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1. Full Text The microdomain-organizing protein MPP1 is required for insulinstimulated activation of H-Ras
by Podkalicka, Joanna and Biernatowska, Agnieszka and Olszewska, Paulina and Tabaczar, Sabina and Sikorski, Aleksander F
Oncotarget, 04/2018, Volume 9, Issue 26, pp. 18410 - 18421
MPP1 | H-Ras | PM-lateral organization | Small GTPases
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2. Full Text Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
by Commisso, Cosimo and Davidson, Shawn M and Soydaner-Azeloglu, Rengin G and Parker, Seth J and Kamphorst, Jurre J and Hackett, Sean and Grabocka, Elda and Nofal, Michel and Drebin, Jeffrey A and Thompson, Craig B and Rabinowitz, Joshua D and Metallo, Christian M and Vander Heiden, Matthew G and Bar-Sagi, Dafna
Nature, ISSN 0028-0836, 05/2013, Volume 497, Issue 7451, pp. 633 - 637
Macropinocytosis is a highly conserved endocytic process by which extracellular fluid and its contents are internalized into cells through large, heterogeneous... 
PATHWAYS | H-RAS | K-RAS | SRC | MULTIDISCIPLINARY SCIENCES | GROWTH | MASS ISOTOPOMER DISTRIBUTIONS | CANCER | CARCINOMA | FIBROBLASTS | GLUTAMINE-METABOLISM | Carbon - metabolism | NIH 3T3 Cells | Cell Proliferation | Pancreatic Neoplasms - metabolism | Pancreatic Neoplasms - pathology | Glutamine - metabolism | Pancreatic Neoplasms - genetics | Pinocytosis | Oncogene Protein p21(ras) - metabolism | Amino Acids - metabolism | Animals | Biological Transport | Cell Transformation, Neoplastic - genetics | Mice, Nude | Proteolysis | Cell Line, Tumor | Female | Mice | Cell Line, Transformed | Disease Models, Animal | Oncogene Protein p21(ras) - genetics | Proteins | Physiological aspects | Research | Cancer cells | Mutation | Metabolites | Cancer | Index Medicus
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3. Full Text A comprehensive survey of ras mutations in cancer
by Prior, Ian A and Lewis, Paul D and Mattos, Carla
Cancer Research, ISSN 0008-5472, 05/2012, Volume 72, Issue 10, pp. 2457 - 2467
All mammalian cells express 3 closely related Ras proteins, termed H-Ras, K-Ras, and N-Ras, that promote oncogenesis when they are mutationally activated at... 
ONCOGENES | LUNG-CANCER | H-RAS | K-RAS | ONCOLOGY | N-RAS | ACTIVATE RAF-1 | KRAS | PROTEINS | STEM-CELL EXPANSION | HUMAN P53 GENE | Catalytic Domain | Signal Transduction | Epigenesis, Genetic | Humans | Molecular Conformation | Databases, Genetic | Models, Molecular | Protein Isoforms - physiology | Point Mutation | Codon | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | ras Proteins - chemistry | Genes, ras | Index Medicus | NRAS | mutation hotspot | HRAS | GTPase | mutagenesis
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4. Full Text The microdomain-organizing protein MPP1 is required for insulin-stimulated activation of H-Ras
by Podkalicka, Joanna and Biernatowska, Agnieszka and Olszewska, Paulina and Tabaczar, Sabina and Sikorski, Aleksander F
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 26, pp. 18410 - 18421
Signaling complexes are localized to distinct plasma-membrane domains which undergo precise spatiotemporal regulation. A crucial link between membrane dynamics... 
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5. Full Text Galectin-1 promotes lung cancer tumor metastasis by potentiating integrin alpha 6 beta 4 and Notch1/Jagged2 signaling pathway
by Hsu, YL and Wu, CY and Hung, JY and Lin, YS and Huang, MS and Kuo, PL
CARCINOGENESIS, ISSN 0143-3334, 06/2013, Volume 34, Issue 6, pp. 1370 - 1381
Lung cancer is a major cancer, leading in both incidence and mortality in the world, and metastasis underlies the majority of lung cancerrelated deaths.... 
INVASION | H-RAS | BETA-1-INTEGRIN | ONCOLOGY | NOTCH | RESISTANCE | RECEPTOR | FOCAL ADHESION KINASE | CELL MIGRATION | HUMAN BREAST-CANCER | BINDING
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6. Full Text Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling
by Buckles, Thomas C and Ziemba, Brian P and Masson, Glenn R and Williams, Roger L and Falke, Joseph J
Biophysical Journal, ISSN 0006-3495, 12/2017, Volume 113, Issue 11, pp. 2396 - 2405
Cellular pathways controlling chemotaxis, growth, survival, and oncogenesis are activated by receptor tyrosine kinases and small G-proteins of the Ras... 
TRANSFORMATION | H-RAS | BIOPHYSICS | HUMAN-ERYTHROCYTES | PI3K | MECHANISM | PATHWAY | ONCOGENIC MUTATIONS | PHOSPHOINOSITIDE 3-KINASES | DIFFUSION | MEMBRANE-PROTEINS | Index Medicus | Membranes
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7. Full Text K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
by Ostrem, Jonathan M and Peters, Ulf and Sos, Martin L and Wells, James A and Shokat, Kevan M
Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7477, pp. 548 - 551
Somatic mutations in the small GTPase K-Ras are the most common activating lesions found in human cancer, and are generally associated with poor response to... 
H-RAS P21 | SITE | LUNG | MUTAGENESIS | NUCLEOTIDE EXCHANGE | SMALL-MOLECULE | MULTIDISCIPLINARY SCIENCES | ONCOGENE PRODUCT P21 | KRAS | DISCOVERY | PROTEIN COMPLEX | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Substrate Specificity | Crystallography, X-Ray | Lung Neoplasms - pathology | Guanosine Triphosphate - metabolism | raf Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | Cysteine - genetics | Oncogene Protein p21(ras) - antagonists & inhibitors | Cysteine - metabolism | Guanosine Diphosphate - metabolism | Mutant Proteins - antagonists & inhibitors | Genes, ras - genetics | Allosteric Regulation - drug effects | Allosteric Site - drug effects | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Static Electricity | Drug Discovery | Cell Line, Tumor | Oncogene Protein p21(ras) - genetics | Proteins | Cysteine | GTP | Physiological aspects | Genetic aspects | Research | Health aspects | Oncogenes | Mutation (Biology) | Cancer | Labeling | Crystal structure | Index Medicus
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8. Full Text Targeting the α4–α5 dimerization interface of K-RAS inhibits tumor formation in vivo
by Khan, Imran and Spencer-Smith, Russell and O’Bryan, John P
Oncogene, ISSN 0950-9232, 2018, Volume 38, Issue 16, pp. 2984 - 2993
RAS genes are the most commonly mutated oncogenes in human cancers. Despite tremendous efforts over the past several decades, however, RAS-specific inhibitors... 
Growth conditions | Transformation | H-Ras protein | Doxycycline | Dimerization | K-Ras protein | Tumors | Cancer | tumorigenesis | RAS GTPases | monobody | oncogenesis
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9. Full Text Interplay between Membrane Curvature and Cholesterol: Role of Palmitoylated Caveolin-1
by Krishna, Anjali and Sengupta, Durba
Biophysical Journal, ISSN 0006-3495, 01/2019, Volume 116, Issue 1, pp. 69 - 78
Caveolin-1 (cav-1) is an important player in cell signaling and endocytosis that has been shown to colocalize with cholesterol-rich membrane domains.... 
LIPID MODIFICATIONS | VESICLE FUSION | H-RAS PROTEIN | BIOPHYSICS | PEPTIDE CONCENTRATION | DYNAMICS | FORCE-FIELD | MOLECULAR VIEW | BAR DOMAINS | BINDING | SCAFFOLDING DOMAIN
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10. Full Text Isoform-specific Ras signaling is growth factor dependent
by Hood, FE and Klinger, B and Newlaczyl, AU and Sieber, A and Dorel, M and Oliver, SP and Coulson, JM and Bluthgen, N and Prior, IA
MOLECULAR BIOLOGY OF THE CELL, ISSN 1059-1524, 04/2019, Volume 30, Issue 9, pp. 1108 - 1117
HRAS, NRAS, and KRAS isoforms are almost identical proteins that are ubiquitously expressed and activate a common set of effectors. In vivo studies have... 
ONCOGENIC K-RAS | REPLACEMENT | CELLS | H-RAS | N-RAS | PATHWAY | ACTIVATE RAF-1 | PROLIFERATION | MUTATIONS | CANCER | CELL BIOLOGY | Index Medicus
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11. Full Text The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins
by Rocks, Oliver and Gerauer, Marc and Vartak, Nachiket and Koch, Sebastian and Huang, Zhi-Ping and Pechlivanis, Markos and Kuhlmann, Jürgen and Brunsveld, Lucas and Chandra, Anchal and Ellinger, Bernhard and Waldmann, Herbert and Bastiaens, Philippe I.H
Cell, ISSN 0092-8674, 04/2010, Volume 141, Issue 3, pp. 458 - 471
Reversible S-palmitoylation of cysteine residues critically controls transient membrane tethering of peripheral membrane proteins. Little is known about how... 
CELLBIO | Cellbio | CYSTEINE-RICH DOMAIN | H-RAS | ACYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAFFICKING | GOLGI | PSD-95 | PLASMA-MEMBRANE | STRUCTURAL DETERMINANTS | PALMITATE TURNOVER | FAMILY | CELL BIOLOGY | Amino Acid Sequence | Cell Line | Sequence Alignment | Animals | Lipoylation | Humans | Molecular Sequence Data | Golgi Apparatus - metabolism | Membrane Proteins - metabolism | HeLa Cells | Phylogeny | Physiological aspects | Cysteine | Magneto-electric machines | Machinery | Membrane proteins | Index Medicus
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12. Full Text Transient GPI-anchored protein homodimers are units for raft organization and function
by Suzuki, Kenichi G. N and Kasai, Rinshi S and Hirosawa, Koichiro M and Nemoto, Yuri L and Ishibashi, Munenori and Miwa, Yoshihiro and Fujiwara, Takahiro K and Kusumi, Akihiro
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 9, pp. 774 - 783
Advanced single-molecule fluorescent imaging was applied to study the dynamic organization of raft-associated glycosylphosphatidylinositol- anchored proteins... 
ACTIVATION | MICRODOMAINS | H-RAS | SINGLE-MOLECULE TRACKING | K-RAS | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | PLASMA-MEMBRANE | LIVE CELLS | LIVING CELLS | Membrane Microdomains | Fluorescence Resonance Energy Transfer | CD59 Antigens - metabolism | Glycosylphosphatidylinositols - metabolism | Dimerization | Proteins | Signal transduction | Membranes | Cellular biology | Gene expression | Index Medicus
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13. Full Text Inhibition of RAS function through targeting an allosteric regulatory site
by Spencer-Smith, Russell and Koide, Akiko and Zhou, Yong and Eguchi, Raphael R and Sha, Fern and Gajwani, Priyanka and Santana, Dianicha and Gupta, Ankit and Jacobs, Miranda and Herrero-Garcia, Erika and Cobbert, Jacqueline and Lavoie, Hugo and Smith, Matthew and Rajakulendran, Thanashan and Dowdell, Evan and Okur, Mustafa Nazir and Dementieva, Irina and Sicheri, Frank and Therrien, Marc and Hancock, John F and Ikura, Mitsuhiko and Koide, Shohei and O'Bryan, John P and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Nature Chemical Biology, ISSN 1552-4450, 01/2017, Volume 13, Issue 1, pp. 62 - 68
RAS GTPases are important mediators of oncogenesis in humans. However, pharmacological inhibition of RAS has proved challenging. Here we describe a... 
ACTIVATION | GTP | III DOMAIN | H-RAS | K-RAS | STRUCTURAL BASIS | SOS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EFFECTOR INTERACTIONS | DIMERIZATION | BINDING-PROTEINS | NIH 3T3 Cells | Allosteric Site - drug effects | Antibodies, Monoclonal - pharmacology | Humans | Cells, Cultured | ras Proteins - antagonists & inhibitors | Cercopithecus aethiops | ras Proteins - metabolism | Animals | ras Proteins - chemistry | HEK293 Cells | Mice | Antibodies, Monoclonal - metabolism | COS Cells | Antibodies, Monoclonal - chemistry | Index Medicus
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14. Full Text The Role and Function of Ras-association domain family in Cancer: A Review
by Zinatizadeh, Mohammad Reza and Momeni, Seyed Ali and Zarandi, Peyman Kheirandish and Chalbatani, Ghanbar Mahmoodi and Dana, Hassan and Mirzaei, Hamidreza and Akbari, Mohammad Esmaeil and Miri, Seyed Rouhollah
Genes & Diseases, ISSN 2352-3042, 07/2019
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15. Full Text Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway
by Xiaolin Nan and Tanja M. Tamgüney and Eric A. Collisson and Li-Jung Linc and Cameron Pitt and Jacqueline Galeas and Sophia Lewis and Joe W. Gray and Frank McCormick and Steven Chu and Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2015, Volume 112, Issue 26, pp. 7996 - 8001
Rat sarcoma (Ras) GTPases regulate cell proliferation and survival through effector pathways including Raf-MAPK, and are the most frequently mutated genes in... 
Superresolution microscopy | Single molecule imaging | Ras dimer | Cancer | MAPK signaling | ONCOGENES | LOCALIZATION | single molecule imaging | N-RAS | MEMBRANE | MULTIDISCIPLINARY SCIENCES | superresolution microscopy | BRAF | MICROSCOPY | FORMS DIMERS | H-RAS | K-RAS | cancer | INHIBITORS | Cell Line | Cricetinae | Animals | ras Proteins - metabolism | Guanosine Triphosphate - metabolism | Enzyme Activation | Dimerization | MAP Kinase Signaling System | Mitogen-Activated Protein Kinases - metabolism | Usage | Research | Mammals | Electron microscopy | Health aspects | Risk factors | Mutation (Biology) | Mitogen-activated protein kinases | Proteins | Cell division | Signal transduction | Membranes | Microscopy | Kinases | Index Medicus | BASIC BIOLOGICAL SCIENCES | Biological Sciences
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