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1. Full Text Studies into prekallikrein activation pave the way for new avenues of antithrombotic research
by Li, Xian and Wood, Jeremy P
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 05/2019, Volume 17, Issue 5, pp. 717 - 719
In recent years, the contact pathway of coagulation has received increased attention as it appears to be more relevant to pathologic thrombosis than to normal... 
PLASMA | HUMAN HAGEMAN-FACTOR | FACTOR-XI | PERIPHERAL VASCULAR DISEASE | CONTACT ACTIVATION | HEMATOLOGY | BINDING | REVEALS
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2. Full Text The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo
by Maeda, Hiroshi and Nakamura, Hideaki and Fang, Jun
Advanced Drug Delivery Reviews, ISSN 0169-409X, 01/2013, Volume 65, Issue 1, pp. 71 - 79
The EPR effect results from the extravasation of macromolecules or nanoparticles through tumor blood vessels. We here provide a historical review of the EPR... 
Tumor-selective drug delivery | Enhancement of the EPR effect | Fluorescent nanoprobes | Tumor blood vessel architecture | Inflammation | EPR effect mediators | Vascular effectors | Cancer | MOLECULAR-WEIGHT | SERRATIAL PROTEASE | ELEVATING BLOOD-PRESSURE | CANCER-CHEMOTHERAPY | KININ-GENERATING CASCADE | OILY CONTRAST-MEDIUM | ENHANCED VASCULAR-PERMEABILITY | NITRIC-OXIDE SCAVENGER | HAGEMAN-FACTOR | PHARMACOLOGY & PHARMACY | TARGETED DELIVERY | Neoplasms - metabolism | Nanoparticles - chemistry | Humans | Macromolecular Substances - administration & dosage | Capillary Permeability - drug effects | Neoplasms - blood supply | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - chemistry | Antineoplastic Agents - toxicity | Neoplasms - drug therapy | Animals | Macromolecular Substances - chemistry | Antineoplastic Agents - pharmacokinetics | Nanoparticles - administration & dosage | Neoplasms - pathology | Drug Delivery Systems - methods | Hypertension | Drugs | Drug delivery systems | Care and treatment | Architecture | Albumin | Nitrogen compounds | Permeability | Endothelium | Vehicles | Nitric oxide | Angiotensin converting enzyme | Angiotensin | Physiological aspects | Vascular endothelial growth factor | Nanotechnology
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3. Full Text Misfolded proteins activate Factor XII in humans, leading to kallikrein formation without initiating coagulation
by Maas, C and Govers-Riemslag, JWP and Bouma, B and Schiks, B and Hazenberg, BPC and Lokhorst, HM and Hammarstrom, P and ten Cate, H and de Groot, PG and Bouma, BN and Gebbink, MFBG
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 09/2008, Volume 118, Issue 9, pp. 3208 - 3218
When blood is exposed to negatively charged surface materials such as glass, an enzymatic cascade known as the contact system becomes activated. This cascade... 
CROSS-BETA STRUCTURE | MEDICINE, RESEARCH & EXPERIMENTAL | CONTACT SYSTEM | INTRINSIC PATHWAY | BLOOD-COAGULATION | MOLECULAR-WEIGHT KININOGEN | AMYLOID FIBRIL | ADVERSE CLINICAL EVENTS | HAGEMAN-FACTOR | COMMON MECHANISM | BOVINE ALPHA-LACTALBUMIN
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4. Full Text Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects
by Maeda, Hiroshi
Bioconjugate Chemistry, ISSN 1043-1802, 05/2010, Volume 21, Issue 5, pp. 797 - 802
This paper briefly documents the history of the discovery of the EPR (enhanced permeability and retention) effect and elucidates an analogy between bacterial... 
ELEVATING BLOOD-PRESSURE | CANCER-CHEMOTHERAPY | KININ-GENERATING CASCADE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | CHEMISTRY, MULTIDISCIPLINARY | OILY CONTRAST-MEDIUM | ENHANCED VASCULAR-PERMEABILITY | IMAGE-ENHANCEMENT | NITRIC-OXIDE SCAVENGER | HAGEMAN-FACTOR | SOLID TUMOR | TARGETED DELIVERY | Animals | Capillary Permeability | Humans | Macromolecular Substances - administration & dosage | Macromolecular Substances - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - administration & dosage | Drug Delivery Systems - trends | Pharmaceutical Preparations - administration & dosage | Pharmacokinetics | Drug Delivery Systems - methods | Neoplasms - drug therapy
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5. Full Text In vivo roles of factor XII
by Renné, Thomas and Schmaier, Alvin H and Nickel, Katrin F and Blombäck, Margareta and Maas, Coen
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 22, pp. 4296 - 4303
Coagulation factor XII (FXII, Hageman factor, EC = 3.4.21.38) is the zymogen of the serine protease, factor XIIa (FXIIa). FXII is converted to FXIIa through... 
COAGULATION-FACTOR-XII | CONTACT SYSTEM | BLOOD-COAGULATION | HEREDITARY ANGIOEDEMA | MAST-CELLS | HAGEMAN-FACTOR | VASCULAR-PERMEABILITY | ARTERIAL THROMBUS FORMATION | HEMATOLOGY | TISSUE FACTOR | KININOGEN-BINDING-SITE | Factor XII - genetics | Hemostasis - physiology | Blood Vessels - metabolism | Humans | Hemostasis - genetics | Factor XII - physiology | Inflammation - etiology | Inflammation - blood | Mice, Knockout | Animals | Models, Biological | Thrombosis - etiology | Factor XII - metabolism | Inflammation - genetics | Blood Coagulation - genetics | Thrombosis - genetics | Mice | Blood Coagulation - physiology | Thrombosis - blood | Blood Vessels - physiology | Review
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6. Full Text Design and characterization of alpha 1-antitrypsin variants for treatment of contact system-driven thromboinflammation
by de Maat, S and Sanrattana, W and Mailer, RK and Parr, NMJ and Hessing, M and Koetsier, RM and Meijers, JCM and Pasterkamp, G and Renne, T and Maas, C
BLOOD, ISSN 0006-4971, 11/2019, Volume 134, Issue 19, pp. 1658 - 1669
The contact system produces the inflammatory peptide bradykinin and contributes to experimental thrombosis. C1 esterase-inhibitor (C1INH) deficiency or... 
PLASMA KALLIKREIN | SUBSTRATE-SPECIFICITY | PROPROTEIN CONVERTASE | ACTIVATED PROTEIN-C | HEREDITARY ANGIOEDEMA | ADENOASSOCIATED VIRUS | FACTOR-XIA | ULCERATIVE-COLITIS | HAGEMAN-FACTOR | HEMATOLOGY | RECEPTOR ANTAGONIST
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7. Full Text Fibrinolysis and bradykinin formation: From in vitro observations to human disease in "just'' 45 years
by Kaplan, AP
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 11/2016, Volume 138, Issue 5, pp. 1424 - 1425
KALLIKREIN | ACTIVATION | Hereditary angioedema | THERAPY | PLASMA | ALLERGY | SURFACE | HAGEMAN-FACTOR | ANGIOEDEMA TYPE-III | IMMUNOLOGY | PREKALLIKREIN
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8. Full Text Proteins, platelets, and blood coagulation at biomaterial interfaces
by Xu, Li-Chong and Bauer, James W and Siedlecki, Christopher A
Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, 12/2014, Volume 124, pp. 49 - 68
Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices. There is still significant... 
Surfaces | Blood compatibility | Biological response | Thrombosis | Coagulation | Biomaterials | MATERIALS SCIENCE, BIOMATERIALS | SELF-ASSEMBLED MONOLAYERS | DEPENDENT FUNCTIONAL-ACTIVITY | CHEMISTRY, PHYSICAL | CONTACT ACTIVATION | VON-WILLEBRAND-FACTOR | ATOMIC-FORCE MICROSCOPY | BIOPHYSICS | HUMAN HAGEMAN-FACTOR | MONOCLONAL-ANTIBODY BINDING | FIBRINOGEN ADSORPTION | ACTIVATED HUMAN PLATELETS | FACTOR FACTOR-XII | Blood Coagulation - drug effects | Humans | Surface Properties | Fibrinogen - chemistry | Blood Platelets - physiology | Proteins - chemistry | Biocompatible Materials - adverse effects | Biological products | Biomedical engineering | Blood coagulation | Surgical implants | Biomedical materials | Medical devices | Interrogation | Biological | Platelets
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9. Full Text The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities
by Schmaier, A. H
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 01/2016, Volume 14, Issue 1, pp. 28 - 39
Summary The contact activation system (CAS) and kallikrein/kinin system (KKS) are older recognized biochemical pathways that include several proteins that... 
bradykinin | contact activation | kallikrein/kinin system | kininogen | prekallikrein | factor XII | Kininogen | Kallikrein/kinin system | Contact activation | Factor XII | Prekallikrein | Bradykinin | HEREDITARY ANGIOEDEMA | BLOOD-COAGULATION | MOLECULAR-WEIGHT KININOGEN | 4 TANDEM REPEATS | COAGULATION-FACTOR-XII | PLASMA PREKALLIKREIN | ENDOTHELIAL-CELLS | HAGEMAN-FACTOR | PERIPHERAL VASCULAR DISEASE | HEPARAN-SULFATE PROTEOGLYCANS | ANGIOEDEMA TYPE-III | HEMATOLOGY | Factor XIIa - metabolism | Plasma Kallikrein - metabolism | Thrombosis - physiopathology | Bradykinin - metabolism | Prekallikrein - immunology | Humans | Homeostasis | Inflammation | Kininogen, High-Molecular-Weight - metabolism | Prekallikrein - deficiency | Prekallikrein - metabolism | Animals | Kallikrein-Kinin System | Receptors, Bradykinin - metabolism | Blood Coagulation Disorders - immunology | Hemostasis | Factor XII - metabolism | Blood Coagulation | Mice | Proteins | Physiological aspects | Cells | Angiotensin
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10. Full Text Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System
by Kishimoto, Takashi Kei and Viswanathan, Karthik and Ganguly, Tanmoy and Elankumaran, Subbiah and Smith, Sean and Pelzer, Kevin and Lansing, Jonathan C and Sriranganathan, Nammalwar and Zhao, Ganlin and Galcheva-Gargova, Zoya and Al-Hakim, Ali and Bailey, Gregory Scott and Fraser, Blair and Roy, Sucharita and Rogers-Cotrone, Thomas and Buhse, Lucinda and Whary, Mark and Fox, James and Nasr, Moheb and Dal Pan, Gerald J and Shriver, Zachary and Langer, Robert S and Venkataraman, Ganesh and Austen, K. Frank and Woodcock, Janet and Sasisekharan, Ram
The New England Journal of Medicine, ISSN 0028-4793, 06/2008, Volume 358, Issue 23, pp. 2457 - 2467
Recently the heparin supply in 12 countries was found to be contaminated with a substance that caused hypotension and, in some cases, death. The contaminant... 
MEDICINE, GENERAL & INTERNAL | PLASMA KALLIKREIN | COMPLEMENT | DEXTRAN SULFATE | INHIBITION | ALTERNATIVE PATHWAY | HAGEMAN-FACTOR | ANTITHROMBIN | COFACTOR | RABBIT | FACTOR-XII | Complement C3a - drug effects | United States | Humans | Middle Aged | Complement C5a - biosynthesis | Heparin - adverse effects | Complement C5a - drug effects | Chondroitin Sulfates - adverse effects | Anaphylaxis - chemically induced | China | Chondroitin Sulfates - analysis | Female | Complement Activation - drug effects | United States Food and Drug Administration | Complement C3a - biosynthesis | Drug Industry | Chondroitin Sulfates - pharmacology | Hypotension - chemically induced | Animals | Kallikreins - drug effects | Sus scrofa | Drug Contamination | Germany | Heparin - chemistry | Kallikreins - metabolism | Composition | Heparin | Health aspects | Chondroitin | Drug therapy | Hemodialysis | Family medical history | Index Medicus | Abridged Index Medicus
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11. Full Text Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: opposite and synergistic effects of factors XI and YII
by Doggen, CJM and Rosendaal, FR and Meijers, JCM
BLOOD, ISSN 0006-4971, 12/2006, Volume 108, Issue 13, pp. 4045 - 4051
The role of the intrinsic coagulation system on the risk of myocardial infarction is unclear. In the Study of Myocardial Infarctions Leiden (SMILE) that... 
FIBRINOLYSIS | ACTIVATION | MIDDLE-AGED MEN | MOLECULAR-WEIGHT KININOGEN | FACTOR-VIII | VENOUS THROMBOSIS | HAGEMAN-FACTOR | HEMOSTATIC FACTORS | CORONARY-HEART-DISEASE | HEMATOLOGY | DEFICIENCY
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12. Full Text Hereditary Angioedema Attacks Resolve Faster and Are Shorter after Early Icatibant Treatment
by Maurer, Marcus and Aberer, Werner and Bouillet, Laurence and Caballero, Teresa and Fabien, Vincent and Kanny, Gisèle and Kaplan, Allen and Longhurst, Hilary and Zanichelli, Andrea and I O S Investigators
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e53773
Background: Attacks of hereditary angioedema (HAE) are unpredictable and, if affecting the upper airway, can be lethal. Icatibant is used for physician- or... 
ANTAGONIST ICATIBANT | ACTIVATION | C1-INHIBITOR CONCENTRATE | PLASMA | EDEMA | MULTIDISCIPLINARY SCIENCES | HAGEMAN-FACTOR | RECEPTOR ANTAGONIST | BRADYKININ | PREKALLIKREIN | DEFICIENCY | Angioneurotic edema | Care and treatment | Bradykinin | Physiological aspects | Genetic aspects | Research | Diagnosis | Health care | Edema | Dermatology | Angioedema | Patients | Asthma | Mode of action | Studies | Respiratory tract | Hospitals | Early experience | Adults
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13. Full Text Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations
by de Maat, Steven, MSc and Björkqvist, Jenny, PhD and Suffritti, Chiara, PhD and Wiesenekker, Chantal P., MSc and Nagtegaal, Willem and Koekman, Arnold, BSc and van Dooremalen, Sanne, BSc and Pasterkamp, Gerard, PhD and de Groot, Philip G., PhD and Cicardi, Marco, PhD and Renné, Thomas, PhD and Maas, Coen, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 5, pp. 1414 - 1423.e9
Background Patients with angioedema experience unpredictable attacks of tissue swelling in which bradykinin is implicated. Several distinct mutations in Factor... 
Allergy and Immunology | kininogen | Angioedema | plasmin | bradykinin | plasma kallikrein | Factor XII | C1 esterase inhibitor | Kininogen | Immunology | Bradykinin | Plasma kallikrein | Immunology and Allergy | Plasmin | Journal Article | KALLIKREIN CLEAVAGE | CONTACT SYSTEM ACTIVATION | IMMUNOLOGY | FIBRINOLYTIC SYSTEM | NORMAL C1-INHIBITOR | DEFICIENCY | C1 INHIBITOR | F12 GENE | ALLERGY | HAGEMAN-FACTOR | COAGULATION | ALTEPLASE TREATMENT | Pregnancy | Bradykinin - metabolism | Factor XII - genetics | Angioedemas, Hereditary - metabolism | Factor XII - metabolism | Humans | Antifibrinolytic Agents - pharmacology | Female | Complement C1 Inhibitor Protein - metabolism | Mutation | Fibrinolysin - metabolism | Aminocaproic Acid - pharmacology | Angioneurotic edema | Care and treatment | Genetic aspects | Medical research | Medicine, Experimental | Kallikrein | Proteins | Plasma | Life sciences | Patients
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