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Journal of Clinical Investigation, ISSN 0021-9738, 08/2004, Volume 114, Issue 4, pp. 569 - 581
The transcription factor NF-kappaB is activated in a range of human cancers and is thought to promote tumorigenesis, mainly due to its ability to protect... 
TRANSCRIPTION FACTORS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | TUMOR PROGRESSION | HA-RAS | KINASE | INDUCIBLE CHEMORESISTANCE | CLASS-I GENES | MELANOMA-CELLS | INDUCTION | EXPRESSION
Journal Article
Journal Article
NATURE STRUCTURAL & MOLECULAR BIOLOGY, ISSN 1545-9993, 11/2013, Volume 20, Issue 11, pp. 1273 - 1280
Entomopathogenic Photorhabdus asymbiotica is an emerging pathogen in humans. Here, we identified a P. asymbiotica protein toxin (PaTox), which contains a... 
ACTIVATION | DOMAIN | PATHOGEN | ASYMBIOTICA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SALMONELLA | HOST | CELL BIOLOGY | BIOPHYSICS | HA-RAS | GLUCOSYLATION | GLYCOSYLTRANSFERASES | PHOTORHABDUS-LUMINESCENS
Journal Article
Cancer Research, ISSN 0008-5472, 03/2000, Volume 60, Issue 6, pp. 1541 - 1545
Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B), and its effector... 
TARGET | ONCOLOGY | ENOLASE-1 | PHOSPHATIDYLINOSITOL 3-KINASE | PROTEIN-KINASE | HA-RAS | GENE-EXPRESSION | AKT | V-SRC
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 05/2005, Volume 65, Issue 10, pp. 4005 - 4011
In human cutaneous malignant melanoma, a predominance of activated mutations in the N-ras gene has been documented. To obtain a mouse model most closely... 
STEM-CELLS | K-RAS | ONCOLOGY | N-RAS | HA-RAS | CUTANEOUS MELANOMA | IN-VIVO | MOUSE | MALIGNANT-MELANOMA | P16(INK4A) | TRANSGENIC MICE
Journal Article
by Yan, XX and Zhang, GJ and Bie, FJ and Lv, YH and Ma, Y and Ma, M and Wang, YR and Hao, XQ and Yuan, NJ and Jiang, XF
SCIENTIFIC REPORTS, ISSN 2045-2322, 10/2017, Volume 7
Alteration in cellular energy metabolism plays a critical role in the development and progression of cancer. Targeting metabolic pathways for cancer treatment... 
ONCOGENES | APOPTOSIS | MICROENVIRONMENT | ERR-ALPHA | HA-RAS | MULTIDISCIPLINARY SCIENCES | C-MYC | BREAST-CANCER STATISTICS | METABOLIC FLUX | TUMOR-GROWTH | PROGRESSION
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2006, Volume 116, Issue 1, pp. 261 - 270
Recent gene profiling studies have identified a new breast cancer subtype, the basal-like group, which expresses genes characteristic of basal epithelial cells... 
TRANSFORMATION | MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR RECEPTOR | ACTIVATED PROTEIN-KINASE | INDUCED APOPTOSIS | C-HA-RAS | CASPASE-3 | EXPRESSION | CARCINOMA | TUMORS | MAMMARY EPITHELIAL-CELLS
Journal Article
The American Journal of Pathology, ISSN 0002-9440, 2001, Volume 159, Issue 2, pp. 431 - 437
Extensive studies have demonstrated that the Akt/AKT1 pathway is essential for cell survival and inhibition of apoptosis; however, alterations of Akt/AKT1 in... 
V-HA-RAS | SERINE-THREONINE KINASE | C-AKT | PHOSPHORYLATION | PROTEIN-KINASE | PHOSPHATIDYLINOSITOL 3-KINASE | GROWTH-FACTORS | MOLECULAR-CLONING | OVARIAN-CANCER | PATHOLOGY | NF-KAPPA-B | Short Communications
Journal Article
JOURNAL OF VIROLOGY, ISSN 0022-538X, 09/2007, Volume 81, Issue 17, pp. 9299 - 9306
Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A) is widely expressed in EBV-infected cells within the infected human host and EBV-associated... 
SIGNAL-TRANSDUCTION | NASOPHARYNGEAL CARCINOMA | IN-VITRO | VIROLOGY | EPITHELIAL-CELLS | TYROSINE PHOSPHORYLATION | HA-RAS | ENCODED LMP2A | GROWTH | LYMPHOCYTE INFECTION | HODGKIN LYMPHOMA
Journal Article
NEOPLASIA, ISSN 1476-5586, 09/2004, Volume 6, Issue 5, pp. 603 - 610
Transforming growth factor-beta1 (TGF-beta1) can be tumor-suppressive through the activation of the Smad-mediated signaling pathway. TGF-beta1 can also enhance... 
SIGNAL-REGULATED KINASE-2 | CANCER CELLS | PROXIMAL TUBULAR CELLS | MESENCHYMAL TRANSITION | EMT | TGF-beta | GROWTH-FACTOR-BETA | EPITHELIAL-CELLS | ONCOLOGY | HA-RAS | in vitro | TRANSFORMING GROWTH-FACTOR-BETA-1 | GENE-EXPRESSION | pathway | DEPENDENT MECHANISM | Erk
Journal Article
Cell Cycle, ISSN 1538-4101, 01/2019, Volume 18, Issue 2, pp. 204 - 225
Numerous studies exploring oncogenic Ras or manipulating physiological Ras signalling have established an irrefutable role for Ras as driver of cell cycle... 
cyclin D | DNA synthesis | S-phase | Ras | PI3K cell cycle | Erk | G1 | KINASE 1 | PROLIFERATION | PLASMA-MEMBRANE | CELL BIOLOGY | HA-RAS | SUSTAINED ACTIVATION | CELL-CYCLE | GROWTH-FACTOR | DEPENDENT ACTIVATION | EXPRESSION
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 06/2014, Volume 74, Issue 12, pp. 3344 - 3356
The c-Jun N-terminal protein kinase (JNK) and its two direct activators, namely the mitogen-activated protein kinase (MAPK) kinase 4 (MKK4) and MKK7,... 
ONCOGENIC K-RAS | ONCOLOGY | PROTEIN-KINASE | HA-RAS | JUN ACTIVATION DOMAIN | TUMOR-SUPPRESSOR | ADULT MICE | C-JUN | INTRAEPITHELIAL NEOPLASIA | TRANSDUCTION PATHWAY | CANCER
Journal Article
MUTAGENESIS, ISSN 0267-8357, 07/2018, Volume 33, Issue 4, pp. 301 - 310
Reactive oxygen species generate 8-oxo-7,8-dihydroguanine (G(o), 8-hydroxyguanine), which induces G:C -> T:A transversion mutations. The knockdowns of the... 
FUNCTIONAL INTERACTION | C-HA-RAS | GENETICS & HEREDITY | FLAP ENDONUCLEASE-1 | TOXICOLOGY | HUMAN RECQ HELICASES | BASE DAMAGE | SEQUENCE CONTEXTS | MAMMALIAN-CELLS | WERNER-SYNDROME PROTEIN | MUTY HOMOLOG HMYH | 8-HYDROXYGUANINE 7,8-DIHYDRO-8-OXOGUANINE
Journal Article