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Frontiers in Pharmacology, ISSN 1663-9812, 11/2017, Volume 8
...), while the chlorinated compound LINS01007 has moderate affinity for H4R (pKi 6.06). In addition, BRET assays to assess the functional activity of Gi1 coupling indicate that all compounds have no intrinsic activity and act as antagonists of these receptors... 
Histamine receptors | Anti-inflammatory activity | Dihydrobenzofuran | R antagonists | SAR | Asthma | Care and treatment | Inflammation | Health aspects | H3R antagonists | histamine receptors | dihydrobenzofuran | H4R antagonists | anti-inflammatory activity
Journal Article
Pharmacological Research, ISSN 1043-6618, 02/2018, Volume 128, pp. 18 - 28
[Display omitted] Due to the incidence of diabetes and the related morbidity of diabetic nephropathy, identification of new therapeutic strategies represents a... 
Histamine | Diabetic nephropathy | Diabetes | Histamine H4R antagonist | Kidney | JNJ39758979 | Histamine H | R antagonist
Journal Article
Allergy, ISSN 0105-4538, 11/2016, Volume 71, Issue 11, pp. 1561 - 1574
.... During the challenge phase, mice were treated orally with the H1R antagonist, loratadine, and/or the H4R antagonist, JNJ7777120. Bone marrow‐derived DCs (BMDCs... 
H1R | peanut allergy | dendritic cells | CD4+ T cells | H4R | CD4 | T cells | ALLERGIC INFLAMMATION | INDUCED AIRWAY INFLAMMATION | MAST-CELLS | T-CELL | IMMUNOLOGY | HYPERRESPONSIVENESS | RESPONSES | ALLERGY | LORATADINE | H-4 RECEPTOR | SKIN | CD4(+) T cells | EXPRESSION | Intestinal Mucosa - metabolism | Calcium - metabolism | Arachis - adverse effects | Dendritic Cells - immunology | Th2 Cells - immunology | Adoptive Transfer | Th2 Cells - drug effects | Intestinal Mucosa - drug effects | CD4-Positive T-Lymphocytes - immunology | Intestinal Mucosa - cytology | Th17 Cells - drug effects | Allergens - immunology | Th17 Cells - metabolism | Histamine H1 Antagonists - pharmacology | Intestinal Mucosa - immunology | Anaphylaxis - immunology | Histamine Antagonists - pharmacology | Dendritic Cells - drug effects | Female | Chemotaxis - immunology | Disease Models, Animal | Antigen-Presenting Cells - metabolism | Receptors, Histamine H4 - antagonists & inhibitors | Anaphylaxis - drug therapy | Cytokines - metabolism | Antigen-Presenting Cells - drug effects | Anaphylaxis - pathology | CD4-Positive T-Lymphocytes - metabolism | Chemotaxis - drug effects | Peanut Hypersensitivity - immunology | Transcription Factors - genetics | Antigen-Presenting Cells - immunology | Th2 Cells - metabolism | Transcription Factors - metabolism | Cell Lineage | Animals | Peanut Hypersensitivity - metabolism | Th17 Cells - immunology | Mice | Peanut Hypersensitivity - drug therapy | Peanut Hypersensitivity - pathology | Anaphylaxis - metabolism | CD4-Positive T-Lymphocytes - drug effects | Histamine receptors | Histamine | Food allergy | Allergens | Anaphylaxis | Dendritic cells | Analysis | Food allergies | Antigens | Lymphatic system | Inflammation | Rodents
Journal Article
亚太热带医药杂志:英文版, ISSN 1995-7645, 2010, Volume 3, Issue 6, pp. 465 - 470
... (100μg/kg×b.i.d.),and intramuscular H1R-antagonist(pheniramine,10 mg/kg×b.i.d.), H2R-antagonist(ranitidine,10 mg/kg×b.i.d.),H3R-antagonist(iodophenpropit,1μg/kg... 
Histamine | immune | receptors | Immunomodulation | Humoral | response | H3R-antagonist | H4R-antagonist | Histamine receptors | Humoral immune response | IMMUNE MODULATION | ALLERGIC INFLAMMATION | RESPONSES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | CELL | H-1 | TROPICAL MEDICINE
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 01/2012, Volume 22, Issue 1, pp. 461 - 467
... (VUF11489), as a new H R antagonist. Analysis of its binding kinetics at the human H R showed this compound to have a very different dissociative half-life in comparison with reference antagonist JNJ7777120. © 2011 Elsevier Ltd... 
Histamine | GPCR | Binding kinetics | Fragment optimization | R antagonist | CHEMISTRY, MEDICINAL | PHARMACOLOGICAL CHARACTERIZATION | CHEMISTRY, ORGANIC | DISCOVERY | INVERSE AGONISTS | POTENT | ANTIINFLAMMATORY PROPERTIES | CLONING | H4R antagonist | INFLAMMATION | IN-VIVO | BENZIMIDAZOLE | EXPRESSION
Journal Article
Journal Article
European Journal of Immunology, ISSN 0014-2980, 04/2015, Volume 45, Issue 4, pp. 1129 - 1140
Journal Article
Journal Article
Handbook of Experimental Pharmacology, ISSN 0171-2004, 2015, Volume 226, pp. 257 - 290
Histamine is one of the best-characterized pruritogens in humans. It is known to play a role in pruritus associated with urticaria as well as ocular and nasal... 
Allergic conjunctivitis | H1R antagonists | Atopic dermatitis | Urticaria | Allergic rhinitis | Pruritus | H4R antagonists | Receptors, Histamine - physiology | Animals | Histamine - physiology | Histamine Antagonists - therapeutic use | Pruritus - drug therapy | Humans
Journal Article
CURRENT ORGANIC CHEMISTRY, ISSN 1385-2728, 2018, Volume 22, Issue 17, pp. 1663 - 1672
Background: Histamine is a chemical transmitter widely distributed in the human body. It exerts its effects through the interaction with histaminergic... 
H4R inverse agonists | PHARMACOLOGICAL CHARACTERIZATION | CHEMISTRY, ORGANIC | anti-inflammatory drugs | DISCOVERY | H4 RECEPTOR | INVERSE AGONISTS | ANTIINFLAMMATORY PROPERTIES | PAIN | LIGANDS | inflammation | CLONING | IN-VIVO | antihistamines | H4R ligands | H-4 receptor | ANTAGONISTS | H4R antagonists
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 10/2009, Volume 18, Issue 10, pp. 1519 - 1531
Journal Article