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Nature (London), ISSN 1476-4687, 2011, Volume 480, Issue 7377, pp. 379 - 382
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e68347
Journal Article
Journal Article
Journal of virology, ISSN 1098-5514, 2018, Volume 92, Issue 19
A third of humans carry genetic variants of the ITP pyrophosphatase (ITPase) gene (ITPA) that lead to reduced enzyme activity. Reduced ITPase activity was... 
ribavirin | ITP pyrophosphatase | inosine triphosphate pyrophosphatase | hepatitis C virus | ITPase | mutagenesis | ITPA | PYROPHOSPHOHYDROLASE DEFICIENCY | POPULATION | REAL-TIME PCR | INTERFERON | THERAPY | VIROLOGY | TREATMENT RESPONSE | GENE-EXPRESSION | ANTIVIRAL ACTIVITY | INFECTION | MYCOPHENOLIC-ACID | RNA, Small Interfering - genetics | Humans | Pyrophosphatases - genetics | Hepacivirus - genetics | Hepatitis B Core Antigens - metabolism | Guanosine Triphosphate - metabolism | Antiviral Agents - metabolism | Hepacivirus - metabolism | Dose-Response Relationship, Drug | Pyrophosphatases - antagonists & inhibitors | RNA, Viral - genetics | RNA, Viral - metabolism | Hepatocytes - drug effects | Hepacivirus - drug effects | Antiviral Agents - pharmacology | Signal Transduction | Gene Expression Regulation | Ribavirin - metabolism | Nucleotides - metabolism | Hepatitis B Core Antigens - genetics | Host-Pathogen Interactions | Pyrophosphatases - metabolism | Mutagenesis | Cell Line, Tumor | Hepatocytes - virology | Hepacivirus - growth & development | High-Throughput Nucleotide Sequencing | Ribavirin - pharmacology | Hepatocytes - enzymology | RNA, Small Interfering - metabolism | Index Medicus | infection | therapy | gene-expression | real-time pcr | antiviral activity | Mikrobiologi inom det medicinska området | inosine triphosphate | interferon | population | Microbiology in the medical area | pyrophosphohydrolase deficiency | treatment response | mycophenolic-acid
Journal Article
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 2009, Volume 35, Issue 5, pp. 563 - 573
The target of rapamycin complex 1 (TORC1) is a central regulator of eukaryotic cell growth that is activated by a variety of hormones (e.g., insulin) and... 
CELLBIO | PROTEINS | SIGNALING | YEAST SACCHAROMYCES-CEREVISIAE | CELL-GROWTH CONTROL | SIGNALING PATHWAYS | FUNCTIONAL HOMOLOG | RAG GTPASES | VACUOLE FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMINO-ACID PERMEASE | COMPONENT | GTP-BINDING PROTEINS | GAP1 PERMEASE | CELL BIOLOGY | Vacuoles - enzymology | Intracellular Membranes - enzymology | Saccharomyces cerevisiae - genetics | Multiprotein Complexes | Adaptor Proteins, Vesicular Transport - genetics | Saccharomyces cerevisiae - drug effects | Guanosine Triphosphate - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Vacuoles - drug effects | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Guanosine Diphosphate - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Monomeric GTP-Binding Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Transport Systems - metabolism | Sirolimus - pharmacology | Cycloheximide - pharmacology | Protein Transport | Transcription Factors - metabolism | Monomeric GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Endosomes - enzymology | Intracellular Membranes - drug effects | Mutation | Saccharomyces cerevisiae - growth & development | Proteins | Purines | Amino acids | Gross domestic product | Guanosine
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2011, Volume 108, Issue 24, pp. 9815 - 9820
.... Its mode of cytotoxicity is thought to be associated in part with the triphosphate functioning as an allosteric inhibitor of hRNR... 
Enzymes | Ribonucleotides | Elution | Biochemical mechanisms | Substrate specificity | DNA | Nucleosides | Biochemistry | Nucleotides | Diphosphates | Allosteric regulation | Slow-binding inhibitor | Oligomerization | EFFECTORS | ASSAY | oligomerization | 5'-TRIPHOSPHATE | slow-binding inhibitor | MULTIDISCIPLINARY SCIENCES | allosteric regulation | DNA-SYNTHESIS | 2-CHLORO-9-(2-DEOXY-2-FLUORO-BETA-D-ARABINOFURANOSYL)ADENINE | BINDING | Diphosphates - metabolism | Ribonucleotide Reductases - chemistry | Adenine Nucleotides - pharmacology | Allosteric Regulation | Humans | Protein Multimerization | Substrate Specificity | Adenine Nucleotides - chemistry | Guanosine Triphosphate - metabolism | Protein Subunits - metabolism | Time Factors | Biocatalysis - drug effects | Adenosine Triphosphate - metabolism | Protein Structure, Quaternary | Antineoplastic Agents - pharmacology | Molecular Structure | Protein Subunits - genetics | Arabinonucleosides - metabolism | Arabinonucleosides - chemistry | Catalytic Domain - genetics | Arabinonucleosides - pharmacology | Binding Sites - genetics | Antineoplastic Agents - chemistry | Polyphosphates - metabolism | Diphosphates - chemistry | Algorithms | Adenine Nucleotides - metabolism | Ribonucleotide Reductases - antagonists & inhibitors | Ribonucleotide Reductases - metabolism | Protein Subunits - antagonists & inhibitors | Kinetics | Mutation | Polyphosphates - chemistry | Enzyme binding | Research | Properties | Binding sites (Biochemistry) | Biological Sciences
Journal Article
Journal Article
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2015, Volume 38, Issue 3, pp. 380 - 388
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2015, Volume 290, Issue 1, pp. 640 - 657
Background: Fe-S cluster assembly in mitochondria involves generation of an activated form of sulfur called persulfide. Results: A novel experimental system... 
CELLS | Yeast | HUMAN-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Iron | Iron-Sulfur Protein | YEAST FRATAXIN | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | Metal Homeostasis | CYSTEINE DESULFURASE | Mitochondria | Iron Metabolism | INTERACTING PROTEIN | Mitochondrial Aconitase | SUCCINYL-COA SYNTHETASES | INTACT MITOCHONDRIA | SCAFFOLD PROTEIN | Sulfur | Friedreich Ataxia | Mitochondrial Metabolism | Aconitate Hydratase - metabolism | Ferredoxins - genetics | Humans | Ferredoxins - chemistry | Sulfides - chemistry | Neurons - cytology | Guanosine Triphosphate - metabolism | Mitochondrial Proteins - genetics | NAD - chemistry | Aconitate Hydratase - chemistry | Carbon-Sulfur Lyases - genetics | Mitochondrial Proteins - metabolism | Adenosine Triphosphate - metabolism | Escherichia coli - metabolism | Aconitate Hydratase - genetics | Cysteine - metabolism | Guanosine Triphosphate - chemistry | Neurons - metabolism | Sulfides - metabolism | Mitochondria - chemistry | NAD - metabolism | Recombinant Proteins - metabolism | Cell Line | Gene Expression | Ferredoxins - metabolism | Iron - chemistry | HSP70 Heat-Shock Proteins - genetics | Sulfur Radioisotopes | Mitochondria - metabolism | Recombinant Proteins - genetics | Cysteine - chemistry | Carbon-Sulfur Lyases - metabolism | Iron - metabolism | HSP70 Heat-Shock Proteins - metabolism | Animals | Escherichia coli - genetics | Mitochondrial Proteins - chemistry | Mice | HeLa Cells | Adenosine Triphosphate - chemistry | Metabolism
Journal Article
The Journal of Physical Chemistry B, ISSN 1520-6106, 10/2015, Volume 119, Issue 40, pp. 12838 - 12845
Molecular mechanisms of the hydrolysis of guanosine triphosphate (GTP) to guanosine diphosphate (GDP... 
Hydrolysis | Models, Molecular | Quantum Theory | ras GTPase-Activating Proteins - metabolism | Guanosine Triphosphate - metabolism | Kinetics
Journal Article