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PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0167145 - e0167145
RAS effectors specifically interact with the GTP-bound form of RAS in response to extracellular signals and link them to downstream signaling pathways. The... 
R-RAS | KRAS MUTATIONS | H-RAS | PHOSPHOINOSITIDE 3-OH KINASE | K-RAS | N-RAS | GTPASE-ACTIVATING PROTEINS | MULTIDISCIPLINARY SCIENCES | SWITCH I-REGION | PHOSPHOLIPASE-C-EPSILON | HYPERVARIABLE REGION | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Phosphatidylinositol 3-Kinases - metabolism | GTP Phosphohydrolases - chemistry | ral Guanine Nucleotide Exchange Factor - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Protein Domains | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Binding, Competitive | Amino Acid Sequence | Protein Structure, Secondary | Signal Transduction | Membrane Proteins - genetics | Phosphatidylinositol 3-Kinases - chemistry | Models, Molecular | Binding Sites - genetics | Monomeric GTP-Binding Proteins - genetics | ral Guanine Nucleotide Exchange Factor - genetics | Phosphatidylinositol 3-Kinases - genetics | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Carrier Proteins - metabolism | Class I Phosphatidylinositol 3-Kinases | GTP Phosphohydrolases - metabolism | Membrane Proteins - chemistry | Monomeric GTP-Binding Proteins - metabolism | GTP Phosphohydrolases - genetics | Monomeric GTP-Binding Proteins - chemistry | Protein Binding | Kinetics | ral Guanine Nucleotide Exchange Factor - metabolism | Structure | Analysis | Crystals | Protein binding | Binding | Fluorescence polarization | GTP | Hot spots | Fluorescence | Amino acids | Biochemistry | Kinases | Gene expression | K-Ras protein | Proteins | Studies | Signal transduction | Signaling | Cell growth | Next-generation sequencing | Isoforms | Cell cycle | Effectors | Mutation | Molecular biology | Cancer | Crystal structure | Structure-function relationships | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e62667 - e62667
Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase... 
SIGNAL-TRANSDUCTION PATHWAYS | PPAR-ALPHA | B TYPE-I | SCAVENGER RECEPTOR | REVERSE CHOLESTEROL TRANSPORT | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | APOA-I | LIVER-X-RECEPTORS | E-DEFICIENT MICE | HIGH-DENSITY-LIPOPROTEIN | Cricetinae | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cricetulus | Humans | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | ras Proteins - metabolism | ATP Binding Cassette Transporter 1 - chemistry | Cholesterol - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Gene Expression Regulation - drug effects | Proteolysis - drug effects | ATP-Binding Cassette Transporters - chemistry | Animals | MAP Kinase Signaling System - drug effects | ATP-Binding Cassette Transporters - genetics | Protein Stability - drug effects | ATP-Binding Cassette Transporters - metabolism | Biological Transport - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | ATP Binding Cassette Transporter 1 - genetics | CHO Cells | Proteolysis | DNA polymerases | Cellular signal transduction | Blood lipids | Macrophages | Mitogens | Protein kinases | Cholesterol | Protein binding | Phosphorylation | H-Ras protein | RNA-directed DNA polymerase | Transcription | Syngeneic grafts | Liver | Gene regulation | Kinases | Cell surface | Protein turnover | K-Ras protein | Degradation | ABCA1 protein | Proteins | Signal transduction | Pathways | Rodents | Atherosclerosis | Cell cycle | Inhibition | Lipoproteins (high density) | Efflux | Liver X receptors | Extracellular signal-regulated kinase | MAP kinase | Ras protein | Gene expression | Apolipoproteins | Polymerase chain reaction | Signaling | Lipoproteins | Inhibitors | Protein kinase | Pharmacy | Cell lines | ATP-binding protein | Transduction | ATP | Transporter | ABC transporter | Kidney transplantation | Index Medicus | Reacció en cadena de la polimerasa | Colesterol | Proteïnes quinases
Journal Article
Aging Cell, ISSN 1474-9718, 10/2017, Volume 16, Issue 5, pp. 1094 - 1103
Cellular senescence has been implicated in normal aging, tissue homeostasis, and tumor suppression. Although p53 has been shown to be a central mediator of... 
senescence | Akt | NOX | reactive oxygen species | p53 | NOX4 | CELLS | ACTIVATION | P53-INDUCED SENESCENCE | MTOR | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | OVEREXPRESSION | INHIBITION | ONCOGENIC RAS | GROWTH ARREST | ACCUMULATION | Interleukin-8 - genetics | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Proto-Oncogene Proteins p21(ras) - genetics | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | NF-kappa B - metabolism | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cell Cycle Checkpoints - genetics | Interleukin-8 - metabolism | Epithelial Cells - cytology | Mechanistic Target of Rapamycin Complex 2 - genetics | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Fibroblasts - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Lymphocytes - metabolism | Cellular Senescence - genetics | Promoter Regions, Genetic | NADPH Oxidase 4 - genetics | Interleukin-6 - genetics | Signal Transduction | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors | Lymphocytes - cytology | Morpholines | Mechanistic Target of Rapamycin Complex 2 - metabolism | NADPH Oxidase 4 - metabolism | NF-kappa B - genetics | Cell Cycle Checkpoints - drug effects | Fibroblasts - drug effects | Lymphocytes - drug effects | Cell Line, Tumor | Protein Binding | Fibroblasts - cytology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Chromones | RNA, Small Interfering - metabolism | Tumor proteins | Analysis | TOR protein | NF-κB protein | Senescence | H-Ras protein | p53 Protein | Homeostasis | AKT protein | Rapamycin | Interleukin 6 | Signal transduction | Cyclin-dependent kinase inhibitor p21 | NOX4 protein | Cell cycle | Fibroblasts | Interleukin 8 | Index Medicus | Original
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 11/2001, Volume 21, Issue 21, pp. 7345 - 7354
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2014, Volume 289, Issue 45, pp. 31102 - 31110
Ras is the most frequently activated oncogene found in human cancer, but its mechanisms of action remain only partially understood. Ras activates multiple... 
ORGAN SIZE | H-RAS | HIPPO-YAP PATHWAY | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATENIN | WNT | NF-KAPPA-B | CANCER | TUMOR-SUPPRESSOR RASSF1A | DEPENDENT DEGRADATION | Wnt Signaling | E3 Ubiquitin Ligase | Ras Protein | Tumor Suppressor Gene | Signal Transduction | Oncogene
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2017, Volume 19, Issue 4, pp. 292 - 305
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 20, pp. E3964 - E3973
Activation of phosphatidylinositol 3 kinase (PI3K), Ras, and Her2 signaling plays a critical role in cancer development. Hotspot constitutive activating... 
ΔNp63α | Cancer metastasis | PIK3CA | Ras | Her2 | SIGNALING PATHWAYS | PIK3CA MUTATIONS | CANCER CELLS | MULTIDISCIPLINARY SCIENCES | P63 | COMPREHENSIVE GENOMIC CHARACTERIZATION | LUNG-CANCER | PHOSPHATIDYLINOSITOL 3-KINASES | PI3K PATHWAY | PHOSPHOINOSITIDE 3-KINASES | Delta Np63 alpha | EXPRESSION | cancer metastasis | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Receptor, ErbB-2 - genetics | Humans | Receptor, ErbB-2 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Cell Movement - genetics | Forkhead Box Protein O3 - genetics | Tumor Suppressor Proteins - genetics | Female | Phosphatidylinositol 3-Kinase - metabolism | Gene Expression Regulation, Neoplastic - genetics | Genes, ras - genetics | PTEN Phosphohydrolase - genetics | Tumor Suppressor Proteins - metabolism | Signal Transduction | Transcription Factors - genetics | Forkhead Box Protein O3 - metabolism | Transcription Factors - metabolism | Neoplasm Metastasis - genetics | Animals | Breast Neoplasms - pathology | Protein Isoforms | Cell Line, Tumor | Mice | Mutation | Animal models | H-Ras protein | Epithelial cells | p53 Protein | Hot spots | AKT protein | Activation | Ras protein | Metastasis | ErbB-2 protein | Cells | K-Ras protein | 1-Phosphatidylinositol 3-kinase | Metastases | Proteins | Biopsy | Catalysis | In vitro methods and tests | Tumors | Cancer | FOXO3 protein | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Journal Article
Journal Article