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Journal of Virology, ISSN 0022-538X, 02/2014, Volume 88, Issue 3, pp. 1447 - 1460
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2019, Volume 27, Issue 18, pp. 4048 - 4058
3- -β-chacotriosyl ursolic acid amide derivative 14 displayed strong anti-H5N1 (IC50 = 1.05 μM) and the selectivity index greater than 952. Currently, entry... 
Structure-activity relationships | 3-O-β-chacotriosyl pentacyclic triterpenoids | H5N1 entry inhibitors | CHEMISTRY, MEDICINAL | VIRUS-INFECTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | 3-O-beta chacotriosyl pentacyclic triterpenoids | INFLUENZA | CHEMISTRY, ORGANIC | DISCOVERY | PENTACYCLIC TRITERPENOIDS | AGENTS | DERIVATIVES | BINDING
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2014, Volume 24, Issue 12, pp. 2680 - 2684
Compound exhibits excellent activity against H N and may serve as a lead compound or scaffold for the further development of H N entry inhibitor. To find novel... 
HA2 | Small molecular polyphenols | Synthesis | Entry inhibitor | Molecular modeling | Anti-H5N1 activity | OLIVE-OIL | HIV-1 FUSION | CHEMISTRY, MEDICINAL | HEMAGGLUTININ | INTEGRASE INHIBITION | CHEMISTRY, ORGANIC | OLEUROPEIN | DISCOVERY | GOSSYPOL DERIVATIVES | HYDROXYTYROSOL | INFLUENZA-VIRUS | BINDING
Journal Article
Journal of Carbohydrate Chemistry, ISSN 0732-8303, 10/2012, Volume 31, Issue 8, pp. 647 - 658
Journal Article
Journal of Carbohydrate Chemistry, ISSN 0732-8303, 10/2012, Volume 31, Issue 8, pp. 647 - 658
The earliest stage of influenza virus infection is the viral entry to the host cell. In our previous work, we discovered the first three small molecule H5N1... 
Entry inhibitors | H5N1 | Influenza | Structure-activity relationship | CONFORMATIONAL-CHANGE | HEMAGGLUTININ | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | OSELTAMIVIR | Infection | Carbohydrates | Saponins | Disaccharides | Structure-activity relationships
Journal Article
Reviews in Medical Virology, ISSN 1052-9276, 07/2016, Volume 26, Issue 4, pp. 242 - 250
Summary The entire life cycle of influenza virus involves viral attachment, entry, replication, and release. Previous studies have demonstrated that... 
ANTIVIRAL AGENTS | A H7N9 VIRUS | VIROLOGY | H5N1 VIRUS | DRUG DESIGN | FUSION INHIBITOR | SIALIC-ACID | A(H3N2) VIRUSES | CATALYTIC SITE | HIV ENTRY INHIBITORS | OSELTAMIVIR | Virus Release | Animals | Humans | Virus Attachment | Neuraminidase - metabolism | Orthomyxoviridae - physiology | Virus Internalization | Influenza viruses | Influenza
Journal Article
Jiegou Huaxue, ISSN 0254-5861, 12/2017, Volume 36, Issue 12, pp. 1987 - 1999
In this work, 25 3-O-beta-chacotriosyl ursolic acid derivatives were employed to achieve the highly reliable and predictive 3D-QSAR models by CoMFA and CoMSIA... 
3D-QSAR | Molecular design | DFT | H5N1 avian influenza A virus | H5N1 entry inhibitor | DESIGN | DOCKING | VALIDATION | CRYSTALLOGRAPHY | MODEL | FIELD ANALYSIS | CHEMISTRY, INORGANIC & NUCLEAR | TYROSINE KINASE INHIBITORS | molecular design | QSAR | COMSIA | MOLECULAR SIMILARITY INDEXES | BINDING
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 06/2011, Volume 660, Issue 2-3, pp. 460 - 467
Journal Article
Journal Article
Journal Article