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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 22, pp. 8107 - 8112
The source, timing, and geographical origin of the 1918–1920 pandemic influenza A virus have remained tenaciously obscure for nearly a century, as have the... 
H1N1 subtype influenza A virus | Pandemics | Influenza A virus | Swine | Mortality | Childhood | Antibodies | Viruses | Immunity | Age groups | Pathogenicity | Cohort immunity | Phylogeny | Reassortment | Virulence | UNITED-STATES | MORTALITY | reassortment | ORIGINAL ANTIGENIC SIN | NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | HUMAN SERA | PATTERNS | cohort immunity | pathogenicity | RESPONSES | DIFFERENT AGES | virulence | phylogeny | INFECTION | EPIDEMIOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Reassortant Viruses - pathogenicity | Humans | Influenza A virus - genetics | Reassortant Viruses - genetics | Disease Resistance - immunology | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Influenza A Virus, H3N8 Subtype - genetics | Influenza A Virus, H3N8 Subtype - pathogenicity | Influenza A Virus, H7N9 Subtype - immunology | Genetic Variation | Reassortant Viruses - immunology | Influenza A Virus, H7N9 Subtype - pathogenicity | Influenza A virus - pathogenicity | Influenza, Human - mortality | Adult | Influenza A virus - immunology | Influenza, Human - virology | Child | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - pathogenicity | Influenza Pandemic, 1918-1919 - mortality | Birds | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza A Virus, H3N2 Subtype - immunology | Biological Evolution | Animals | Influenza A Virus, H3N8 Subtype - immunology | Influenza A Virus, H5N1 Subtype - immunology | Influenza A Virus, H5N1 Subtype - pathogenicity | Aged | Influenza A Virus, H7N9 Subtype - genetics | Causes of | Epidemics | United States | Swine influenza | Biological Sciences
Journal Article
Journal Article
Science, ISSN 0036-8075, 7/2009, Volume 325, Issue 5937, pp. 197 - 201
Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages... 
H1N1 subtype influenza A virus | Maps | Pandemics | Influenza A virus | Swine | Environmental laboratories | Viruses | Orthomyxoviridae | Reports | Genomes | Public health | A VIRUS | UNITED-STATES | PIGS | TRANSMISSION | EVOLUTION | PATHOGENICITY | PHYLOGENETIC ANALYSIS | MULTIDISCIPLINARY SCIENCES | INFECTION | EMERGENCE | NORTH-AMERICA | Influenza A Virus, H1N1 Subtype - immunology | Viral Matrix Proteins - genetics | Influenza A Virus, H1N1 Subtype - classification | Swine Diseases - virology | Humans | Influenza A virus - genetics | Neuraminidase - genetics | Reassortant Viruses - genetics | Antigens, Viral - genetics | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Influenza A Virus, H3N2 Subtype - genetics | Phylogeny | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Genetic Variation | Hemagglutination Inhibition Tests | Influenza A Virus, H1N1 Subtype - isolation & purification | Disease Outbreaks | Genes, Viral | Influenza, Human - virology | Influenza A Virus, H1N1 Subtype - genetics | Genome, Viral | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Orthomyxoviridae Infections - veterinary | Viral Nonstructural Proteins - genetics | Influenza, Human - epidemiology | Antigens, Viral - immunology | Animals | Antibodies, Viral - immunology | Mutation | Orthomyxoviridae Infections - virology | Evolution, Molecular | Influenza, Human - immunology | Influenza viruses | Genetic aspects | Research | Health aspects | Swine influenza
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2008, Volume 105, Issue 11, pp. 4381 - 4386
The virulence of influenza virus is a multigenic trait. One determinant of virulence is the multifunctional NS1 protein that functions in several ways to... 
Proteins | H1N1 subtype influenza A virus | Lungs | Influenza A virus | Virulence | Viruses | Orthomyxoviridae | Amino acids | H5N1 subtype influenza A virus | Genetic mutation | PDZ domains | Influenza reverse genetics | PDZ ligand | H5N1 influenza | Mouse model for influenza | 1918 PANDEMIC VIRUS | ACTIVATION | BETA INDUCTION | MULTIDISCIPLINARY SCIENCES | PRE-MESSENGER-RNAS | NUCLEAR EXPORT | A-VIRUS | INTERFERON | IN-VIVO | mouse model for influenza | INFECTED-CELLS | influenza reverse genetics | V-PROTEIN | Interferons - biosynthesis | Lung Diseases - metabolism | Virulence Factors - genetics | Humans | Molecular Sequence Data | Influenza A Virus, H5N1 Subtype - genetics | Viral Nonstructural Proteins - chemistry | Recombination, Genetic - genetics | Female | Influenza A Virus, H5N1 Subtype - metabolism | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Disease Models, Animal | Amino Acid Sequence | Cell Line | Viral Nonstructural Proteins - genetics | Influenza A Virus, H1N1 Subtype - pathogenicity | Virulence Factors - chemistry | Mutation - genetics | Animals | Dogs | Influenza A Virus, H5N1 Subtype - chemistry | Influenza A Virus, H5N1 Subtype - pathogenicity | Viral Nonstructural Proteins - metabolism | Virulence Factors - metabolism | Influenza A Virus, H1N1 Subtype - chemistry | Mice | Mice, Inbred BALB C | Lung Diseases - pathology | Ligand binding (Biochemistry) | Viral proteins | Influenza | Influence | Models | Genetic aspects | Virulence (Microbiology) | Research | Properties | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 8/2010, Volume 329, Issue 5995, pp. 1060 - 1064
The rapid dissemination of the 2009 pandemic influenza virus underscores the need for universal influenza vaccines that elicit protective immunity to diverse... 
H1N1 subtype influenza A virus | Influenza vaccines | Immunization | Neutralizing antibodies | Vaccination | DNA | REPORTS | Antibodies | Viruses | Trimers | H3N2 subtype influenza A virus | HIV-1 | IMMUNIZATION | IMMUNITY | IMMUNOGENICITY | VIRUS | MULTIDISCIPLINARY SCIENCES | RECOMBINANT ADENOVIRAL VECTORS | Influenza A Virus, H1N1 Subtype - immunology | Orthomyxoviridae Infections - prevention & control | Influenza Vaccines - administration & dosage | Humans | Vaccines, DNA - immunology | Cross Protection | Male | Influenza A Virus, H2N2 Subtype - immunology | Macaca mulatta | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Vaccines, DNA - administration & dosage | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Antibodies, Neutralizing - immunology | Immunization, Secondary | Female | Mutant Proteins - immunology | Antibodies, Viral - biosynthesis | Ferrets | Influenza A Virus, H3N2 Subtype - immunology | Animals | Influenza Vaccines - immunology | Antibodies, Neutralizing - biosynthesis | Influenza A Virus, H5N1 Subtype - immunology | Plasmids | Antibodies, Viral - immunology | Mice | Mice, Inbred BALB C | Genetic Vectors | Influenza, Human - prevention & control | Orthomyxoviridae Infections - immunology | Influenza, Human - immunology | Research | Swine influenza | Vaccines | Swine flu | Influenza | Immune system
Journal Article
Journal Article
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 1/2013, Volume 207, Issue 2, pp. 262 - 271
Journal Article
Science, ISSN 0036-8075, 6/2013, Volume 340, Issue 6139, pp. 1459 - 1463
In the past, avian influenza viruses have crossed species barriers to trigger human pandemics by reassorting with mammal-infective viruses in intermediate... 
Disease transmission | Guinea pigs | Virulence | REPORTS | Data transmission | Viruses | Orthomyxoviridae | Mice | H5N1 subtype influenza A virus | Ferrets | Transmission efficiency | MAMMALIAN HOST | ORIGIN | INFLUENZA-A VIRUS | AVIAN FLU TRANSMISSION | HEMAGGLUTININ | H1N1 2009 VIRUS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | HUMANS | FERRETS | RECEPTOR SPECIFICITY | Reassortant Viruses - pathogenicity | Receptors, Virus - metabolism | Humans | Brain - virology | Molecular Sequence Data | Reassortant Viruses - genetics | Influenza A Virus, H5N1 Subtype - genetics | Viral Proteins - metabolism | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Respiratory System - virology | Genes, Viral | Influenza, Human - virology | Influenza A Virus, H1N1 Subtype - genetics | Amino Acid Sequence | Cell Line | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Reverse Genetics | Guinea Pigs | Receptors, Cell Surface - metabolism | Viral Proteins - genetics | Influenza A Virus, H1N1 Subtype - pathogenicity | Ribonucleoproteins - metabolism | Influenza, Human - transmission | Animals | Orthomyxoviridae Infections - transmission | Virus Replication | Influenza A Virus, H5N1 Subtype - pathogenicity | Mice, Inbred BALB C | Mutation | Orthomyxoviridae Infections - virology | Avian influenza | Viral genetics | Physiological aspects | Host-parasite relationships | Genetic aspects | Research | Epidemics | Neurons | Avian flu | Genes | Respiratory diseases
Journal Article