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Human Vaccines & Immunotherapeutics, ISSN 2164-5515, 11/2014, Volume 10, Issue 11, pp. 3270 - 3285
Research on innate immune signaling and regulation has recently focused on pathogen recognition receptors (PRRs) and their signaling pathways. Members of PRRs... 
IFI16, interferon, gamma-inducible protein 16 | IRF, interferon regulatory factor | CDNs, cyclic dinucleotides | AIM2, absent in melanoma 2 | LT, lethal toxin | MIB, mind bomb | ALRs, AIM2-like receptors | MDP, muramyl dipeptide | LUBAC, linear ubiquitin assembly complex | innate immunity | TRIF, TIR domain-containing adaptor inducing IFN-b | DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | IKK, IkB kinase | MyD88, myeloid differentiation factor 88 | TRAILR, tumor-necrosis factor-related apoptosis-inducing ligand receptor | AMPK, AMP activated protein kinase | LBP, LPS-binding protein | NEMO, NF-kB essential modulator | TRIMs, tripartite motif containing proteins | IKKi, inducible IkB kinase | PKC-d, protein kinase C delta | LRR, leucine-rich repeat | TAK1, TGF-b-activating kinase 1 | RIP, receptor-interacting protein | TBK1, TANK binding kinase 1 | TRIP, TRAF-interacting protein | TLRs, Toll-like receptors | LGP 2, laboratory of genetics and physiology 2 | PKR, dsRNA-dependent protein kinase | PRRs, pathogen recognition receptors | STING, stimulator of interferon gene | GBP5, guanylate-binding protein 5 | RLRs, RIG-I-like receptors | ULK1, autophagy related serine threonine UNC-51- like kinase | TIR, Toll IL-1 receptor | LPS, lipopolysaccharide | TRAF, TNFR-associated factor | Atg16L, autophagy related 16-like | cDC, conventional dendritic cell | MDA5, melanoma differentiation-associated protein 5 | DCs, dendritic cells | CARD, caspase recruitment domain | PRRs | KSHV, Kaposi's sarcoma-associated herpesvirus | RAUL, RTA-associated E3 ligase | CLRs, C-type lectin receptors | pDC, plasmacytoid dendritic cell | MAVS, mitochondrial antiviral signaling protein | inflammation | NAIPs, neuronal apoptosis inhibitory proteins | CYLD, the familial cylindromatosis tumor suppressor gene | SIGIRR, single Ig IL-1-related receptor | ROS, reactive oxygen species | RIG-I, retinoic acid-inducible gene 1 | TANK, TRAF family-member-associated NF-kB activator | ASC, apoptosis-associated speck-like protein containing a CARD | DAMPs, danger-associated molecular patterns | IFN, interferon | TRAM, TRIF-related adaptor molecule | TIRAP, TIR domain-containing adapter protein | iE-DAP, g-D-glutamyl-meso-diaminopimelic acid | PAMPs, pathogen-associated molecular patterns | cGAS, cyclic GMP-AMP synthase | cIAP, cellular inhibitor of apoptosis protein | GSK3β, Glycogen synthase kinase 3β | NOD, nucleotide-binding oligomerization domain | IRAK, interleukin-1 receptor-associated kinase | BMM, bone marrow-derived macrophage | type I interferon | RACK1, receptor for activated C kinase 1 | SARM, sterile a- and armadillo motif-containing protein | SOCS, suppressor of cytokine signaling | CMV, cytomegalovirus | cancer | NLRs, Nod- like receptors | Nrdp1, neuregulin receptor degradation protein 1 | HCC, hepatocellular carcinoma | ER, endoplasmic reticulum | Innate immunity | Inflammation | Type I interferon | Cancer | linear ubiquitin assembly complex | C-type lectin receptors | IKKi | TRIP | TRAF | apoptosis-associated speck-like protein containing a CARD | neuregulin receptor degradation protein 1 | RIG-I | TRAM | CARD | TRIF-related adaptor molecule | dendritic cells | TBK1 | cytomegalovirus | cyclic dinucleotides | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | cellular inhibitor of apoptosis protein | GSK3 | PAMPs | retinoic acid-inducible gene 1 | CDNs | hepatocellular carcinoma | TANK binding kinase 1 | RAUL | GBP5 | Toll IL-1 receptor | cDC | MIB | protein kinase C delta | iE-DAP | CMV | SARM | SIGIRR | IRAK | sterile a- and armadillo motif-containing protein | cyclic GMP-AMP synthase | TNFR-associated factor | autophagy related serine threonine UNC-51-like kinase | AMPK | ULK1 | lipopolysaccharide | TRIF | IRF | RLRs | Nrdp1 | receptor-interacting protein | LPS-binding protein | plasmacytoid dendritic cell | tripartite motif containing proteins | LPS | DAMPs | melanoma differentiation-associated protein 5 | ASC | TAK1 | KSHV | LGP 2 | neuronal apoptosis inhibitory proteins | TRIMs | danger-associated molecular patterns | cGAS | T-CELL DEVELOPMENT | RIG-I-like receptors | lethal toxin | BMM | muramyl dipeptide | interleukin-1 receptor-associated kinase | IKK | AMP activated protein kinase | absent in melanoma 2 | IkB kinase | CYLD | dsRNA-dependent protein kinase | MAVS | Kaposi's sarcoma-associated herpesvirus | TIR domain-containing adaptor inducing IFN-b | STING | TIR | AIM2-like receptors | laboratory of genetics and physiology 2 | DDX41 | IMMUNOLOGY | LRR | MyD88 | nucleotide-binding oligomerization domain | CLRs | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | myeloid differentiation factor 88 | MDP | RACK1 | LBP | TRAF-interacting protein | bone marrow-derived macrophage | NF-KAPPA-B | NOD-LIKE RECEPTOR | NOD | conventional dendritic cell | IFN-BETA PRODUCTION | HCC | TGF-b-activating kinase 1 | inducible IkB kinase | TUMOR-SUPPRESSOR CYLD | TIRAP | Atg16L | mind bomb | pathogen-associated molecular patterns | AIM2 | PKR | SINGLE-STRANDED RNA | TRAF family-member-associated NF-kB activator | ROS | interferon regulatory factor | g-D-glutamyl-meso-diaminopimelic acid | pathogen recognition receptors | NLRs | UBIQUITIN-DEPENDENT KINASE | NEMO | stimulator of interferon gene | RTA-associated E3 ligase | Nod- like receptors | CYTOSOLIC DNA SENSOR | the familial cylindromatosis tumor suppressor gene | tumor-necrosis factor-related apoptosis-inducing ligand receptor | TANK | MDA5 | IFN | mitochondrial antiviral signaling protein | ALRs | IFI16 | DCs | TRAILR | reactive oxygen species | Toll-like receptors | cIAP | TIR domain-containing adapter protein | PATTERN-RECOGNITION RECEPTORS | single Ig IL-1-related receptor | guanylate-binding protein 5 | suppressor of cytokine signaling | autophagy related 16-like | leucine-rich repeat | NF-kB essential modulator | Glycogen synthase kinase 3 | SOCS | interferon | LUBAC | caspase recruitment domain | pDC | NAIPs | receptor for activated C kinase 1 | PKC-d | RIP | gamma-inducible protein 16 | TLRs | endoplasmic reticulum | Immunity, Innate - immunology | Signal Transduction - immunology | Neoplasms - immunology | Humans | Inflammasomes - immunology | RNA Viruses - immunology | Toll-Like Receptors - immunology | Interferon Type I - immunology | DNA Viruses - immunology
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2009, Volume 29, Issue 24, pp. 7929 - 7943
A-kinase anchoring protein (AKAP) 79/150 is a scaffold protein found in dendritic spines that recruits the cAMP-dependent protein kinase (PKA) and protein... 
GLUR1 SUBUNIT | DENDRITIC SPINE MORPHOGENESIS | NMDA RECEPTOR | AKAP150-ANCHORED PKA | LONG-TERM POTENTIATION | AMPA-RECEPTOR TRAFFICKING | SILENT SYNAPSES | SYNAPTIC PLASTICITY | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | PHOSPHORYLATION SITES | Disks Large Homolog 4 Protein | Guanylate Kinases - genetics | Protein Binding - genetics | Age Factors | Humans | Gene Expression Regulation, Developmental - genetics | Neurons - cytology | Dendritic Spines - metabolism | Synapses - genetics | Miniature Postsynaptic Potentials - drug effects | Excitatory Postsynaptic Potentials - drug effects | A Kinase Anchor Proteins - genetics | Mutation - physiology | Calcineurin - genetics | Transfection - methods | Time Factors | Neurons - physiology | RNA Interference - physiology | Intracellular Signaling Peptides and Proteins - genetics | Receptors, AMPA - genetics | A Kinase Anchor Proteins - metabolism | Excitatory Postsynaptic Potentials - genetics | Miniature Postsynaptic Potentials - genetics | Receptors, AMPA - metabolism | Animals, Newborn | Presynaptic Terminals - drug effects | Membrane Proteins - genetics | Synapses - physiology | Cells, Cultured | Rats | Presynaptic Terminals - physiology | Protein Structure, Tertiary - genetics | Hippocampus - cytology | Rats, Sprague-Dawley | Animals | Analysis of Variance | Guanylate Kinases - metabolism | Luminescent Proteins - genetics | Calcineurin - metabolism | Protein Structure, Tertiary - physiology
Journal Article
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2013, Volume 50, Issue 1, pp. 43 - 55
The Raf/MEK/ERK and PI3K/Akt pathways are prominent effectors of oncogenic Ras. These pathways negatively regulate each other, but the mechanism involved is... 
B-CELL HOMEOSTASIS | PROTEIN | CANCER CELLS | PATHWAY | PHOSPHATIDYLINOSITOL 3-KINASE | GUANYLATE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | INHIBITORS | TUMOR-SUPPRESSOR PTEN | T-CELLS | CELL BIOLOGY | Fibroblasts - enzymology | Multienzyme Complexes | Phosphatidylinositol Phosphates - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Myeloproliferative Disorders - immunology | Mice, 129 Strain | Autoimmune Diseases - genetics | RNA Interference | Time Factors | Proto-Oncogene Proteins c-akt - metabolism | Cell Membrane - drug effects | Tyrosine | MAP Kinase Kinase 1 - antagonists & inhibitors | Autoimmune Diseases - enzymology | Signal Transduction | Lymphocyte Activation | Membrane Proteins - genetics | Genotype | MAP Kinase Kinase 1 - metabolism | Fibroblasts - pathology | Mice, Knockout | Lymphocytes - pathology | Phenotype | Fibroblasts - drug effects | Lymphocytes - enzymology | Fibroblasts - immunology | Cell Membrane - immunology | Mice | Enzyme Activation | COS Cells | Myeloproliferative Disorders - enzymology | Phosphorylation | Cercopithecus aethiops | Extracellular Signal-Regulated MAP Kinases - metabolism | Myeloproliferative Disorders - genetics | MAP Kinase Kinase 1 - genetics | Lymphocytes - immunology | Transfection | Cell Death | Cell Membrane - pathology | Female | Membrane Proteins - metabolism | Mice, Inbred C57BL | Autoimmune Diseases - immunology | Self Tolerance | PTEN Phosphohydrolase - metabolism | Protein Transport | Cell Membrane - enzymology | Animals | Adaptor Proteins, Signal Transducing - genetics | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | MAP Kinase Kinase 1 - deficiency | Lupus | Phosphates | Employee recruitment
Journal Article
The Plant Journal, ISSN 0960-7412, 04/2018, Volume 94, Issue 2, pp. 327 - 339
Journal Article
Analytical Biochemistry, ISSN 0003-2697, 06/2019, Volume 575, pp. 63 - 69
The development of a high-performance liquid chromatography (HPLC)-based method, for guanosine monophosphate kinase activity assays, is presented. The method... 
Nucleotide | Sigmoidal kinetics | Substrate inhibition | Guanosine monophosphate kinase | Guanylate kinase | HPLC | CHEMISTRY, ANALYTICAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | Enzymes | Nucleotides | Drug discovery | Malaria | High performance liquid chromatography
Journal Article
The Journal of Immunology, ISSN 0022-1767, 01/2004, Volume 172, Issue 2, pp. 1220 - 1226
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2012, Volume 32, Issue 31, pp. 10767 - 10779
Understanding how brief synaptic events can lead to sustained changes in synaptic structure and strength is a necessary step in solving the rules governing... 
F-ACTIN | NR2B-CONTAINING NMDA RECEPTORS | LONG-TERM-POTENTIATION | SUBUNIT COMPOSITION | D-ASPARTATE RECEPTOR | SYNAPTIC PLASTICITY | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | PROTEIN-KINASE-II | SINGLE DENDRITIC SPINES | DIFFERENTIAL ROLES | Disks Large Homolog 4 Protein | RNA, Small Interfering - genetics | MAP Kinase Signaling System - physiology | Immunoprecipitation | Calcium - metabolism | Microtubule-Associated Proteins - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Neuronal Plasticity - drug effects | Male | Neurons - cytology | Dendritic Spines - metabolism | Cerebral Cortex - cytology | Receptors, N-Methyl-D-Aspartate - genetics | Neuronal Plasticity - physiology | Transfection | Membrane Proteins - metabolism | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | 4-Aminopyridine - pharmacology | Potassium Channel Blockers - pharmacology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | GABA-A Receptor Antagonists - pharmacology | Photobleaching | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Bicuculline - pharmacology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Animals | Analysis of Variance | Guanylate Kinases - metabolism | Luminescent Proteins - genetics | Mice | In Vitro Techniques | Luminescent Proteins - metabolism | RNA, Small Interfering - metabolism | Phosphorylation | Neurons | Neurons and Cognition | Neurobiology | Cerebral Cortex | Receptors, N-Methyl-D-Aspartate | MAP Kinase Signaling System | Guanylate Kinase | Life Sciences | Neuronal Plasticity | Dendritic Spines | Calcium-Calmodulin-Dependent Protein Kinase Type 2
Journal Article
Journal Article