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by Kim, DS and Fang, FG and Choi, HW and Fang, H
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 04/2019, Volume 84, Issue 8, pp. 4898 - 4903
Syntheses of a crystalline polycyclic halichondrin C1-C14 building block starting from a D-gulono-1,4-lactone-derived intermediate in the current Halaven... 
CONSTRUCTION | HALAVEN(R) SYNTHESIS | CHEMISTRY, ORGANIC | ANTITUMOR POLYETHER MACROLIDE | POLYHALOGENATED NUCLEOPHILES | MARINE SPONGE | CHLORIDE
Journal Article
Tetrahedron, ISSN 0040-4020, 08/2019, Volume 75, Issue 33, pp. 4570 - 4576
Synthesis of the C1–C13 fragment of eribulin mesylate has been accomplished. It features a highly stereoselective construction of a -dihydropyran framework... 
EPOTHILONE-B ANALOG | II CLINICAL-TRIAL | IXABEPILONE BMS-247550 | HALAVEN(R) SYNTHESIS | CHEMISTRY, ORGANIC | PHASE-II | STEREOSELECTIVE-SYNTHESIS | BUILDING-BLOCK | PHOSPHORORGANISCHE VERBINDUNGEN | MACROCYCLIC KETONE ANALOGS | POLYHALOGENATED NUCLEOPHILES | Eribulin mesylate | Fine chemicals
Journal Article
Natural Product Reports, ISSN 0265-0568, 8/2013, Volume 3, Issue 9, pp. 1158 - 1164
Journal Article
Organic Process Research & Development, ISSN 1083-6160, 02/2016, Volume 20, Issue 2, pp. 503 - 509
Here we examined the use of continuous flow conditions for the final assembly of eribulin mesylate aimed to avoid cryogenic condition. The diisobutylaluminum... 
SYSTEM | HALICHONDRIN-B | REACTORS | MICROREACTORS | HALAVEN(R) SYNTHESIS | CHEMISTRY | FRAGMENT | CHEMISTRY, ORGANIC | CHEMISTRY, APPLIED | MACROCYCLIC KETONE ANALOGS | MARINE SPONGE
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 06/2016, Volume 162, pp. 1 - 9
Journal Article
Organic Process Research & Development, ISSN 1083-6160, 01/2016, Volume 20, Issue 1, pp. 100 - 104
Potential issues associated with the scale up of a catalytic Nozaki–Hiyama–Kishi reaction and a Cr/Mn-mediated desulfonylation used in eribulin mesylate... 
HALICHONDRIN-B | SCALE-UP | COUPLING REACTIONS | MANUFACTURE | HALAVEN(R) SYNTHESIS | CHEMISTRY, ORGANIC | ALDEHYDES | CHEMISTRY, APPLIED | CHROMIUM | MACROCYCLIC KETONE ANALOGS | MARINE SPONGE | CHLORIDE
Journal Article
Synthesis, ISSN 0039-7881, 05/2018, Volume 50, Issue 9, pp. 1901 - 1906
Abstract Stereoselective synthesis of northern fragment of eribulin mesylate is reported by coupling of the C1–C13 fragment with the C28–C35 fragment. The key... 
paper | eribulin mesylate | total synthesis | samarium(II) iodide | d -mannose | desulfonylation | HALICHONDRIN-B | NORHALICHONDRIN-B | NATURAL-PRODUCTS | HALAVEN(R) SYNTHESIS | CHEMISTRY, ORGANIC | C1-C-13 FRAGMENT | ANTITUMOR POLYETHER MACROLIDE | MICHAEL REACTIONS | MARINE SPONGE | D-mannose | MACROCYCLIC KETONE ANALOGS | D-GLUCOSE
Journal Article
Organic Letters, ISSN 1523-7060, 11/2017, Volume 19, Issue 22, pp. 6092 - 6095
Prins reaction of homoallenyl alcohols with aldehyde dimethylacetals in the presence of methoxyacetic acid directly affords tetrasubstituted pyrans relevant to... 
SELECTIVE DEPROTECTION | HYDROGENOLYSIS | ALLYLIC CARBONATES | HALAVEN(R) SYNTHESIS | FRAGMENT | CHEMISTRY, ORGANIC | CATALYZED FORMATE REDUCTION | EN-ROUTE | CYCLIZATION | MACROCYCLIZATION | MARINE SPONGE
Journal Article
Planta Medica, ISSN 0032-0943, 06/2016, Volume 82, Issue 9-10, pp. 775 - 789
Journal Article
Organic Letters, ISSN 1523-7060, 06/2015, Volume 17, Issue 12, pp. 3158 - 3161
A novel and efficient method for the Cr(II)-mediated desulfonylation of alpha-sulfonyl ketone by a Cr-ligand-Mn system has been developed during the course of... 
HALICHONDRIN-B | ORGANIC-SYNTHESIS | REAGENTS | ANALOGS | HALAVEN(R) SYNTHESIS | FRAGMENT | CHEMISTRY, ORGANIC | ERIBULIN | CHROMIUM | MARINE SPONGE | Furans - chemistry | 2,2'-Dipyridyl - chemistry | Ketones - chemistry | Ligands | Sulfhydryl Compounds - chemistry | Molecular Structure | Catalysis | Chromium - chemistry | Manganese - chemistry
Journal Article
ACS Sustainable Chemistry & Engineering, ISSN 2168-0485, 01/2018, Volume 6, Issue 1, pp. 1121 - 1132
Designing efficient and green approaches to complex molecules is a challenge faced by any organization seeking to deliver modern pharmaceutical compounds to... 
Option analysis | Synthetic efficiency | Green chemistry | PMI | Predictive analytics | ENGINEERING, CHEMICAL | GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | HALAVEN(R) SYNTHESIS | FRAGMENT | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Frontiers in Marine Science, ISSN 2296-7745, 10/2018, Volume 5
Journal Article
Nature Reviews Chemistry, ISSN 2397-3358, 01/2017, Volume 1, Issue 2
The overall goal of a process chemistry department within the pharmaceutical industry is to identify and develop a commercially viable approach to a drug... 
TERTIARY BORONIC ESTERS | SECONDARY ALCOHOLS | KETONES | ASYMMETRIC-SYNTHESIS | ACID | ENANTIOSELECTIVE SYNTHESIS | CONVERSION | HALAVEN(R) SYNTHESIS | INHIBITOR | CHEMISTRY, MULTIDISCIPLINARY | DYNAMIC KINETIC RESOLUTION
Journal Article
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