabolism | Fatty Acids, Nonesterified - metabolism | Flow Cytometry | Bone Marrow | Cyclic AMP - metabolism | Calcium Signaling | CHO Cells | Cricetinae | RNA, Messenger - genetics | Receptors, Cell Surface - metabolism | Immune System - cytology | Reverse Transcriptase Polymerase Chain Reaction | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Macrophages - metabolism | Animals | Immune System - metabolism | Fluorescent Antibody Technique | Lipopolysaccharides - pharmacology | Ligands | Mice | Receptors, G-Protein-Coupled - genetics | DNA, Complementary - metabolism | Leukocytes - metabolism | Receptors, Cell Surface - genetics
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9. Full Text mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis
by Rios, C and Gomes, I and Devi, LA
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 06/2006, Volume 148, Issue 4, pp. 387 - 395
1 Several studies have described functional interactions between opioid and cannabinoid receptors; the underlying mechanism(s) have not been well explored. One... 
ACTIVATION | dimerization | PROTEIN-COUPLED RECEPTORS | CLASSIFICATION | marijuana | HETERODIMERIZATION | CELL-LINES | PHOSPHOINOSITIDE 3-KINASE | THC | morphine | INTERNATIONAL UNION | oligomerization | NEURITE OUTGROWTH | INTERFACE | GPCR | PHARMACOLOGY & PHARMACY | neuritogenesis | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Phosphorylation | Neurites - physiology | Enkephalin, Ala-MePhe-Gly- - pharmacology | Humans | Cells, Cultured | Signal Transduction - physiology | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Cannabinoid, CB1 - physiology | Receptors, Opioid, mu - physiology
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10. Full Text Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation
by Emmanuel Le Poul and Cécile Loison and Sofie Struyf and Jean-Yves Springael and Vincent Lannoy and Marie-Eve Decobecq and Stéphane Brezillon and Vincent Dupriez and Gilbert Vassart and Jo Van Damme and Marc Parmentier and Michel Detheux
Journal of Biological Chemistry, ISSN 0021-9258, 07/2003, Volume 278, Issue 28, pp. 25481 - 25489
Short chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are produced at high concentration by bacteria in the gut and subsequently... 
RETRACTED ARTICLE. SEE | GENE | PROTEIN-COUPLED RECEPTOR | PERIPHERAL-BLOOD NEUTROPHILS | CHEMOTACTIC-FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPHINGOSYLPHOSPHORYLCHOLINE | CALCIUM MOBILIZATION | ALCOHOL-CONSUMPTION | NATURAL LIGANDS | IDENTIFICATION | Calcium - metabolism | Humans | Molecular Sequence Data | Phylogeny | Fatty Acids, Volatile - metabolism | MAP Kinase Signaling System | Dose-Response Relationship, Drug | Tissue Distribution | Transfection | Time Factors | Receptors, Cell Surface - chemistry | Receptors, Cell Surface - physiology | Cyclic AMP - metabolism | Neutrophils - metabolism | CHO Cells | Pertussis Toxin - pharmacology | Recombinant Proteins - metabolism | Amino Acid Sequence | Cricetinae | Acetates - metabolism | Receptors, G-Protein-Coupled | Receptors, Cell Surface - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Chemotaxis | Sequence Homology, Amino Acid | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Aequorin - pharmacology | Inositol 1,4,5-Trisphosphate - metabolism | Leukocytes - metabolism | Mitogen-Activated Protein Kinase 3 | GTP-Binding Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism
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11. Full Text Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
by Thomas, A and Baillie, G L and Phillips, A M and Razdan, R K and Ross, R A and Pertwee, R G
British Journal of Pharmacology, ISSN 0007-1188, 03/2007, Volume 150, Issue 5, pp. 613 - 623
Background and purpose: A nonpsychoactive constituent of the cannabis plant, cannabidiol has been demonstrated to have low affinity for both cannabinoid CB1... 
cannabidiol | CB2 receptor | CP55940 | O‐2654 | GTPγS assay | CB1 receptor | mouse brain | inverse agonism | neutral antagonism | O-2654 | GTP gamma S assay | INHIBITION | LIGANDS | SELECTIVE INVERSE AGONIST | MOUSE VAS-DEFERENS | PERIPHERAL CANNABINOID RECEPTOR | PHARMACOLOGY & PHARMACY | BINDING | BRAIN | Cricetulus | Cyclohexanols | Receptor, Cannabinoid, CB2 - agonists | Cannabinoid Receptor Antagonists | Cyclohexanes - pharmacology | Humans | Bornanes - pharmacology | Anti-Inflammatory Agents - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Receptors, Cannabinoid - metabolism | Receptor, Cannabinoid, CB1 - agonists | Transfection | Piperidines - pharmacology | Morpholines - antagonists & inhibitors | Phenols - antagonists & inhibitors | Cyclohexanes - antagonists & inhibitors | Benzoxazines - antagonists & inhibitors | Cell Membrane - metabolism | Cell Membrane - drug effects | Receptors, Cannabinoid - genetics | CHO Cells | Phenols - pharmacology | Pyrazoles - pharmacology | Cricetinae | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Morpholines - pharmacology | Cannabidiol - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Brain - drug effects | Cannabinoid Receptor Agonists | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Benzoxazines - pharmacology | Protein Binding | Mice | Cannabidiol - metabolism | In Vitro Techniques | Naphthalenes - antagonists & inhibitors | Research Papers
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12. Full Text A Bifunctional Bacterial Protein Links Gdi Displacement to Rab1 Activation
by Matthias P. Machner and Ralph R. Isberg
Science, ISSN 0036-8075, 11/2007, Volume 318, Issue 5852, pp. 974 - 977
Rab guanosine triphosphatases (GTPases) regulate vesicle trafficking in eukaryotic cells by reversibly associating with lipid membranes. Inactive Rab GTPases... 
Proteins | COS cells | Antibodies | Amino acids | Reports | Nucleotides | Liposomes | Physiological regulation | Guanine nucleotide dissociation inhibitors | Cytosol | Vacuoles | SMG P25A | GTP-BINDING PROTEIN | LEGIONELLA-PNEUMOPHILA | DISSOCIATION INHIBITOR | MEMBRANE | MULTIDISCIPLINARY SCIENCES | CYSTEINE MOTIFS | VESICULAR TRANSPORT | NUCLEOTIDE-EXCHANGE | ENDOPLASMIC-RETICULUM | GOLGI COMPARTMENTS | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Vacuoles - microbiology | rab1 GTP-Binding Proteins - metabolism | Guanine Nucleotide Dissociation Inhibitors - metabolism | Humans | Bacterial Proteins - chemistry | Recombinant Proteins - chemistry | Cytoplasm - metabolism | Legionella pneumophila - metabolism | rho-Specific Guanine Nucleotide Dissociation Inhibitors | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Guanine Nucleotide Exchange Factors - metabolism | Protein Binding | Vacuoles - metabolism | Bacterial Proteins - metabolism | Guanosine Diphosphate - metabolism | Bacteria | Membranes | Cellular biology | Legionnaires disease
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13. Full Text A G Protein-coupled Receptor Responsive to Bile Acids
by Yuji Kawamata and Ryo Fujii and Masaki Hosoya and Masataka Harada and Hiromi Yoshida and Masanori Miwa and Shoji Fukusumi and Yugo Habata and Takashi Itoh and Yasushi Shintani and Shuji Hinuma and Yukio Fujisawa and Masahiko Fujino
Journal of Biological Chemistry, ISSN 0021-9258, 03/2003, Volume 278, Issue 11, pp. 9435 - 9440
So far some nuclear receptors for bile acids have been identified. However, no cell surface receptor for bile acids has yet been reported. We found that a... 
CELLS | TUMOR-NECROSIS-FACTOR | OBSTRUCTIVE-JAUNDICE | PROLACTIN-RELEASING PEPTIDE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOCYTES | IDENTIFICATION | EXPRESSION | NUCLEAR RECEPTOR | FACTOR-ALPHA | BETA | Green Fluorescent Proteins | Humans | Bile Acids and Salts - chemistry | Molecular Sequence Data | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | MAP Kinase Signaling System | Dose-Response Relationship, Drug | Tissue Distribution | Transfection | Time Factors | Receptors, Cell Surface - chemistry | Cell Membrane - metabolism | Cyclic AMP - metabolism | CHO Cells | Amino Acid Sequence | Cell Line | Rabbits | Cricetinae | Cytokines - metabolism | GTP-Binding Proteins - chemistry | Receptors, G-Protein-Coupled | Rats | Receptors, Cell Surface - metabolism | Bile Acids and Salts - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Macrophages - metabolism | Animals | Protein Binding | Mice | Genetic Vectors | Phagocytosis | Luminescent Proteins - metabolism | Mitogen-Activated Protein Kinases - metabolism
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14. Full Text Crosstalk in G Protein-Coupled Receptors: Changes at the Transmembrane Homodimer Interface Determine Activation
by Wen Guo and Lei Shi and Marta Filizola and Harel Weinstein and Jonathan A. Javitch and Arthur Karlin
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2005, Volume 102, Issue 48, pp. 17495 - 17500
Functional crosstalk between G protein-coupled receptors in a homo- or heterodimeric assembly likely involves conformational changes at the dimer interface,... 
Proteins | Biological Sciences | Receptors | Crosstalk | Crosslinking | Agonists | Ligands | Dimers | Cell membranes | Modeling | Protein subunits | Cysteine | Rhodopsin | Dopamine | Oligomer | HORMONE-RECEPTORS | METABOTROPIC GLUTAMATE-RECEPTOR | LIGAND-BINDING | MULTIDISCIPLINARY SCIENCES | cysteine | oligomer | DIMERIZATION | rhodopsin | DOPAMINE D2 RECEPTOR | CONFORMATIONAL-CHANGES | METARHODOPSIN-I | GABA-B RECEPTOR | crosslinking | dopamine | REVEALS | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Mutagenesis, Site-Directed | Phenanthrolines - pharmacology | Cross-Linking Reagents - pharmacology | Receptors, Dopamine D2 - agonists | Models, Molecular | Immunoblotting | Mercuric Chloride - pharmacology | Receptors, Dopamine D2 - metabolism | Cyclic AMP - metabolism | Dimerization | Receptors, Dopamine D2 - genetics | G proteins | Research
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15. Full Text Smoothened Is a Fully Competent Activator of the Heterotrimeric G Protein G(i)
by Shen, F and Cheng, L and Douglas, AE and Riobo, NA and Manning, DR
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 03/2013, Volume 83, Issue 3, pp. 691 - 697
Smoothened (Smo) is a 7-transmembrane protein essential to the activation of Gli transcription factors (Gli) by hedgehog morphogens. The structure of Smo... 
ALPHA FUSION PROTEINS | ENDOTHELIAL-CELLS | RECEPTOR | TRANSDUCTION | PHARMACOLOGY & PHARMACY | PROLIFERATION | EXPRESSION | HEDGEHOG SIGNALING PATHWAY | SUBUNIT | FAMILY | Cell Line | Receptors, G-Protein-Coupled - metabolism | Humans | Hedgehog Proteins - metabolism | Heterotrimeric GTP-Binding Proteins - metabolism | Adenylyl Cyclases - metabolism | Transcription Factors - metabolism | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Serotonin - metabolism | Smoothened Receptor | HEK293 Cells | Cyclic AMP - metabolism | Receptor, Serotonin, 5-HT1A - metabolism
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16. Full Text Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
by Suzanne Mandala and Richard Hajdu and James Bergstrom and Elizabeth Quackenbush and Jenny Xie and James Milligan and Rosemary Thornton and Gan-Ju Shei and Deborah Card and CarolAnn Keohane and Mark Rosenbach and Jeffrey Hale and Christopher L. Lynch and Kathleen Rupprecht and William Parsons and Hugh Rosen
Science, ISSN 0036-8075, 4/2002, Volume 296, Issue 5566, pp. 346 - 349
Blood lymphocyte numbers, essential for the development of efficient immune responses, are maintained by recirculation through secondary lymphoid organs. We... 
T lymphocytes | Receptors | Sinuses | Lymphopenia | Lymphocytes | Rats | Agonists | Reports | Physiological regulation | Plants | Blood | IMMUNOSUPPRESSANT | FTY720 | MULTIDISCIPLINARY SCIENCES | SPHINGOSINE 1-PHOSPHATE | Organophosphates - metabolism | T-Lymphocytes - physiology | Phosphorylation | Calcium - metabolism | Stereoisomerism | Humans | Organophosphonates - metabolism | Spleen - drug effects | Receptors, Lysophospholipid | Organophosphonates - chemical synthesis | T-Lymphocytes - drug effects | Organophosphates - chemical synthesis | Immunosuppressive Agents - metabolism | Lymph Nodes - drug effects | Sphingosine - metabolism | Cyclic AMP - metabolism | Immunosuppressive Agents - pharmacology | CHO Cells | Binding, Competitive | Propylene Glycols - pharmacology | Cricetinae | Propylene Glycols - metabolism | Receptors, Cell Surface - agonists | Receptors, G-Protein-Coupled | B-Lymphocytes - physiology | Fingolimod Hydrochloride | Receptors, Cell Surface - metabolism | Spleen - cytology | Lymph Nodes - cytology | Organophosphates - pharmacology | Sphingosine - pharmacology | B-Lymphocytes - drug effects | Lysophospholipids | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Organophosphonates - pharmacology | Sphingosine - analogs & derivatives | Animals | Organophosphonates - chemistry | Lymphocyte Count | Ligands | Organophosphates - chemistry | Mice | Lymphopenia - chemically induced | Phosphates | Protein research | Evaluation | Lipid research | Research | Pharmaceutical industry | Immune system | Lymphatic system | Immunology
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